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Sentinel

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Starts $53.74 $38.69 
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Dog
02-10 lbs
11-25 lbs
26-50 lbs
51-100 lbs
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6 pack
$53.74
$42.99
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12 pack
$99.98
$79.98
$71.98
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Product Info
How to Use
Ingredients
Customer Reviews
Q&A
Product Info
What is Sentinel?

Sentinel is the only monthly oral preventive that guards against heartworms, adult roundworms, adult hookworms, whipworms, and prevents the development of flea eggs. Sentinel requires a prescription from your veterinarian.

For:

Dogs

Benefits:
  • Comes in palatable flavored tabs
  • Easy to administer just once a month
How it Works:

Milbemycin oxime eliminates the tissue stage of heartworm larvae and the adult stage of hookworm, roundworm, and whipworm infestations. Lufenuron, the other active ingredient, is an insect development inhibitor that breaks the flea life cycle by inhibiting egg development. Lufenuron prevents most flea eggs from hatching or maturing into adults and thus prevents and controls flea populations by breaking the life cycle. Sentinel may be given along with Capstar, which treats flea infestation.

Cautions:

Side effects are rare, though some animals may exhibit depression, drowsiness, vomiting, itching, hives, loss of appetite, diarrhea, or seizures. If these or other symptoms develop contact your veterinarian. It's important to maintain good personal hygiene, since humans can contract hookworms and roundworms. It's also important to eliminate fleas and to not feed your pet uncooked meat or fish. To prevent re-infection, clean up stools on a daily basis. Consult your veterinarian for pregnant or lactating dogs.

Brand Name:

Sentinel (Novartis)

Generic Name:

Milbemycin Oxime (mil-beh-my-sin ox-eem) and Lufenuron (lew-fen-your-on)

What is Sentinel:

Sentinel is given once a month for the prevention of heartworm disease in dogs. Sentinel also protects against hookworms, roundworms, and whipworms. Sentinel is also used to control fleas by preventing the development of flea eggs. Sentinel does not kill adult fleas. The American Heartworm Society recommends that heartworm prevention be used year-round. Sentinel may also be used for purposes other than those listed in this guide.

What should I discuss with my veterinarian before giving Sentinel to my pet:

Tell your veterinarian if your pet has ever had an allergic reaction to the medication.

What is the most important information I should know about Sentinel:

Sentinel is a prescription medication FDA-approved for use in dogs. Sentinel is available as artificial beef flavored (derived from pork and soy protein) chewable tablets. This medication should be given once a month year-round.

How should this medication be given:

Give Sentinel exactly as directed by the veterinarian. If you do not understand the directions ask your pharmacist or veterinarian to explain them to you. The usual dose of Sentinel for dogs 2 to 10 pounds is 2.3mg/46mg, 11 to 25 pounds is 5.75mg/115mg, 26 to 50 pounds is 11.5mg/230mg and 51 to 100 pounds is 23mg/460mg given once a month year-round. For dogs over 100 pounds give the appropriate combination of tablets. Heartworm testing should be performed prior to the start of prevention therapy. If your pet is off Sentinel for 6 months or less, re-start the medication and test after 6 months since microfilaria, that take 6 months to mature, will result in a positive test result. Store Sentinel at room temperature. Do not remove the tablet from its wrapper until ready to give the medicine. Keep this medication away from children and pets. Consult your veterinarian for pregnant or lactating dogs.

What happens if I miss giving a dose:

Give the missed dose as soon as you remember. Do not give a double dose of the medication.

What should I avoid while giving Sentinel to my pet:

Because humans can contract hookworms and roundworms from animals, it is important to maintain good personal hygiene. It is also important to eliminate fleas on your pet and in the household and to not feed your pet rodents or uncooked meat or fish. To prevent reinfection, daily cleanup of stools is recommended.

What are the possible side effects of Sentinel:

Side effects of Sentinel are rare although some animals may exhibit depression, drowsiness, vomiting, itching, hives, loss of appetite, diarrhea, hypersalivation, seizures, and weakness. If these or other symptoms develop contact your veterinarian.

What other drugs will affect Sentinel:

While Sentinel is safe to use in dogs at risk for MDRI-allele mutation (Australian Shepherds, Collies, Shelties, etc.), unless tested normal, caution is advised if your pet is also being given amiodarone (Cordarone), azole antifungals such as ketoconazole, carvedilol (Coreg), cyclosporine (Atopica), diltiazem (Cardizem), erythromycin (Ery-Tabs) or clarithromycin (Biaxin), quinidine, spironolactone (Aldactone), tamoxifen, and verapamil (Calan). Do not give Sentinel to your pet if already giving an alternate heartworm medication.

How to Use
Directions:
  • Give Sentinel Flavor Tabs once a month on the same day of each month year-round.
  • Sentinel Flavor Tabs is for use in dogs only. Do not give to cats.
  • Watch your dog closely following dosing to be sure the entire dose has been swallowed. If it is not completely swallowed, give one more full recommended dose as soon as possible.
Tip:

Do not remove Sentinel from its wrapper until ready to give to your pet.

Dosage:
Dogs/puppies: (4 weeks of age or older)
Weight
Dosage
2-10 lbs
Give 1 Flavor Tab every month (Brown Box)
11-25 lbs
Give 1 Flavor Tab every month (Green Box)
26-50 lbs
Give 1 Flavor Tab every month (Yellow Box)
51-100 lbs
Give 1 Flavor Tab every month (White Box)
Over 100 lbs
Give combination of Flavor Tabs based on weight
Cats:
Do not use!
Horses:
Do not use!
Storage:

Should be stored at room temperature between 59° and 77° F.

Ingredients
Sentinel Brown for Dogs 2-10 lbs:
Active Ingredient (per tablet)
Amount
Milbemycin Oxime
2.3 mg
Lufenuron
46 mg
Sentinel Green for Dogs 11-25 lbs:
Active Ingredient (per tablet)
Amount
Milbemycin Oxime
5.75 mg
Lufenuron
115 mg
Sentinel Yellow for Dogs 26-50 lbs:
Active Ingredient (per tablet)
Amount
Milbemycin Oxime
11.5 mg
Lufenuron
230 mg
Sentinel White for Dogs 51-100 lbs:
Active Ingredient (per tablet)
Amount
Milbemycin Oxime
23 mg
Lufenuron
460 mg
Customer Reviews
Sentinel is rated 4.424778761061947 out of 5 by 678.
Rated 1 out of 5 by from Fleas We just got a puppy a week ago from a breeder, and I took her to the vet, and they prescribed Sentinel. I just picked two fleas off of my puppy in my house. I'm pretty disgusted and creeped out.
Date published: 2016-08-27
Rated 4 out of 5 by from Happy to make the switch! I talked to my vet about switching from trifexis as my dog always seemed to get sick after using that product. My vet recommended sentinel and she hasn't gotten sick since! Really glad we made the switch as trifexis was too hard on her stomach.
Date published: 2016-08-20
Rated 2 out of 5 by from Not Great After many recommendations from friends and family we choose this over Trifexis for our 3 year old Golden Retriever. This is suppose to be prevent both fleas and heart worms however our Korra is covered with fleas every few days. We have tried this for two months now. We will be switching to a different two in one medication.
Date published: 2016-08-17
Rated 5 out of 5 by from Works Great!!!!! I have been using this product since the day I adopt each of my 3 pups. All tolerate it well. Little to no stomach upset even in my sensitive stomach Border Collie mix.
Date published: 2016-08-06
Rated 5 out of 5 by from Amazing I used to use trifexis until my vet switched due to health concerns. I am so happy I switched to sentinel. I have not seen any side effects and my dog doesn't get sick like she did with trifexis. It's easy for her to eat and she loves it mixed with a little peanut butter. I would definitely recommend this for every other owner
Date published: 2016-08-06
Rated 5 out of 5 by from Love it! Sadie had a severe reaction to Heartguard Plus so my vet suggested Sentinel. She is doing just fine after her first dose. I hope it continues!!
Date published: 2016-07-26
Rated 4 out of 5 by from Sentinal is a great product Sentinal is a great product but more so this review is about the EXCEPTIONAL customer service I got from 1800petmeds !! Thank you !!
Date published: 2016-07-24
Rated 5 out of 5 by from Works great! i have been giving this to my dogs for many years mainly for the flea prevention. We never have to worry about fleas. During a rough season we might see a flea on them but nothing becomes of it. It works. I have been concerned about whether is is healthy for my dogs, but I see the other options for flea control causing all kinds of health issues and seizurs and not controlling the fleas. ie like the drops, shampoos, sprays and collars. Those options can poison not only the animal but anyone that touches them.
Date published: 2016-07-21
  • 2016-09-26T06:05CST
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Q&A

How do I get the coupon?

Asked by: Joe J
jj777
Answered by: jackie
Date published: 2016-09-06

How safe or not safe is Sentinel?

Specifically, what does Milbemycin Oxime do to a dog's body? And what does Lufenuron do to a dog's body?
Asked by: Jo
Milbemycin oxime eliminates the tissue stage of heartworm larvae and the adult stage of hookworm, roundworm, and whipworm infestations. Lufenuron, the other active ingredient, is an insect development inhibitor that breaks the flea life cycle by inhibiting egg development. Lufenuron prevents most flea eggs from hatching or maturing into adults and thus prevents and controls flea populations by breaking the life cycle.
Answered by: paulpharmacistintern
Date published: 2016-08-19

Can I use a topical flea and tick like K-9 Advantix or Frontline with Sentinel?

Asked by: Lisa
Yes Sentinel can be used with either of those products.
Answered by: paulpharmacistintern
Date published: 2016-08-18

I was given Sentinel for my 86 lb dog and they're great and want to keep buying them but unforunately can't afford the vet's price for them and i was just wondering that if i can buy them off the website, do i have to contact my vet for a prescription ?

Asked by: Rosie
Yes you will need to get a prescription from your veterinarian to buy that med here.
Answered by: paulpharmacistintern
Date published: 2016-08-13

Does this also cover ticks or do we need to by Frontline or something similar as well?

Asked by: enb555
You'll need an additional medication for tick coverage.
Answered by: paulpharmacistintern
Date published: 2016-08-11

Is this a years supply?

Asked by: Sadie
If ordering the 12 pack, this will last you for a year.
Answered by: paulpharmacistintern
Date published: 2016-08-11

My puppy has gained 20 lbs in less than 2 months. She is 46 lbs now and still has much more growth to go. Should I order the 50lb+ pack?

Asked by: Andals
It is an idea but one you should discuss with your veterinarian before deciding.
Answered by: paulpharmacistintern
Date published: 2016-08-03

My Catahoula loves the water and outdoors but also loves to taste everything on the ground and lick me! She's currently on Heartguard and K9 Advantix ll and I feel that's too much medicine for her. Does Sentinel have more or less medicine?

Asked by: SiouxzQ
Sentinel does cover the general bugs your other two medications cover, but not all, Advantix II covers a wider range of fleas and ticks. This would be a judgment call between you and your veterinarian to drop the two medications for Sentinel.
Answered by: paulpharmacistintern
Date published: 2016-08-02
  • 2016-09-26T06:03CST
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