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Sentinel

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Product Info
How to Use
Ingredients
Customer Reviews
Q&A
Product Info

What is Sentinel?

Sentinel is the only monthly oral preventive that guards against heartworms, adult roundworms, adult hookworms, whipworms, and prevents the development of flea eggs. Sentinel requires a prescription from your veterinarian.

NOTE: Sentinel does not kill adult fleas. If you see fleas on your pet, use Capstar Flea Treatment Tablets to quickly kill adult fleas within 30 minutes of administration.

For:

Dogs and Puppies (4+ weeks of age, weighing 2+ lbs)

Benefits:

  • Comes in palatable flavored tabs
  • Easy to administer just once a month

How does Sentinel work?

Milbemycin oxime eliminates the tissue stage of heartworm larvae and the adult stage of hookworm, roundworm, and whipworm infestations. Lufenuron, the other active ingredient, is an insect development inhibitor that breaks the flea life cycle by inhibiting egg development. Lufenuron prevents most flea eggs from hatching or maturing into adults and thus prevents and controls flea populations by breaking the life cycle. Sentinel may be given along with Capstar Flea Treatment Tablets, which treats flea infestation and kills adult fleas.

Cautions:

Side effects are rare, though some pets may exhibit vomiting, depression, drowsiness, itching, hives, loss of appetite, diarrhea, or seizures, hypersalivation, and weakness. If these or other symptoms develop contact your veterinarian. It's important to maintain good personal hygiene, since humans can contract hookworms and roundworms. It's also important to eliminate fleas and to not feed your pet rodents or uncooked meat or fish. To prevent re-infection, clean up stools on a daily basis. Consult your veterinarian for pregnant or lactating dogs.

Brand Name:

Sentinel (Virbac)

Generic Name:

Milbemycin Oxime (mil-beh-my-sin ox-eem) and Lufenuron (lew-fen-your-on)

What is the most important information I should know about Sentinel?

Sentinel is a prescription medication FDA-approved for use in dogs. Sentinel is available as artificial beef flavored (derived from pork and soy protein) chewable tablets. This medication should be given once a month year-round.

What should I discuss with my veterinarian before giving Sentinel to my pet?

Tell your veterinarian if your pet has ever had an allergic reaction to the medication.

How should Sentinel be given?

Give Sentinel exactly as directed by your veterinarian. If you do not understand the directions ask your pharmacist or veterinarian to explain them to you. The usual dose of Sentinel for dogs 2 to 10 pounds is 1 Flavor Tab every month (Brown Box), 11 to 25 pounds is 1 Flavor Tab every month (Green Box), 26 to 50 pounds is 1 Flavor Tab every month (Yellow Box) and 51 to 100 pounds is 1 Flavor Tab every month (White Box). For dogs over 100 pounds give the appropriate combination of tablets. To ensure adequate absorption, always administer Sentinel to dogs immediately after or in conjunction with a normal meal. Heartworm testing should be performed prior to the start of prevention therapy. If your pet is off Sentinel for 6 months or less, re-start the medication and test after 6 months since microfilaria, that take 6 months to mature, will result in a positive test result. Store Sentinel in a dry place at controlled room temperature, between 59-77F (15-25 C). Do not remove the tablet from its wrapper until ready to give the medicine. Keep this medication away from children and pets. Consult your veterinarian for pregnant or lactating dogs.

What are the possible side effects of Sentinel?

Side effects of Sentinel are rare although some pets may exhibit vomiting, depression, drowsiness, itching, hives, loss of appetite, diarrhea, or seizures, hypersalivation, and weakness. If these or other symptoms develop contact your veterinarian.

What happens if I miss giving a dose of Sentinel?

If a dose is missed and a 30-day interval between dosing is exceeded, administer Sentinel immediately and resume the monthly dosing schedule. If Sentinel replaces daily diethylcarbamazine (DEC) for heartworm prevention, the first dose must be given within 30 days after the last dose of DEC.

What happens if I overdose my pet on Sentinel?

Contact your veterinarian immediately.

What should I avoid while giving Sentinel to my pet?

Because humans can contract hookworms and roundworms from pets, it is important to maintain good personal hygiene. It is also important to eliminate fleas on your pet and in the household.

What other drugs will affect Sentinel?

While Sentinel is safe to use in dogs at risk for MDRI-allele mutation (Australian Shepherds, Collies, Shelties, etc.), unless tested normal, caution is advised if your pet is also being given amiodarone (Cordarone), azole antifungals such as ketoconazole, carvedilol (Coreg), cyclosporine (Atopica), diltiazem (Cardizem), erythromycin (Ery-Tabs) or clarithromycin (Biaxin), quinidine, spironolactone (Aldactone), tamoxifen, and verapamil (Calan). Do not give Sentinel to your pet if already giving an alternate heartworm medication.

How to Use
Directions:
  • Give Sentinel Flavor Tabs once a month on the same day of each month year-round.
  • Sentinel Flavor Tabs is for use in dogs only. Do not give to cats.
  • Watch your dog closely following dosing to be sure the entire dose has been swallowed. If it is not completely swallowed, give one more full recommended dose as soon as possible.
  • To ensure adequate absorption, always administer Sentinel to dogs immediately after or in conjunction with a normal meal.
  • Sentinel has no effect on adult fleas, but controls flea populations by breaking the flea life cycle at the egg stage.
  • To speed control of flea infestation, products that kill adult fleas like Capstar Flea Treatment Tablets may be used temporarily with Sentinel depending on the severity of the infestation.
  • Treatment may begin at any time of the year.
  • It is important to treat all dogs in the household for fleas. Cats in the same household should be treated with approved products for heartworm prevention for cats.
Tip:

Do not remove Sentinel from its wrapper until ready to give to your pet.

Dosage:
Dogs/puppies: (4+ weeks of age, weighing 2+ lbs)
Weight
Dosage
2-10 lbs
Give 1 Flavor Tab every month (Brown Box)
11-25 lbs
Give 1 Flavor Tab every month (Green Box)
26-50 lbs
Give 1 Flavor Tab every month (Yellow Box)
51-100 lbs
Give 1 Flavor Tab every month (White Box)
Over 100 lbs
Give combination of Flavor Tabs based on weight
Cats:
Do not use!
Horses:
Do not use!
Storage:

Should be stored at room temperature between 59° and 77° F.

Ingredients
Sentinel Brown for Dogs 2-10 lbs:
Active Ingredient (per tablet)
Amount
Milbemycin Oxime
2.3 mg
Lufenuron
46 mg
Sentinel Green for Dogs 11-25 lbs:
Active Ingredient (per tablet)
Amount
Milbemycin Oxime
5.75 mg
Lufenuron
115 mg
Sentinel Yellow for Dogs 26-50 lbs:
Active Ingredient (per tablet)
Amount
Milbemycin Oxime
11.5 mg
Lufenuron
230 mg
Sentinel White for Dogs 51-100 lbs:
Active Ingredient (per tablet)
Amount
Milbemycin Oxime
23 mg
Lufenuron
460 mg
Customer Reviews
Sentinel is rated 4.4 out of 5 by 717.
Rated 5 out of 5 by from Excellent product and service I have been using Sentinal with all of my dogs since the mid 1990s and it has kept them safe from the ravages of flea and tick borne diseases, including heart-worm with no apparent ill effect. The dogs take the liver-tabs willingly, even eagerly, so there is no need to 'trick' them into taking it by hiding it in food or pill pockets. I am a big fan of this product and hope it will continue to be available for a long time. Pet-Meds' service was top-notch as well. "Miss Polly" and I are grateful. Thank you.
Date published: 2017-03-20
Rated 1 out of 5 by from Sugar Pill? Starting to think I've been purchasing sugar pills for my poor golden. Have been using these for a little over a year now and my pup has gotten fleas at least 3-4 times while on Sentinel. We have never forgotten to give him his monthly dose, so adherence really isnt an issue. He currently is not on any other medications, so drug to drug interactions cannot possibly be the issue for the lack of efficacy. His dose is also the proper dose....cant seem to figure out why my guy cant kick the fleas. Anyway, although he never puts up a fuss when we give him his Sentinel, we're going to have to make a switch. We wanted Sentinel to work for us, but sadly it's just not the product for us.
Date published: 2017-03-19
Rated 5 out of 5 by from Great product I love this product and have been using it on all my dogs for years. I love shopping here at 1800petmeds, very reasonable prices.
Date published: 2017-03-15
Rated 5 out of 5 by from Good product and excellent customer service
Date published: 2017-03-06
Rated 5 out of 5 by from Life Saver! In June 2016 my dog Baby Girl tested positive for heartworms. I put her on sentinel heartworm prevention pills for 6 months and had her retested. Negative. Heartworms all gone. This is a miracle drug. Thank You.
Date published: 2017-03-06
Rated 5 out of 5 by from Excelent service Could not find Sentinel for my dogs and because they had been on that since I've had them I did not want to change to something new. Pet Meds had it and all I had to do was supply them with a prescription and they mailed it to me.
Date published: 2017-02-18
Rated 5 out of 5 by from So easy to purchase. Quick ordering & delivery process
Date published: 2017-02-18
Rated 5 out of 5 by from Sentinel small breed We tried everything she would not take it. She loves sentinel, comes in the small pill she can take easily since she is only 4lbs. her mouth is very small. Hope they don't discontinue it, works great.
Date published: 2017-02-17
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Q&A

So, I read a question and it said that they give their pet comfortis and asked if this will still kill the fleas, the response was that sentinol will sterilize the fleas but still live. So, if I want to kill the fleas should I give her comfortis as well?

Asked by: Cyndy
Yes, Comfortis is approved to kill fleas, while Sentinel is approved to prevent development of flea egg formation.
Answered by: Ben B
Date published: 2017-03-15

Can an adult dog with a history of seizures take Sentinel SAFELY? We've taken him off of Trifexis in case that medication could be contributing to his episodes. And we discounted Nexgard because it is contraindicated in dogs with seizures. Thanks. 

Asked by: Masha
This product does have rare side effects of seizures. I would consult with your veterinarian before use.
Answered by: Ben B
Date published: 2017-03-14

How come the 50.1 to 100 lbs is 56 and some change here but my vet is charging me $87 and some change for a six pack of Sentinel.

Asked by: Shelly
Your vet does not just have a warehouse full of product purchased at a bulk discount. He/she also has a hospital to maintain, staff and operate.
Answered by: SuzyCVT
Date published: 2017-03-14

Does Sentinel prevent against ticks too???? Thank you. 

Asked by: Mindy1234
No, you will need a separate product to control ticks. It is safe to use medication that not only kills ticks but fleas as well as Sentinel does not kill fleas, it sterilizes them instead.
Answered by: SuzyCVT
Date published: 2017-03-11

My dog weighed in at a winter weight of 100.2 pounds this morning with heavy collar and no bm yet today. The vet is demanding that I purchase both the 51-100 and 2-10 pound doses for him. Seems like massive overkill. Is this really necessary?

Asked by: laurie29
If you are actually worried about your pets health then yes you should get both sizes. If you are not wanting to spend the money then buy one 2-10lb dose and cut back on your pet's food and treats so next month your dog will actually be under 100lb. Manufacture companies have product guarentees so when you don't get the right dosage for your pet the company won't pay for treatment if it comes up positive for something the medication is supposed to cover.
Answered by: GracieLyn
Date published: 2017-03-07

Does this product also take care of tapeworms?

Asked by: Kari
Sentinel Spectrum is what you are looking for, but honestly if you plan on using an additional flea and tick medicine its not worth it to pay the extra money for me. Me personally I use Sentinel and Seresto and animals get tapeworms from fleas so if you dont have a flea problem its unnecessary.
Answered by: GracieLyn
Date published: 2017-03-07

Will sentinel harm the puppy if u skip a month? 

Asked by: Panpers287
Hello, Thank you for the question. Sentinel is given once a month to prevent worm infections as well as preventing the development of flea eggs. If you miss a dose, you should give it right away when you remember. However, doubling the dose in 1 month is not recommended. You should try to stay on the once a month regimen. Missing a month will not harm the puppy, but it could put the puppy more at risk for developing worms/fleas during that timeframe. Hope this helps. Thanks, Pharmacy student intern
Answered by: Trey W
Date published: 2017-02-16

I've been using trifexis for my dogs and it works great, but been hearing negative things about it....is this product just as effective

Asked by: Dawn3425
Hello Dawn, Thanks for your question. Both products are similar in action and side effects. Trifexis has more flea control as it will prevent and treat flea infestations as well as treat any worm infections. Sentinel will prevent worm infections and flea infestations but does not actively kill fleas. Potential side effects for both medications are vomiting, diarrhea, drowsiness, changes in appetite and activity. If anything serious develops or becomes abnormal, talk to your veterinarian right away. If your dogs are tolerating Trifexis well, I would just continue that. Remember to talk to your vet before starting any new medications or changing them. Hope this helps. Thanks, Pharmacy student intern
Answered by: Trey W
Date published: 2017-02-16
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