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Amitriptyline


 
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  Product Info   How to use   Ingredients   Customer Reviews   Q & A  

What is Amitriptyline?

Amitriptyline is a tricyclic antidepressant. It’s used to treat certain behavioral problems, such as separation anxiety, fear of noises, and anxiety in dogs, and urinating out of the litter box, spraying, and anxiety in cats. Amitriptyline requires a prescription from your veterinarian.
For: Cats and Dogs

Benefits:
Treats behavioral issues in dogs, such as separation anxiety
Remedies feline behavioral problems, like urinating outside the litter box
Reduces the frequency of vet visits

How it works:
Amitriptyline affects chemicals in the brain that become unbalanced, leading to behavioral problems in your pet.

Cautions:
Side effects of Amitriptyline may include drowsiness, dizziness, loss of appetite, and urinary retention, and this product may interact with other products your pet is taking.


More Information:
 
Brand Name
Elavil (Merck)
Generic Name
Amitriptyline (am-e-tripí-ta-lean)

What is the most important information I should know about amitriptyline:
Amitriptyline is a prescription medication not FDA approved for veterinary use; however, it is a commonly accepted practice for veterinarians to use this medication in dogs and cats. Amitriptyline is available as 10mg, 25mg, 50mg and 75mg tablets. The usual initial dose for dogs is 0.5-2mg per pound every 8-12 hours. The usual dose in cats is 5-10mg per cat once a day, at night. This medication may not help symptoms right away. It may take a number of days before symptoms begin to lessen. Contact your veterinarian if symptoms get worse or if new symptoms develop while the pet is on this medication. Amitriptyline may cause drowsiness or dizziness.
 
What is Amitriptyline:
Amitriptyline is a Tricyclic antidepressant. Amitriptyline affects chemicals in the brain that may become unbalanced leading to behavioral problems in dogs and cats. Amitriptyline is used in dogs to treat conditions such as separation anxiety, anxiety and fear of noise. In cats, amitriptyline is used to treat conditions such as urinating outside of the litter box, spraying, excessive grooming and anxiety. Amitriptyline may also be used for purposes other than those listed in this guide.
 
What should I discuss with my veterinarian before giving amitriptyline to my pet:
Do not give this medication if your pet has taken or used a monoamine oxidase inhibitor (MAOI) such as selegiline, Mitaban Dip or Preventic Collar within the last 14 days. Tell your veterinarian if your pet has liver or kidney disease; asthma; thyroid disease; diabetes; stomach or intestinal problems; high blood pressure or heart disease; difficulty urinating, or glaucoma. Tell your veterinarian if the pet is pregnant or lactating.
 
How should this medication be given:
Give this medication exactly as directed by your veterinarian. Allow pet to drink plenty of water. If you do not understand the directions ask the pharmacist or veterinarian to explain them to you. Do not stop giving amitriptyline suddenly. This could cause symptoms such as nausea, headache and malaise. Store amitriptyline at room temperature away from moisture and heat. Keep this medication away from children and pets.
 
What happens if I miss giving a dose:
Give the missed dose as soon as you remember. However, if is almost time for the next regularly scheduled dose, skip the missed dose and take the next one as directed. Do not give a double dose of the medication.
 
What happens if I overdose the pet:
Seek emergency veterinary medical treatment. Symptoms of amitriptyline overdose include seizures, confusion, drowsiness, agitation, hallucinations and low blood pressure (dizziness, fatigue, fainting).
 
What should I avoid while giving Amitriptyline to my pet:
Amitriptyline may cause dizziness or drowsiness.
 
What are the possible side effects of Amitriptyline:
If any of the following serious side effects occur, stop giving amitriptyline and seek emergency veterinary medical attention; an allergic reaction (difficulty breathing; swelling of the lips, tongue or face, or hives); seizures; a fast or irregular heartbeat; high blood pressure; difficulty urinating; panting, muscle stiffness or severe muscle weakness. Other less serious side effects may occur. Continue giving amitriptyline and talk to your veterinarian if your pet has drowsiness or dizziness; dry mouth and eyes; constipation; panting; mild agitation, weakness or headache; nausea or loss of weight or appetite. Other side effects may also occur. Talk to your veterinarian about any side effect that seems unusual or bothersome to the animal.
 
What other drugs will affect Amitriptyline:
Do not give this medication if your pet has taken or used a monoamine oxidase inhibitor (MAOI) such as selegiline, Mitaban Dip or Preventic Collar within the last 14 days. Amitriptyline may increase the effects of other drugs that may cause drowsiness, including other antidepressants, antihistamines, sedatives, pain relievers, anxiety medications, and muscle relaxants. Drugs other than those listed may also interact with amitriptyline. Talk to your veterinarian or pharmacist before giving any prescription or over the counter medicines including herbal products.
 
Where can I get more information:
Your pharmacist has additional information about amitriptyline written for health professionals that you may read.



Call your veterinarian for medical advice about any side effects to your pet. You may report side effects to the FDA at 1-800-FDA-1088.

Directions:

Amitriptyline is a tricyclic antidepressant available by prescription for use in dogs to treat certain behavioral problems such as separation anxiety, fear of noises, and anxiety.
Amitriptyline is not FDA approved for use in veterinary medicine; however, it is a commonly accepted practice for veterinarians to prescribe this medication for dogs and cats.
Amitriptyline is used in cats to treat urinating out of the litter box, spraying, and anxiety.
Do not give this medication if your pet is or has been using an MAOi (monoamine oxidase inhibitor) such as Selegiline, Anipryl, Mitaban Dip, or Preventic Collar within the last 14 days.

Tip: It may take a number of days before symptoms begin to lessen. Allow pet to drink plenty of water. Do not stop giving Amitriptyline suddenly.
Dosage:
Pet Weight Dosage
Dogs: All weights The usual initial dose is 0.5-2 mg per pound of pet’s body weight every 8-12 hours
Cats/Kittens: All weights The usual dose is 5-10 mg once a day, at night
Horses:
Storage: Store Amitriptyline at room temperature away from moisture and heat.
Amitriptyline:
Active Ingredient Amount
Amitriptyline HCL 10 mg
Other Ingredients:
Colloidal silicone dioxide, hydroxypropyl cellulose, hydroxypropyl methylcellulose, lactose (monohydrate), magnesium stearate, microcrystalline cellulose, polyethylene glycol, pregelatinized starch (corn), titanium dioxide. 10 mg dose also includes: D & C Red # 27 Aluminum Lake, D & C Yellow #10 Aluminum Lake, and FD & C Blue #1 Aluminum Lake. 25 mg dose also includes: D & C Yellow Aluminum Lake. 50 mg dose also includes: FD & C Blue #2 Aluminum Lake, and FD & C Red #40 Aluminum Lake. 75 mg dose also includes: D & C Red #7 Calcium Lake, and FD & C Blue #2 Aluminum Lake.

Amitriptyline:
Active Ingredient Amount
Amitriptyline HCL 25 mg
Other Ingredients: Colloidal silicone dioxide, hydroxypropyl cellulose, hydroxypropyl methylcellulose, lactose (monohydrate), magnesium stearate, microcrystalline cellulose, polyethylene glycol, pregelatinized starch (corn), titanium dioxide. 10 mg dose also includes: D & C Red # 27 Aluminum Lake, D & C Yellow #10 Aluminum Lake, and FD & C Blue #1 Aluminum Lake. 25 mg dose also includes: D & C Yellow Aluminum Lake. 50 mg dose also includes: FD & C Blue #2 Aluminum Lake, and FD & C Red #40 Aluminum Lake. 75 mg dose also includes: D & C Red #7 Calcium Lake, and FD & C Blue #2 Aluminum Lake.

Amitriptyline:
Active Ingredient Amount
Amitriptyline HCL 50 mg
Other Ingredients: Colloidal silicone dioxide, hydroxypropyl cellulose, hydroxypropyl methylcellulose, lactose (monohydrate), magnesium stearate, microcrystalline cellulose, polyethylene glycol, pregelatinized starch (corn), titanium dioxide. 10 mg dose also includes: D & C Red # 27 Aluminum Lake, D & C Yellow #10 Aluminum Lake, and FD & C Blue #1 Aluminum Lake. 25 mg dose also includes: D & C Yellow Aluminum Lake. 50 mg dose also includes: FD & C Blue #2 Aluminum Lake, and FD & C Red #40 Aluminum Lake. 75 mg dose also includes: D & C Red #7 Calcium Lake, and FD & C Blue #2 Aluminum Lake.

Amitriptyline:
Active Ingredient Amount
Amitriptyline HCL 75 mg
Other Ingredients: Colloidal silicone dioxide, hydroxypropyl cellulose, hydroxypropyl methylcellulose, lactose (monohydrate), magnesium stearate, microcrystalline cellulose, polyethylene glycol, pregelatinized starch (corn), titanium dioxide. 10 mg dose also includes: D & C Red # 27 Aluminum Lake, D & C Yellow #10 Aluminum Lake, and FD & C Blue #1 Aluminum Lake. 25 mg dose also includes: D & C Yellow Aluminum Lake. 50 mg dose also includes: FD & C Blue #2 Aluminum Lake, and FD & C Red #40 Aluminum Lake. 75 mg dose also includes: D & C Red #7 Calcium Lake, and FD & C Blue #2 Aluminum Lake.

Amitriptyline 4.1 5 41 41
Hasn't worked for us yet I had such high hopes for this medication, but after 4 weeks on it (10 mg a day) my 5-year old neutered male Sammie is still spraying and going outside the box. We got him as a rescue about 2 months ago and he started spraying a few days after coming here. Had been told the reason he'd been given up was for spraying but the rescue place said they'd never seen him spray so I thought I'd take a chance on him. We have another cat (they get along OK but do have the ocassional altercation) and a dog who ignores him. Sammie was found to have some crystals in his urine, so he's been on Prescription Diet c/d. Was tested last week and still has a few crystals; was put on an antibiotic because they found a few red & white blood cells in his urine, too. The antibiotic gave him diarrhea, but thank goodness he at least does #2 in the litter boxes. The vet says she wants to clear up his urine before trying another medication, which I guess I can understand, but cleaning up after him every day is no fun. I can easily see why spraying is the #1 reason for turning in a beloved kitty cat, but I haven't given up on this guy yet. The vet suggested I get a leash and harness for him and get him outside, as that might help. I'll try anything at this point. There's also a new Prescription Diet food for "urinary stress" which I'll try. One of the vet techs says it helped her mother's spraying cat enormously. 07/26/2014
kitty uses litter box again Honeycat was semi-feral when I adopted her, and she's always been nervous. I've had her 10 months and suddenly she started going outside the litter box. I suspected it was her nerves, and a urinary test cleared her of medical issues, so the vet prescribed amitriptyline to settle her down and make her feel more secure so she doesn't need to "mark" territory. The one drawback is that it's hard to get her to take the pills, especially half-pills, because they are so bitter. 02/17/2014
PetMeds Came Through My cat started marking furniture (he's 7 and was neutered as a kitten#. After a series of test my local vet felt it was all anxiety disorder #my other cat was determined to have total control). She put LE on Amitriptyline & it worked! However, I was buying from my vet as a much higher price. Since I have 2 cats, 2 dogs & a horse to take care of, I welcome any discount I can get! I've dealt with PetMeds for years so new to go to their site. Highly recommend them. 12/29/2013
Excellent product Two female dogs of mine were prone to fights, although infrequently, were damaging to them and to me. There was little warning. After the vet recommended this drug for them, they have become reliable friends, playing together, and no fights or even threatening behavior. I am thrilled. 800PetMeds offers this drug made by Sandoz. I had tried the same drug but manufactured by another company through my local drugstore, and it did not work. 01/26/2013
Life changer! Our dog was adopted from a local shelter this year, who had rescued him from another shelter in northern KY. He's a Tibetian terrier and unknown to all had lots of anxiety/abandonment issues. After destroying several pieces of furniture and a large area rug, we were running out of options and didn't want to crate him all the time. He is a lover and has ton of energy. We turned to this product, and have a changed dog! I highly recommend it...has calmed our dog down, and he has quit chewing up everything in sight! 12/08/2012
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37 Questions · 48 Answers

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Can other natural supplements such as trumeel tablets (on 1800petmeds) and zeel be used with Amitriptyline?Traumeel Tablets are a homeopathic product, they have Belladonna 4X 75mg, Arnica Montana radix 3X 40mg, Aconitum napellus 3X 30mg, Chamomilla 3X, Symphytum officinale 8X 24mg each, Calendula officianalis 2X, Hamamelis virginiana 2X, Milefonium 3X, Hepar sulphurus calcaeum 8X, Mercurius solubilis 8X 15mg each, Hypericum perforatum 3X 8mg, Bellis perennis 2X, Echinacea angustifolia 2X, Echinacea purpurea 2X 6mg, in each tablet.
User submitted photo
2 months, 3 weeks ago
by
tootie
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Answer: 
There is limited information regarding homeopathic medications being used in combination with psychotropic drugs. Please consult with your veterinarian.
2 months, 3 weeks ago
by
Lilli Pharmacist
Pompano Beach, FL
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I have a 13 almost 14 year old pit bull terrior, she takes metacam liquid for her arthritis. Can Amitriptyline be given with metacam? Are there any known side affects related to other natural ingredients with this medication that anyone would know off also? I give her other natural things for her pain also.
User submitted photo
2 months, 4 weeks ago
by
tootie
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Answer: 
amitriptyline and metacam can be used together. You are right to check for any drug interactions
especially with amitriptline. Can you get the specific names of the natural products you are giving her ? It is important you get it any herbal/natural products checked out before you mix them with
drugs such as amitriptyline. Did you inform the vet ?
PS...the picture is adorable !
2 months, 3 weeks ago
by
Linda M 1800petmeds pharmacist
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5 months, 1 week ago
by
KOA
Maui, Hawaii
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Answer: 
Seizures; a fast or irregular heartbeat; high blood pressure; difficulty urinating; panting, muscle stiffness or severe muscle weakness are some of the more common side effects of this drug.
5 months ago
by
Pharmacist
Pompano beach
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7 months ago
by
Anonymous
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Answer: 
Yes, the two can be used together
7 months ago
by
Linda M 1800petmeds pharmacist
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8 months ago
by
Anonymous
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Answer: 
Please contact our pharmacy directly for the answer to this question.
7 months ago
by
Lilli Pharmacist
Pompano Beach, FL
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This information sheet is for educational purposes only and is intended to be a supplement to, and not a substitute for, the expertise and professional judgment of your veterinarian. The information is NOT to be used for diagnosis or treatment of your pet. You should always consult your own veterinarian for specific advice concerning the treatment of your pet. The information is not intended to cover all possible uses, directions, precautions, warnings, allergic reactions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for your pet. It is not a substitute for a veterinary exam, and it does not replace the need for services provided by your veterinarian.
Note: Any trademarks are the property of their respective companies.
 
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