Denosyl is a daily supplement that helps support proper liver function. Support of a compromised liver, regardless of the cause, is essential if function is to be improved. Denosyl has not only been shown to markedly increase glutathione levels in the livers of dogs and cats, but to go far beyond that. Denosyl has been shown to protect liver cells from cell death and may be useful in cell repair and healing. Its main ingredient is S-Adenosylmethionine (SAMe).
For: Cats and Dogs
Benefits:
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Increases glutathione levels, an important antioxidant that protects your pet’s cells from dangerous toxins
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Improves a pet’s liver health
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No reported side effects
How it works: Denosyl has been shown to increase the level of glutathione, an antioxidant that can fight deadly toxins in your pet’s body. For optimal absorption, it should be taken on an empty stomach.
Cautions: Denosyl tablets must be given to your pet whole. Store this product in a cool and dry place. Keep tablets in the original blister pack until they are used.
More Information:
Brand Name Denosyl (Nutramax)
Active Ingredient(s): S-Adenosylmethionine
What is this product used for: Denosyl has been shown to increase hepatic glutathione levels in cats and dogs. Glutathione is a potent antioxidant that protects liver cells from toxins and death. Denosyl is recommended to improve hepatic glutathione levels in compromised animals to help maintain and protect liver function.
Availability: Denosyl is a non-prescription (OTC) product available as 90mg, 225mg and 425mg stabilized tablets.
How this product should be used: The tablets should be given on an empty stomach at least one hour before feeding. Research shows that, if possible, a fasting period of 8-12 hours before giving this product is optimal. The usual dose in cats and dogs is based on weight. For pets up to 12 lbs give 1 tablet of the 90mg strength, for pets 13 to 34 lbs give 1 tablet of the 225mg strength, for pets 35 to 65 lbs give 1 tablet of the 425mg strength, for pets 66 to 120 lbs give 2 tablets of the 425mg strength and for pets over 120 lbs give 3 tablets of the 425mg strength. When giving more than 1 tablet the total number of tablets may be divided into morning and evening. For example, a dose of 3 tablets could be divided into 2 tablets in the morning and 1 tablet in the evening.
What are the side effects: There are no reported side effects. However, Denosyl should be used with caution when given with medications such as amitriptyline, fluoxetine, clomipramine, tramadol, or Mitaban Dip.
What special precautions are there: Tablets must be given whole. Do not break or split. Research shows that this product may be of benefit to pets that are also taking primidone, Phenobarbital, prednisone, azathioprine, cyclosporine and certain anti-depressants.
In the event of overdose: Contact a veterinarian or veterinary emergency room.
How should I store this product: Store this product in a cool, dry, place. Keep tablets in the original blister pack until used. Tablets are sensitive to moisture and extreme heat and should not be split or crumbled. Keep out of the reach of children.
Directions:
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Denosyl is a Liver Support Formula.
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Denosyl is available for small dogs and cats, medium dogs, and large dogs.
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Do not crush or break the tablet as this will damage the tablet’s enteric coat and inhibit absorption.
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Do not remove tablets from blister pack until ready to use.
Tip: Denosyl should be given on an empty stomach at least one hour before feeding. If giving more than 1 tablet divide the daily dose between morning and evening.
Dosage:
Pet
Weight
Dosage
Small Dogs and Cats – Denosyl (90 mg)
Up to 12 lbs
Give 1 tablet daily
Medium Dogs – Denosyl (225 mg)
13-34 lbs
Give 1 tablet daily
Large Dogs – Densoyl (425 mg)
35-65 lbs
Give 1 tablet daily
66-120 lbs
Give 2 tablets daily
121 lbs and over
Give 3 tablets daily
Horses:
Storage: Should be stored in a cool dry place. Do not refrigerate.
Maddie is my 12 year old bichon. She is my heart. I'm not sure about the technical terminology but one of her liver enzymes has been escalating for years and was way way above normal. It's supposed to be under 100 and her count was over 800. Shortly after giving her this pill that number was cut in half and it continues to go down, I am thrilled. Since the pill has to be given whole, it's kind of hard to give it to her. She hates it... But it is so worth it. I need my girl with me a long time, so she's taking it. It's very effective.
We use to be able to get this medicine in a small round orange pill. Was able to push down our dogs throat easily. Now they have changed this to a larger thicker oval shaped pill. Our little dog has trouble swallowing it. It says on the bottle not to be split or crumbled. It is too easy for a little dog to choke on it. It is also very difficult when says has to be on a empty stomach a hour before meals. We end up giving in the evening after meals. Getting this medicine from the Vet costs $32.50, the only good thing is PetMeds is only $17.99. But our Vet can at least get the small thin ones where Petmeds only has the long thick ones.
This drug literally saved my dog's life and has enabled her to continue to live 2 years past being diagnosed with liver failure. She was very sick and it took about 7 days on the denosyl before she improved. Don't give up if you are struggling with watching your dog suffer. It just might be the miracle you are praying for.
When I got my 2lb MiKi he was playful but never too much. I called him my anorexic dog because it was a chore to get him to eat and even while training him I had to use toys instead of food. Well, when he went in to get neutered his liver enzyme count was over 1200 when it should be more in between 100-200. We went to the U of M where I found out after a biopsy that he had a liver infection that caused some major damage and they weren't sure how long he would last. My vet put him on Denosyl right away. The change was phenomenal in just a couple days. He ate with out a syringe...not a lot but he was only 1.5 lbs. He is now 3.5 pounds, almost 7 years old and he runs and plays like he is a puppy still. Still to this day when he is not on Denosyl I notice a metallic odor to his breath, he doesn't eat as much and he sleeps a lot more. When he is on it no bad breath, he is energetic and eats a lot, wakes me up early AND his liver count has dramatically dropped down to normal. Thanks to this product I truly believe he is going to get to live out the full length his life was intended to. PS I have to wrap it in something like cheese, peanut butter, or liverwurst for him to take it...AND sometimes I just have to push it down his throat...but well worth it.
Denosyl is an antioxidant (Sam-e) used for liver health. Denamarin contains the same antioxidant but also includes the ingredient Silybin A+B. This added ingredient (derived from milk thistle) is used to aid digestion and absorption of nutrients from your pet's diet which also helps protect the liver.
I have read that SAM-E has benefits in humans with regard to arthritis. I have read that SAM-E (Denosyl) helps support the incorporation of sulfate groups into proteoglycans which help maintain cartilage and protect joints.
Is there any information on the use of SAM-E in cats with arthritis?
SAMe is a popular human supplement that has recently been used in dogs and cats to preserve and fortify liver function. SAMe is a molecule naturally synthesized by cells throughout the body. It is formed from the amino acid methionine and is especially important to liver cells.
SAMe increases the amount of naturally occurring glutathione in the body. Glutathione is a potent antioxidant that protects liver cells from toxins and cell death. No studies at this time suggest it can maintain carilage and protect joints in cats with arthritis.
SAM-E is involved in the production of creatine, so it seems this would not be a safe supplement to give to a cat that has renal failure. I have been unable to find any articles or information about the use of SAM-E (Denosyl) in cats with chronic renal failure.
This information sheet is for educational purposes only and is intended to be a supplement to, and not a substitute for, the expertise and professional judgment of your veterinarian. The information is NOT to be used for diagnosis or treatment of your pet. You should always consult your own veterinarian for specific advice concerning the treatment of your pet. The information is not intended to cover all possible uses, directions, precautions, warnings, allergic reactions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for your pet. It is not a substitute for a veterinary exam, and it does not replace the need for services provided by your veterinarian. Note: Any trademarks are the property of their respective companies.
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