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Simplicef

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Product Info
How to Use
Ingredients
Customer Reviews
Q&A
Product Info
What is Simplicef?

Simplicef is a once-a-day cephalosporin antibiotic used to treat skin infections (wounds and abscesses) caused by susceptible strains of bacteria. Simplicef requires a prescription from your veterinarian, and is sold per tablet.

For:

Dogs

Benefits:
  • FDA-approved for treating canine bacterial skin infections
  • Simple once-a-day dosing
  • Can be given with or without food
  • Comes in a film-coated tablet for easy administration
How it Works:

Simplicef is effective against most gram-positive and gram-negative bacteria. Cephalosporin antibiotics suppress the growth of micro-organisms such as bacteria, fungi, or protozoa.

Cautions:

Contact your veterinarian in the event of an allergic reaction (such as shortness of breath, hives, swelling, rash, fainting, vomiting, diarrhea, mucus or blood in the stool, unusual bleeding, or bruising). Do not give Simplicef at the same time as antacids such as Maalox or other stomach acid-reducers, like Tagamet.

Brand Name:

Simplicef (Pfizer Animal Health), Vantin (Pharmacia and Upjohn)

Generic Name:

Cefpodoxime proxetil

What is the most important information I should know about Simplicef:

Simplicef is a prescription medication FDA-approved for use in dogs. Simplicef is available as 100mg elliptical scored tablets and 200mg tablets that can either be elliptical, unscored tablets marked 5229 or capsule-shaped, scored tablets marked 5229. The usual dose of Simplicef in dogs is 2.3-4.5mg/pound, given by mouth, once a day for 5 to 7 days or 2 to 3 days beyond the cessation of clinical signs, up to a maximum of 28 days. Simplicef should be given with food to increase absorption by the body. Give all of the Simplicef that is prescribed for your pet. Symptoms may begin to improve before the infection is completely treated.

What is Simplicef:

Simplicef is an antibiotic belonging to a class of drugs called cephalosporins that fight bacteria in the body. Simplicef can be used to treat many different types of infections such as bronchitis or pneumonia as well as ear, skin, and urinary tract infections. Simplicef may also be used for purposes other than those listed.

What should I discuss with my veterinarian before giving Simplicef to my pet:

Tell your veterinarian if your pet has ever had an allergic reaction to another penicillin or to a cephalosporin. Tell your veterinarian if your pet has kidney disease or stomach or intestinal disease. Tell your veterinarian if your pet is pregnant or lactating.

How should this medication be given:

Give this medication exactly as directed by your veterinarian. Simplicef should be given with food to increase absorption in the body. Keep plenty of water available for your pet to drink. Do not give Simplicef at the same time as giving antacids such as Maalox or other stomach acid reducers such as Tagamet as this may decrease the absorption of Simplicef. Give all of the Simplicef even if your pet appears to be better. Symptoms may improve before the infection is completely treated. Store tablets at room temperature away from moisture or heat. 

What happens if I miss giving a dose:

Give the missed dose as soon as you remember. Do not give a double dose unless otherwise directed by your veterinarian.

What happens if I overdose the pet:

Seek emergency veterinary medical treatment if an overdose is suspected. Symptoms of overdose may include nausea, vomiting, diarrhea, and abdominal cramps.

What should I avoid while giving Simplicef to my pet:

Do not give Simplicef at the same time as giving antacids such as Maalox or other stomach acid reducers such as Tagamet.

What are the possible side effects of Simplicef:

Stop giving Simplicef and seek emergency veterinary medical care in the event of an allergic reaction (shortness of breath; hives; swelling of the lips, tongue, or face; rash; or fainting), severe nausea, vomiting or diarrhea, mucus or blood in the stool, and unusual bleeding or bruising. Other, less serious side effects such as mild nausea, diarrhea, or yeast infection may be more likely to occur.  Continue to give Simplicef and notify your veterinarian if these symptoms occur. Talk to your veterinarian about any side effect that seems unusual or bothersome to your pet.

What other drugs will affect Simplicef:

Before giving Simplicef, tell your veterinarian if your pet is being given another antibiotic (for the same or a different infection), probenecid, a loop diuretic such as furosemide, or warfarin. You may need to have the dosage adjusted. Drugs other than those listed here may also interact with Simplicef. Talk to your veterinarian or pharmacist before giving any prescription or over-the-counter medicines, including vitamins, minerals, and herbal products.

Where can I get more information:

Your pharmacist has additional information about Simplicef written for health professionals that you may read.

How to Use
Directions:
  • Simplicef is an antibiotic belonging to a class of drugs called cephalosporins that fight bacteria in the body.
  • Simplicef can be used to treat many different types of infections such as bronchitis and pneumonia as well as ear, skin, and urinary tract infections.
Tip:

Simplicef should be given with food to increase absorption by the body.

Dosage:
Dogs:
Weight
Dosage
All weights
Give this medication exactly as directed by your veterinarian. The usual dose of Simplicef in dogs is 2.3-4.5mg/pound, given by mouth, once a day for 5 to 7 days or 2 to 3 days beyond the cessation of clinical signs, up to a maximum of 28 days.
Cats
Do not use!
Horses:
Do not use!
Storage:

Should be stored in a cool dry place.

Ingredients
Simplicef 100 mg:
Ingredient
Strength
Cefpodoxime proxetil
100 mg
Simplicef 200 mg:
Ingredient
Strength
Cefpodoxime proxetil
200 mg
Customer Reviews
Simplicef is rated 4.5517 out of 5 by 29.
Rated 3 out of 5 by from bad product My pet was prescribed this on Tuesday Gave him a half pill for 2 days. He became very lathargic,feverish and now has some kind of muscle or joint pain. Whines when he moves. Stopped giving him the pill, hopefully he'll get back to his old self. Will never use again.
Date published: 2016-10-08
Rated 5 out of 5 by from Great service My dog gets allergies in the summer months and this product really helps his skin. I love dealing with petmeds they are great
Date published: 2015-12-14
Rated 5 out of 5 by from This works great, all sores gone. We had our little guy on the two week, or 20 day plan whenever the sores started. We read about someone giving their dog the Simplicef only on weekends and this kept it clean. We started Zorro on this plan and it has been 100% effective for him. When he was on the one a day 1/2 pill regiment he seemed to gain weight. Now he has lost a few pounds and is back to his "bossy" self with lots of energy.
Date published: 2014-02-03
Rated 5 out of 5 by from Very good product My Ali suffers from bacteria around his chin and lips because he is a Boxer and they tend to slobber. His bumps are more like acne and when ruptured by scratching they bleed and become more irritating. Simplicef, after three days he is cured. Of course if I want to avoid future breakouts I give him a pill a day. This gives me peace of mind and a happy pet.
Date published: 2014-01-20
Rated 5 out of 5 by from Excellent! My dog gets really dry skin, and when I say really, I mean REALLY BAD. It was getting to the point where I was giving him baths every day just so he would stop itchy. After a nice week wait to get an appointment, when the vet finally saw me, she gave my sheltie these pills. That was over a year ago. Now, when the whether is bad, which sets off the dryness/raw spots on my dog, I call in, and they give me a refill. It is the ONLY thing that I have found to work for my dog's dry skin.
Date published: 2013-08-02
Rated 5 out of 5 by from Happy Dog My Shih Tzu suffers from year round allergies. She is allergic to most foods and pollens (I am not exaggerating). She has been plagued with chronic Staph Infections since I adopted her 3.5 years ago. Her health issues have literally cost us a small fortune. I couldn't get my pup into the vet this last time. So, she prescribed me Simplicef 100mg ($28/7pills) that I could pick up since she had just been treated 6 weeks prior with the usual meds, injectable Convenia and Steroids. To my amazement, she had NO obvious side effects and this is the first time that the infection has actually stayed away for any length of time. She usually would have the lingering allergy/staph odor and itchiness by now. But, so far so good. Fingers crossed that she (and I) will have some long lasting relief. It is great that other owners with similar issues are having such great success with this product as well. The other reviews assure me that long term relief is possible for my pup with this product. Thanks to Pet Meds for offering this product with fair pricing.
Date published: 2013-06-09
Rated 5 out of 5 by from Great for treating skin allergies Our cavalier king charles spaniel is susceptible to skin allergies - apparently common in this breed. A flare up usually results in large scabs. Ever since our vet suggested Simplicef as an alternative to the allergist route, we start it at the first sign of a flare up and the irritation clears up without going through the scab stage. And no apparent side effects. Love it!
Date published: 2013-01-01
Rated 1 out of 5 by from Bad Side effects Got this med from our vet with no explaination of side effects. Simplicef caused our dog to drink lots and lots of water which required us to let her out many, many times a day and Night. She's had several 'accidents' because she couldn't get up and let us know. It also caused her some pain either muscular or joint so she wouldn't let us pick her up, etc. In a few cases, she slipped on the hardwood floor and couldn't get up and would snap at us if we tried to help. I think clindamycin might have been a better choice. We've given her this med for the prescribed duration. Her skin infection seems to have dried up but the 'dandruff' is horrible.
Date published: 2012-08-16
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Q&A

Can this medication cause drowsiness in dogs? My dog seems to get really sleepy an hour at rr taking it. 

Asked by: Heather08
Drowsiness is not a common side effect associated with Simplicef but it is possible. Consult your veterinarian if it is excessive.
Answered by: Lisa M
Date published: 2016-11-24

What are the long term affects? I have a very itchy lab that weighs 110lbs. When he's on it he is fine but a few day after he is off he is iching again. His joints also seem to be much better while he is on it. He seems like a puppy but he's 7.

Asked by: Sdcd
Simplicef is an antibiotic that may be used to treat skin infections, that my have caused your pet to be itchy. Common side effects include diarrhea, vomiting or blood in stool.
Answered by: S Duesler PharmD MBA
Date published: 2016-11-17

My 4 month old puppy snuck up and took my older dogs simplicef tab this morning. Half of a 100mg tab. Should I be worried?

Asked by: Lmwgogs
It is best to contact your veterinarian for advice on any side effects to look for or if they recommend your pet should be examined.
Answered by: S Duesler PharmD MBA
Date published: 2016-11-17

My vet prescribed two pills a day (200 mg) for my 60 pound dog. Is that too much? Last time he had it this medication it was only one pill a day and he was same weight. Wondering if it was an error and can't call until they open on Monday 

Asked by: Megan
The usual dose of Simplicef in dogs is 2.3-4.5mg/pound, given by mouth, once a day for 5 to 7 days or 2 to 3 days beyond the cessation of clinical signs, up to a maximum of 28 days. For a 60 lb dog, this could range from 138 mg - 270 mg daily. 200 mg is not too much and falls within the range of typical doses. Doses can vary based on severity of infection and type of infection, which could be why your dog was on a lower dose last time.
Answered by: Christine
Date published: 2016-10-18

My dog is on simplifcef. Is it safe to give him Benadryl as well?

Asked by: Hammah
Yes, it is safe to give Simplicef and Benadryl together.
Answered by: Christine
Date published: 2016-10-13

Is 50mg daily of this safe for my 25 lb westie if she's on 10 mg of prednisone daily?

Asked by: John
Yes, this medication is safe to take with prednisone.
Answered by: Christine
Date published: 2016-10-10

Can cats take this medication?  My cat has upset tummy.

Asked by: Southernbell
Yes, cats can take Simplicef; however, it is only FDA approved for use in dogs. If your cat has an upset stomach, this may not be the best medication for them. Simplicef is an antibiotic, which can cause an upset stomach itself. Simplicef is used to treat infections, and would only benefit your cat if its upset stomach is due to an infection. More likely, your cats upset stomach is being caused by something else. I recommend contacting your veterinarian to determine the best treatment for your cats upset stomach.
Answered by: Christine
Date published: 2016-10-05

My foster dog has taken simplicef for 3 days. Now is having allergy cough, not full blown Kc and sneezing. Also is showing yellow nasal discharge. Continue 10 day script or call ask for a diff script or one in addition to?

Asked by: Jamie
Speak with your veterinarian before discontinuing the medication. They may want to change it to something else, or they may want to continue the medication for the full 10 days.
Answered by: Christine
Date published: 2016-10-04
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