My Account
Errors:

Advantage II

Starts $53.74 $38.69 
Ships in one business day or less
1
Select Pet's Weight:
Dog
03-10 lbs
11-20 lbs
21-55 lbs
55 lbs & up
Cat
02-05 lbs
05-09 lbs
09 lbs & up
2
Select a Supply:
4 pack
$53.74
$42.99
$38.69
Price w/coupon TENOFF
6 pack
$76.85
$61.48
$55.33
Price w/coupon TENOFF
Free Shipping
Save $2 over 4 pk
12 pack
$148.70
$118.96
$107.06
Price w/coupon TENOFF
Free Shipping
Save $9 over 4 pk
Starts $53.74 $38.69 
Ships in one business day or less
Please select all product options.
3
Select a Quantity:
Quantity
Please select all product options.
Product Info
How to Use
Ingredients
Customer Reviews
Q&A
Product Info
What is Advantage II?

Advantage II is a monthly flea preventative for dogs and cats that offers comprehensive flea protection by killing adult fleas, larvae, and eggs. Plus, it kills fleas through contact, which means fleas don't have to bite your pet to die. Advantage II also treats, prevents, and controls lice on dogs. Advantage II does not kill ticks, so we recommend using the Preventic Tick Collar along with Advantage II (dogs only). Advantage II for small cats 5-9 lbs can also be used for ferrets weighing 1 lb or over and 10 weeks of age or older.

For:

Dogs (3 lbs or over and 7 weeks of age or older), Cats (2 lbs or over and 8 weeks of age or older), Ferrets (1 lb or over and 10 weeks of age or older)

Benefits:
  • Convenient, once-a-month application
  • Kills through contact - fleas don't have to bite to die
  • Kills fleas within 12 hours of application on cats and dogs
  • Kills fleas within 24 hours of application on ferrets
  • Kills all flea life stages including flea eggs and larvae to prevent infestation
  • Treats, prevents, and controls lice infestations (dogs only)
  • Safe and easy to apply
  • Waterproof - remains effective even if pet gets wet (use of a soap-free shampoo is recommended)
How it Works:

The first active ingredient is imidacloprid, which acts on the nervous system of the flea to cause paralysis and subsequent death. Within 12 hours of application on cats and dogs, 98-100 percent of fleas are dead. Advantage II Small Cat kills the existing fleas on ferrets within 24 hours. The second active ingredient, pyriproxyfen, is an insect growth regulator. Once a female flea lays her eggs, pyriproxyfen works to prevent the eggs from hatching, ending the flea life cycle. Also, the active ingredient in Advantage II kills through contact, which means that fleas don't have to bite your pet to die. Reinfesting fleas are killed with protection against further flea infestation lasting for up to 4 weeks. Pre-existing pupae in the environment may continue to emerge for 6 weeks or longer depending upon the climactic conditions.

Cautions:

Individual sensitivities, while rare, may occur after using any pesticide product for pets. If signs persist, or become severe, consult a veterinarian immediately. Do not get this product in your pet's eyes or mouth.

Brand Name:

Advantage II (Bayer)

Active Ingredient(s):

Imidacloprid (9.1%), Pyriproxyfen (0.46%) Other ingredients (90.44%)

What is this product used for:

Advantage II Kitten, Advantage II Small Cat and Advantage II Large Cat are once a month topical flea prevention and treatment for cats and kittens over 8 weeks or older. Advantage II Small Cat may also be used for ferrets weighing 1 lb or over and 10 weeks of age or older. Advantage II Small Dog, Advantage II Medium Dog, Advantage II Large Dog, and Advantage II Extra Large Dog are once a month topical flea prevention and treatment for dogs and puppies 4 lbs or more and 7 weeks or older. Advantage II kills all flea life stages. Advantage II kills fleas within 12 hours of application. Advantage II for Dogs also treats, prevents, and controls lice infestations. Advantage II is waterproof and fragrance free.

Availability:

Advantage II for cats or ferrets and Advantage II for dogs are non-prescription (OTC) products.

How this product should be used:

Advantage II Kitten is available in 0.23 ml applicators for kittens 2-5 lbs (turquoise). Advantage II Small Cat is available in 0.4 ml applicators for cats 5-9 lbs or ferrets weighing 1 lb or over and 10 weeks of age or older (orange). Advantage II Large Cat is available in 0.8 ml applicators for cats 9 lbs & up (purple). Advantage II Small Dog is available in 0.4 ml applicators for dogs 3-10 lbs (green). Advantage II Medium Dog is available in 1.0 ml applicators for dogs 11-20 lbs (teal). Advantage II Large Dog is available in 2.5 ml applicators for dogs 21-55 lbs (red). Advantage II Extra Large Dog is available in 4.0 ml applicators for dogs over 55 lbs (blue). To apply, place the applicator tip through your pet's hair to the skin level. On cats and ferrets, apply to skin on neck at the base of the skull. For dogs up to 20 lbs, apply to skin on back between the shoulder blades. For dogs 21 lbs or over apply the contents of one tube to 3 or 4 spots along the skin on back from the shoulder to the tail. Do not get this product in the pet's eyes or mouth.

What are the side effects:

Individual sensitivities, while rare, may occur after using any pesticide product for pets. If signs persist, or become more severe, consult a veterinarian immediately.

What special precautions are there:

Advantage II is for external use on dogs and puppies 3 lbs or more and 7 weeks or older, cats and kittens 2 lbs or more and 8 weeks or older, or ferrets weighing 1 lb or over and 10 weeks of age or older. Consult a veterinarian before using on medicated pets, if the pet is being given this product along with other pesticides, and debilitated, aged, pregnant or nursing pets. This product causes eye irritation in humans and is harmful if swallowed. Avoid contact with skin. Call poison control center if swallowed. If on skin, wash with plenty of soap and water. If in eyes, flush with plenty of water.

In the event of overdose:

Contact your veterinarian or veterinary emergency room.

How should I store this product:

Store this product in a cool dry place. Do not store in the refrigerator. Do not reuse empty container. Do not contaminate water, food or feed by storage or disposal. To dispose of empty container place in trash or offer for recycling if available. If container is partly filled call local solid waste agency for disposal instructions. Never place unused product down any indoor or outdoor drain. Keep out of reach of children and pets.

How to Use
Directions:
  • Only use Advantage II on dogs/puppies over 3 lbs and over 7 weeks of age, cats/kittens over 2 lbs and over 8 weeks of age, and ferrets 1 lb or over and 10 weeks of age or older.
  • Apply Advantage II once a month every month.
  • For dogs up to 20 lbs, part the pet's hair between the shoulder blades until you can see the skin. Place the tip of the applicator on the skin and release all of the tube's contents on a single spot directly on the skin.
  • For dogs 21 lbs and over, apply entire contents of the tube evenly in 3 or 4 spots on the top of the back from the shoulder to the base of the tail. At each spot, part the hair until the skin is visible. Place the tip of the applicator on the skin and release a portion of the Advantage II solution directly on the skin. Do not apply an excessive amount of solution at any one spot that could cause some of the solution to run off the side of the dog.
  • For kittens, cats and ferrets, place the applicator tip through the cat's hair to the skin on the neck at the base of the skull and release all of the tube's contents on a single spot directly on the skin.
  • Use only one applicator per treatment.
Tip:

Under normal conditions Advantage II is effective for a month. However, in case of severe flea infestation, retreatment may be necessary earlier than four weeks. Do not re-treat cats or dogs more often than once every 7 days. For ferrets, do not retreat more often than every 14 days. After flea control is obtained, return to a monthly treatment.

Dosage:
Dogs/Puppies: (7 weeks of age or older)
Weight
Dosage
3-10 lbs
Apply contents of 1 applicator once a month (Green Box)
11-20 lbs
Apply contents of 1 applicator once a month (Teal Box)
21-55 lbs
Apply contents of 1 applicator once a month (Red Box)
Over 55 lbs
Apply contents of 1 applicator once a month (Blue Box)
Kittens: (8 weeks of age or older)
Weight
Dosage
2-5 lbs
Apply contents of 1 applicator once a month (Turquoise Box)
Cats: (8 weeks of age or older)
Ferrets: (1 lb or over and 10 weeks of age or older)
Weight
Dosage
Ferrets 1+ lbs
Apply contents of 1 applicator once a month (Orange Box)
5-9 lbs
Apply contents of 1 applicator once a month (Orange Box)
9 lbs & up
Apply contents of 1 applicator once a month (Purple Box)
Horses:
Do not use!
Storage:

Should be stored in a cool dry place. Do not refrigerate.

Ingredients
Advantage II for Kittens 2-5 lbs (Kitten - Turquoise Box) (0.23 mL):
Active Ingredients
% By Weight
Imidacloprid
9.10%
Pyriproxyfen
0.46%
Other Ingredients (not specified)
90.44%
Advantage II for Cats 5- 9 lbs or Ferrets 1 lb or over and 10 weeks of age or older (Small Cat - Orange Box) (0.4 mL):
Active Ingredients
% By Weight
Imidacloprid
9.10%
Pyriproxyfen
0.46%
Other Ingredients (not specified)
90.44%
Advantage II for Cats Over 9 lbs (Large Cat - Purple Box) (0.8 mL):
Active Ingredients
% By Weight
Imidacloprid
9.10%
Pyriproxyfen
0.46%
Other Ingredients (not specified)
90.44%
Advantage II for Dogs 3 to 10 lbs (Small Dog - Green Box) (0.4 mL):
Active Ingredients
% By Weight
Imidacloprid
9.10%
Pyriproxyfen
0.46%
Other Ingredients (not specified)
90.44%
Advantage II for Dogs 11 to 20 lbs (Medium Dog - Teal Box) (1.0 mL):
Active Ingredients
% By Weight
Imidacloprid
9.10%
Pyriproxyfen
0.46%
Other Ingredients (not specified)
90.44%
Advantage II for Dogs 21 to 55 lbs (Large Dog - Red Box) (2.5 mL):
Active Ingredients
% By Weight
Imidacloprid
9.10%
Pyriproxyfen
0.46%
Other Ingredients (not specified)
90.44%
Advantage II for Dogs 55 lbs and Over (Extra Large Dog - Blue Box) (4.0 mL):
Active Ingredients
% By Weight
Imidacloprid
9.10%
Pyriproxyfen
0.46%
Other Ingredients (not specified)
90.44%
Customer Reviews
Advantage II is rated 4.2378886478669555 out of 5 by 2,766.
Rated 4 out of 5 by from SWITCH BACK I've used this for several years and then decided to go with a cheaper spot on. Well, as you can see I went back to old faithful. It'll probably take a couple a months for it to start controlling fleas like it used to.
Date published: 2016-07-18
Rated 5 out of 5 by from Fast action Fast acting on dog in summertime. Dogs have stopped itching and fleas are gone! I didn't bathe dogs prior based on prior recommendations.
Date published: 2016-07-12
Rated 4 out of 5 by from Great product! I've had my cat for 8 years and he's never had a flea problem, so when he got them out of the blue, I tried everything. This kills the ones on your cat, and then poisons the ones who jump on them later. If you have a flea problem like I do, I'd suggest treating your house as well, or your cat will still get bitten. Overall, I'll be purchasing this again. Toki the cat thanks you!
Date published: 2016-07-11
Rated 5 out of 5 by from Works great! Been using Advantage II products for 5+ years for my cat. We tried cheaper flea treatments (Zodiac, carpet sprays, etc.) but to no avail. One product gave my cat a bad reaction so we finally caved and paid the extra dollars for Advantage II. Now our home and pets are flea-free! We apply Advantage II on our pets once every 2-3 months during the summer. Our cat does not have any bad reactions to it but he still does not enjoy the treatment -- maybe the wet spot on his back bothers him or the odor. As a result, my husband helps me hold him down while I apply it on him. We use the dog version of Advantage II for our dogs as well and the dogs do not mind it at all.
Date published: 2016-06-28
Rated 5 out of 5 by from Best product ever! No odor, no fur discoloration, no irritation to skin at application site, no scratching at application site, and best of all, NO FLEAS! I used small and medium dog product and small cat product. I couldn't be happier with this product. Thank you so much.
Date published: 2016-06-20
Rated 4 out of 5 by from Waiting longer for results My boyfriend and I just bought this for our fur babies, and so far it's working awesomely! I'm waiting to see the full results, since it's a 4 month supply. It definitely works better than some of the flea medicine we bought before.
Date published: 2016-06-19
Rated 5 out of 5 by from Easy to use Now I can take my fur babies outside on their leashes and not worry about them getting fleas
Date published: 2016-06-13
Rated 5 out of 5 by from It's awesome! With in a week all the fleas were gone and we haven't had an issue!
Date published: 2016-06-04
  • 2016-07-24T06:02CST
  • bvseo_cps, prod_bvrr, vn_cps_3.3.0
  • cp_1, bvpage1
  • co_hasreviews, tv_33, tr_2,733
  • loc_en_US, sid_prod10433, PRD, sort_mostRecent
  • clientName_1800petmeds
Q&A

My cat is 9lbs. Should I get the 5-9lbs dose or the 9lbs and up dose?

Asked by: Rotsuoy
Thank you for your question, IF your Kitty weighs exactly 9lbs then I would choose the 5-9lbs, and if your Kitty is 9.1 and over , I would use the 9lb and up. Please give your Kitty a hug for me.
Answered by: Joey
Date published: 2016-07-22

Will there be any effective results for pouring this treatment on the carpets? 

Asked by: Niki
This product is suppose to be used on cats. If you want products for the carpet we do carry products that can be used for that.
Answered by: Carolyn Petmed Pro
Date published: 2016-07-21

I have a advantage II  for my dog that I think is about 1 yr old. I dont find any expiration date anywhere.  is it safe to apply in my dog? Thank you

Asked by: Lizzy
Yes, the Advantage II does not expire.
Answered by: Cherley Petmeds Pro
Date published: 2016-07-07

Does advantage 11 for large cats cover ticks as well as fleas

Asked by: Sophia
The Advantage II for cats offers comprehensive flea protection by killing adult fleas, larvae, and eggs only. Plus, it kills fleas through contact, which means fleas don't have to bite your pet to die. Advantage II also treats, prevents, and controls lice on dogs. Advantage II does not kill ticks.
Answered by: Cherley Petmeds Pro
Date published: 2016-06-28

Can I use PayPal as payment?

Asked by: Cinders
Yes, you may checkout with PayPal when placing your order online.
Answered by: Cherley Petmeds Pro
Date published: 2016-06-22

My chihuahua has been running around since I put the Advantage on her. How long will she itch like that?

Asked by: Aimz1111
Individual sensitivities, while rare, may occur after using any pesticide product for pets. If signs persist, or become more severe, consult a veterinarian immediately.
Answered by: Cherley Petmeds Pro
Date published: 2016-06-21

?-Regarding dosing, is the concentration the same in ALL wts/breeds- only the volume is different?

Asked by: allyson
That is correct. Same concentration. However, the volume is different.
Answered by: Cherley Petmeds Pro
Date published: 2016-06-14

I have used this product on my cats for about 7 yrs now and I have always ordered it from 1800petmeds however last month, I applied advantage on one of my cat and a few days later I noticed that her skin is bare and furless there. Is this a known effect?

Asked by: Liv31
Individual sensitivities, while rare, may occur after using any pesticide product for pets. We guarantee your complete satisfaction or you get your money back. Please contact us at 1-800-738-6337 or email us at customerservice@1800petmeds.com so we can process a replacement or refund for you.
Answered by: Cherley Petmeds Pro
Date published: 2016-06-09
  • 2016-07-24T06:07CST
  • bvseo_cps, prod_bvqa, vn_cps_3.3.0
  • cp_1, bvpage1
  • co_hasquestionsanswers, tq_832
  • loc_en_US, sid_prod10433, PRD, sort_recentAnswersFirst
  • clientName_1800petmeds
Close
Share Website Feedback
Name:
Email:
Phone:
Feedback: