What is Reconcile?

• Within 8 weeks, 73% of dogs treated with Reconcile showed significant improvement as compared to behavior modification alone (51%).
• 42% of dogs receiving Reconcile showed significant improvement within the 1st week, which was significantly greater than with behavior modification alone (18%).

How it works:
Reconcile (fluoxetine hydrochloride) affects chemicals in the brain that can cause depression, panic, anxiety, or obsessive-compulsive behaviors.

Cautions:
Do not use in animals allergic to fluoxetine or other SSRIs. Do not use in animals with a history of epilepsy or seizures. Use with caution in pregnant animals. Do not use in lactating animals.

What is the most important information I should know about Reconcile: Do not give Reconcile to dogs using acepromazine or an MAOI such as Anipryl, selegiline, Preventic Collar, or Mitaban Dip. You must wait at least 14 days after stopping an MAOI before you can give Reconcile. You must wait 6 weeks after stopping Reconcile before you can use an MAOI. Do not give Reconcile to dogs with epilepsy or seizures. Do not give Reconcile to lactating females.

What is Reconcile: Reconcile is an antidepressant in a group of drugs called selective serotonin reuptake inhibitors (SSRIs). Reconcile is a prescription medication FDA approved for use in dogs for the treatment of canine separation anxiety in conjunction with a behavior modification plan. A typical behavior modification plan consists of the pet owner implementing standard training techniques based on principals such as rewarding appropriate behavior, coming and going in a manner that does not elicit inappropriate responses from the dog, and teaching the dog to be content while alone. Reconcile is available as 8mg, 16mg, 32mg and 64mg chewable tablets.The usual dose in dogs is 0.5mg-0.9mg/pound given once a day. It may take from 1 to 4 weeks before the medication becomes effective.

What should I discuss with my veterinarian before giving Reconcile: Tell your veterinarian if your pet is being given Anipryl (selegiline) or if your pet is using Mitaban Dip or a Preventic Collar. Tell your veterinarian about any other medications your pet is being given. Tell your veterinarian if your pet is allergic to any medications of if your pet has liver disease, kidney disease, diabetes, or seizures. Reconcile should not be given to lactating animals. Reconcile should not be used in pets with epilepsy or seizures.

How should this medication be given: Give Reconcile exactly as prescribed by your veterinarian. If you do not understand the directions ask your pharmacist or veterinarian to explain them to you. Do not give larger amounts or give it for longer than recommended by your veterinarian. Your veterinarian may occasionally change the dose to achieve the best result. It may take 1 to 4 weeks or longer before Reconcile takes effect. Do not stop using Reconcile without first consulting with your veterinarian. Store Reconcile in the package it came in, tightly closed. Do not remove the dessicant canister from the bottle. Store this medication at room temperature (68º -77ºF). Excursions are permitted between (59º-86º F). Keep this medication away from children and other pets.

What happens if I miss giving a dose: Give the missed dose as soon as you remember. However, if it is almost time for the next regularly scheduled dose, skip the missed dose and give the next one as directed. Do not give a double dose of the medication.

What happens if I overdose the pet: Contact your veterinarian or veterinary emergency room. Symptoms of overdose may include behavior changes, tremors, fever, sleepiness, rapid or uneven heartbeat, panting, irritability, confusion, fainting, seizures, vomiting ( a symptom of liver disease), and coma.

What should I avoid while giving Reconcile to my pet: Tell your veterinarian before giving any other medications. Reconcile is not for use in humans. In case of accidental ingestion by a human, contact your physician immediately.

What are the possible side effects of Reconcile: If any of the following serious side effects occur, stop giving Reconcile and seek emergency veterinary medical attention; an allergic reaction (skin rash or hives, difficulty breathing, swelling of the face, lips, tongue, or throat). Call your veterinarian at once if your pet has any new or worsening symptoms such as mood or behavior changes such as aggression, temporary weight loss, lethargy, vomiting, shaking, diarrhea, restlessness, anxiety, panting, sleep disturbances, excess barking, hyperactivity, and irritability. Talk to your veterinarian about any side effect that seems unusual or bothersome to the animal or if the pet's appetite does not return to normal.

What other drugs will affect Reconcile: Before giving Reconcile, tell your veterinarian if your pet is being given metoclopramide (Reglan), digoxin (Lanoxin), diazepam (Valium), phenytoin (Dilantin), warfarin (Coumadin), tricyclic antidepressnts such as amitriptyline (Elavil), imipramine (Tofranil), and clomipramine (Clomicalm). Drugs other than those listed may also interact with Reconcile. Talk to your veterinarian or pharmacist before giving any prescription or over the counter medicines including herbal supplement.

Where can I get more information: Your pharmacist has additional information about Reconcile written for health professionals that you may read.