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Diphenhydramine (Generic Benadryl)

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What is Diphenhydramine?

Diphenhydramine is an antihistamine used to relieve allergy symptoms, insect stings, motion sickness, travel anxiety, and other conditions.

For: Cats and Dogs

Benefits:
•	Effectively relieves allergy symptoms and itching caused by insect bites
•	Can be used as a sedative to treat motion sickness or travel anxiety
•	Relieves coughing

How it works:
Diphenhydramine comes in 25mg minitabs or 50mg capsules, and is a generic version of Benadryl. As an antihistamine, it counteracts the effect of histamine, which causes symptoms like itching and sneezing.

Cautions:
This medication should not be used in pregnant or nursing animals. Do not use the diphenhydramine available in combination with sinus or cold medicines in your pet.

Click on links below to see different views:

Diphenhydramine 50mg Capsules
Diphenhydramine 25mg Minitabs

More Information:

Brand Name
Benadryl (Warner Lambert), Histacalm (Virbac)

Generic Name
Diphenhydramine (dye-fen-hy�-dra-meen)

Manufacturer:
Various

What is this medication used for:
Diphenhydramine is an antihistamine used to relieve allergy symptoms, insect bites or stings and other causes of itching. It is also used for its sedative and antiemetic effects in the treatment of motion sickness and travel anxiety. It is also used for its antitussive effect.

Availability:
Diphenhydramine is a non-prescription (OTC) product available as 25mg tablets and 50mg capsules.

How this medicine should be used:
Oral diphenhydramine is not FDA-approved for use in veterinary medicine; however, it is a commonly accepted practice to use this medication in dogs and cats. The usual dose in dogs and cats is 0.5-2mg/pound every 8-12 hours. The slow release capsule should not be mixed or dissolved in food. Do not give sinus or cold medicines containing diphenhydramine to your pet.

What are the side effects:
Side effects of diphenhydramine include drowsiness, dry mouth and urinary retention. Rarely, vomiting and diarrhea can occur.

What special precautions are there:
Do not use this medication in animals that are allergic to it or other antihistamines. Do not use in animals with glaucoma, prostate disease, urinary obstruction, and high blood pressure. Do not use in pregnant or nursing animals. Use with caution when given with other CNS (central nervous system)-depressant drugs such as tranquilizers or barbiturates. Always tell your veterinarian and pharmacist what other medications your pet is taking.

In the event of an overdose:
Contact your veterinarian or veterinary emergency room. Symptoms of overdose can include seizures, extreme drowsiness, coma, respiratory depression, and death.

How should I store this medication:
Keep this medication in the container it came in, tightly closed. Store this medication at room temperature, away from excess heat, light, and moisture. Do not store in the bathroom. Throw away any medication that is outdated or no longer needed. Keep medication away from children and pets.

Directions:

• Diphenhydramine is an antihistamine used to relieve allergy symptoms, insect stings, motion sickness, travel anxiety and other conditions.

• It is available over-the-counter (OTC) as 25mg tablets and 50mg capsules.

• Diphenhydramine should not be used in dogs or cats that are pregnant or nursing.

Tip: The slow release capsule should NOT be mixed or dissolved in food. Do not use sinus or cold medications containing diphenydramine in your pet.

Dosage:

Pet	Weight	Dosage
Dogs/Cats:	All weights	Give 0.5 - 2mg per lb of pets body weight every 8 -12 hours
Horses:

Storage: Store this medication at room temperature, away from excess heat, light and moisture.

Diphenhydramine

Active Ingredients (per Minitab):

Product	Active Ingredients
Diphenhydramine HCl 25 mg Minitab	Diphenhydramine 25 mg
Other Ingredients (per capsule): Corn starch, D&C red #27, Dicalcium Phosphate, Magnesium Stearate, Microcrystalline Cellulose, Polyethylene Glycol, Polyvinyl Alcohol, Silicon Dioxide, Stearic Acid, Talc, Titanium Dioxide.

Active Ingredients (per capsule):

Product Active Ingredients

Diphenhydramine 50 mg Capsules Diphenhydramine Hydrochloride 50 mg
Other Ingredients (per capsule):
Colloidal Silicon Dioxide, Croscamellose Sodium, D&C Red #28, FD&C Blue #1, FD&C Red #3, FD&C Red #40, Gelatin, Lactose, Magnesium Stearate. May also contain Polysorbate 80 and iron oxide.

Diphenhydramine (Generic Benadryl) 4.5 5 33 33

stop the itch Sebastian is a 14yr, old 5# pomerian, We live in Key Largo with all kinds of allergens all year. We also frequent the mangroves in search of treasures, with just 1/2 a pill a day the scratching seems to be under control. Have anything to keep the crocs away? 04/21/2012

SO glad you carry this!! When I found my Great Dane puppy had allergies, I was buying Benadryl from the drug store, since he's over 100lbs, I was giving him more than 4+ tablets 2x a day (though my dr. suggested 3x a day). I am SO happy to find this product, not only because I can give him less pills (thanks to the 100mg bottle), but because i don't have to pop each pill out of those annoying foil packages!! THANK YOU for having this product, my puppy's allergies are SO much better, and now, that I got your product, I've been able to give it to him the recommended 3x a day! I've recommended you to a couple other large dog owners that have allergies as well :D 04/04/2012

GENERIC BENADRYL WORKS Boo takes 1/2 tablet twice a day along with generic pepcid ac in a half chicken pill pocket in her dry dog food. Everything combined has reduced her scratching and sensitive stomach. 03/31/2012

It works After extensive vet tests (and $) and expressions and flushing for anal issues, and a diet change; these sometimes didn't work or only lasted for several weeks, we tried 25mg/day (2 1/2pills) for 25# pug and the next day all the itching stopped. Has been several weeks and no itch reoccurance. Give three grape size chunky peanut butter globs, first just plain, second with 1/2 pill imbedded and third for a "chaser". Hope there are no long term effects. 02/12/2012

Works for 110 lb Dobie Dobie has some allergies. 1 in the am & 1 after dinner works for him. 10/31/2011

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88 Questions · 119 Answers

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2 answers

can i give my dog benedryl before i cut his nails

My dachshund hates toe nail clipping

1 month ago

nancy

Answers

Giving Benadryl to your pet before cutting his nails is okay if this helps calm him. Just make sure you are giving him a dose that is appropriate for his weight. Check with your Veterinarian for the dose that is safe for your pet.

1 month ago

Marty Pharmacist

Top 10 Contributor

Yes, it is used for anxiety and allergies. If it does not give you the results you are looking for talk to your vet. My vet prescribed something for when I take my Lula for her nails to get done.

1 month ago

Laura, PetMed Pro

- Pompano Beach Florida

1 answer

Can Benadryl help my cat's swollen paw caused by a wasp sting? How much of an adult tablet should i give my 8 pound cat?

1 month, 1 week ago

Ray

Answers

Top 10 Contributor

Benadryl may help with a cat's swollen paw caused by a wasp sting. I would give one half childrens benadryl up to twice daily or you can give 1/4 of an adult tablet up to twice daily.

1 month ago

Dr. Michael Dym, VMD veterinarian

1 answer

Is benedryl more effective if given reccommended dosage twice daily or one pill every few hours?

70 lb dog with nasal draingage and sneezing. Vet recommended 70 mgs twice a day. Is benadryl more effective if all 70mgs are given at the same time or better if we give 25mgs every few hours?

1 month, 1 week ago

Buddy

Answers

Top 10 Contributor

If the vet said 70mg twice per day. He would want that amount given.

1 month ago

Laura, Petmeds Pro

- Pompano Beach, Florida

1 answer

Can I used these and worm him also?

My cat is semi-feral...He needs worming and flea treatment. Can I use this product while doing these two things?

1 month, 3 weeks ago

Anonymous

Answers

Top 10 Contributor

Yes, Diphenhydramine can be used during flea and worming treatments.

1 month, 1 week ago

Lisa, Pharmacist 1800Petmeds

- Pompano Beach, Florida

2 answers

Can this medication cause serious or fatal reactions when taken by certain breeds as, for instance, Ivermectin is with Collies and Shepherds?

2 months, 1 week ago

Sig

Answers

Although this medication can cause different side effects, no specificities among different breeds are noted. Just be aware of the common side effects such as lethargy, somnolence, dry mouth, urinary retention, diarrhea, vomiting, and anorexia. The sedative effects of the drug may diminish with time.

1 month, 1 week ago

Yoliset, Student Pharmacist

- Pompano Beach

No. Generally, diphenhydramine (Benadryl) is exceptionally safe in all dog breeds. However, there are a few precautions:

1. Diphenhydramine should not be administered to dogs with certain conditions: cardiovascular disease, glaucoma, prostatic disease, and hyperthyroidism.

2. Diphenhydramine may not be appropriate for a puppy. If you do have a puppy, please be sure to consult with your veterinarian first.

3. Many people recommend using small amounts of the medication first, then checking for any reaction to it.

1 month, 1 week ago

Rich, Pharmacy Intern

- Pompano Beach

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This information sheet is for educational purposes only and is intended to be a supplement to, and not a substitute for, the expertise and professional judgment of your veterinarian. The information is NOT to be used for diagnosis or treatment of your pet. You should always consult your own veterinarian for specific advice concerning the treatment of your pet. The information is not intended to cover all possible uses, directions, precautions, warnings, allergic reactions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for your pet. It is not a substitute for a veterinary exam, and it does not replace the need for services provided by your veterinarian.
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