Use your 15% OFF coupon code:
PETS15
Expires in:
days hrs min secs
15% OFF Coupon:
PETS15
Expires in:
days hrs min secs
My Account
Errors:

Frontline Plus

Starts $52.74 $37.77 
Ships in one business day or less
1
Select Pet's Weight:
Dog
05-22 lbs
23-44 lbs
45-88 lbs
89-132 lbs
Cat
All Weights
Save with Generic
$27.62
Shop Now
Save with Generic
Shop Now
2
Select a Supply:
3 pack
$52.74
$44.43
$37.77
Price w/coupon PETS15
6 pack
$97.10
$81.98
$69.68
Price w/coupon PETS15
Free Shipping
Save $5 over 3 pk
12 pack
$189.95
$159.96
$135.97
Price w/coupon PETS15
Free Shipping
Save $15 over 3 pk
Starts $52.74 $37.77 
Ships in one business day or less
Please select all product options.
3
Select a Quantity:
Quantity
Please select all product options.
Save with Generic
$27.62
Shop Now
Save with Generic
Shop Now
Product Info
How to Use
Ingredients
Customer Reviews
Q&A
Product Info
What is Frontline Plus?

Frontline Plus is a monthly topical flea and tick preventative for dogs and cats. Frontline Plus kills 100% of adult fleas on your pet within 12 hours and 100% of all ticks and chewing lice within 48 hours. Frontline Plus contains an insect growth regulator, S-methoprene, which kills flea eggs and larvae. It's effective against all stages of the brown dog tick, the American dog tick, the lone star tick and the deer tick (the major carrier of Lyme disease). (3 Pack = 3 doses which lasts 3 months.)

For:

Cats/Kittens and Dogs/Puppies (8 weeks of age and older)

Benefits:
  • Kills all existing fleas on your pet within 12 hours
  • Each application provides a full month of protection
  • Also aids in the control of sarcoptic mange infections in dogs
  • Great for pets that swim since it's waterproof
  • Kills ticks and chewing lice
How it Works:

Frontline Plus contains fipronil, a broad-spectrum insecticide and slow-acting poison that disrupts the central nervous system of fleas and ticks and S-Methoprene, an insect growth regulator that kills flea eggs and larvae. The active ingredients are stored in the sebaceous glands and are wicked out of the hair follicles and continuously re-applied to the coat for long-lasting, waterproof protection.

Cautions:

Your pet may experience some temporary irritation at the site of application. If signs persist or become severe within a few days of application, consult your veterinarian immediately.

Brand Name:

Frontline Plus (Merial)

Generic Name:

Fipronil, S-methoprene

What is Frontline Plus used for:

Frontline Plus provides convenient and effective flea and tick control in dogs and cats, puppies and kittens. It is effective against all stages of the brown dog tick, the American dog tick, lone star tick and deer ticks (the major carrier of Lyme disease). It also kills flea eggs and flea larvae. Frontline Plus rapidly eliminates infestations with chewing lice. Frontline Plus for Dogs and Puppies also aids in the control of sarcoptic mange infections.

Availability of Frontline Plus:

Frontline Plus is a non-prescription (OTC) product.

How Frontline Plus should be used:

Use Frontline Plus for Dogs (fipronil 9.8% and S-methoprene 8.8%) on dogs and puppies 8 weeks or older. Frontline Plus for Dogs is available as 0.67 ml applicators for use on dogs and puppies up to 22 lbs, 1.34 ml applicators for dogs 23-44 lbs, 2.68 ml applicators for dogs 45-88 lbs and 4.02 ml applicators for dogs 89-132 lbs. Wait 24 hours to fully dry before swimming or bathing. Do not reapply for 30 days. Use Frontline Plus for Cats (fipronil 9.8% and S-methoprene 11.8%), available as 0.5 ml applicators, on cats and kittens 8 weeks or older. Place the applicator tip through the animal's hair to the skin level between the shoulder blades. Apply the entire contents of the applicator in a single spot to the animal's skin. Use only one applicator per treatment.

What are the side effects of Frontline Plus:

Pets may experience some temporary irritation at the site of product application. If signs persist or become more severe within a few days of application, consult a veterinarian immediately.

What special precautions are there for Frontline Plus:

This product is for external use on dogs and puppies, cats and kittens 8 weeks or older. Frontline Plus is approved for use on breeding, pregnant, or nursing animals. Consult a veterinarian before using on medicated animals, animals using this product with other pesticides, and debilitated, or aged animals. This product is flammable. Keep away from heat and open flame. This product is harmful to humans if swallowed. Call a physician or poison control center for advice. Have patient sip water do not induce vomiting unless advised to and patient is conscious. This product can cause eye injury. Flush eyes with plenty of water. Call a physician if irritation persists. Avoid contact with skin, eyes or clothing. Wash thoroughly with soap and water after handling.

In the event of a Frontline Plus overdose:

Contact your veterinarian or veterinary emergency room.

How should I store Frontline Plus:

Store this product at room temperature. Store in the original container only. To dispose wrap original container in several layers of newspaper and discard in trash. Keep out of the reach of children and pets.

How to Use
Directions:
  • Remove the Frontline Plus applicator from the child-resistant package. You can use scissors to snip the foil, or pull the tab to remove the applicator.
  • Snap open the tip of the Frontline applicator - away from your body and face.
  • Part your pet's hair between the shoulder blades until you can see the skin, and place the tip of the applicator on the skin.
Tip:

Wait until application site is fully dry (usually 24 hours) before bathing your pet or letting your pet go swimming.

Dosage:
Dogs/Puppies: (8 weeks of age or older)
Weight
Dosage
Up to 22 lbs
Apply contents of 1 applicator once a month (0.67 ml)
23-44 lbs
Apply contents of 1 applicator once a month (1.34 ml)
45-88 lbs
Apply contents of 1 applicator once a month (2.68 ml)
89-132 lbs
Apply contents of 1 applicator once a month (4.02 ml)
Cats/Kittens: (8 weeks of age or older)
Weight
Dosage
All weights
Apply contents of 1 applicator once a month (0.5 ml)
Horses:
Do not use!
Storage:

Should be stored at room temperature.

Ingredients
Frontline Plus for Dogs & Puppies 8 weeks or older and up to 22 lbs:
Active ingredients (per 0.67 ml applicator)
Amount
Fipronil
9.8%
(S)-methoprene
8.8%
Frontline Plus for Dogs 23-44 lbs:
Active ingredients (per 1.34 ml applicator)
Amount
Fipronil
9.8%
(S)-methoprene
8.8%
Frontline Plus for Dogs 45-88 lbs:
Active ingredients (per 2.68 ml applicator)
Amount
Fipronil
9.8%
(S)-methoprene
8.8%
Frontline Plus for Dogs 89-132 lbs:
Active ingredients (per 4.02 ml applicator)
Amount
Fipronil
9.8%
(S)-methoprene
8.8%
Frontline Plus for Cats & Kittens 8 weeks or older:
Active ingredients (per 0.50 ml applicator)
Amount
Fipronil
9.8%
(S)-methoprene
11.8%
Customer Reviews
Frontline Plus is rated 3.4 out of 5 by 3968.
Rated 5 out of 5 by from Important part of flea allergy regimen! My beagle, Zephyr, has a serious flea allergy. If she gets bitten she runs a fever, her skin turns bright red, her ears swell to 3 times their normal thickness, & she becomes very lethargic. Even with the help of antihistamines it takes her a week to get back to normal. I now have her on a regimen of Frontline, followed by another flea product 2 weeks later, then back to Frontline again. This is NOT something anyone should try without specific advice from a veterinarian, but I sure am glad that we have Frontline to help keep her allergy under control. My other dog, Jasper, uses just Frontline & he is flea free & happy.
Date published: 2017-02-22
Rated 5 out of 5 by from Works well in Hawaii, Does not work in SC My dog is 11 years old and when we lived in south caroline, I had to get advantix and then, advantix II. However, Frontline plus works here. I think it really depends on your area and how bad the fleas get. I recently tried the generic brand and the smell is bad. I'll be going back to the Frontline plus!
Date published: 2017-02-10
Rated 1 out of 5 by from Frontline Have used Frontline for my dogs for many years....it no longer works! Vet said the fleas have become immune to it. Had to switch to another product.
Date published: 2017-02-01
Rated 1 out of 5 by from I don't know what is wrong with Frontline now??? I used to use Frontline all the time but just bought some a month ago for my dog and two cats and it has not helped at all, I'm not the first reviewer to say that something is wrong with Frontline. I had to go to my local vet and purchase comfortis to get rid of the fleas.
Date published: 2017-01-28
Rated 1 out of 5 by from Bad Batch I've been using this product for years and this is the first time that it did not work, even with a puppy which was the first time for him. I have dogs for every weight range and not one of them killed fleas or ticks.
Date published: 2017-01-23
Rated 5 out of 5 by from Great product Is a good product and a good price
Date published: 2017-01-20
Rated 5 out of 5 by from Works well. I been purchasing Frontline for over 16 years and it's been great.
Date published: 2017-01-20
Rated 5 out of 5 by from It works great. I have two cats and one small dog. Frontline Plus works for all of them. Once I tried Advantage II. It worked but my dog kept scratching, so went back to Frontline Plus. Also, one of my cats is a male Ragdoll and he weighs 21 pounds. With Frontline Plus, I don't have to pay extra because of his weight. I'm staying with Frontline Plus.
Date published: 2017-01-18
  • y_2017, m_2, d_25, h_22
  • bvseo_bulk, prod_bvrr, vn_bulk_0.0
  • cp_1, bvpage1
  • co_hasreviews, tv_50, tr_3918
  • loc_en_US, sid_prod10459, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_1800petmeds
Q&A

My dog is 22-24 pounds. I got her the 5-22 pound box because I did not want to put the stronger one on her since she's right on the border. She is an italian greyhound so she has very little fur. Is this okay?

Asked by: Kate
We can only advise to administer the medication the way the manufacturer intended, which is by weight class. If your pet is over 22lbs there is no guarantee that she will fully protected if you are using the 5-22lb weight class.
Answered by: Amy Petmed Pro
Date published: 2017-02-20

Does the number ex. 3 pack ? ..mean it's good for 3 months, 6pack- 6 months?

Asked by: Debdeb
Yes
Answered by: Amy Petmed Pro
Date published: 2017-02-13

My puppy is 2.16 lb i think she has flees,  because she itches alot.  It seems you don't have one for puppy.  Can i still use the one for 5 lb ? Would it hurt her? 

Asked by: reb 5
Frontline has not been approved for puppies that small. Advantage II is a little better, but still, the minimum weight is 3 pounds. A better choice for now would be Capstar tablets. They are approved for puppies 4 weeks old and older and there is no minimum weight. It will kill all the fleas that get on your puppy, but only lasts for 24 hours so you may need to give additional tablets every couple of days until your puppy is large enough for one of the other products.
Answered by: SuzyCVT
Date published: 2017-01-24

My cat weighs 20lbs and it seems like only 1 dose doesn't work. Can i use 2 would it hurt him? I put it on him about 2 weeks ago

Asked by: Michelle
Adult fleas that are living ON your pet are the last 5% of the lifecycle and population of the flea. Seriously, if you find one adult flea on your pet and they spend any amount of time indoors, you have A LOT of fleas in your house (eggs, larvae, pupae). Hit them hard and go all out. Treat all pets at the same time. Vacuum everything. Throw the vacuum bags directly in a trash bag and close it. Bomb the whole house. Do the same thing in a month (and continue if needed). It sounds like a lot of work (and money), but trust me it will end up being 10x that if you don't.
Answered by: vernzimm
Date published: 2017-01-14

For what size dog is Frontlibe Plus Lot no. A48501?

Asked by: Robby
We are very sorry, we do not have a way of checking the size by the lot number. However if the application is still in the foil package the maximum size is printed on the back.
Answered by: Amy Petmed Pro
Date published: 2017-01-10

I lost the box and only have the applicators. what size is this for dog 88 0.091 fl oz lot no L60704

Asked by: kelly
Dogs 45-88lbs
Answered by: Amy Petmed Pro
Date published: 2016-12-29

Do I have this right? I have 2 Irish Wolfhounds. Our male is 154lbs & our female is 130-ish. She getssssst 1 dose and my male would get... 1 dose of the 89-132 AND one dose of 11 -22? So I have to buy multiple boxes. Seems excessive. Is there an easier wa

Asked by: Wolfhoundhairdontcare
Yes you have it correct! The manufacturer recommends to use 2 packages for your furry friend weighing over 132lbs to accommodate his weight.
Answered by: Amy Petmed Pro
Date published: 2016-12-20

Can this be used on pregnant dog close to due date of delivery

Asked by: Lottie
Frontline Plus is approved for use on breeding, pregnant, or nursing animals
Answered by: Amy Petmed Pro
Date published: 2017-01-08
  • y_2017, m_2, d_25, h_22CST
  • bvseo_bulk, prod_bvqa, vn_bulk_0.0
  • cp_1, bvpage1
  • co_hasquestionsanswers, tq_1407
  • loc_en_US, sid_prod10459, prod, sort_[SortEntry(order=LAST_APPROVED_ANSWER_SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_1800petmeds
Close
Live Chat Share Website Feedback
Name:
Email:
Phone:
Feedback: