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Treats bacterial skin infections in dogs.
 
  • FDA-approved for dogs
  • Simple once-a-day dosing
  • Requires veterinary prescription
  •  
     

    Simplicef


     
    Q & A
     
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      Product Info   How to use   Ingredients   Customer Reviews   Q & A  

    What is Simplicef?

    Simplicef is a once-a-day cephalosporin antibiotic used to treat skin infections (wounds and abscesses) caused by susceptible strains of bacteria. Simplicef requires a prescription from your veterinarian, and is sold per tablet.
    For: Dogs

    Benefits:
    FDA-approved for treating canine bacterial skin infections
    Simple once-a-day dosing
    Can be given with or without food
    Comes in a film-coated tablet for easy administration

    How it works:
    Simplicef is effective against most gram-positive and gram-negative bacteria. Cephalosporin antibiotics suppress the growth of micro-organisms such as bacteria, fungi, or protozoa.

    Cautions:
    Contact your veterinarian in the event of an allergic reaction (such as shortness of breath, hives, swelling, rash, fainting, vomiting, diarrhea, muous or blood in the stool, unusual bleeding, or bruising). Do not give Simplicef at the same time as antacids such as Maalox or other stomach acid-reducers, like Tagamet.


    More Information:
     
    Brand Name
    Simplicef (Pfizer Animal Health), Vantin (Pharmacia and Upjohn)
    Generic Name
    Cefpodoxime proxetil

    What is the most important information I should know about Simplicef: Simplicef is a prescription medication FDA-approved for use in dogs. Simplicef is available as 100mg elliptical scored tablets and 200mg tablets that can either be elliptical, unscored tablets marked 5229 or capsule-shaped, scored tablets marked 5229. The usual dose of Simplicef in dogs is 2.3-4.5mg/pound, given by mouth, once a day for 5 to 7 days or 2 to 3 days beyond the cessation of clinical signs, up to a maximum of 28 days. Simplicef should be given with food to increase absorption by the body. Give all of the Simplicef that is prescribed for your pet. Symptoms may begin to improve before the infection is completely treated.

    What is Simplicef: Simplicef is an antibiotic belonging to a class of drugs called cephalosporins that fight bacteria in the body. Simplicef can be used to treat many different types of infections such as bronchitis or pneumonia as well as ear, skin, and urinary tract infections. Simplicef may also be used for purposes other than those listed.

    What should I discuss with my veterinarian before giving Simplicef to my pet: Tell your veterinarian if your pet has ever had an allergic reaction to another penicillin or to a cephalosporin. Tell your veterinarian if your pet has kidney disease or stomach or intestinal disease. Tell your veterinarian if your pet is pregnant or lactating.

    How should this medication be given: Give this medication exactly as directed by your veterinarian. Simplicef should be given with food to increase absorption in the body. Keep plenty of water available for your pet to drink. Do not give Simplicef at the same time as giving antacids such as Maalox or other stomach acid reducers such as Tagamet as this may decrease the absorption of Simplicef. Give all of the Simplicef even if your pet appears to be better. Symptoms may improve before the infection is completely treated. Store tablets at room temperature away from moisture or heat. 

    What happens if I miss giving a dose: Give the missed dose as soon as you remember. Do not give a double dose unless otherwise directed by your veterinarian.

    What happens if I overdose the pet: Seek emergency veterinary medical treatment if an overdose is suspected. Symptoms of overdose may include nausea, vomiting, diarrhea, and abdominal cramps.

    What should I avoid while giving Simplicef to my pet: Do not give Simplicef at the same time as giving antacids such as Maalox or other stomach acid reducers such as Tagamet.

    What are the possible side effects of Simplicef: Stop giving Simplicef and seek emergency veterinary medical care in the event of an allergic reaction (shortness of breath; hives; swelling of the lips, tongue, or face; rash; or fainting), severe nausea, vomiting or diarrhea, mucus or blood in the stool, and unusual bleeding or bruising. Other, less serious side effects such as mild nausea, diarrhea, or yeast infection may be more likely to occur.  Continue to give Simplicef and notify your veterinarian if these symptoms occur. Talk to your veterinarian about any side effect that seems unusual or bothersome to your pet.

    What other drugs will affect Simplicef: Before giving Simplicef, tell your veterinarian if your pet is being given another antibiotic (for the same or a different infection), probenecid, a loop diuretic such as furosemide, or warfarin. You may need to have the dosage adjusted. Drugs other than those listed here may also interact with Simplicef. Talk to your veterinarian or pharmacist before giving any prescription or over-the-counter medicines, including vitamins, minerals, and herbal products.

    Where can I get more information: Your pharmacist has additional information about Simplicef written for health professionals that you may read.

     

    Directions:
    Simplicef is an antibiotic belonging to a class of drugs called cephalosporins that fight bacteria in the body.
    Simplicef can be used to treat many different types of infections such as bronchitis and pneumonia as well as ear, skin, and urinary tract infections.
    Tip: Simplicef should be given with food to increase absorption by the body.
    Dosage:
    Pet Weight Dosage
    Dogs: All weights Give this medication exactly as directed by your veterinarian. The usual dose of Simplicef in dogs is 2.3-4.5mg/pound, given by mouth, once a day for 5 to 7 days or 2 to 3 days beyond the cessation of clinical signs, up to a maximum of 28 days.
    Cats
    Horses:
    Storage: Should be stored in a cool dry place.
    Simplicef 100 mg:
    Ingredient Strength
    Cefpodoxime proxetil 100 mg

    Simplicef 200 mg:
    Ingredient Strength
    Cefpodoxime proxetil 200 mg

    Simplicef 4.6 5 27 27
    great product we had done everything for our dog and her severe allergies, nothing worked. she was unhappy.she has been on simplicef 100 mg 1/1/2 tablet with food a dy for over 3 years on this drug. her allergies, fallen hair, red bumps, scratching etc stop a few days after she started drug. she is almost 13 healthy, coat is shinny and full, no red bumps, no scratching, nothing. she is happy. this is a miracle drug and very expensive. she is worth it. 05/16/2011
    Simplicef Product Review One of the most frustrating problems I have faced as a veterinarian of 18 plus years experience is in client compliance in treating various infections at the appropriate dosing frequency and length of time. Many commonly used veterinary antibiotics either are very large to administer, often being in large capsule form, or have very poor palatability thereby frustrating animal guardians who will then be more likely not to follow the prescribed course of antibiotics, if there is too much of a struggle in administering a prescribed medication.. When Pfizer came out with this wonderful, easy to administer ONCE daily antibiotic, the compliance rate and clinical success rate in treated dogs improved dramatically for my clients. From its coated formulation and small size, this antibiotic is much easier to administer and use by my clients. Unlike other cephalosporins, like cephalexin, that often have to be given twice or three times daily, this small caplet reaches therapeutic concentrations in the blood for prolonged periods with only once daily administration. In particular this is most useful when treating the common staph skin infections in dogs , where length of therapy is sometimes 4-6 weeks or longer. With the development and efficacy of simplicef, I have seen much better case outcomes, especially with these skin cases, as well as other soft tissue infections including those of the urinary tract and lungs. I find that giving it with a small amount of food cuts down on any small chance at digestive upset. Of course like other antibiotics administered orally to our animals, a written prescription is necessary from your veterinarian. It is slightly more expensive, however in my opinion, the extra cost is certainly worth it, given the improved compliance and clinical outcome of my cases. I therefore give this product an overall rating and efficacy of a 5 with a taste and ease of use a 5 as well. 05/04/2009
    This works great, all sores gone. We had our little guy on the two week, or 20 day plan whenever the sores started. We read about someone giving their dog the Simplicef only on weekends and this kept it clean. We started Zorro on this plan and it has been 100% effective for him. When he was on the one a day 1/2 pill regiment he seemed to gain weight. Now he has lost a few pounds and is back to his "bossy" self with lots of energy. 02/03/2014
    Very good product My Ali suffers from bacteria around his chin and lips because he is a Boxer and they tend to slobber. His bumps are more like acne and when ruptured by scratching they bleed and become more irritating. Simplicef, after three days he is cured. Of course if I want to avoid future breakouts I give him a pill a day. This gives me peace of mind and a happy pet. 01/20/2014
    Excellent! My dog gets really dry skin, and when I say really, I mean REALLY BAD. It was getting to the point where I was giving him baths every day just so he would stop itchy. After a nice week wait to get an appointment, when the vet finally saw me, she gave my sheltie these pills. That was over a year ago. Now, when the whether is bad, which sets off the dryness/raw spots on my dog, I call in, and they give me a refill. It is the ONLY thing that I have found to work for my dog's dry skin. 08/02/2013
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    52 Questions · 64 Answers

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    Another option

    My dog was spayed and part of her uterus was left. It became terribly infected, she just had surgery and it was removed. She was put on Simplicef but is still having the infected discharge. Is there another medication that may work better for this issue
    1 month, 1 week ago
    by
    Abby's Mom
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    Answer: 
    If you think your pet is not responding well to the antibiotic, please call your veterinarian to discuss this. It may just take a while to heal or you could talk to your vet about changing antibiotics if he/she thinks that it may be necessary.
    1 month, 1 week ago
    by
    Kelly P
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    Can I give her this medicine?
    1 month, 3 weeks ago
    by
    Kurpster
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    Answer: 
    We would NOT recommend that you give an expired medication to your pet. We also would NOT recommend that you give an antibiotic to your pet without being prescribed by a veterinarian.
    1 month, 2 weeks ago
    by
    Kelly P
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    Since starting Simplicef, my dog has been shaking her head and scratching her ears. Can this be caused by this medication?
    3 months, 2 weeks ago
    by
    Jon K
    California
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    Answer: 
    I suggest calling your vet right away. There may be something else going on like an ear infection.
    3 months, 1 week ago
    by
    Linda M 1800petmeds pharmacist
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    5 months, 4 weeks ago
    by
    Nancy
    Wisconsin
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    Answer: 
    Yes
    5 months, 2 weeks ago
    by
    Lilli Pharmacist
    Pompano Beach, FL
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    she is 70 # and has taken a 200mg tablet for a bacterial infection. she is also taking 350mg aspirin for fever. puppies are 4 weeks old and eating puppy chow as well as nursing
    1 year ago
    by
    lorraine
    new castle, pa
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    Answer: 
    Your veterinarian is aware that your dog is lactating ? At times veterinarians have to decide
    benefits versus risks. As long as your vet is monitoring the situation , chances are that all will be ok.
    There is some risk with any medication, however the infection in the mother dog has to be
    addressed quickly. If anything seems not right to you....trouble breathing, oversedation...then call your vet immediately
    .
    1 year ago
    by
    Linda M 1800petmeds pharmacist
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    This information sheet is for educational purposes only and is intended to be a supplement to, and not a substitute for, the expertise and professional judgment of your veterinarian. The information is NOT to be used for diagnosis or treatment of your pet. You should always consult your own veterinarian for specific advice concerning the treatment of your pet. The information is not intended to cover all possible uses, directions, precautions, warnings, allergic reactions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for your pet. It is not a substitute for a veterinary exam, and it does not replace the need for services provided by your veterinarian.
    Note: Any trademarks are the property of their respective companies.
     
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