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Anipryl


 
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  Product Info   How to use   Ingredients   Customer Reviews   Q & A  

What is Anipryl?

Anipryl (selegiline), also known as L-Deprenyl, is a monoamine oxidase inhibitor (MAOI) that treats Cushing's Disease and Canine Cognitive Dysfunction Syndrome (senility). Anipryl requires a prescription from your veterinarian.
For: Dogs

Benefits:
First and only FDA-approved drug used to control clinical signs associated with Canine Cognitive Dysfunction Syndrome
First and only product approved to control uncomplicated PDH (pituitary-dependent hyperadrenocorticism) Cushing’s disease

How it works:
Anipryl increases the concentration of a nervous system messenger chemical called dopamine. Higher levels of dopamine improve many cognitive processes. Treating Cushing's Disease has traditionally been centered on suppressing the adrenal gland’s production and release of cortisone. However, this approach has a high potential for side effects. Selegiline has allowed for a new approach by suppressing the pituitary gland directly.

Cautions:
Because Anipryl belongs to a class of drugs called Monoamine Oxidase Inhibitors (MAOI) it should not be given with antidepressants such as Prozac. Do not use in pregnant or nursing animals. If any serious side effects occur (difficulty breathing, hives, agitation; swelling of the lips, tongue or face), stop giving Anipryl and seek emergency veterinary medical attention.


More Information:
 
Brand Name
Anipryl (Pfizer Animal Health), Eldepryl (Somerset)
Generic Name
selegiline

What is the most important information I should know about Anipryl:
Anipryl is a prescription medication FDA approved for veterinary use in the treatment of Cushing's disease caused by a pituitary tumor in dogs. Anipryl is also used to treat canine cognitive dysfunction. Anipryl is available as 5mg, 10mg, 15mg and 30mg tablets. The usual initial starting dose to treat Cushing's disease in dogs is 0.45mg/pound given once a day in the morning. If no results within 2 months may increase to 0.9mg/pound once a day. If still no response after one month of the increased dose, reevaluate the pet. The dose for canine cognitive dysfunction is 0.2-0.45mg/pound. It may take up to one month or more to see improvement. Do not give more of this medication than is prescribed without consulting your veterinarian. Anipryl may cause drowsiness or dizziness.
 
What is Anipryl:
Anipryl, also known as L-deprenyl, is a monoamine oxidase inhibitor (MAOi) used in dogs for the treatment of Cushing's disease and canine cognitive dysfunction. It is not known specifically how Anipryl works. However, it is believed that Anipryl prevents the breakdown of dopamine. Anipryl may also be used for purposes other than those listed in this guide.
 
What should I discuss with my veterinarian before giving Anipryl to my pet:
Anipryl should not be given if the pet is taking meperidine. Tell your veterinarian about any other medical conditions your pet has. Tell your veterinarian if your pet is pregnant or lactating.
 
How should this medication be given:
Give this medication exactly as directed by your veterinarian. Allow pet to drink plenty of water. If you do not understand the directions ask the pharmacist or veterinarian to explain them to you. Store Anipryl at room temperature away from moisture and heat. Keep this medication away from children and pets.
 
What happens if I miss giving a dose:
Give the missed dose as soon as you remember. However, if is almost time for the next regularly scheduled dose, skip the missed dose and take the next one as directed. Do not give a double dose of the medication.
 
What happens if I overdose the pet:
Seek emergency veterinary medical treatment. Symptoms of Anipryl overdose include excitement, irritability, nervousness, insomnia, dizziness, severe headache, hallucinations, weakness, sweating and seizures.
 
What should I avoid while giving Anipryl to my pet:
Anipryl may cause dizziness or drowsiness. Do not give higher doses than those prescribed.
 
What are the possible side effects of Anipryl:
If any of the following serious side effects occur, stop giving Anipryl and seek emergency veterinary medical attention; an allergic reaction (difficulty breathing; swelling of the lips, tongue or face; hives), a severe headache, restlessness, agitation, or irritability, sweating, convulsions, uncontrollable or irregular movements. Other less serious side effects may occur. Continue giving Anipryl and talk to your veterinarian if your pet develops dizziness or drowsiness, nausea, abdominal pain or diarrhea, insomnia, mild confusion, agitation or anxiety, dry mouth. Other side effects may also occur. Talk to your veterinarian about any side effect that seems unusual or bothersome to the animal.
 
What other drugs will affect Anipryl:
Before giving Anipryl tell your veterinarian if your pet is also taking fluoxetine or meperidine. Talk to your veterinarian or pharmacist before giving any prescription or over the counter medicines.
 
Where can I get more information:
Your pharmacist has additional information about Anipryl written for health professionals that you may read.

Directions:

Anipryl is a prescription medication used in dogs for the treatment of Cushing’s disease caused by a pituitary tumor.
Anipryl is also used in dogs to treat canine cognitive dysfunction.

Tip: Do not give more of this medication than is prescribed without consulting your veterinarian. Anipryl may cause drowsiness or dizziness.
Dosage:
Pet Weight Dosage
Dogs: (when used for cognitive dysfunction) All weights The dose for canine cognitive dysfunction is 0.2mg-0.45mg per pound of body weight. It may take up to one month or more to see improvement
Dogs: (when used for Cushing’s disease) All weights The usual starting dose to treat Cushing’s disease is 0.45mg per pound of pet’s body weight given once a day in the morning. If no result within two months, may increase to 0.9mg per pound of pet’s body weight. If still no response after one month of the increased dose, reevaluate the pet
Cats:
Horses:
Storage: Should be stored at room temperature, away from moisture and heat.
Anipryl 10:
Active Ingredient Amount
Selegiline Hydrochloride 10 mg

Anipryl 15:
Active Ingredient Amount
Selegiline Hydrochloride 15 mg

Anipryl 30:
Active Ingredient: Amount
Selegiline Hydrochloride 30 mg

Anipryl 4.5 5 35 35
Newly, my 13 year old Westie, has been on Anipryl since January 2011. He has stopped his midnight pacing and panting and no longer experiences the early evening panic attacks ("sundowners?") that included barking, pawing and extreme trembling. This morning he was back outside, running like a mad man, barking at birds and bugs and having a great time! 04/12/2011
Effective in short amount of time We are amazed how active our 14 year old Shellie mix is since being on anipryl. She is more alert and runs with our other dog. At the beginning of this year she used to sleep all the time. Now she is awake almost all day long. Her incontinence of urine has subsided. She does occasionally regurgitate her saliva but not sure the cause of this. 08/08/2014
We are thankful for Anipryl! Our 15 yr. old mixed breed dog began to get confused when we would let her outside to use the bathroom. She would wander around and not come in when we called her. She began to use the bathroom in the house - during the night, and sometimes during the day (she had never done this in her lifetime!). She also began to whine and whimper a lot throughout the day - for no apparent reason. Our vet diagnosed dementia and recommended Anipryl. We have been very happy with the improvement!! She rarely uses the bathroom in the house. Her whining is much reduced. She is much like her old self. We are soooo thankful that this medicine has worked for her. 05/21/2014
Anipryl for Cog. Dysfunction My 17 year old Jack Russell has been on Anipryl for dementia for 2 months now. Previously he was so disoriented he would walk into his food or water dish and get stuck there whining until someone rescued him. He would also get stuck in corners and bark for help - not remembering how to back up or get free. After about a week on Anipryl he stopped walking into his dishes and getting stuck in corners. He will still walk up against corners but after a while he'll turn his head and move along. I have not seen any change in his disposition. He is still pretty low energy and no interest in toys or people like he used to exhibit when he was younger. He also doesn't run around or wag his tail as some other reviewers have noted (unfortunately). However, we are keeping him on Anipryl as it keeps him from getting stuck and waking us up at night. He also seems to rest better at night (somewhat). So although it has not been a miracle drug for us we have seen some improvement - enough to keep our dog with us for a while longer. We were at the point prior to Anipryl that we were going to have to euthanize him as neither the dog nor the humans in our house could get any sleep at night. If you are having severe issues with dementia this is worth a try. 03/10/2014
my 18 yr old male cairn Had come to the point of just staring at the wall most of the time. The first 2 weeks on this great drug brought him back AND he was also walking and reacting like his old self. He's still with me! going on 19! dw 09/04/2013
11 Questions · 11 Answers

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1 answer

ANIPRYL

Why are you completely out of this medication is all doses?
1 year, 8 months ago
by
Percy
Inland Emprire, California
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Answer: 
Our supply issues would correlate with how much medication is being manufactured. If the product is unavailable, it's most likely due to it being on back order with the manufacturer.
1 year, 8 months ago
by
Lilli Pharmacist
Pompano Beach, FL
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1 answer

cutting anipryl

started my dog on 5mg anipryl for cushings can i buy 10mg and split them ? and will they work as good.
2 years, 3 months ago
by
Anonymous
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Answer: 
Spencer, it would be best to contact your vet to see if the 10mg tabs are an option for your furry friend.
2 years, 3 months ago
by
Jason Pet Med Pro
Pompano Beach, FL
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can the vet prescribe a 30mg packet and I split it in half to get the recommended 15mg dosage? please let me know. thanks
smita
2 years, 7 months ago
by
Anonymous
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Answer: 
Great question. Yes. You can take the 30mg tablet and cut it in half if the recommended dose is 15mg. I would recommend using a pill splitter to do this.
2 years, 7 months ago
by
Gary, Dir. of Pharmacy Services
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Do the side affects eventually subside or do I need to stop giving them to her? Her vet is unfortunately not familiar with this medication. So I have to do all the ground work. I would appreciate any input
Thank you
2 years, 9 months ago
by
Nite
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Answer: 
You're saying your veterinarian prescribed a medication for your pet that she is not familiar with? Diarrhea and vomiting are common side effects for this medication. It's possible that the symptoms will go away as the pet gets used to the medication. However, if these symptoms continue more than 4 or 5 days, your veterinarian may want to consider either adjusting the dose or possibly using a different medication. In the meantime you should watch what you feed your pet and keep plenty of water available for her to drink.
2 years, 9 months ago
by
Gary, Dir. of Pharmacy Services
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Or coupons from the drug manufacturer to help pay for this very costly medication? My Lab takes 2, 30mg tabs every morning for Cushings.
3 years ago
by
Anonymous
Clarksburg, MA
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Unfortunately there is no generic available for this product.
3 years ago
by
Gary, Dir. of Pharmacy Services
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This information sheet is for educational purposes only and is intended to be a supplement to, and not a substitute for, the expertise and professional judgment of your veterinarian. The information is NOT to be used for diagnosis or treatment of your pet. You should always consult your own veterinarian for specific advice concerning the treatment of your pet. The information is not intended to cover all possible uses, directions, precautions, warnings, allergic reactions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for your pet. It is not a substitute for a veterinary exam, and it does not replace the need for services provided by your veterinarian.
Note: Any trademarks are the property of their respective companies.
 
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