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Simplicef

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Starts $2.64 $1.90 per tablet
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Product Info
How to Use
Ingredients
Customer Reviews
Q&A
Product Info
What is Simplicef?

Simplicef is a once-a-day cephalosporin antibiotic used to treat skin infections (wounds and abscesses) caused by susceptible strains of bacteria. Simplicef requires a prescription from your veterinarian, and is sold per tablet.

For:

Dogs

Benefits:
  • FDA-approved for treating canine bacterial skin infections
  • Simple once-a-day dosing
  • Can be given with or without food
  • Comes in a film-coated tablet for easy administration
How it Works:

Simplicef is effective against most gram-positive and gram-negative bacteria. Cephalosporin antibiotics suppress the growth of micro-organisms such as bacteria, fungi, or protozoa.

Cautions:

Contact your veterinarian in the event of an allergic reaction (such as shortness of breath, hives, swelling, rash, fainting, vomiting, diarrhea, mucus or blood in the stool, unusual bleeding, or bruising). Do not give Simplicef at the same time as antacids such as Maalox or other stomach acid-reducers, like Tagamet.

Brand Name:

Simplicef (Pfizer Animal Health), Vantin (Pharmacia and Upjohn)

Generic Name:

Cefpodoxime proxetil

What is the most important information I should know about Simplicef:

Simplicef is a prescription medication FDA-approved for use in dogs. Simplicef is available as 100mg elliptical scored tablets and 200mg tablets that can either be elliptical, unscored tablets marked 5229 or capsule-shaped, scored tablets marked 5229. The usual dose of Simplicef in dogs is 2.3-4.5mg/pound, given by mouth, once a day for 5 to 7 days or 2 to 3 days beyond the cessation of clinical signs, up to a maximum of 28 days. Simplicef should be given with food to increase absorption by the body. Give all of the Simplicef that is prescribed for your pet. Symptoms may begin to improve before the infection is completely treated.

What is Simplicef:

Simplicef is an antibiotic belonging to a class of drugs called cephalosporins that fight bacteria in the body. Simplicef can be used to treat many different types of infections such as bronchitis or pneumonia as well as ear, skin, and urinary tract infections. Simplicef may also be used for purposes other than those listed.

What should I discuss with my veterinarian before giving Simplicef to my pet:

Tell your veterinarian if your pet has ever had an allergic reaction to another penicillin or to a cephalosporin. Tell your veterinarian if your pet has kidney disease or stomach or intestinal disease. Tell your veterinarian if your pet is pregnant or lactating.

How should this medication be given:

Give this medication exactly as directed by your veterinarian. Simplicef should be given with food to increase absorption in the body. Keep plenty of water available for your pet to drink. Do not give Simplicef at the same time as giving antacids such as Maalox or other stomach acid reducers such as Tagamet as this may decrease the absorption of Simplicef. Give all of the Simplicef even if your pet appears to be better. Symptoms may improve before the infection is completely treated. Store tablets at room temperature away from moisture or heat. 

What happens if I miss giving a dose:

Give the missed dose as soon as you remember. Do not give a double dose unless otherwise directed by your veterinarian.

What happens if I overdose the pet:

Seek emergency veterinary medical treatment if an overdose is suspected. Symptoms of overdose may include nausea, vomiting, diarrhea, and abdominal cramps.

What should I avoid while giving Simplicef to my pet:

Do not give Simplicef at the same time as giving antacids such as Maalox or other stomach acid reducers such as Tagamet.

What are the possible side effects of Simplicef:

Stop giving Simplicef and seek emergency veterinary medical care in the event of an allergic reaction (shortness of breath; hives; swelling of the lips, tongue, or face; rash; or fainting), severe nausea, vomiting or diarrhea, mucus or blood in the stool, and unusual bleeding or bruising. Other, less serious side effects such as mild nausea, diarrhea, or yeast infection may be more likely to occur.  Continue to give Simplicef and notify your veterinarian if these symptoms occur. Talk to your veterinarian about any side effect that seems unusual or bothersome to your pet.

What other drugs will affect Simplicef:

Before giving Simplicef, tell your veterinarian if your pet is being given another antibiotic (for the same or a different infection), probenecid, a loop diuretic such as furosemide, or warfarin. You may need to have the dosage adjusted. Drugs other than those listed here may also interact with Simplicef. Talk to your veterinarian or pharmacist before giving any prescription or over-the-counter medicines, including vitamins, minerals, and herbal products.

Where can I get more information:

Your pharmacist has additional information about Simplicef written for health professionals that you may read.

How to Use
Directions:
  • Simplicef is an antibiotic belonging to a class of drugs called cephalosporins that fight bacteria in the body.
  • Simplicef can be used to treat many different types of infections such as bronchitis and pneumonia as well as ear, skin, and urinary tract infections.
Tip:

Simplicef should be given with food to increase absorption by the body.

Dosage:
Dogs:
Weight
Dosage
All weights
Give this medication exactly as directed by your veterinarian. The usual dose of Simplicef in dogs is 2.3-4.5mg/pound, given by mouth, once a day for 5 to 7 days or 2 to 3 days beyond the cessation of clinical signs, up to a maximum of 28 days.
Cats
Do not use!
Horses:
Do not use!
Storage:

Should be stored in a cool dry place.

Ingredients
Simplicef 100 mg:
Ingredient
Strength
Cefpodoxime proxetil
100 mg
Simplicef 200 mg:
Ingredient
Strength
Cefpodoxime proxetil
200 mg
Customer Reviews
Simplicef is rated 4.6071 out of 5 by 28.
Rated 5 out of 5 by from Great service My dog gets allergies in the summer months and this product really helps his skin. I love dealing with petmeds they are great
Date published: 2015-12-14
Rated 5 out of 5 by from This works great, all sores gone. We had our little guy on the two week, or 20 day plan whenever the sores started. We read about someone giving their dog the Simplicef only on weekends and this kept it clean. We started Zorro on this plan and it has been 100% effective for him. When he was on the one a day 1/2 pill regiment he seemed to gain weight. Now he has lost a few pounds and is back to his "bossy" self with lots of energy.
Date published: 2014-02-03
Rated 5 out of 5 by from Very good product My Ali suffers from bacteria around his chin and lips because he is a Boxer and they tend to slobber. His bumps are more like acne and when ruptured by scratching they bleed and become more irritating. Simplicef, after three days he is cured. Of course if I want to avoid future breakouts I give him a pill a day. This gives me peace of mind and a happy pet.
Date published: 2014-01-20
Rated 5 out of 5 by from Excellent! My dog gets really dry skin, and when I say really, I mean REALLY BAD. It was getting to the point where I was giving him baths every day just so he would stop itchy. After a nice week wait to get an appointment, when the vet finally saw me, she gave my sheltie these pills. That was over a year ago. Now, when the whether is bad, which sets off the dryness/raw spots on my dog, I call in, and they give me a refill. It is the ONLY thing that I have found to work for my dog's dry skin.
Date published: 2013-08-02
Rated 5 out of 5 by from Happy Dog My Shih Tzu suffers from year round allergies. She is allergic to most foods and pollens (I am not exaggerating). She has been plagued with chronic Staph Infections since I adopted her 3.5 years ago. Her health issues have literally cost us a small fortune. I couldn't get my pup into the vet this last time. So, she prescribed me Simplicef 100mg ($28/7pills) that I could pick up since she had just been treated 6 weeks prior with the usual meds, injectable Convenia and Steroids. To my amazement, she had NO obvious side effects and this is the first time that the infection has actually stayed away for any length of time. She usually would have the lingering allergy/staph odor and itchiness by now. But, so far so good. Fingers crossed that she (and I) will have some long lasting relief. It is great that other owners with similar issues are having such great success with this product as well. The other reviews assure me that long term relief is possible for my pup with this product. Thanks to Pet Meds for offering this product with fair pricing.
Date published: 2013-06-09
Rated 5 out of 5 by from Great for treating skin allergies Our cavalier king charles spaniel is susceptible to skin allergies - apparently common in this breed. A flare up usually results in large scabs. Ever since our vet suggested Simplicef as an alternative to the allergist route, we start it at the first sign of a flare up and the irritation clears up without going through the scab stage. And no apparent side effects. Love it!
Date published: 2013-01-01
Rated 1 out of 5 by from Bad Side effects Got this med from our vet with no explaination of side effects. Simplicef caused our dog to drink lots and lots of water which required us to let her out many, many times a day and Night. She's had several 'accidents' because she couldn't get up and let us know. It also caused her some pain either muscular or joint so she wouldn't let us pick her up, etc. In a few cases, she slipped on the hardwood floor and couldn't get up and would snap at us if we tried to help. I think clindamycin might have been a better choice. We've given her this med for the prescribed duration. Her skin infection seems to have dried up but the 'dandruff' is horrible.
Date published: 2012-08-16
Rated 5 out of 5 by from Best Our black lab.is getting her hair back on her legs. She has a bactr.infection that makes the hair and her front legs swell up and this product works very well.
Date published: 2012-07-08
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Q&A

Can Simplicef be crushed?

My dog doesn't like pills, even when given with peanut butter. Can it be safely administered crushed?
Asked by: Candi
Yes however please make sure that the entire crushed tablet and the small amount of food it is mixed into is consumed in one sitting.
Answered by: Lilli Pharmacist
Date published: 2015-08-25

Another option

My dog was spayed and part of her uterus was left. It became terribly infected, she just had surgery and it was removed. She was put on Simplicef but is still having the infected discharge. Is there another medication that may work better for this issue
Asked by: Abby's Mom
If you think your pet is not responding well to the antibiotic, please call your veterinarian to discuss this. It may just take a while to heal or you could talk to your vet about changing antibiotics if he/she thinks that it may be necessary.
Answered by: Kelly P
Date published: 2015-03-03

I have some expired Simplicef 100 mg. tabs with expiration date 1/1/13. My 18 lb. shih tzu now has what appears to be an inflamation in her right paw

Can I give her this medicine?
Asked by: Kurpster
We would NOT recommend that you give an expired medication to your pet. We also would NOT recommend that you give an antibiotic to your pet without being prescribed by a veterinarian.
Answered by: Kelly P
Date published: 2015-02-25

Can Simplicef cause inner ear irritation in dogs?

Since starting Simplicef, my dog has been shaking her head and scratching her ears. Can this be caused by this medication?
Asked by: Jon K
I suggest calling your vet right away. There may be something else going on like an ear infection.
Answered by: Linda M 1800petmeds pharmacist
Date published: 2014-12-31

Do to Cushings disease my dog needs to be sedated before getting trimmed. She is currently on simplicef. Is this safe with the sedative?

Asked by: Nancy
Yes
Answered by: Lilli Pharmacist
Date published: 2014-10-27

I gave my lactating dog simplicef for infection. will this adversely affect the puppies

she is 70 # and has taken a 200mg tablet for a bacterial infection. she is also taking 350mg aspirin for fever. puppies are 4 weeks old and eating puppy chow as well as nursing
Asked by: lorraine
Your veterinarian is aware that your dog is lactating ? At times veterinarians have to decide benefits versus risks. As long as your vet is monitoring the situation , chances are that all will be ok. There is some risk with any medication, however the infection in the mother dog has to be addressed quickly. If anything seems not right to you....trouble breathing, oversedation...then call your vet immediately .
Answered by: Linda M 1800petmeds pharmacist
Date published: 2014-04-02

Should this cause any problems with our dog's third eye?

Her third eye is drifting out to cover her left eye. This has never happened before.
Asked by: Anonymous
Meant to type third eyelid.
Answered by: Ella
Date published: 2014-01-07

My 20lb dog took a 200mg pill by accident. what should i do?

Asked by: Anonymous
Please contact your veterinarian as soon as possible.
Answered by: Stephanie Duesler, Pharm. D, MBA
Date published: 2013-08-16
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