What is Ursodiol?

How it works:
Ursodiol (Ursodeoxycholic acid) can restore healthy liver function by improving the flow of bile through the tiny ducts into the gall bladder and improving the flow of bile from the gall bladder into the intestine. It also prevents a potentially toxic build up of bile.

Ursodiol decreases the amount of cholesterol in bile by reducing the amount of cholesterol the liver produces. Ursodiol also reduces the amount of cholesterol absorbed from food and increases its breakdown, especially cholesterol that has formed into gallbladder stones.

Cautions:
Tell your veterinarian if your pet has any medical conditions. Don’t give your pet over-the-counter antacids that contain aluminum, such as Maalox or Mylanta, unless your veterinarian approves. Aluminum may decrease the effectiveness of this medication.

What is the most important information I should know about Ursodiol: Ursodiol is a prescription medication not FDA approved for use in animals; however, it is a commonly accepted practice for veterinarians to use this medication in dogs and cats. Ursodiol is available as 300mg capsules. The usual dose for dogs and cats depends on the condition and the severity of symptoms. Do not give over the counter antacids that contain aluminum, such as Maalox or Mylanta unless your veterinarian approves. Aluminum may decrease the effectiveness of this medication. Ursodiol may need to be taken for a long period of time. Do not stop giving ursodiol to your pet unless told to by your veterinarian.

What is Ursodiol: Ursodiol decreases the amount of cholesterol in bile and bile stones, by reducing the amount of cholesterol the liver produces. Ursodiol reduces the amount of cholesterol that is absorbed from food and also increases the breakdown of cholesterol, especially cholesterol that has formed into gallbladder stones. Ursodiol is not used to treat gallstones that are calcified. Ursodiol may also be used for purposes other than those listed in this guide.

What should I discuss with my veterinarian before giving Ursodiol to my pet: Tell your veterinarian if your pet has cholecystitis, biliary obstruction, gallstone pancreatitis or biliary-gastrointestinal fistula. Also tell your veterinarian if your pet has any other medical conditions, especially heart, liver or kidney disease. Tell your veterinarian if your pet is pregnant or lactating.

How should this medication be given: Give this medication exactly as directed by your veterinarian. If you do not understand the directions ask the pharmacist or veterinarian to explain them to you. Allow pet to drink plenty of water. Store Ursodiol at room temperature, away from moisture and heat. Keep this medication away from children and pets. 

What happens if I miss giving a dose: Give the missed dose as soon as you remember. However, if is almost time for the next regularly scheduled dose, skip the missed dose and take the next one as directed. Do not give a double dose of the medication.

What happens if I overdose the pet: Seek emergency veterinary medical treatment. Symptoms of ursodiol overdose are unknown but may include diarrhea.

What should I avoid while giving Ursodiol to my pet: You should avoid giving your pet any over the counter antacids that contain aluminum. Examples include Maalox or Mylanta.

What are the possible side effects of Ursodiol: If any of the following serious side effects occur, stop giving ursodiol and seek emergency veterinary medical attention; an allergic reaction (difficulty breathing; swelling of the lips; tongue or face; hives). Other less serious side effects may occur. Continue giving ursodiol and talk to your veterinarian if your pet experiences nausea or upset stomach, diarrhea or headache. Other side effects may also occur. Talk to your veterinarian about any side effect that seems unusual or bothersome to the animal.

What other drugs will affect Ursodiol: Tell your veterinarian if your pet is being given an antacid containing aluminum as this may decrease the amount of ursodiol being absorbed. Estrogens (D.E.S. or diethylstilbesterol) may increase the amount of cholesterol in the body which would decrease the effectiveness of Ursodiol. Drugs other than those listed may also interact with Ursodiol. Talk to your veterinarian before giving your pet any prescription or over the counter medicines.

Where can I get more information: Your pharmacist has additional information about Ursodiol written for health professionals that you may read.