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ProZinc Cat Insulin

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40 units/ml 10 ml Vial
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Product Info
How to Use
Ingredients
Customer Reviews
Q&A
Product Info
What is ProZinc Cat Insulin?

ProZinc is insulin combined with zinc and protamine which helps to prolong the release of the insulin into your cat's body. ProZinc requires a prescription from your veterinarian. U-40 Syringes are sold separately. ProZinc Cat Insulin requires refrigeration and must be kept at refrigerator temperatures at all times. To ensure proper temperature, it requires overnight shipping at an additional cost.

For:

Cats

Benefits:
  • Helps control blood glucose and alleviate symptoms of diabetes.
  • It is the first and only FDA-approved insulin for cats made from recombinant DNA (DNA molecules created from the DNA of two unrelated organisms) that is identical to human insulin.
  • The ingredients in ProZinc (protamine zinc insulin) are classified as long-acting with duration of effect for 10-14 hours.
How it Works:

Like other insulins, ProZinc controls blood glucose by stimulating carbohydrate metabolism in heart, bone and fat tissue, helping these cells to use glucose for energy.

Cautions:

Syringes are sold separately. We recommend using U-40 syringes. ProZinc is for use in cats only. Keep out of reach of children. Avoid contact with eyes. Accidental injection may cause hypoglycemia. In case of accidental injection, seek medical attention immediately. Exposure to product may induce a local or systematic allergic reaction in sensitized individuals. Do not switch from one type insulin to another unless under the directions of a veterinarian. Changing from one insulin to another may require an adjustment in the dose.

Brand Name:

ProZinc

Generic Name:

protamine zinc recombinant human insulin

What is the most important information I should know about ProZinc:

Diabetes mellitus is a disease where the body produces insufficient insulin. The low insulin levels may result in high blood glucose that could produce the following changes in a cat; increased thirst, urination and appetite; weight loss; high levels of glucose in the urine. ProZinc is not a cure for diabetes mellitus, it can control the levels of glucose in the blood to help alleviate the clinical signs. Follow any diet or exercise plan developed by your Veterinarian.

What is ProZinc:

Insulin is a hormone naturally produced by the pancreas. Insulin enables the body to use the sugar in food as a source of energy. When the body does not produce enough insulin, or when the insulin produced by the body is not effective enough, this condition is called diabetes mellitus. This condition allows sugar levels in the body to become very high. ProZinc is a protamine zinc insulin, a type of long-acting insulin derived from recombinant human insulin used to reduce hyperglycemia (high blood glucose or sugar) in cats with diabetes mellitus. A licensed veterinarian must prescribe ProZinc insulin for your cat. ProZinc insulin should be given to cats only. Seek medical attention immediately if you accidentally inject yourself with ProZinc insulin. ProZinc is available by prescription as a sterile injectable suspension in 10 ml multidose vials. Each ml of ProZinc product contains 40 International Units (U) of recombinant human insulin and is given to cats by subcutaneous injection.

What should I discuss with my veterinarian before giving ProZinc:

Do not give ProZinc to cats sensitive to Protamine zinc recombinant human insulin or any other ingredients in the ProZinc product. Do not give ProZinc during episodes of hypoglycemia. Before using ProZinc, tell your veterinarian if your cat has any other medical conditions or allergies, or if your cat takes any other prescription or over the counter medications, including vitamins, minerals, and herbal supplements. Tell your veterinarian if your cat is pregnant, nursing, or if you plan to breed your cat.

How should this medication be given:

Do not switch from one type insulin to another unless under the directions of a veterinarian. Changing from one insulin to another may require an adjustment in the dose. ProZinc should be given according to your veterinarian's instructions. ProZinc is given using a U-40 syringe only. Use of a syringe other than a U-40 syringe will result in incorrect dosing. ProZinc should not be shaken. Just prior to use, the vial should be mixed by rolling the vial between the palms of your hands. Do not reuse a syringe. Dispose of all syringes in an appropriate puncture-resistant disposal container. Dosage regimens of ProZinc will vary among patients. The recommended starting dose is 0.1 to 0.3 units per lb of body weight every 12 hours. This dose should be adjusted based on changes in blood glucose levels and resolution of clinical signs. Further adjustments may be necessary with changes in the cat's diet, body weight or other medications, or if the cat develops an infection, inflammation, neoplasia or an additional endocrine or other medical disorder. Store ProZinc in an upright position, in the refrigerator, between 36°-46° F. Do not freeze. Protect from light. Keep this medication out of the reach of children and pets.

What happens if I miss giving a dose:

Contact and follow your veterinarian's directions if you miss giving a dose of ProZinc. If you cannot contact your veterinarian and your cat is eating and acting normally, give your cat the usual dose at the next regularly scheduled time. To prevent missed doses, be sure to always have enough ProZinc on hand.

What happens if I overdose the pet:

Contact your veterinarian immediately if you inject more than the prescribed amount of ProZinc. Signs of hypoglycemia that may occur include; weakness; depression, lethargy, sluggishness; staggering gait; behavioral changes; muscle twitching; seizures; coma; death.

What should I avoid while giving ProZinc:

ProZinc should be given to cats only. ProZinc should not be administered to humans. Call a physician immediately if you accidentally inject yourself with ProZinc. Do not give a dose of ProZinc to a cat experiencing an episode of low blood glucose (hypoglycemia). Common causes for hypoglycemia include excessive doses of insulin, failure to eat, accidental doubling of insulin dose, strenuous exercise, correction of obesity or diabetes-inducing disease, drug effects. Do not give a dose of PROZINC if the cat has not eaten or is vomiting.

What are the possible side effects of ProZinc:

Rarely, allergic reactions to insulin can occur. Seek emergency veterinary medical attention if an allergic reaction is experienced (difficulty breathing, swelling of the lips, tongue, or face; or hives). Other serious side effects can occur with or without warning. The most common insulin-related side effect is low blood sugar (hypoglycemia) with symptoms that include; weakness; depression, lethargy, sluggishness; staggering gait; behavioral changes; muscle twitching; seizures; coma; death. Contact your veterinarian immediately if your cat has a medical problem or side effect from ProZinc therapy. Other side effects may occur. Talk to your veterinarian about any side effect that seems unusual or bothersome to the cat.

What other drugs will affect ProZinc:

ProZinc can be given with other medications, but the dose may need to be adjusted due to the medication resulting in either increased or decreased insulin requirements. Do not give any other prescription or over the counter medications, including vitamins, minerals and herbal products, without first talking to your veterinarian or pharmacist during treatment with ProZinc.

Where can I get more information:

Your pharmacist has additional information about ProZinc written for health professionals that you can read.

How to Use
Directions:
  • ProZinc is the first and only FDA-approved protamine zinc insulin for cats containing human recombinant insulin.
  • ProZinc helps control blood glucose by stimulating carbohydrate metabolism in heart, bone and fat tissue, helping these cells to use glucose for energy.
  • The ingredients in ProZinc (protamine zinc insulin) are classified as long-acting with a duration of effect for 10-14 hours.
Tip:

Speak to your veterinarian about your cat's exercise and diet, as these can help maintain healthy glucose levels.

Dosage:
Cats:
Weight
Dosage
All weights
Before using ProZinc you should have your vet the proper way to inject insulin. Your cat's injection should be given at feeding time or just afterward. Give the injections at the same time every day, approximately 12 hours apart to help your cat maintain the most stable blood glucose levels. The initial recommended dose is 0.1 - 0.3 IU insulin/pound of body weight (0.2-0.7 IU/kg) every 12 hours.
Dogs:
Do not use!
Horses:
Do not use!
Ingredients
ProZinc Insulin for Cats:
Active Ingredients per mL
Amount
Recombinant Human Insulin
40 IU (International Units)
Protamine Sulfate
.466 mg
Zinc Oxide
0.088 mg
Glycerin
16.00 mg
Dibasic Sodium Phosphate Heptahydrate
3.78 mg
Phenol (added as a preservative)
2.50 mg
Hydrochloric Acid
1.63 mg
Water for injection (maximum)
1005 mg
Other: pH is adjusted with hydrochloric acid and/or sodium hydroxide.
Customer Reviews
ProZinc Cat Insulin is rated 4.6667 out of 5 by 9.
Rated 5 out of 5 by from Over $40 less here than from the Vet! The exact same insulin the Vet sold me for $179! Yah, yah - they have to make a living, but isn't that an overly generous mark-up? They charge exorbitant prices for everything as it is...just waiting till they start charging you to make an appointment for your pet.... Thank you "1-800-PetMeds" for existing!
Date published: 2015-06-15
Rated 4 out of 5 by from Seems to be working.. The king of black cats, J.J. was diagnosed with diabetes recently. His vet wrote a prescription, but when I went to fill it, it was $380.00!!! no way can I afford that, especially if he needs to be on it for a while. So my search began, and ended at 1800 PetMeds. I was happy to find this insulin, told the vet- he checked it out and gave us the green light. We go for a check this next week to see how J.J.'s insulin levels are doing. Will report back soon..
Date published: 2014-11-28
Rated 5 out of 5 by from About ProZinc My sweet little Felix has been on ProZinc since 2009. And I still have him around. He has enjoyed a normal life since he has been on this insulin. It works ! We tried others first, not very good results. He runs , plays, loves to sit in the windows and watch the birds for hours. He is a happy kitty and so am I !!!! Thanks to ProZinc
Date published: 2014-04-28
Rated 3 out of 5 by from It works but has side effects. I have been using it now for over one and a half years. My Zoey is 14 it works well but she has side effects. I didn't read the info that came with it...everyone should. I coudn't understand why her eyes kept pusing..and had to keep giving her antibiotics to off set that...I called the ProZinc people and they were very helpful. explaining it is a side efffect in some cats...so if I don't want to keep buying antibiotics every month...I have to find a different insulin... sorry to say...
Date published: 2013-08-20
Rated 5 out of 5 by from Used for my Dog i have a 13 yr old mix pug/boxer has been diabetic for over 1 year. we have tried all insulin and nothing would hold him. My vet suggested this insulin, i was alarmed as it is a cat insulin only. Guess what, it works on my Ewok. I did read a few cases it has been used on dogs hard to regulate, and it does work on mine. thank you ProZinc we laugh waiting for him to meow.
Date published: 2013-03-13
Rated 5 out of 5 by from Diabetic cat - long life Our cat, has been diabetic for 5 years. He has been on Prozinc and is 18 years old. Theis proves that animals can have a happy, health, and good life while diabetic.
Date published: 2012-07-01
Rated 5 out of 5 by from A product that works! My 12-year-old male cat developed diabetes 1 1/2 years ago and was put on ProZinc immediately. He continued having severe symptoms, including diabetic neuropathy in his back legs, until the therapeutic dose was found. At that point, the neuropathy disappeared as did all other symptoms. That was 6 months ago and he is now full of energy, walking normally, and a healthy-appearing cat in every way. ProZinc works!
Date published: 2012-06-29
Rated 5 out of 5 by from My happy kitty My cat Baby was near death with his numbers at 531. The vet put him on Prozinc and he immediately felt much better. He is now a new cat, and he is 13 years old. I give him only 2 units after his breakfast and I am very happy myself. Thank you Prozinc you saved his life!
Date published: 2012-05-12
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Q&A

If kitty did exceptionally well on Vetsulin, how likely is it he will do well on ProZinc?

Asked by: Scaredy's mom
This is a question in need of a professional answer...spend the money & ask your vet.
Answered by: Pearl'sMom
Date published: 2015-08-25

Dosage conversion

When switching from Prozinc to Humilin N was is the conversion +/-? I keep reading that you may need to adjust the dosage, however are the two products relatively the same, and you may have to adjust the dosage up or down? Better yet, should you administer the same dosage of the prozinc, and adjust humilin according to response.
Asked by: catlady
Spend the money & ask your vet.
Answered by: Pearl'sMom
Date published: 2015-08-25

Can I use ProZinc for my dogs diabetes?

Asked by: Teddy
A couple of ProZinc reviewers on this very website are have great results using it for their dogs.
Answered by: Pearl'sMom
Date published: 2015-06-15

If prozinc is left out overnight will it be ruined?

If I leave prozinc out over night without putting it back in the refrigirator until the next morning, is the insulin ruined?
Asked by: cass
As long as it wasn't 100 degs overnight inside your house it's still perfectly okay.
Answered by: Pearl'sMom
Date published: 2015-06-15

How long does in the insuline last in a syringe if it is refridgerated?

Asked by: Anonymous
In the bottle if refrigerated properly it should last until the bottle's empty - not too sure about the life of insulin in a syringe. Did see it mentioned on a website tho about feline diabetes I saw just today.
Answered by: Pearl'sMom
Date published: 2015-06-15

My cat has severe allergic reactions to human insulin. Will this insulin have the same reaction?

Asked by: Miss Muffet
From what I've read on a multitude of websites - PZI insulin is diabetic human insulin made for felines. The other major brand is different.
Answered by: Pearl'sMom
Date published: 2015-06-15

I accidently left the insuline out on a cool granite counter for 2 1/2 hrs is it still good?

Asked by: jewel
Yes it is.
Answered by: Pearl'sMom
Date published: 2015-06-15

Can you use any other syringes with the Prozinc insulin?

My cat is currently on the Prozinc insulin and I am using u40 syringes 28g 1/2". I really want to get some syringes that the length of the needle is shorter to avoid poking all the way through the skin. Are there any shorter u40 syringes?
Asked by: Alisa
There are several great websites on the care of diabetic felines. I remember reading about needles lengths in one just today. There appears to be different lengths available.
Answered by: Pearl'sMom
Date published: 2015-06-15
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