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Denosyl


 
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  Product Info   How to use   Ingredients   Customer Reviews   Q & A  

What is Denosyl?

Denosyl is a daily supplement that helps support proper liver function. Support of a compromised liver, regardless of the cause, is essential if function is to be improved. Denosyl has not only been shown to markedly increase glutathione levels in the livers of dogs and cats, but to go far beyond that. Denosyl has been shown to protect liver cells from cell death and may be useful in cell repair and healing. Its main ingredient is S-Adenosylmethionine (SAMe).
For: Cats and Dogs

Benefits:
Increases glutathione levels, an important antioxidant that protects your pet’s cells from dangerous toxins
Improves a pet’s liver health
No reported side effects

How it works:
Denosyl has been shown to increase the level of glutathione, an antioxidant that can fight deadly toxins in your pet’s body. For optimal absorption, it should be taken on an empty stomach.

Cautions:
Denosyl tablets must be given to your pet whole. Store this product in a cool and dry place. Keep tablets in the original blister pack until they are used.


More Information:
Brand Name
Denosyl (Nutramax)

Active Ingredient(s):
S-Adenosylmethionine

What is this product used for:
Denosyl has been shown to increase hepatic glutathione levels in cats and dogs. Glutathione is a potent antioxidant that protects liver cells from toxins and death. Denosyl is recommended to improve hepatic glutathione levels in compromised animals to help maintain and protect liver function.

Availability:
Denosyl is a non-prescription (OTC) product available as 90mg, 225mg and 425mg stabilized tablets.

How this product should be used:
The tablets should be given on an empty stomach at least one hour before feeding. Research shows that, if possible, a fasting period of 8-12 hours before giving this product is optimal. The usual dose in cats and dogs is based on weight. For pets up to 12 lbs give 1 tablet of the 90mg strength, for pets 13 to 34 lbs give 1 tablet of the 225mg strength, for pets 35 to 65 lbs give 1 tablet of the 425mg strength, for pets 66 to 120 lbs give 2 tablets of the 425mg strength and for pets over 120 lbs give 3 tablets of the 425mg strength. When giving more than 1 tablet the total number of tablets may be divided into morning and evening. For example, a dose of 3 tablets could be divided into 2 tablets in the morning and 1 tablet in the evening.

What are the side effects:
There are no reported side effects. However, Denosyl should be used with caution when given with medications such as amitriptyline, fluoxetine, clomipramine, tramadol, or Mitaban Dip.

What special precautions are there:
Tablets must be given whole. Do not break or split. Research shows that this product may be of benefit to pets that are also taking primidone, Phenobarbital, prednisone, azathioprine, cyclosporine and certain anti-depressants.

In the event of overdose:
Contact a veterinarian or veterinary emergency room.

How should I store this product:
Store this product in a cool, dry, place. Keep tablets in the original blister pack until used. Tablets are sensitive to moisture and extreme heat and should not be split or crumbled. Keep out of the reach of children.

Directions:
Denosyl is a Liver Support Formula.
Denosyl is available for small dogs and cats, medium dogs, and large dogs.
Do not crush or break the tablet as this will damage the tablet’s enteric coat and inhibit absorption.
Do not remove tablets from blister pack until ready to use.
Tip: Denosyl should be given on an empty stomach at least one hour before feeding. If giving more than 1 tablet divide the daily dose between morning and evening.
Dosage:

Pet Weight Dosage
Small Dogs and Cats – Denosyl (90 mg) Up to 12 lbs Give 1 tablet daily
Medium Dogs – Denosyl (225 mg) 13-34 lbs Give 1 tablet daily
Large Dogs – Densoyl (425 mg) 35-65 lbs Give 1 tablet daily
  66-120 lbs Give 2 tablets daily
 
121 lbs and over Give 3 tablets daily
Horses:

Storage: Should be stored in a cool dry place. Do not refrigerate.

Denosyl for Cats and Small Dogs:
Active Ingredients (up to 12 lbs) Amount Product Dimensions
S-Adenosylmethionine 90 mg 1/2 cm L (round pea-shaped pill)

Denosyl for Medium Dogs:
Active Ingredients (13-34 lbs) Amount Product Dimensions
S-Adenosylmethionine 225 mg 1 1/2 cm L x 1/2 cm W

Denosyl for Larger Dogs:
Active Ingredients (35 lbs and over) Amount Product Dimensions
S-Adenosylmethionine 425 mg 2 cm L x 1/2 cm W
Denosyl 4.5 5 16 16
Genetic Liver Dysfunction My adopted beagle had seizure the second day after we brought her home. She was one year old then. We thought it was due to the new environment. Clinic vet prescribe her with only some relaxant medication and vitamins. She continues to have seizure once every few weeks. Till a serious episode in the middle of the night one day made us to bring her to the animal hospital. A thorough check by the vet and after few follow-up check diagnosed her with genetic liver dysfunction and also genetic epilepsy. Her liver reading was far exceeding the normal range. Denosyl had helped to keep her liver at normal range with her seizure medication that is not good for her liver . She is put on long term Denosyl, a pill a day before her l/d diet. She is healthy and active after 2 years now. All of us are happy with this cutie pie at home! 06/01/2013
Best Medicine in the World My 13yr old cat had blood work drawn for her dental and her ALT enzyme was 1965, normal level should be from 10-100. The vet recommended Denosyl and Prednosone for 30 days and to retest her levels. I got the results back today and her ALT is 44-which is astonishing. I was given the prognosis of having to put her down if the pill didn't work, and now we're instructed to give it to her 2x a week for maint. This pill is a miracle!! Lifesaver 09/10/2012
Miracle worker Maddie is my 12 year old bichon. She is my heart. I'm not sure about the technical terminology but one of her liver enzymes has been escalating for years and was way way above normal. It's supposed to be under 100 and her count was over 800. Shortly after giving her this pill that number was cut in half and it continues to go down, I am thrilled. Since the pill has to be given whole, it's kind of hard to give it to her. She hates it... But it is so worth it. I need my girl with me a long time, so she's taking it. It's very effective. 10/19/2011
Denosyl liver med's We use to be able to get this medicine in a small round orange pill. Was able to push down our dogs throat easily. Now they have changed this to a larger thicker oval shaped pill. Our little dog has trouble swallowing it. It says on the bottle not to be split or crumbled. It is too easy for a little dog to choke on it. It is also very difficult when says has to be on a empty stomach a hour before meals. We end up giving in the evening after meals. Getting this medicine from the Vet costs $32.50, the only good thing is PetMeds is only $17.99. But our Vet can at least get the small thin ones where Petmeds only has the long thick ones. 01/18/2010
life saver This drug literally saved my dog's life and has enabled her to continue to live 2 years past being diagnosed with liver failure. She was very sick and it took about 7 days on the denosyl before she improved. Don't give up if you are struggling with watching your dog suffer. It just might be the miracle you are praying for. 10/07/2009
26 Questions · 30 Answers

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I read the answer where it says:

"The ideal situation is 8 - 12 hours after the last meal if possible."

This isn't feasible for a cat; especially one that needs to keep eating at this point. It's also not feasible for my other household cats (withholding food). For this medication to work, what is the MINIMUM amount of time I must wait after a meal prior to giving the pill?

Are there any formulations that do NOT require a waiting period (before or after food)?

Thank you!
1 month, 2 weeks ago
by
Chelles
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Answer: 
For best results it should be given 1 hour before feeding on an empty stomach.
1 month, 2 weeks ago
by
Pharmacist
Pompano beach
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denosyl - milk thistle

I have been giving my cat denosyl that I got from my vet and also liquid milk thistle. Are they both the same? The milk thistle is liquid and much easier to administer - should I discontinue one of them?
10 months ago
by
Paul L
Florida
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Answer: 
Denosyl contains S-Adenosylmethionine (SAMe) known for protecting liver cells from cell death and may be useful in cell repair and healing. Milk thistle contains silybin which is known for protecting and promoting the growth of liver cells, fighting oxidation (a chemical process that can damage cells), and inhibiting inflammation. Please consult with your veterinarian with any concerns.
10 months ago
by
Lilli Pharmacist
Pompano Beach, FL
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11 months ago
by
Anna
New York
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Answer: 
Yes there should be nothing wrong with adding this to your furry pals diet but since everyone can be affected different we would suggest to contact your vets office to make sure they agree that this is the best route for your furry pal.
11 months ago
by
Chris H, PetMedPro
Florida
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1 year, 8 months ago
by
Romulofn
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Answer: 
You want to consult your vet before using this medication if your Furry Friend currently is not having liver issues.
1 year, 8 months ago
by
James, PetMeds Pro
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1 year, 10 months ago
by
kyla
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Answer: 
Exactly! It would definitely help treat elevated liver Enzymes. I would definitely suggest to look at some of the reviews and the difference it made in there Furry Friends lives. :)
Denosyl is recommended to improve hepatic glutathione levels in compromised animals to help maintain and protect liver function. :)
1 year, 10 months ago
by
James, PetMeds Pro
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This information sheet is for educational purposes only and is intended to be a supplement to, and not a substitute for, the expertise and professional judgment of your veterinarian. The information is NOT to be used for diagnosis or treatment of your pet. You should always consult your own veterinarian for specific advice concerning the treatment of your pet. The information is not intended to cover all possible uses, directions, precautions, warnings, allergic reactions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for your pet. It is not a substitute for a veterinary exam, and it does not replace the need for services provided by your veterinarian.
Note: Any trademarks are the property of their respective companies.
 
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