ProZinc is insulin combined with zinc and protamine which helps to prolong the release of the insulin into your cat's body. ProZinc requires a prescription from your veterinarian. U-40 Syringes are sold separately. ProZinc Cat Insulin requires refrigeration and must be kept at refrigerator temperatures at all times. To ensure proper temperature, it requires overnight shipping at an additional cost.
Helps control blood glucose and alleviate symptoms of diabetes.
It is the first and only FDA-approved insulin for cats made from recombinant DNA (DNA molecules created from the DNA of two unrelated organisms) that is identical to human insulin.
The ingredients in ProZinc (protamine zinc insulin) are classified as long-acting with duration of effect for 10-14 hours.
How it works:
Like other insulins, ProZinc controls blood glucose by stimulating carbohydrate metabolism in heart, bone and fat tissue, helping these cells to use glucose for energy.
Syringes are sold separately. We recommend using U-40 syringes. ProZinc is for use in cats only. Keep out of reach of children. Avoid contact with eyes. Accidental injection may cause hypoglycemia. In case of accidental injection, seek medical attention immediately. Exposure to product may induce a local or systematic allergic reaction in sensitized individuals. Do not switch from one type insulin to another unless under the directions of a veterinarian. Changing from one insulin to another may require an adjustment in the dose.
Generic Name protamine zinc recombinant human insulin
What is the most important information I should know about ProZinc: Diabetes mellitus is a disease where the body produces insufficient insulin. The low insulin levels may result in high blood glucose that could produce the following changes in a cat; increased thirst, urination and appetite; weight loss; high levels of glucose in the urine. ProZinc is not a cure for diabetes mellitus, it can control the levels of glucose in the blood to help alleviate the clinical signs. Follow any diet or exercise plan developed by your Veterinarian.
What is ProZinc: Insulin is a hormone naturally produced by the pancreas. Insulin enables the body to use the sugar in food as a source of energy. When the body does not produce enough insulin, or when the insulin produced by the body is not effective enough, this condition is called diabetes mellitus. This condition allows sugar levels in the body to become very high. ProZinc is a protamine zinc insulin, a type of long-acting insulin derived from recombinant human insulin used to reduce hyperglycemia (high blood glucose or sugar) in cats with diabetes mellitus. A licensed veterinarian must prescribe ProZinc insulin for your cat. ProZinc insulin should be given to cats only. Seek medical attention immediately if you accidentally inject yourself with ProZinc insulin. ProZinc is available by prescription as a sterile injectable suspension in 10 ml multidose vials. Each ml of ProZinc product contains 40 International Units (U) of recombinant human insulin and is given to cats by subcutaneous injection.
What should I discuss with my veterinarian before giving ProZinc: Do not give ProZinc to cats sensitive to Protamine zinc recombinant human insulin or any other ingredients in the ProZinc product. Do not give ProZinc during episodes of hypoglycemia. Before using ProZinc, tell your veterinarian if your cat has any other medical conditions or allergies, or if your cat takes any other prescription or over the counter medications, including vitamins, minerals, and herbal supplements. Tell your veterinarian if your cat is pregnant, nursing, or if you plan to breed your cat.
How should this medication be given: Do not switch from one type insulin to another unless under the directions of a veterinarian. Changing from one insulin to another may require an adjustment in the dose. ProZinc should be given according to your veterinarian's instructions. ProZinc is given using a U-40 syringe only. Use of a syringe other than a U-40 syringe will result in incorrect dosing. ProZinc should not be shaken. Just prior to use, the vial should be mixed by rolling the vial between the palms of your hands. Do not reuse a syringe. Dispose of all syringes in an appropriate puncture-resistant disposal container. Dosage regimens of ProZinc will vary among patients. The recommended starting dose is 0.1 to 0.3 units per lb of body weight every 12 hours. This dose should be adjusted based on changes in blood glucose levels and resolution of clinical signs. Further adjustments may be necessary with changes in the cat's diet, body weight or other medications, or if the cat develops an infection, inflammation, neoplasia or an additional endocrine or other medical disorder. Store ProZinc in an upright position, in the refrigerator, between 36º-46º F. Do not freeze. Protect from light. Keep this medication out of the reach of children and pets.
What happens if I miss giving a dose: Contact and follow your veterinarian¿s directions if you miss giving a dose of ProZinc. If you cannot contact your veterinarian and your cat is eating and acting normally, give your cat the usual dose at the next regularly scheduled time. To prevent missed doses, be sure to always have enough ProZinc on hand.
What happens if I overdose the pet: Contact your veterinarian immediately if you inject more than the prescribed amount of ProZinc. Signs of hypoglycemia that may occur include; weakness; depression, lethargy, sluggishness; staggering gait; behavioral changes; muscle twitching; seizures; coma; death.
What should I avoid while giving ProZinc: ProZinc should be given to cats only. ProZinc should not be administered to humans. Call a physician immediately if you accidentally inject yourself with ProZinc. Do not give a dose of ProZinc to a cat experiencing an episode of low blood glucose (hypoglycemia). Common causes for hypoglycemia include excessive doses of insulin, failure to eat, accidental doubling of insulin dose, strenuous exercise, correction of obesity or diabetes-inducing disease, drug effects. Do not give a dose of PROZINC if the cat has not eaten or is vomiting.
What are the possible side effects of ProZinc: Rarely, allergic reactions to insulin can occur. Seek emergency veterinary medical attention if an allergic reaction is experienced (difficulty breathing, swelling of the lips, tongue, or face; or hives). Other serious side effects can occur with or without warning. The most common insulin-related side effect is low blood sugar (hypoglycemia) with symptoms that include; weakness; depression, lethargy, sluggishness; staggering gait; behavioral changes; muscle twitching; seizures; coma; death.
Contact your veterinarian immediately if your cat has a medical problem or side effect from ProZinc therapy. Other side effects may occur. Talk to your veterinarian about any side effect that seems unusual or bothersome to the cat.
What other drugs will affect ProZinc: ProZinc can be given with other medications, but the dose may need to be adjusted due to the medication resulting in either increased or decreased insulin requirements. Do not give any other prescription or over the counter medications, including vitamins, minerals and herbal products, without first talking to your veterinarian or pharmacist during treatment with ProZinc.
Where can I get more information: Your pharmacist has additional information about ProZinc written for health professionals that you can read.
ProZinc is the first and only FDA-approved protamine zinc insulin for cats containing human recombinant insulin.
ProZinc helps control blood glucose by stimulating carbohydrate metabolism in heart, bone and fat tissue, helping these cells to use glucose for energy.
The ingredients in ProZinc (protamine zinc insulin) are classified as long-acting with a duration of effect for 10-14 hours.
Tip: Speak to your veterinarian about your cat's exercise and diet, as these can help maintain healthy glucose levels.
Before using ProZinc you should have your vet the proper way to inject insulin. Your cat's injection should be given at feeding time or just afterward. Give the injections at the same time every day, approximately 12 hours apart to help your cat maintain the most stable blood glucose levels.
The initial recommended dose is 0.1 - 0.3 IU insulin/pound of body weight (0.2-0.7 IU/kg) every 12 hours.
ProZinc Insulin for Cats:
Active Ingredients per mL
Recombinant Human Insulin
40 IU (International Units)
Dibasic Sodium Phosphate Heptahydrate
Phenol (added as a preservative)
Water for injection (maximum)
pH is adjusted with hydrochloric acid and/or sodium hydroxide.
ProZinc Cat Insulin
Seems to be working..
The king of black cats, J.J. was diagnosed with diabetes recently. His vet wrote a prescription, but when I went to fill it, it was $380.00!!! no way can I afford that, especially if he needs to be on it for a while. So my search began, and ended at 1800 PetMeds. I was happy to find this insulin, told the vet- he checked it out and gave us the green light. We go for a check this next week to see how J.J.'s insulin levels are doing. Will report back soon..
My sweet little Felix has been on ProZinc since
2009. And I still have him around. He has enjoyed
a normal life since he has been on this insulin. It works ! We tried others first, not very good results. He runs , plays, loves to sit in the windows and watch the birds for hours. He is a happy kitty
and so am I !!!! Thanks to ProZinc
It works but has side effects.
I have been using it now for over one and a half years. My Zoey is 14 it works well but she has side effects. I didn't read the info that came with it...everyone should. I coudn't understand why her eyes kept pusing..and had to keep giving her antibiotics to off set that...I called the ProZinc people and they were very helpful. explaining it is a side efffect in some cats...so if I don't want to keep buying antibiotics every month...I have to find a different insulin... sorry to say...
Used for my Dog
i have a 13 yr old mix pug/boxer has been diabetic for over 1 year. we have tried all insulin and nothing would hold him. My vet suggested this insulin, i was alarmed as it is a cat insulin only. Guess what, it works on my Ewok. I did read a few cases it has been used on dogs hard to regulate, and it does work on mine.
thank you ProZinc
we laugh waiting for him to meow.
Diabetic cat - long life
Our cat, has been diabetic for 5 years. He has been on Prozinc and is 18 years old. Theis proves that animals can have a happy, health, and good life while diabetic.
My cat is very difficult to inject the insulin by lifting the skin and giving subcutaneously. We have been bitten and scratched and now the cat runs from us. This morning I gave the insulin intra muscular in the hip while she was sleeping. By the time she realized what had happened it was over. It was so much easier. Is it ok to give this way?
7 months ago
SURE !! that is a very good strategy. You saved her from getting stressed out ( and yourself too ! ) Maybe a treat afterwards, will help ease the pain also
They have been office kitties. One of them was losing weight rapidly, and he took Charlie to the Vet. He was diagnosed with diabetes. The Vet recommended he be put on insulin and his diet changed to wet food. The problem is that the owner gets to, and leaves his office at different times. The directions say - insulin every 12 hours. It is impossible to make that a all the time routine & schedule. Does it hurt if it is off by a couple of hours between insulin shots? He is afraid it will hurt Charlie to have him on insulin, if he can't be there for the 12 hour window that is suggested for the shots. Or also, will it be disasterous for Charlie if he misses a day once in a while, if he doesn't get to the office on a week-end day? He is always there on Saturday, but not always on Sundays. Please advice what is best for Charlie.
1 year, 3 months ago
Diabetes is a serious condition that requires Charlie to receive his insulin at the required times. Charlie would benefit by living in a home that can tend to his medical needs on a full time basis.
This information sheet is for educational purposes only and is intended to be a supplement to, and not a substitute for, the expertise and professional judgment of your veterinarian. The information is NOT to be used for diagnosis or treatment of your pet. You should always consult your own veterinarian for specific advice concerning the treatment of your pet. The information is not intended to cover all possible uses, directions, precautions, warnings, allergic reactions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for your pet. It is not a substitute for a veterinary exam, and it does not replace the need for services provided by your veterinarian. Note: Any trademarks are the property of their respective companies.