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Product Info
How to Use
Customer Reviews
Product Info
What is Acepromazine?

Acepromazine is a phenothiazine tranquilizer that is used prior to anesthesia and surgery because of its sedative effects and its ability to prevent vomiting. It's also used as an aid in controlling excited animals during examinations, treatments, and grooming. Acepromazine requires a prescription from your veterinarian, and is sold per tablet.


Cats and Dogs

  • An effective tranquilizer
  • Controls overly excitable animals
  • Can prevent vomiting post surgery
  • Sold affordably per tablet
How it Works:

Acepromazine is classified as a phenothiazine neuroleptic, which means it modifies the chemicals in your pets brain to change their behavior. Its a tranquilizer that depresses the central nervous system. The mechanism of action is not exactly known, however, its thought to block receptors of dopamine in the brain, a chemical used for cell-to-cell communication.


Tell your veterinarian if your pet has liver disease, heart disease, seizure disorders, or if the pet is pregnant or lactating. You should also mention other CNS (Central Nervous System) medications such as clomipramine, fluoxetine, and Reconcile or monoamine oxidase inhibitors such as Anipryl, Selegiline, or Preventic Collar that you are giving or using on your pet.

Brand Name:

Aceproject (Vetus), Aceprotabs (Vetus), PromAce (Fort Dodge)

Generic Name:

Acepromazine (ace PRO ma zeen)

What is the most important information I should know about Acepromazine:

Acepromazine is a prescription medicine FDA approved for veterinary use in dogs only; however it is a commonly accepted practice for veterinarians to use acepromazine in cats. Acepromazine is available as 10mg and 25mg tablets. Each tablet is quarter scored. The usual dose for dogs and cats is 0.25-1 mg/lb. Acepromazine may color the urine pink. Occasionally, this medication may have an opposite effect causing stimulation, therefore this medication should not be used to treat aggression.

What is Acepromazine:

Acepromazine is a phenothiazine tranquilizer used by veterinarians as an aid in tranquilization and before using anesthesia. Acepromazine may also be used for purposes other than those listed.

What should I discuss with my veterinarian before giving acepromazine to my pet:

Tell your veterinarian if your pet has liver disease, heart disease, seizure disorders or if the pet is pregnant or lactating. Also mention other CNS medications, such as Phenobarbital, that your pet may be taking.

How should this medication be given:

Give this medication exactly as directed by your veterinarian. Acepromazine should be given 45 minutes to 1 hour prior to the procedure for the medication to take effect. If you do not understand the directions ask the pharmacist or veterinarian to explain them to you. Store acepromazine at room temperature, away from moisture and heat.

What happens if I miss giving a dose:

Give the missed dose as soon as you remember during the same day. However, if you don't remember until the next day, skip the dose you missed and give only the next regularly scheduled dose. Do not give a double dose of the medication.

What happens if I overdose the pet:

Seek emergency veterinary medical treatment. Symptoms of overdose may include excess drowsiness, slow heart rate and breathing, unsteady movement, unconsciousness, low blood pressure or seizures.

What should I avoid while giving acepromazine to my pet:

Do not give your pet epinephrine or CNS depressant medications such as Phenobarbital.

What are the possible side effects of acepromazine:

Stop giving acepromazine and seek emergency veterinary medical care in the event of rare allergic reaction (difficulty breathing; swelling of the lips; tongue; or face; or hives). Other, less serious side effects that have been reported but may resolve with continued treatment. Continue to give acepromazine and notify your veterinarian if your pet show signs of sedation, depression, incoordination, low blood pressure, slower heart rate and breathing. Other side effects may also occur. Talk to your veterinarian about any side effect that seems unusual or bothersome to the animal.

What other drugs will affect acepromazine:

Before giving acepromazine, tell your veterinarian if your pet is being given phenytoin, antiarrhythmics such as quinidine and beta blockers such as propranolol. Antidiarrheal medications and antacids may reduce the effectiveness of acepromazine.

Where can I get more information:

Your pharmacist has additional information about acepromazine written for health professionals that you may read.

How to Use
  • Acepromazine is a prescription tranquilizer use by veterinarians in dogs and cats.
  • Acepromazine is typically used prior to anesthesia and surgery because of its sedative effects and because it can prevent vomiting.
  • It is also used as an aid in controlling excited animals during examination, treatment, and grooming.

Acepromazine may color the urine pink. Occasionally, this medication may have an opposite effect causing stimulation; therefore this medication should not be used to treat aggression.

All weights
Give 0.25-1 mg per pound of pet's body weight by mouth. Should be given 45 minutes to 1 hour prior to the procedure
Do not use!

Should be stored at room temperature. Keep away from moisture and heat.

Active Ingredient (per tablet)
Acepromazine Maleate
25 mg
Customer Reviews
Acepromazine is rated 4.028985507246377 out of 5 by 69.
Rated 5 out of 5 by from Dog had broke foot I have a Doberman and she gets anxiety even if she had pain pills during her recovery got this medication from my veterinarian on a follow-up because my dog would jump around like a poodle and I was concerned with her injuring herself further during this healing time this medication is great it subsided her anxiety and from her bolting out the door to go to the bathroom I would give this a high review as the first time I've ever seen my dog relax as she should after surgery
Date published: 2016-09-01
Rated 4 out of 5 by from My 11 year old Rat terrier is scared to death of lighting and thunderstorms, up till recently this drug has worked great, but the last few times, even though I have only given her 1/2 the dosage, she has been experiencing light seizure activity. Very scary! I have decided to quit giving it to her entirely.
Date published: 2016-07-17
Rated 5 out of 5 by from Great for separation anxiety. My dog is part husky and they are known for expressing themselves. Joey has some separation anxiety that used to be pretty bad. I tried every single kind of chew/treat out there to help him with this, but it didn't work in the least. Acepromazine has, though, and the only thing to consistently work. Be advised, however, to give your pup their pill 30-60 minutes BEFORE whatever causes the anxiety is about to happen (thunderstorm, leaving, vet, etc.) as it needs the time to distribute in their body. It WILL NOT work if they are already upset/scared/freaking out to say the least.
Date published: 2016-07-11
Rated 5 out of 5 by from worked very well Our 15 yr old, 40 lb (a bit chubby) cockapoo is a sweet, loving member of our family, but recently has been vicious when attempting to clip her nails or even groom her. We gave her 25 mg but she still tried to bite when grooming her face. I reluctantly gave her half a pill more..she was soon very easy to handle. She did have a difficult time walking for about 16 hrs and her eyes were a bit scary. The next day..back to normal and we felt blessed.
Date published: 2016-04-01
Rated 5 out of 5 by from Product calmed her down. Lulu is a Lab/pit mix and is approx. 65-70 lbs. She got frightened of having her nails clipped and she won't even let us touch her nails. We gave her two pills and were able to trim her nails without any problems. She acted drunk for awhile but came out of it her normal active self. \ \
Date published: 2014-06-18
Rated 4 out of 5 by from Great for surgery recovery My six-month 25lb Border Collie puppy was spayed a few days ago and I was told to prevent her from running or jumping for at least one week. I had no idea how on earth I would possibly manage this, as she has hours and hours of full-speed dog park energy every day. After research and talking with the vet I started with half of the lowest recommended dose. It worked like a charm for the first 48 hours, but then she started getting excited well before the six hour dose period was up. So I increased it from a quarter pill every six hours to a quarter pill every four hours. This worked great for a day, and then needed to up the dose to half a pill every six. It has been two days on half a pill and while she will get up and try to play if the opportunity is there, as long as I keep the room quiet and keep her away from distractions she is still content to sleep for most of the duration of the dose. Eventually I may need to up the dose again, but it looks like she'll be fully healed long before we get to the point where we need the maximum dose. Start low and slow, be patient and use this as an aid to a problem, not a cure-all. p.s. For large breeds, herding dogs, and sight hounds - do some research first! Maybe get your dog tested for the MDR1 gene. And bigger dogs have a higher chance of blood pressure dropping too low.
Date published: 2014-04-29
Rated 5 out of 5 by from Excellent product My dog Rose petal was a puppy mill dog for six years. She has been with me a year and has come a long way learning to be a dog. She becomes tramatized when I groom her. This product is a God send-thank you
Date published: 2014-04-08
Rated 5 out of 5 by from A big help We had a terrible series of storms in our area shortly after we rescued our lab/pit mix female dog from out of state. With each major thunderstorm over the next couple of years, our Daisy got more and more anxious. I was afraid she'd have a heart attack the last time, so my vet prescribed this medication. It really helped her. The trick is getting it into the dog an hour before bad storms. Storms can pop up out of nowhere, and the med needs time to get into Daisy's system. But I am thrilled with the result. Daisy is much calmer during thunderstorms now.
Date published: 2013-09-17
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May I cut Acepromazine in half?

I give 10 mg. to my dog when I take him to get his nails cut becasue he hates his paws touched. Yesterday I tried one when I went out because he is terrifiied of thunderstorms and talked to Vet about giving to him when I am not here for severe thunderstorms, she said it was ok to do. Can I cut the 25 mg. in half for him, he is 25 lb. Shiba Inu and any more than that is too much for him. Thank you.
Asked by: Sandy
My dog is hyper sensitive to this drug . A lot of herding dogs can be. I can break the pill into many pin head size doses and it still knocks him completely out. So yes you can break it in half or into many doses. If it is for noise i recommend a drug called sileo. It inhibits just the noise without sedation
Answered by: Gena
Date published: 2016-09-14

I have a 5 pound Pomeranian how much should I give her without over dosing?

Asked by: Melonie
I have 10 mg left over from my other dog who was 20lbs. And we would give him 1/4 tablet 2 to 3 hours prior to fire works and the meds are only 4 months old and I would hate to just throw away all these meds.
Answered by: Sharon
Date published: 2016-09-10

How many mg for my Yorkie who weighs 6 pounds

Asked by: Gayle
An estimated dose would be 1.5-6mg. Talk to your vet for a more specific dose for your Yorkie.
Answered by: paulpharmacistintern
Date published: 2016-08-16

Does it require a prescription? I have some from the vet but need to get more.

Asked by: JoyceT
Yes, Acepromazine requires a prescription from your veterinarian.
Answered by: paulpharmacistintern
Date published: 2016-07-28

how long does the medication work if given 20mg for a 112 lb labrador retriever?

Asked by: jewels
Depends on the dog. That seems to be a low dose for a dog that size. But usually it last about 6 to 8 hrs.
Answered by: dogs dogs dogs
Date published: 2015-07-06

Where is the acepromazine that you carry made?

Asked by: Mama
Please contact our pharmacy by phone for this information.
Answered by: Lilli Pharmacist
Date published: 2015-06-19

How much does a container of 30 acepromazine pills cost?

Asked by: Mandys Mum
please call our customer care department and we will be happy to discuss the price with you Thank You
Answered by: Linda M 1800petmeds pharmacist
Date published: 2015-04-14

My 45 pound dog was given 25mg of Ace at 7:30 am and at 5 pm is still disoriented and wobbly. Is this normal?

Asked by: Lynn
Acepromazine can cause some sedation and drowsiness. Let your veterinarian know about this and see if maybe a lower dose or alternate drug might be considered by your veterinarian.
Answered by: Kelly P
Date published: 2015-04-09
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