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Product Info
How to Use
Customer Reviews
Product Info
What is Proin?

Proin is an aid in the management of urinary incontinence in dogs. Proin requires a prescription from your veterinarian, and is considered a controlled substance in Iowa and Louisiana.



  • Is a supplement for urinary incontinence in dogs
  • Ensures sustained phenylpropanolamine levels in the blood stream and may help reduce the conditions often associated with high levels of phenylpropanolamine such as: decreased appetite, changes in heart rate, increased blood pressure, hyperexcitability
How it Works:

Proin contains the active ingredient phenylpropanolamine, an adrenergic agent that works by tightening the bladder sphincter muscle, which helps to control urine leakage.


Don't give Proin with ephedrine or epinephrine, and don't give it within two weeks of using a MAOi, such as Anipryl, selegiline or a Preventic Collar. Possible side effects can occur, including restlessness, or loss of appetite, difficulty breathing, hives, and swelling of the lips, tongue, or face. If these or any other side effects occur, contact your veterinarian immediately. Proin is unavailable to be shipped to Arkansas, Iowa or Oregon.

Brand Name:

Proin (PRN Pharmacal)

Generic Name:


What is the most important information I should know about Proin:

Proin is a prescription medication for veterinary use in dogs. Proin is available as 25mg, 50mg and 75mg chewable, liver flavor tablets. Proin may cause restlessness, irritability, or loss of appetite.

What is Proin:

Proin is an adrenergic agent used as a supplemental product for urinary incontinence in dogs. Proin may also be used for purposes other than those listed in this guide.

What should I discuss with my veterinarian before giving Proin to my pet:

Tell your veterinarian if your pet has ever had an allergic reaction to this medication. Tell your veterinarian if your pet has glaucoma, hyperthyroid disease, diabetes, heart problems or high blood pressure. Tell your veterinarian if your pet is pregnant or lactating.

How should this medication be given:

The usual dose for dogs is 0.4-0.8mg/pound every 12 hours. Give Proin exactly as directed by the veterinarian. If you do not understand the directions ask the pharmacist or veterinarian to explain them to you. Store Proin at room temperature away from moisture and heat. Keep this medication away from children and pets. 

What happens if I miss giving a dose:

Give the missed dose as soon as you remember during the same day. However, if you don't remember until the next day, skip the dose you missed and give only the next regularly scheduled dose. Do not give a double dose of the medication.

What happens if I overdose the pet:

Seek emergency veterinary medical treatment. Symptoms of overdose may include increased blood pressure, increased heart rate, seizures or coma.

What should I avoid while giving Proin to my pet:

Do not give Proin with ephedrine or epinephrine and do not give within 2 weeks of using an MAOi such as selegiline or Preventic Collar.

What are the possible side effects of Proin:

Stop giving Proin and contact your veterinarian immediately if your pet has an allergic reaction (difficulty breathing; swelling of the lips, tongue, face; and hives). Other side effects that may occur include restlessness, irritability, increased heart rate, increased blood pressure and loss of appetite. Continue to give the medication and contact your veterinarian. Other less serious side effects may occur. Contact your veterinarian about any side effects that seem bothersome.

What other drugs will affect Proin:

Before giving Proin, tell your veterinarian if your pet is being given digoxin, NSAIDs such as aspirin or Rimadyl, tricyclic antidepressants such as clomipramine, and beta blockers such as atenolol, or any other prescription or over the counter medications. 

Where can I get more information:

Your pharmacist has additional information about Proin written for health professionals that you may read.

How to Use
  • Proin liver flavored chewable tablets are available by prescription for use in dogs to treat urinary incontinence.
  • Proin may cause restlessness, irritability, or loss of appetite.
  • Tell your veterinarian about any other medication you may be giving your pet.

Give this medication exactly as directed by your veterinarian. Do not exceed 1.8mg/lb per day. The medication may be given with food.

All weights
The usual dose for dogs is 0.4-0.8mg/pound every 12 hours.
Do not use!
Do not use!

Should be stored at room temperature away from moisture and heat. Keep this medication away from children and pets.

Proin Chewable Flavor Tabs 25 mg:
Active Ingredients
25 mg
Proin Chewable Flavor Tabs 50 mg:
Active Ingredients
50 mg
Proin Chewable Flavor Tabs 75 mg:
Active Ingredients
75 mg
Customer Reviews
Proin is rated 4.6484 out of 5 by 583.
Rated 5 out of 5 by from Very Effective drug! Within days of starting Proin, my 12 year old lab went from leaving puddles wherever she would lie down to absolutely no leakage!! She has been on it about 8 months now and it has saved my floors and rugs and her dignity!
Date published: 2016-06-20
Rated 5 out of 5 by from Works Like a Charm! Our 14 year old Yellow lab began experiencing incontinence out of the blue two years ago. I began to research incontinence issues with dogs and came across the use of Proin. She is 62 lbs and one 50 mg tab with peanut butter in the morning and another 50 mg at night cured the problem. And the few times we forgot to give it to her, we were reminded by a puddle on the kitchen floor within a few hours of missing the dose. It truly helps, and we are all much happier!
Date published: 2016-06-07
Rated 5 out of 5 by from No more wet spots My Doberman is a 6 year old female and spayed. Athena has the problem of wetting herself when lying down to nap or simply relaxing. Started about the time she turned 3 years old. Keep a shower curtain and blanket on her bed and mine during the day. Plus where ever she wants lie in the living room. Athena is a bed hog so she sleeps in her own bed at night. . Poor girl looked ashamed every time she wet herself after waking up for her rump would be wet. Athena's veterinary Dr T recommended for her to take Proin once a day but that did not stop the dribbling until she started on 2 pills a day. Since starting Proin twice a day, she will occasionally have a little accident during the night or sick, only a small wet spot not a full wetting as before taking her Proin. Athena refuses to take the pill. Can't hide the pill in her food or treat nor can I crush it to hide in wet food. Wasted a lot of crushed pills and can food in attempts to get her take anything with medicine. Until I got smart (bad mommy) and started pushing the pill down her throat twice a day and each time she gets a kiss and treat.
Date published: 2016-05-31
Rated 5 out of 5 by from No more leaking! What a blessing! I say leaking but my sweet blue heeler literally wakes up in a pool of pea. Not sure exactly why cuz I did not do all the testing, started with the proin. It's only been about 2 months now & we're already starting to lower the dose, she's doing great! No more drips, no more wet couch!!! Way better price than at vets office too! yay!
Date published: 2016-05-09
Rated 5 out of 5 by from Works quickly! I bought this last week and started my dog on it less than a week ago. I've already been able to tell a difference. Before Proin, she would be laying down and then startle herself because she had urinated where she was laying. This would happen anywhere from 1-6 times a day. Since using Proin, I've only noticed 2 small wet spots over the past week! It's incredible! Also, my dog is a 50lb boxer/pit mix, and I'm giving her 1 25mg per day.
Date published: 2016-04-27
Rated 5 out of 5 by from Fantastic product! I have been amazed how well Proin works for our 20 year old mixed breed dog. She has been on Proin for 6 months and the leaking has completely stopped (Actually it stopped after about 4 days of consistent doses). Before Proin, she would leak every time she laid down and was miserable (not to mention making a mess of the carpet and her doggy bed). Proin has stopped the leaking completely and there are absolutely no side effects. Just make sure to stay on top of it though and be consistent with the doses..if you forget a couple of doses they will start leaking again and it can take awhile for the Proin to start working again.
Date published: 2016-04-26
Rated 5 out of 5 by from safe I had read over the internet that this was a dangerous drug and a lot of dogs died from it. My Pit is 27 years old and has been on these for 2 months and urine accidents are now rare. Love it!
Date published: 2016-04-26
Rated 5 out of 5 by from Lifesaver! My Giant Schnauzer was born with a weak urethral sphincter and has had trouble holding her urine while sleeping since we got her at 3 months. After a little tweaking of dosing, Proin has been a lifesaver for us. No more bed wetting.
Date published: 2016-04-15
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Is there a liquid form of ProIn

My dog is 16 yrs old and I have literally tried everything including steak to give her the proin, she will spit it out everytime, I am at my wits end and because of this she has to wear a diaper at night
Asked by: Anonymous
I give my dog proin and have got a pill crusher. It grinds it up and then I mix it in with her dry food and just a bit of soft food. 
Answered by: Lisa
Date published: 2016-03-14

I have a written Rx for this item, how Domingo about ordering? Can I email copy of Rx?

Asked by: Boo1
Prescriptions cannot be emailed by law. Please mail the written prescription to the following address: 1800PetMeds 1441 SW 29 Avenue Pompano Beach, FL 33069
Answered by: Lisa M
Date published: 2016-03-26

breaking Proin 50 tablets

Should you wear gloves when breaking these tablets? Is is possible for the powder to be absorbed through the skin and thus create human health issues?
Asked by: Marty
I never do. Just use a knife to split it.
Answered by: Bort
Date published: 2015-12-23

Proin prescription in Arizona

Is this basically saying if I ask the vet for a prescription for Proin they have to do it? Is 1800petmeds considered a dispensing veterinarian? Arizona Administrative Code R3-11-801. Notification That Prescription-only Drugs Or Controlled Substances May Be Available At A Pharmacy A. A dispensing veterinarian shall notify an animal owner that some prescription-only drugs and controlled substances may be available at a pharmacy by: 1. Stating the availability at or before the time of dispensing; 2. Posting a written statement that is visible to the animal owner; or 3. Providing the animal owner with written notification. B. A dispensing veterinarian may provide a written prescription to the animal owner if requested by an animal owner.
Asked by: bluenose
Proin is a prescription medication that may be prescribed by your veterinarian if the veterinarian feels your pet's diagnosis will benefit from the medication. It is to the disgression of your veterinarian to prescribe the medication and they are not obligated to approve the medication. Our company is a registered pharmacy that has dispensing priviledges in all 50 states and is not a veterinarian's office. We can dispense Proin only if we have received the approval from a licensed veterinarian to do so.
Answered by: Lilli Pharmacist
Date published: 2015-09-22

Teacup Yorkie 3.5 lbs, Can use Proin?

I have Yorkie 12 years old, his weight only 3.5 lbs, can use the Proin, if yes, please let me know how to take?
Asked by: Lydia
The dose would be determined by your vet. Please consult your veterinarian.
Answered by: Stephanie Duesler, Pharm. D, MBA
Date published: 2015-08-28

will Proin be effective with leakage from Nuero Myolopathy

My dog is 60 # and is becoming more incontenent as his disease progresses. Is this something Proin can help or is it for other causes?
Asked by: Anonymous
Its possible that Proin may help. Please discuss with your veterinarian. Good luck to you,
Answered by: Linda M 1800petmeds pharmacist
Date published: 2015-07-26

what if my dog wont eat it?

is it ok to grind the pill down and mix with his food? he wont eat even pieces, even if hidden in his food.
Asked by: Anonymous
I have given it to my dog in his food with hot water, wait a few minutes and then crush the pill with a fork. My dog licked the bowl clean. Good luck!
Answered by: Doglover37
Date published: 2015-07-15

can I order Proin 50 from you without going thru my vet

Asked by: Anonymous
No, you need a prescription from your veternarian.
Answered by: sport
Date published: 2015-06-28
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