My Account
Errors:

Activyl

Starts $93.74 $67.49 
Ships in one business day or less
1
Select Pet's Weight:
Dog
04-14 lbs
15-22 lbs
23-44 lbs
45-88 lbs
89-132 lbs
Cat
02-09 lbs
09-25 lbs
2
Select a Supply:
6 pack
$93.74
$74.99
$67.49
Price w/coupon TOPTEN
Free Shipping
12 pack
$181.23
$144.98
$130.48
Price w/coupon TOPTEN
Free Shipping
Save $4 over 6 pk
Starts $93.74 $67.49 
Ships in one business day or less
Please select all product options.
3
Select a Quantity:
Quantity
Please select all product options.
Product Info
How to Use
Ingredients
Customer Reviews
Q&A
Product Info
What is Activyl?

Activyl is a monthly spot-on flea treatment that works like no other flea product on the market. Activyl works by using a method called bioactivation, a method in which the active ingredient, indoxacarb is fully activated by using the flea's own enzymes. Activyl can be used for both dogs and cats, and kills not only adult fleas, but also flea eggs and larvae too; thereby, breaking the flea's lifecycle.

For dogs only, use Activyl Tick Plus to protect against ticks.

For:

Cats/Kittens and Dogs/Puppies (8 weeks or older)

Benefits:
  • New technology for flea control
  • Kills fleas, flea eggs and larvae
  • Breaks flea's lifecycle
  • Quick-drying and fragrance-free
  • Waterproof even after bathing
How it Works:

Activyl works to break the flea's lifecycle by killing not only adult fleas, but also flea eggs and larvae, which reduces the chances of your pet becoming reinfested. Activyl is spread through your pet's skin and coat. When a flea lands on your pet, it takes up the active ingredient of Activyl and causes the enzymes in the flea to change. Activyl then reaches its full active form and the flea becomes paralyzed and unable to feed. This process is called bioactivation - the newest technology in flea control. In addition, Activyl is waterproof, quick-drying, and fragrance free.

Cautions:

Do not use Activyl for dogs on cats, or allow your cat to lick or groom a dog treated with Activyl. Do not use on cats or kittens under 2 lbs, or dogs or puppies under 4 lbs, and no kittens or puppies under 8 weeks of age. Certain medications may interact with pesticides. If signs of sensitivity occur, contact your veterinarian immediately.

Brand Name:

Activyl

Generic Name:

Indoxacarb

What is Activyl used for:

Activyl is a monthly spot-on flea treatment that works like no other flea product on the market. Activyl works by a method called bioactivation. This method uses the flea's own enzymes to change Activyl into its fully active form. It kills not only adult fleas, but it also kills eggs and larvae too; thereby, breaking the flea's lifecycle.

Availability of Activyl:

Activyl is a non-prescription (OTC) product.

How Activyl should be used:

Use Activyl for Dogs, on dogs and puppies 8 weeks of age or older. It is available as 0.51 ml applicators for dogs 4.1-14 lbs, 0.77 ml applicators for dogs 14.1-22 lbs, 1.54 ml applicators for dogs 22.1-44 lbs, 3.08 ml applicators for dogs 44.1-88 lbs and 4.62 ml applicators for dogs 88.1-132 lbs. It is also available for cats 2-9 lbs in 0.51 ml applicators and cats over 9 lbs in 1.03 ml applicators. It lasts for a full 30 days.

To apply Activyl for small dogs and cats:

Hold the applicator in an upright position away from your face and snap the tip by bending it and folding it back on itself. Part the hair and place the applicator tip against the skin on the base of the skull. Applying Activyl at the base of the skull will help prevent your pet from licking the product. Squeeze the applicator firmly and apply the entire contents directly to the skin. Do not allow Activyl to run off and do not have contact with the treated area until it is completely dry. Reapply Activyl every 30 days.
For Larger Dogs: Start applying the contents between the shoulder blades working your way down to the tail while applying Activyl in 2-3 spots along the way. Make sure you thoroughly part the hair on each spot so the applicator touches the skin and not just the fur.

What are the side effects of Activyl:

Individual sensitivities while rare, may occur after using any pesticide product. In cats, accidental ingestion may cause intermittent salivation, licking of the face, shaking of the head, and squinting.

What special precautions are there:

Do not use on pregnant or lactating females. Do not use on puppies or kittens under 8 weeks of age. Use the entire contents on each cat or dog and do not split one tube between pets. Weigh your dog to ensure you are applying the right dose formulated for the weight of your dog. Consult your vet before using on debilitated, aged, or medicated dogs. Certain medications can interact with pesticides. If signs of sensitivity occur, contact your veterinarian immediately.

Causes eye irritation. Avoid contact with skin, eyes, or clothing. Wash hands thoroughly with soap and water after handling and before eating, drinking, chewing gum, using tobacco, or using the toilet.

If swallowed:

Call a physician or poison control center or a doctor for treatment advice. Drink 1 or 2 glasses of water and do not induce vomiting unless told to by poison control center. Do not give anything by mouth to an unconscious person.

If in eyes:

Hold eyes open and rinse slowly and gently with water for 15-20 minutes. Remove contact lenses, if present, after the first 5 minutes, continue rinsing. Call a physician or poison control center or a doctor for treatment advice.

If on skin:

Wash thoroughly with plenty of soap and water. Get medical attention if irritation persists.

In the event of overdose:

Contact your veterinarian or veterinary emergency room.

How should I store Activyl:

Do not remove tube from pack until ready to use. Store in a cool (below 77°F) dry place inaccessible to children and pets. Do not refrigerate and protect from direct sunlight.

How to Use
Directions:
  • Hold the applicator in an upright position away from your face and snap the tip by bending it and folding it back on itself.
  • Part the hair and place the applicator tip against the skin on the base of the skull. Applying Activyl at the base of the skull will help prevent your pet from licking the product.
  • Squeeze the applicator firmly and apply the entire contents directly to the skin.
  • Do not allow Activyl to run off and do not have contact with the treated area until it is completely dry.
  • Reapply Activyl every 30 days.
  • For Larger Dogs: Start applying the contents between the shoulder blades working your way down to the tail while applying Activyl in 2-3 spots along the way. Make sure you thoroughly part the hair on each spot so the applicator touches the skin and not just the fur.
Tip:

Wait until the application site is fully dry (usually 24 hours) before bathing your pet. Also, allow 24 hours before letting your dog go swimming or allowing your cat to get wet.

Dosage:
Dogs/Puppies:
(over 8 weeks of age)
Weight
Dosage
4.1-14 lbs
Apply contents of 1 applicator once a month (0.51 ml/0.02 fl oz)
14.1- 22 lbs
Apply contents of 1 applicator once a month (0.77 ml/0.03 fl oz)
22.1-44 lbs
Apply contents of 1 applicator once a month (1.54 ml/0.05 fl oz)
44.1-88 lbs
Apply contents of 1 applicator once a month (3.08 ml/0.1 fl oz)
88.1-132 lbs
Apply contents of 1 applicator once a month (4.62 ml/0.16 fl oz)
Cats & Kittens:
Weight
Dosage
2-9 lbs
Apply contents of 1 applicator once a month (0.51 ml/0.02 fl oz)
Over 9 lbs
Apply contents of 1 applicator once a month (1.03 ml/0.03 fl oz)
Horses:
Do not use!
Storage:

Should be stored at room temperature.

Ingredients
Activyl for Dogs Over 4.1-14 lbs:
Active ingredients (per 0.51 ml/0.02 fl oz applicator)
Amount
Indoxacarb: (S)-methyl 7-chloro-2,5-dihydro-2-[[(methoxycarbonyl)[4-trifluoromethoxy)phenyl]amino]-carbonyl]indeno[1,2-e][1,3,4]oxadiazine-4a(3H)-carboxylate
19.53%
Other Ingredients
80.47%
Activyl for Dogs Over 14.1-22 lbs:
Active ingredients (per 0.77 ml/0.03 fl oz applicator)
Amount
Indoxacarb: (S)-methyl 7-chloro-2,5-dihydro-2-[[(methoxycarbonyl)[4-trifluoromethoxy)phenyl]amino]-carbonyl]indeno[1,2-e][1,3,4]oxadiazine-4a(3H)-carboxylate
19.53%
Other Ingredients
80.47%
Activyl for Dogs Over 22.1-44 lbs:
Active ingredients (per 1.54 ml/0.05 fl oz applicator)
Amount
Indoxacarb: (S)-methyl 7-chloro-2,5-dihydro-2-[[(methoxycarbonyl)[4-trifluoromethoxy)phenyl]amino]-carbonyl]indeno[1,2-e][1,3,4]oxadiazine-4a(3H)-carboxylate
19.53%
Other Ingredients
80.47%
Activyl for Dogs Over 44.1-88 lbs:
Active ingredients (per 3.08 ml/0.1 fl oz applicator)
Amount
Indoxacarb: (S)-methyl 7-chloro-2,5-dihydro-2-[[(methoxycarbonyl)[4-trifluoromethoxy)phenyl]amino]-carbonyl]indeno[1,2-e][1,3,4]oxadiazine-4a(3H)-carboxylate
19.53%
Other Ingredients
80.47%
Activyl for Dogs Over 88.1-132 lbs:
Active ingredients (per 4.62 ml/0.16 fl oz applicator)
Amount
Indoxacarb: (S)-methyl 7-chloro-2,5-dihydro-2-[[(methoxycarbonyl)[4-trifluoromethoxy)phenyl]amino]-carbonyl]indeno[1,2-e][1,3,4]oxadiazine-4a(3H)-carboxylate
19.53%
Other Ingredients
80.47%
Activyl for Cats 2-9 lbs:
Active Ingredients (per 0.51 ml/0.02 fl oz applicator)
Amount
Indoxacarb: (S)-methyl 7-chloro-2,5-dihydro-2-[[(methoxycarbonyl)[4-trifluoromethoxy)phenyl]amino]-carbonyl]indeno[1,2-e][1,3,4]oxadiazine-4a(3H)-carboxylate
19.53%
Other Ingredients
80.47%
Activyl for Cats Over 9 lbs:
Active Ingredients (per 1.03 ml/0.03 fl oz applicator)
Amount
Indoxacarb: (S)-methyl 7-chloro-2,5-dihydro-2-[[(methoxycarbonyl)[4-trifluoromethoxy)phenyl]amino]-carbonyl]indeno[1,2-e][1,3,4]oxadiazine-4a(3H)-carboxylate
19.53%
Other Ingredients
80.47%
Customer Reviews
Activyl is rated 4.2174 out of 5 by 46.
Rated 5 out of 5 by from Only product that has been successful I have tried so many products over the last eight years. This year for whatever reason the flea situation is bad around where we live. Our Lilly is so sensitive with smells and her skin reacts to Just about everything I put on her but this is the first product that has worked perfectly in all areas. So far so good and will totally recommend that you try this product.
Date published: 2016-11-19
Rated 5 out of 5 by from Only FleaTreatment that works! My new vet prescribed it, advising that the popular brands no longer work - Fleas have become immune. It actually works. Activyl has transformed my cats, who have flea allergies, to healthy happy, furry pets again,
Date published: 2016-11-02
Rated 3 out of 5 by from great at first I have strictly indoor cats. Fleas appeared out of the blue so I administered the Activyl per vet recommendation. All was well for almost two weeks while I vacuumed like mad, did repeated loads of laundry, flea-combed twice a day, and set Victor traps - then suddenly the fleas reappeared -- only two weeks after treatment. Now I have to wait two more weeks before giving the second dose and try to stay vigilant against the fleas. I have mixed feelings about this product. It also smells terrible when put on the cat and you have to police them so they don't groom each other while it's drying.
Date published: 2016-10-23
Rated 5 out of 5 by from Activyl This flea medication is excellent. One of my dogs had seizures on another flea medication so my vet recommended that I try this drug. A year or more later and the fleas have been nonexistent and no seizures. Really excellent.
Date published: 2016-10-18
Rated 5 out of 5 by from Fleas are around all year long in FL. Works great I have a dog that has reactions to flea bites so I can tell that this stuff works great.
Date published: 2016-10-14
Rated 5 out of 5 by from Great product I have tried multiple flea products, and this is the only one that works, even after bathing my dog. I kept hearing my family complain about the products they were previously using as well, and ended up switching to Activyl too, and have experienced no fleas. I recommend it to anyone looking for a flea med that actually works.
Date published: 2016-05-10
Rated 5 out of 5 by from Works great! Best medication I've used so far on my pets!
Date published: 2016-04-08
Rated 1 out of 5 by from Useless.. I wouldn't use on cats I live in California where, with the drought, the flea problem has gotten really bad. I had to go to oral, NexGard which works great, for my dogs and the cats have tried Advantage, Frontline, Seresto collars & even Revolution with terrible results. So I bought this and its been on them a week. They still scratch all day and night. I have hardwood floors so they aren't hiding.. this just isn't working. I wouldn't waste my money. I'm not sure whats going to work but I'm moving on to the next one.
Date published: 2016-03-25
  • 2016-12-07T06:03CST
  • bvseo_cps, prod_bvrr, vn_cps_3.4.0
  • cp_1, bvpage1
  • co_hasreviews, tv_1, tr_45
  • loc_en_US, sid_prod3360, PRD, sort_mostRecent
  • clientName_1800petmeds
Q&A

How long after application is it safe to bathe your pet?

Asked by: Kpalmzz
You should wait at least 48 hours after applying Activyl before bathing your pet.
Answered by: Christine
Date published: 2016-10-14

I rescued av dug from our Humane Society and just realized they double dosed her flea meds. Activyl on Sunday and then Advantix Ii on Wednesday.  She's been extremely lethargic & has hardly drank, eaten, piddled or pooed since I brought her home Wed. 

Asked by: Paula
You may want to contact your veterinarian if your dog is still experiencing these side effects.
Answered by: Christine
Date published: 2016-10-12

Can i put Sentry Natural Defense in my dogs bed even when my dog is wearing Activyl ?

Asked by: Kathleen
Yes, you can spray Sentry Natural Defense on your dogs bedding. However, make sure the bedding is dry before you allow your pet to sleep on it.
Answered by: Christine
Date published: 2016-10-05

How long until the fleas start dying ?

Asked by: Kathleen
Activyl will start killing any fleas on your pet within and within 12 hours 90% of the adult fleas will be dead. It will keep on killing fleas for over 4 weeks. It will also inhibit flea development in the environment of treated pets for at least 28 days after application.
Answered by: Christine
Date published: 2016-10-03

my dog has epilepsy and is prone to seizures. Is this product known to trigger seizures in dogs?

Asked by: cleveland
Individual sensitivities while rare, may occur after using any pesticide product. In cats, accidental ingestion may cause intermittent salivation, licking of the face, shaking of the head, and squinting. Speak with your veterinarian if you have any concerns about taking this medication.
Answered by: Christine
Date published: 2016-10-01

I have a cat and dog who are snuggle buddies. I'm not worried about the cat licking the spots where I've put activyl on the dog, but he does like to groom the dog's paws and ears. Is that dangerous

Asked by: roscoes_mom
This should not be a problem, as long as your cat does not lick the spots where you've applied the Activyl.
Answered by: Christine
Date published: 2016-10-01

STRAY CAT CAME TO OUR HOUSE AND DELIVERED 4 KITTENS. WE PUT FRONTLINE ON MAMA CAT BUT SHE STILL GOES ASTRAY COMING BACK WITH FLEAS. THEN KITTENS GET FLEAS FROM MAMA CAT. IS THERE A FLEA PRODUCT FOR KITTENS THAT ARE 4 WEEKS OLD?

Asked by: CONGO
Unfortunately, we do not have any products availabe to treat flea and ticks for cats under 8 weeks old.
Answered by: Christine
Date published: 2016-09-28

I have a tick issue. No matter what i do in my back yard/ front yard. Professional extermination companies have not solved the issue. Most likely because they don't want to kill my doggys. . I am going to try Seresto . if this don't work any ideas?

Asked by: Spanky
You may want to speak with your veterinarian about prescribing a flea/tick pill for your furry babies.
Answered by: Cherley Petmeds Pro
Date published: 2016-06-21
  • 2016-12-07T06:06CST
  • bvseo_cps, prod_bvqa, vn_cps_3.4.0
  • cp_1, bvpage1
  • co_hasquestionsanswers, tq_43
  • loc_en_US, sid_prod3360, PRD, sort_recentAnswersFirst
  • clientName_1800petmeds
Close
Live Chat Share Website Feedback
Name:
Email:
Phone:
Feedback: