My Account
Errors:

Advantage II

Starts $53.74 $38.69 
Ships in one business day or less
1
Select Pet's Weight:
Dog
03-10 lbs
11-20 lbs
21-55 lbs
55 lbs & up
Cat
02-05 lbs
05-09 lbs
09 lbs & up
2
Select a Supply:
4 pack
$53.74
$42.99
$38.69
Price w/coupon TOPTEN
6 pack
$76.85
$61.48
$55.33
Price w/coupon TOPTEN
Free Shipping
Save $2 over 4 pk
12 pack
$148.70
$118.96
$107.06
Price w/coupon TOPTEN
Free Shipping
Save $9 over 4 pk
Starts $53.74 $38.69 
Ships in one business day or less
Please select all product options.
3
Select a Quantity:
Quantity
Please select all product options.
Product Info
How to Use
Ingredients
Customer Reviews
Q&A
Product Info
What is Advantage II?

Advantage II is a monthly flea preventative for dogs and cats that offers comprehensive flea protection by killing adult fleas, larvae, and eggs. Plus, it kills fleas through contact, which means fleas don't have to bite your pet to die. Advantage II also treats, prevents, and controls lice on dogs. Advantage II does not kill ticks, so we recommend using the Preventic Tick Collar along with Advantage II (dogs only). Advantage II for small cats 5-9 lbs can also be used for ferrets weighing 1 lb or over.

For:

Dogs (3 lbs or over and 7 weeks of age or older), Cats (2 lbs or over and 8 weeks of age or older), Ferrets (1 lb or over)

Benefits:
  • Convenient, once-a-month application
  • Kills through contact - fleas don't have to bite to die
  • Kills fleas within 12 hours of application
  • Kills all flea life stages including flea eggs and larvae to prevent infestation
  • Treats, prevents, and controls lice infestations (dogs only)
  • Safe and easy to apply
  • Waterproof - remains effective even if pet gets wet (use of a soap-free shampoo is recommended)
How it Works:

The first active ingredient is imidacloprid, which acts on the nervous system of the flea to cause paralysis and subsequent death. Within 12 hours of application, 98-100 percent of fleas are dead. The second active ingredient, pyriproxyfen, is an insect growth regulator. Once a female flea lays her eggs, pyriproxyfen works to prevent the eggs from hatching, ending the flea life cycle. Also, the active ingredient in Advantage II kills through contact, which means that fleas don't have to bite your pet to die.

Cautions:

Individual sensitivities, while rare, may occur after using any pesticide product for pets. If signs persist, or become severe, consult a veterinarian immediately. Do not get this product in your pet's eyes or mouth.

Brand Name:

Advantage II (Bayer)

Active Ingredient(s):

Imidacloprid (9.1%), Pyriproxyfen (0.46%) Other ingredients (90.44%)

What is this product used for:

Advantage II Kitten, Advantage II Small Cat and Advantage II Large Cat are once a month topical flea prevention and treatment for cats and kittens over 8 weeks or older. Advantage II Small Cat may also be used for ferrets weighing 1 lb or more. Advantage II Small Dog, Advantage II Medium Dog, Advantage II Large Dog, and Advantage II Extra Large Dog are once a month topical flea prevention and treatment for dogs and puppies 4 lbs or more and 7 weeks or older. Advantage II kills all flea life stages. Advantage II kills fleas within 12 hours of application. Advantage II for Dogs also treats, prevents, and controls lice infestations. Advantage II is waterproof and fragrance free.

Availability:

Advantage II for cats or ferrets and Advantage II for dogs are non-prescription (OTC) products.

How this product should be used:

Advantage II Kitten is available in 0.23 ml applicators for kittens 2-5 lbs (turquoise). Advantage II Small Cat is available in 0.4 ml applicators for cats 5-9 lbs or ferrets weighing 1 lb or over (orange). Advantage II Large Cat is available in 0.8 ml applicators for cats 9 lbs & up (purple). Advantage II Small Dog is available in 0.4 ml applicators for dogs 3-10 lbs (green). Advantage II Medium Dog is available in 1.0 ml applicators for dogs 11-20 lbs (teal). Advantage II Large Dog is available in 2.5 ml applicators for dogs 21-55 lbs (red). Advantage II Extra Large Dog is available in 4.0 ml applicators for dogs over 55 lbs (blue). To apply, place the applicator tip through your pet's hair to the skin level. On cats and ferrets, apply to skin on neck at the base of the skull. For dogs up to 20 lbs, apply to skin on back between the shoulder blades. For dogs 21 lbs or over apply the contents of one tube to 3 or 4 spots along the skin on back from the shoulder to the tail. Do not get this product in the pet's eyes or mouth.

What are the side effects:

Individual sensitivities, while rare, may occur after using any pesticide product for pets. If signs persist, or become more severe, consult a veterinarian immediately.

What special precautions are there:

Advantage II is for external use on dogs and puppies 3 lbs or more and 7 weeks or older, cats and kittens 2 lbs or more and 8 weeks or older, or ferrets weighing over 1 lb. Consult a veterinarian before using on medicated pets, if the pet is being given this product along with other pesticides, and debilitated, aged, pregnant or nursing pets. This product causes eye irritation in humans and is harmful if swallowed. Avoid contact with skin. Call poison control center if swallowed. If on skin, wash with plenty of soap and water. If in eyes, flush with plenty of water.

In the event of overdose:

Contact your veterinarian or veterinary emergency room.

How should I store this product:

Store this product in a cool dry place. Do not store in the refrigerator. Do not reuse empty container. Do not contaminate water, food or feed by storage or disposal. To dispose of empty container place in trash or offer for recycling if available. If container is partly filled call local solid waste agency for disposal instructions. Never place unused product down any indoor or outdoor drain. Keep out of reach of children and pets.

How to Use
Directions:
  • Only use Advantage II on dogs/puppies over 3 lbs and over 7 weeks of age, cats/kittens over 2 lbs and over 8 weeks of age, and ferrets weighing over 1 lb.
  • Apply Advantage II once a month every month.
  • For dogs up to 20 lbs, part the pet's hair between the shoulder blades until you can see the skin. Place the tip of the applicator on the skin and release all of the tube's contents on a single spot directly on the skin.
  • For dogs 21 lbs and over, apply entire contents of the tube evenly in 3 or 4 spots on the top of the back from the shoulder to the base of the tail. At each spot, part the hair until the skin is visible. Place the tip of the applicator on the skin and release a portion of the Advantage II solution directly on the skin. Do not apply an excessive amount of solution at any one spot that could cause some of the solution to run off the side of the dog.
  • For kittens, cats and ferrets, place the applicator tip through the cat's hair to the skin on the neck at the base of the skull and release all of the tube's contents on a single spot directly on the skin.
  • Use only one applicator per treatment.
Tip:

Under normal conditions Advantage II is effective for a month. However, in case of severe flea infestation, retreatment may be necessary earlier than four weeks. Do not re-treat more often than once every seven days. After flea control is obtained, return to a monthly treatment.

Dosage:
Dogs/Puppies: (7 weeks of age or older)
Weight
Dosage
3-10 lbs
Apply contents of 1 applicator once a month (Green Box)
11-20 lbs
Apply contents of 1 applicator once a month (Teal Box)
21-55 lbs
Apply contents of 1 applicator once a month (Red Box)
Over 55 lbs
Apply contents of 1 applicator once a month (Blue Box)
Kittens: (8 weeks of age or older)
Weight
Dosage
2-5 lbs
Apply contents of 1 applicator once a month (Turquoise Box)
Cats: (8 weeks of age or older)
Ferrets: (weighing 1 lb or over)
Weight
Dosage
Ferrets 1+ lbs
Apply contents of 1 applicator once a month (Orange Box)
5-9 lbs
Apply contents of 1 applicator once a month (Orange Box)
9 lbs & up
Apply contents of 1 applicator once a month (Purple Box)
Horses:
Do not use!
Storage:

Should be stored in a cool dry place. Do not refrigerate.

Ingredients
Advantage II for Kittens 2-5 lbs (Kitten - Turquoise Box) (0.23 mL):
Active Ingredients
% By Weight
Imidacloprid
9.10%
Pyriproxyfen
0.46%
Other Ingredients (not specified)
90.44%
Advantage II for Cats 5- 9 lbs or Ferrets 1 lb or more (Small Cat - Orange Box) (0.4 mL):
Active Ingredients
% By Weight
Imidacloprid
9.10%
Pyriproxyfen
0.46%
Other Ingredients (not specified)
90.44%
Advantage II for Cats Over 9 lbs (Large Cat - Purple Box) (0.8 mL):
Active Ingredients
% By Weight
Imidacloprid
9.10%
Pyriproxyfen
0.46%
Other Ingredients (not specified)
90.44%
Advantage II for Dogs 3 to 10 lbs (Small Dog - Green Box) (0.4 mL):
Active Ingredients
% By Weight
Imidacloprid
9.10%
Pyriproxyfen
0.46%
Other Ingredients (not specified)
90.44%
Advantage II for Dogs 11 to 20 lbs (Medium Dog - Teal Box) (1.0 mL):
Active Ingredients
% By Weight
Imidacloprid
9.10%
Pyriproxyfen
0.46%
Other Ingredients (not specified)
90.44%
Advantage II for Dogs 21 to 55 lbs (Large Dog - Red Box) (2.5 mL):
Active Ingredients
% By Weight
Imidacloprid
9.10%
Pyriproxyfen
0.46%
Other Ingredients (not specified)
90.44%
Advantage II for Dogs 55 lbs and Over (Extra Large Dog - Blue Box) (4.0 mL):
Active Ingredients
% By Weight
Imidacloprid
9.10%
Pyriproxyfen
0.46%
Other Ingredients (not specified)
90.44%
Customer Reviews
Advantage II is rated 4.2375 out of 5 by 2,762.
Rated 5 out of 5 by from Best product ever! No odor, no fur discoloration, no irritation to skin at application site, no scratching at application site, and best of all, NO FLEAS! I used small and medium dog product and small cat product. I couldn't be happier with this product. Thank you so much.
Date published: 2016-06-20
Rated 4 out of 5 by from Waiting longer for results My boyfriend and I just bought this for our fur babies, and so far it's working awesomely! I'm waiting to see the full results, since it's a 4 month supply. It definitely works better than some of the flea medicine we bought before.
Date published: 2016-06-19
Rated 5 out of 5 by from Easy to use Now I can take my fur babies outside on their leashes and not worry about them getting fleas
Date published: 2016-06-13
Rated 5 out of 5 by from It's awesome! With in a week all the fleas were gone and we haven't had an issue!
Date published: 2016-06-04
Rated 5 out of 5 by from works great Works really well but you need to treat the living space where your pets stay with something to kill eggs and fleas in the home and yard if you let them outside.
Date published: 2016-06-03
Rated 5 out of 5 by from Life saver! I bought this a couple of weeks ago. The product arrived on time and even included some cat treats for my babies! In a Texas home with four cats, fleas are quite an issue for my family. One of them is hypersensitive to their bites on top of this. I was very nervous when purchasing Advantage as we have tried many flea treatments before and did not get the expected results. So, I treated all four of them and and waited to see what may happen. Low and behold, the fleas started jumping right off of them around the 12 hour mark as stated on the package. Within 24 hours, I could not find a live flea on any of them. It has now been a week and the fleas don't stand a chance against this medication! It really has worked wonders and brought so much peace to our fur babies. The hypersensitive one responded SO well! This is a blessing. Definitely ordering again. Thanks, PetMeds!
Date published: 2016-06-01
Rated 5 out of 5 by from Works great for our 5 cats!! In Austin Tx this year we never really had a winter, no hard freeze! So the fleas will be very bad this year but we don't worry because we have Advantage and it works. Once you start using Advantage you will find your cats are scratching less and sleeping more peacefully than when they have fleas. Our vet told us we could use it every 3 weeks and we do during flea season!!! We would recommend Advantage to everyone and we do!!!!
Date published: 2016-05-23
Rated 5 out of 5 by from Great company ! Always deliver on time and always check with vet on any question they have
Date published: 2016-05-17
  • 2016-06-27T06:00CST
  • bvseo_cps, prod_bvrr, vn_cps_3.2.1
  • cp_1, bvpage1
  • co_hasreviews, tv_33, tr_2,729
  • loc_en_US, sid_prod10433, PRD, sort_mostRecent
  • clientName_1800petmeds
Q&A

Can I use PayPal as payment?

Asked by: Cinders
Yes, you may checkout with PayPal when placing your order online.
Answered by: Cherley Petmeds Pro
Date published: 2016-06-22

My chihuahua has been running around since I put the Advantage on her. How long will she itch like that?

Asked by: Aimz1111
Individual sensitivities, while rare, may occur after using any pesticide product for pets. If signs persist, or become more severe, consult a veterinarian immediately.
Answered by: Cherley Petmeds Pro
Date published: 2016-06-21

?-Regarding dosing, is the concentration the same in ALL wts/breeds- only the volume is different?

Asked by: allyson
That is correct. Same concentration. However, the volume is different.
Answered by: Cherley Petmeds Pro
Date published: 2016-06-14

I have used this product on my cats for about 7 yrs now and I have always ordered it from 1800petmeds however last month, I applied advantage on one of my cat and a few days later I noticed that her skin is bare and furless there. Is this a known effect?

Asked by: Liv31
Individual sensitivities, while rare, may occur after using any pesticide product for pets. We guarantee your complete satisfaction or you get your money back. Please contact us at 1-800-738-6337 or email us at customerservice@1800petmeds.com so we can process a replacement or refund for you.
Answered by: Cherley Petmeds Pro
Date published: 2016-06-09

Is this product safe to use on rabbits?

Asked by: Dynochop
This product is not formulated for rabbits. Please consult with your veterinarian to see if this product is safe for your furry baby.
Answered by: Cherley Petmeds Pro
Date published: 2016-06-09

I have a rescue puppy, vet estimates she's 4 mos old, weighs 2lbs 4oz. She had hookworms, last stool came back clean. Recently she's gotten fleas, but vet thinks she's too small for a topical treatment. Would it be safe to apply half a dosage? 

Asked by: Jules8387
Unfortunately, we cannot recommend applying half a dosage. This product is safe for dogs (3 lbs or over and 7 weeks of age or older).
Answered by: Cherley Petmeds Pro
Date published: 2016-06-09

My dog weighs 50lbs and I accidentally got the 55 and over will this be to strong for him?

Asked by: Katiem
Yes, the correct dosage for a 50 lbs dog would be the 21-55 lbs tube. Please call us at 1-800-738-6337 or email us at customerservice@1800petmeds.com so we can get the correct dose out to you.
Answered by: Cherley Petmeds Pro
Date published: 2016-06-09

I just bought the product tonight and applied it to my cat at 7pm. When can I let her back in my house and when can I pet her? She has been crying for hours at my window, but I do not want fleas in my house.

Asked by: Janella
Within 12 hours of application, 98-100 percent of fleas are dead.
Answered by: Cherley Petmeds Pro
Date published: 2016-06-08
  • 2016-06-27T06:16CST
  • bvseo_cps, prod_bvqa, vn_cps_3.2.1
  • cp_1, bvpage1
  • co_hasquestionsanswers, tq_826
  • loc_en_US, sid_prod10433, PRD, sort_recentAnswersFirst
  • clientName_1800petmeds
Close
Share Website Feedback
Name:
Email:
Phone:
Feedback:
=