Sentinel is the only monthly oral preventive that guards against heartworms, adult roundworms, adult hookworms, whipworms, and prevents the development of flea eggs. Sentinel requires a prescription from your veterinarian.
Comes in palatable flavored tabs
Easy to administer just once a month
How it works:
Milbemycin oxime eliminates the tissue stage of heartworm larvae and the adult stage of hookworm, roundworm, and whipworm infestations. Lufenuron, the other active ingredient, is an insect development inhibitor that breaks the flea life cycle by inhibiting egg development. Lufenuron prevents most flea eggs from hatching or maturing into adults and thus prevents and controls flea populations by breaking the life cycle.
Sentinel may be given along with Capstar, which treats flea infestation.
Side effects are rare, though some animals may exhibit depression, drowsiness, vomiting, itching, hives, loss of appetite, diarrhea, or seizures. If these or other symptoms develop contact your veterinarian. Its important to maintain good personal hygiene, since humans can contract hookworms and roundworms. Its also important to eliminate fleas and to not feed your pet uncooked meat or fish. To prevent re-infection, clean up stools on a daily basis.
Consult your veterinarian for pregnant or lactating
Brand Name Sentinel (Novartis)
Generic Name Milbemycin Oxime (milí-beh-myí-sin oxí-eem) and Lufenuron (lew-fení-your-on)
What is the most important information I should know about Sentinel: Sentinel is a prescription medication FDA-approved for use in dogs. Sentinel is available as artificial beef flavored (derived from pork and soy protein) chewable tablets. This medication should be given once a month year-round.
What is Sentinel: Sentinel is given once a month for the prevention of heartworm disease in dogs. Sentinel also protects against hookworms, roundworms, and whipworms. Sentinel is also used to control fleas by preventing the development of flea eggs. Sentinel does not kill adult fleas. The American Heartworm Society recommends that heartworm prevention be used year-round. Sentinel may also be used for purposes other than those listed in this guide.
What should I discuss with my veterinarian before giving Sentinel to my pet: Tell your veterinarian if your pet has ever had an allergic reaction to the medication.
How should this medication be given: Give Sentinel exactly as directed by the veterinarian. If you do not understand the directions ask your pharmacist or veterinarian to explain them to you. The usual dose of Sentinel for dogs 2 to 10 pounds is 2.3mg/46mg, 11 to 25 pounds is 5.75mg/115mg, 26 to 50 pounds is 11.5mg/230mg and 51 to 100 pounds is 23mg/460mg given once a month year-round. For dogs over 100 pounds give the appropriate combination of tablets. Heartworm testing should be performed prior to the start of prevention therapy. If your pet is off Sentinel for 6 months or less, re-start the medication and test after 6 months since microfilaria, that take 6 months to mature, will result in a positive test result. Store Sentinel at room temperature. Do not remove the tablet from its wrapper until ready to give the medicine. Keep this medication away from children and pets. Consult your veterinarian for pregnant or lactating dogs.
What happens if I miss giving a dose: Give the missed dose as soon as you remember. Do not give a double dose of the medication.
What happens if I overdose the pet: Seek emergency veterinary medical treatment. Symptoms of overdose may include depression, drowsiness, vomiting, loss of appetite, diarrhea, hypersalivation, seizures, and weakness.
What should I avoid while giving Sentinel to my pet: Because humans can contract hookworms and roundworms from animals, it is important to maintain good personal hygiene. It is also important to eliminate fleas on your pet and in the household and to not feed your pet rodents or uncooked meat or fish. To prevent reinfection, daily cleanup of stools is recommended.
What are the possible side effects of Sentinel: Side effects of Sentinel are rare although some animals may exhibit depression, drowsiness, vomiting, itching, hives, loss of appetite, diarrhea, hypersalivation, seizures, and weakness. If these or other symptoms develop contact your veterinarian.
What other drugs will affect Sentinel: While Sentinel is safe to use in dogs at risk for MDRI-allele mutation (Australian Shepherds, Collies, Shelties,etc.), unless tested normal, caution is advised if the pet is also being given amiodarone (Cordarone), azole antifungals such as ketoconazole, carvedilol (Coreg), cyclosporine (Atopica), diltiazem (Cardizem), erthromycin (Ery-Tabs) or clarithromycin (Biaxin), quinidine, spironolactone (Adlactone), tamoxifen, and verapamil (Calan). Do not give Sentinel to your pet if already giving an alternate heartworm medication.
Where can I get more information: Your pharmacist has additional information about Sentinel written for health professionals that you may read.
Give Sentinel Flavor Tabs once a month on the same day of each month year-round.
Sentinel Flavor Tabs is for use in dogs only. Do not give to cats.
Watch your dog closely following dosing to be sure the entire dose has been swallowed. If it is not completely swallowed, give one more full recommended dose as soon as possible.
Tip: Do not remove Sentinel from its wrapper until ready to give to your pet.
Dogs/puppies: (4 weeks of age or older)
Give 1 Flavor Tab every month (Brown Box)
Give 1 Flavor Tab every month (Green Box)
Give 1 Flavor Tab every month (Yellow Box)
Give 1 Flavor Tab every month (White Box)
Over 100 lbs
Give combination of Flavor Tabs based on weight
Storage: Should be stored at room temperature between 59° and 77° F.
Sentinel Brown for Dogs 2-10 lbs:
Active Ingredient (per tablet)
Sentinel Green for Dogs 11-25 lbs:
Active Ingredient (per tablet)
Sentinel Yellow for Dogs 26-50 lbs:
Active Ingredient (per tablet)
Sentinel White for Dogs 51-100 lbs:
Active Ingredient (per tablet)
I have used Sentinel for many years, and I am SO glad that Sentinel is back on the market. It is wonderful for long-term flea control (unlike the flea product in Trifexis, which only works for a couple of weeks per dose) If my dogs act like they've picked up a flea when I'm giving Sentinel, I just give them a dose of Capstar (which I have only had to do on rare occasions#. The insect growth inhibitor in Sentinel (lufenuron) really works because the fleas that bite your dog can't produce viable offspring, and it doesn't seem to wear off between doses.
I won't give Heartguard to my shelties because of possible life-threatening adverse reactions in the collie breeds. Mibemycin oxime #the heartworm product in Sentinel) is the only heartworm product I will give my dogs.
Sentinel is the best!
If it is not broken, don't change it.
Product has worked for pets for years without any problems. A different vet talked us into using another heart worm (more expensive) product. We also had to purchase another product for flea control. It was ridiculous for heart worm and flea treatment for 6 months to have a cost of more than $400.00. We have gone back to sentinel (the one with flea control included). Now, for 2 dogs, the cost for protection from heart worm and flea control is approx. $160.00 for 12 months. Now, if they get sick, I can take then to the vet because I have saved quite a bit and still have my pets protected.
The best we've tried.
I don't know that I would have given this product 5 stars until trying other oral options when Sentinel was unavailable from the clinic and vet. I know pugs are generally very sensitive, and after taking a sentinel pill, puggy is always lethargic and seems to not be feeling his best for about a day. BUT...other options won't stay down at all (induced repetitive vomiting) and the pill was HUGE (had to break it into pieces, and it still came up.)
Sentinal works, is easy to swallow for the little one, and is the most cost effective! I am stocking up also...
We love it
So glad Sentinel is back. It's the easiest and most effective (not to mention a good price) for my toy poodle.
As for the taste...I put a 3 since he doesn't chew it up happily. He takes it easiest when I put it at the back of his throat :o)
I'm so happy that Sentinel has been brought back! I doubled my order of this product and find the effectiveness is excellent (flea control plus heartworm control). PetMeds always ships quickly and is so easy to use and the personnel are extremely friendly and ever so helpful.
This information sheet is for educational purposes only and is intended to be a supplement to, and not a substitute for, the expertise and professional judgment of your veterinarian. The information is NOT to be used for diagnosis or treatment of your pet. You should always consult your own veterinarian for specific advice concerning the treatment of your pet. The information is not intended to cover all possible uses, directions, precautions, warnings, allergic reactions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for your pet. It is not a substitute for a veterinary exam, and it does not replace the need for services provided by your veterinarian. Note: Any trademarks are the property of their respective companies.