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Sentinel

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Product Info
How to Use
Ingredients
Customer Reviews
Q&A
Product Info
What is Sentinel?

Sentinel is the only monthly oral preventive that guards against heartworms, adult roundworms, adult hookworms, whipworms, and prevents the development of flea eggs. Sentinel requires a prescription from your veterinarian.

For:

Dogs

Benefits:
  • Comes in palatable flavored tabs
  • Easy to administer just once a month
How it Works:

Milbemycin oxime eliminates the tissue stage of heartworm larvae and the adult stage of hookworm, roundworm, and whipworm infestations. Lufenuron, the other active ingredient, is an insect development inhibitor that breaks the flea life cycle by inhibiting egg development. Lufenuron prevents most flea eggs from hatching or maturing into adults and thus prevents and controls flea populations by breaking the life cycle. Sentinel may be given along with Capstar, which treats flea infestation.

Cautions:

Side effects are rare, though some animals may exhibit depression, drowsiness, vomiting, itching, hives, loss of appetite, diarrhea, or seizures. If these or other symptoms develop contact your veterinarian. It's important to maintain good personal hygiene, since humans can contract hookworms and roundworms. It's also important to eliminate fleas and to not feed your pet uncooked meat or fish. To prevent re-infection, clean up stools on a daily basis. Consult your veterinarian for pregnant or lactating dogs.

Brand Name:

Sentinel (Novartis)

Generic Name:

Milbemycin Oxime (mil-beh-my-sin ox-eem) and Lufenuron (lew-fen-your-on)

What is Sentinel:

Sentinel is given once a month for the prevention of heartworm disease in dogs. Sentinel also protects against hookworms, roundworms, and whipworms. Sentinel is also used to control fleas by preventing the development of flea eggs. Sentinel does not kill adult fleas. The American Heartworm Society recommends that heartworm prevention be used year-round. Sentinel may also be used for purposes other than those listed in this guide.

What should I discuss with my veterinarian before giving Sentinel to my pet:

Tell your veterinarian if your pet has ever had an allergic reaction to the medication.

What is the most important information I should know about Sentinel:

Sentinel is a prescription medication FDA-approved for use in dogs. Sentinel is available as artificial beef flavored (derived from pork and soy protein) chewable tablets. This medication should be given once a month year-round.

How should this medication be given:

Give Sentinel exactly as directed by the veterinarian. If you do not understand the directions ask your pharmacist or veterinarian to explain them to you. The usual dose of Sentinel for dogs 2 to 10 pounds is 2.3mg/46mg, 11 to 25 pounds is 5.75mg/115mg, 26 to 50 pounds is 11.5mg/230mg and 51 to 100 pounds is 23mg/460mg given once a month year-round. For dogs over 100 pounds give the appropriate combination of tablets. Heartworm testing should be performed prior to the start of prevention therapy. If your pet is off Sentinel for 6 months or less, re-start the medication and test after 6 months since microfilaria, that take 6 months to mature, will result in a positive test result. Store Sentinel at room temperature. Do not remove the tablet from its wrapper until ready to give the medicine. Keep this medication away from children and pets. Consult your veterinarian for pregnant or lactating dogs.

What happens if I miss giving a dose:

Give the missed dose as soon as you remember. Do not give a double dose of the medication.

What should I avoid while giving Sentinel to my pet:

Because humans can contract hookworms and roundworms from animals, it is important to maintain good personal hygiene. It is also important to eliminate fleas on your pet and in the household and to not feed your pet rodents or uncooked meat or fish. To prevent reinfection, daily cleanup of stools is recommended.

What are the possible side effects of Sentinel:

Side effects of Sentinel are rare although some animals may exhibit depression, drowsiness, vomiting, itching, hives, loss of appetite, diarrhea, hypersalivation, seizures, and weakness. If these or other symptoms develop contact your veterinarian.

What other drugs will affect Sentinel:

While Sentinel is safe to use in dogs at risk for MDRI-allele mutation (Australian Shepherds, Collies, Shelties, etc.), unless tested normal, caution is advised if your pet is also being given amiodarone (Cordarone), azole antifungals such as ketoconazole, carvedilol (Coreg), cyclosporine (Atopica), diltiazem (Cardizem), erythromycin (Ery-Tabs) or clarithromycin (Biaxin), quinidine, spironolactone (Aldactone), tamoxifen, and verapamil (Calan). Do not give Sentinel to your pet if already giving an alternate heartworm medication.

How to Use
Directions:
  • Give Sentinel Flavor Tabs once a month on the same day of each month year-round.
  • Sentinel Flavor Tabs is for use in dogs only. Do not give to cats.
  • Watch your dog closely following dosing to be sure the entire dose has been swallowed. If it is not completely swallowed, give one more full recommended dose as soon as possible.
Tip:

Do not remove Sentinel from its wrapper until ready to give to your pet.

Dosage:
Dogs/puppies: (4 weeks of age or older)
Weight
Dosage
2-10 lbs
Give 1 Flavor Tab every month (Brown Box)
11-25 lbs
Give 1 Flavor Tab every month (Green Box)
26-50 lbs
Give 1 Flavor Tab every month (Yellow Box)
51-100 lbs
Give 1 Flavor Tab every month (White Box)
Over 100 lbs
Give combination of Flavor Tabs based on weight
Cats:
Do not use!
Horses:
Do not use!
Storage:

Should be stored at room temperature between 59° and 77° F.

Ingredients
Sentinel Brown for Dogs 2-10 lbs:
Active Ingredient (per tablet)
Amount
Milbemycin Oxime
2.3 mg
Lufenuron
46 mg
Sentinel Green for Dogs 11-25 lbs:
Active Ingredient (per tablet)
Amount
Milbemycin Oxime
5.75 mg
Lufenuron
115 mg
Sentinel Yellow for Dogs 26-50 lbs:
Active Ingredient (per tablet)
Amount
Milbemycin Oxime
11.5 mg
Lufenuron
230 mg
Sentinel White for Dogs 51-100 lbs:
Active Ingredient (per tablet)
Amount
Milbemycin Oxime
23 mg
Lufenuron
460 mg
Customer Reviews
Sentinel is rated 4.4 out of 5 by 712.
Rated 5 out of 5 by from Excelent service Could not find Sentinel for my dogs and because they had been on that since I've had them I did not want to change to something new. Pet Meds had it and all I had to do was supply them with a prescription and they mailed it to me.
Date published: 2017-02-18
Rated 5 out of 5 by from So easy to purchase. Quick ordering & delivery process
Date published: 2017-02-18
Rated 5 out of 5 by from Sentinel small breed We tried everything she would not take it. She loves sentinel, comes in the small pill she can take easily since she is only 4lbs. her mouth is very small. Hope they don't discontinue it, works great.
Date published: 2017-02-17
Rated 5 out of 5 by from Great product! My dog has been on this for 3 years now, and has no side affects.
Date published: 2017-02-17
Rated 5 out of 5 by from My chihuahua has been on Sentinel for many years and is doing well on it. It is difficult to give him pills and since Sentinal is a small pill I can cut it in half and hide it in his food.
Date published: 2017-02-17
Rated 5 out of 5 by from Great, cost effective product I love Sentinel and have used it for years with my other dogs. It is much more inexpensive than other products and works great for our fur family!
Date published: 2017-02-13
Rated 5 out of 5 by from Ruff on fleas! No fleas on my dog since we've been using Sentinel once every month. It's easy to give - I wrap Papillon's in a bit of his favorite cheese, and down it goes. It's a joy not to see him scratching anymore. And Sentinel takes care of heart worms too!
Date published: 2017-02-06
Rated 5 out of 5 by from Great doing business with 1-800 PetMeds..... We have used Sentinel with our pups for several years when my Vet stopped carrying it. We ordered from 1-800 PetMeds and were pleasantly surprised that not only did they carry it, it was significantly less expensive. Better yet,the staff is cordial and easy to work with.
Date published: 2017-02-04
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Q&A

Will sentinel harm the puppy if u skip a month? 

Asked by: Panpers287
Hello, Thank you for the question. Sentinel is given once a month to prevent worm infections as well as preventing the development of flea eggs. If you miss a dose, you should give it right away when you remember. However, doubling the dose in 1 month is not recommended. You should try to stay on the once a month regimen. Missing a month will not harm the puppy, but it could put the puppy more at risk for developing worms/fleas during that timeframe. Hope this helps. Thanks, Pharmacy student intern
Answered by: Trey W
Date published: 2017-02-16

I've been using trifexis for my dogs and it works great, but been hearing negative things about it....is this product just as effective

Asked by: Dawn3425
Hello Dawn, Thanks for your question. Both products are similar in action and side effects. Trifexis has more flea control as it will prevent and treat flea infestations as well as treat any worm infections. Sentinel will prevent worm infections and flea infestations but does not actively kill fleas. Potential side effects for both medications are vomiting, diarrhea, drowsiness, changes in appetite and activity. If anything serious develops or becomes abnormal, talk to your veterinarian right away. If your dogs are tolerating Trifexis well, I would just continue that. Remember to talk to your vet before starting any new medications or changing them. Hope this helps. Thanks, Pharmacy student intern
Answered by: Trey W
Date published: 2017-02-16

Our dog took her Sentinel, then her sister's dose too. Is this double dose something to worry about? 

Asked by: Divinationjones
No. Sentinel as been tested at much higher doses give daily with no ill effects. You dog may be a little nauseous but that should pass.
Answered by: SuzyCVT
Date published: 2017-02-15

I've always given my dog Comfortis for fleas and Heartgard for worms will switching to this product be okay for my dog?

Asked by: Md93
Yes, but the flea control will be different. Instead of killing fleas with the Comfortis, you will instead be sterilizing any fleas so they can not reproduce. The fleas will still live their 2 week life cycle and bite your dog during those 2 weeks.
Answered by: SuzyCVT
Date published: 2017-02-15

If given monthly should I still continue to worm my dogs on top of it or will this take care of it?

Asked by: Aimee1
Your dog will be dewormed every month and in most cases, that should be okay. However, if you have a problem with some intestinal parasites, most often hookworms, treating at week 2 with another dewormer may be necessary.
Answered by: SuzyCVT
Date published: 2017-02-15

Do I need script from my vet

Asked by: Bernard
Yes, all heartworm prevention requires a prescription.
Answered by: SuzyCVT
Date published: 2017-01-24

My dog weighs 180 should he still only get 1 pill for the 50-100 range?

Asked by: Austin
Your dog should actually be receiving 2 of the 50-100 pound tablets each month to fully protect him against heartworms...1 tablet to cover 100 pounds, the second to cover the next 80 pounds.
Answered by: SuzyCVT
Date published: 2017-02-15

I found an unopened box of Sentinel from October of 2013. Should I toss it or is it still safe to use?

Asked by: Doxiemom2
Check the expiration date that should be printed on the box. If it is out of date, I would not use it.
Answered by: SuzyCVT
Date published: 2017-02-15
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