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Proin


 
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Proin is available in all states except Arkansas, Iowa, Louisiana, Illinois and Oregon where it is classified as a controlled substance.
 
                         
 
 
  Product Info   How to use   Ingredients   Customer Reviews   Q & A  

What is Proin?

Proin is an aid in the management of urinary incontinence in dogs. Proin requires a prescription from your veterinarian.
 
For: Dogs
 
Benefits:
Is a supplement for urinary incontinence in dogs
Ensures sustained phenylpropanolamine levels in the blood stream and may help reduce the conditions often associated with high levels of phenylpropanolamine such as: decreased appetite, changes in heart rate, increased blood pressure, hyperexcitability
Proin
 
Alternate photos:
  Proin Chewable Flavor Tabs
  Proin Drops

How it works:
Proin contains the active ingredient phenylpropanolamine, an adrenergic agent that works by tightening the bladder sphincter muscle, which helps to control urine leakage.

Cautions:
Don't give Proin with ephedrine or epinephrine, and don't give it within two weeks of using a MAOi, such as Anipryl, selegiline or a Preventic Collar. Possible side effects can occur, including restlessness, or loss of appetite, difficulty breathing, hives, and swelling of the lips, tongue, or face. If these or any other side effects occur, contact your veterinarian immediately. We do not ship Proin to Arkansas, Iowa, Louisiana and Oregon where it is classified as a controlled substance.


More Information:
Brand Name
Proin (PRN Pharmacal)
Generic Name
Phenylpropanolamine

What is the most important information I should know about Proin: Proin is a prescription medication for veterinary use in dogs. Proin is available as 25mg, 50mg and 75mg chewable, liver flavor tablets and 25mg/ml drops in a 2 oz dropper bottle. Proin may cause restlessness, irritability, or loss of appetite.

What is Proin: Proin is an adrenergic agent used as a supplemental product for urinary incontinence in dogs. Proin may also be used for purposes other than those listed in this guide.

What should I discuss with my veterinarian before giving Proin to my pet: Tell your veterinarian if your pet has ever had an allergic reaction to this medication. Tell your veterinarian if your pet has glaucoma, hyperthyroid disease, diabetes, heart problems or high blood pressure. Tell your veterinarian if your pet is pregnant or lactating.

How should this medication be given: The usual dose for dogs is 0.4-0.8mg/pound every 12 hours. Give Proin exactly as directed by the veterinarian. If you do not understand the directions ask the pharmacist or veterinarian to explain them to you. Store Proin at room temperature away from moisture and heat. Keep this medication away from children and pets. 

What happens if I miss giving a dose: Give the missed dose as soon as you remember during the same day. However, if you don't remember until the next day, skip the dose you missed and give only the next regularly scheduled dose. Do not give a double dose of the medication.

What happens if I overdose the pet: Seek emergency veterinary medical treatment. Symptoms of overdose may include increased blood pressure, increased heart rate, seizures or coma.

What should I avoid while giving Proin to my pet: Do not give Proin with ephedrine or epinephrine and do not give within 2 weeks of using an MAOi such as selegilene or Preventic Collar.

What are the possible side effects of Proin: Stop giving Proin and contact your veterinarian immediately if your pet has an allergic reaction (difficulty breathing; swelling of the lips, tongue, face; and hives). Other side effects that may occur include restlessness, irritability, increased heart rate, increased blood pressure and loss of appetite. Continue to give the medication and contact your veterinarian. Other less serious side effects may occur. Contact your veterinarian about any side effects that seem bothersome.

What other drugs will affect Proin: Before giving Proin, tell your veterinarian if your pet is being given digoxin, NSAIDs such as aspirin or Rimadyl, tricyclic antidepressants such as clomipramine, and beta blockers such as atenolol, or any other prescription or over the counter medications. 

Where can I get more information: Your pharmacist has additional information about Proin written for health professionals that you may read.

Directions:
Proin liver flavored chewable tablets are available by prescription for use in dogs to treat urinary incontinence.
Proin may cause restlessness, irritability, or loss of appetite.
Tell your veterinarian about any other medication you may be giving your pet.
Tip: Give this medication exactly as directed by your veterinarian. Do not exceed 1.8mg/lb per day. The medication may be given with food.
Dosage:
Pet Weight Dosage
Dogs: All weights Tablets: The usual dose for dogs is 0.4-0.8mg/pound every 12 hours.
Drops: 0.4-0.8mg/pound every 12 hours.
Cats:
Horses:
Storage: Should be stored at room temperature away from moisture and heat. Keep this medication away from children and pets.
Proin Chewable Flavor Tabs 25 mg:
Active Ingredients Strength
Phenylpropanolamine 25 mg

Proin Chewable Flavor Tabs 50 mg:
Active Ingredients Strength
Phenylpropanolamine 50 mg

Proin Chewable Flavor Tabs 75 mg:
Active Ingredients Strength
Phenylpropanolamine 75 mg

Proin Drops:
Active Ingredients Strength
Phenylpropanolamine 25 mg/mL
Proin 4.6 5 487 490
WORKS!!! thank goodness I have had my Samoyed for 10 1/2 years. She is diabetic, insuline dependent, blind and has recently become incontinent. My vet prescribed Proin at a VERY high price. :/ I was told to call PetMeds. What a great group of CARING people helping with our pets. The medicine TOTALLY works. Aphro doesn't love the taste so much but she takes them just fine. I am so happy that this is working so well..... THANK YOU 1800 Pet Meds! 05/24/2011
FANTASTIC - WORKED!! I did a little internet research, and decided to try this when our Border Collie (age 14) began to have incontinence when sleeping. When awake, she was OK, used the doggy door, no problem. About 3 days after starting her on the 25 mg. dose (once daily with her food), the incontinence STOPPED completely. I'm amazed and thankful!! No more bed washing, and carpet cleaning every day, and the odor is gone from the house - OUTSTANDING. And working with 1-800 is ALWAYS a pleasure. Their customer service is FANTASTIC and FAST. THANKS!! 05/12/2011
Great Solution My Ruby is a large Great Pyrenees/Airedale mix (94 lbs.). She is two years old and began "wetting her bed" after she was spayed. The Proin has totally eliminated that problem. We are very happy with this solution. 04/20/2011
Great Meds! My dog has been on Proin since he was 9 months old, he is now 4 years old. He was diagnosed with a loose sphincter muscle, which is why the urine would leak out. My two comments are....the sure fire way we have given him Proin for the past several years is whole in PUMPKIN PUREE on a fork! He will not take it on a spoon or with applesauce, yogurt, cheese, etc. This is great because it is healthy for him anyways. And my other comment is, there are times maybe once or twice a year when we have to bump his medicine up for a week or two because it seems to ware off for him. So, instead of doing a 1/2 tab in the morning and a whole tab at night- we will do a whole tab two times a day. This has seemed to work well for us. 04/13/2011
PROIN product review: PROIN product review: One of the most common problems seen in spayed or neutered pets, especially as they get older is the development of urine incontinence, where pets will sometimes leak urine involuntarily while laying, sleeping and even walking sometimes. In my 17 years of medical practice, our profession has looked into many drugs to help treat this frustrating yet common condition. While some of these alternative drugs have helped, they are sometimes very expensive, while in other cases side effects can occur. So most conventional veterinarians will usually reach first for one of two drugs to treat this frustrating problem. Either low dose estrogen/hormonal therapy, or more commonly a prescription drug like proin. The main ingredient(called phenylproponolamine) helps tighten the smooth muscle tone around the urethra thus helping to minimize this frustrating involuntary leaking of urine from the bladder. While it is commonly prescribed twice daily by many veterinarians, I have found it to be as equally effective when given once daily at a dose of 3/4 mg per per pound. I even saw a journal article touting this once day use at this dose over the more common twice daily use. Many clients will notice immediate relief, while others can take several days to a week or two. However I am often able to taper this drug down to every other day or even a once or twice weekly on rare cases, while others need it daily to control the urine leaking. It is very important, however for animal guardians to have a urinary tract infection ruled out first, before starting a drug like this, as well as rule out a genetic anatomic problem of the bladder or urinary tract, if the patient is a young puppy under one year of age, as well as masses/tumors in older animals. If a thorough workup fails to detect an underlying cause of the leaking then certainly ask your vet about possibly writing a prescription for this often effective medication. The only rare side effects I have seen are digestive upset and vomiting in some animals, as well as in some pets a more rapid heart rate, due to the main ingredient in this medicine called phenylproponolamine. In fact, in human medicine, this drug was taken off the market because of worries and risks of cardiovascular issues in human patients. I have not seen this to be a major factor in veterinary medicine, but if you have an older pet with either a heart murmur or heart ailment , or some other illness that might be associated with high blood pressure like kidney disease or Cushings disease, then it is probably best to have your vet monitor the blood pressure both before and if he/she decides to start this medication. And while it does come in a chewable tablet that most dogs will accept, I have found palatability to be a problem in some dogs in taking it, even with clever disguising in treats. My overall rating of this product is a 4, its efficacy a 4.5, and its ease of use/taste a 3. , 12/29/2008
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146 Questions · 227 Answers

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Military family with an Fpo/ap address. Can this be shipped to us?
1 month, 1 week ago
by
Anonymous
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Answer: 
Yes we can ship Proin to military addresses.
1 month, 1 week ago
by
Pharmacist
Pompano beach
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My friend moved to Turkey a few years ago and her dog needs Proin (unavailable there). Cna she order Proin from over there if she provides her Turkish Vet's contact info ?
1 month, 4 weeks ago
by
Gmannnn
NYC
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Answer: 
Unfortunately we cannot ship Proin out of the United States since it is considered a controlled substance in some other countries.
1 month, 3 weeks ago
by
Pharmacist
Pompano beach
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She is approx 48 pounds. We are usually very careful but came home from dinner and each independently gave her her meds... is this an overdose? I would think an overdose would be exceeding 100mg, or if she had gotten into the bottle... please help!!!???
2 months, 4 weeks ago
by
bz
Denver
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Answer: 
The maximum recommended dose for a 48 pound dog is 76.8mg, I would not worry too much about the increased dose this one time since it is still within the treatment range.
2 months, 3 weeks ago
by
Pharmacist
Pompano beach
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I live in south korea. this means i have to send my prescription from here. is it possible to get this?? I rily need to buy this.
also, is it correct that we can`t stop the pill once, he take it?
2 months, 4 weeks ago
by
Anonymous
korea
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Answer: 
We can also call your veterinarian or email them for permission on the script. Is your vet willing
to give a verbal script over the phone ? That would speed up the process.
2 months, 4 weeks ago
by
Linda M 1800petmeds pharmacist
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4 months, 3 weeks ago
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Carla
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Cinnamon has always been hyper. We notice very little change. Other than making sure everybody goes out side at the same time and comes in at the same time. You would think she is a sheep dog.
3 months, 3 weeks ago
by
Cinnamon's Mom
Sacramento, CA
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Answer: 
This medication can have a stimulating effect. Please notify your vet right away. Perhaps a
decrease in dose may make a difference.
4 months, 2 weeks ago
by
Linda M 1800petmeds pharmacist
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This information sheet is for educational purposes only and is intended to be a supplement to, and not a substitute for, the expertise and professional judgment of your veterinarian. The information is NOT to be used for diagnosis or treatment of your pet. You should always consult your own veterinarian for specific advice concerning the treatment of your pet. The information is not intended to cover all possible uses, directions, precautions, warnings, allergic reactions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for your pet. It is not a substitute for a veterinary exam, and it does not replace the need for services provided by your veterinarian.
Note: Any trademarks are the property of their respective companies.
 
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