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Comfortis

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Product Info
How to Use
Ingredients
Customer Reviews
Q&A
Product Info
What is Comfortis?

Comfortis is the first FDA-approved, chewable beef-flavored tablet that kills fleas and prevents flea infestations on dogs and cats for a full month. Comfortis for Dogs & Cats requires a prescription from your veterinarian.

For:

Dogs & Cats (14 weeks of age or older)

Benefits:
  • Starts killing fleas within 30 minutes
  • Lasts a full month
  • Kills fleas before they can lay eggs
  • Comes in a convenient chewable, beef-flavored tablet
  • Spinosad, the active ingredient in Comfortis, is environmentally friendly
How it Works:

Spinosad kills fleas by causing excitation of the insect's nervous system, leading to paralysis and rapid death.

Cautions:

Side effects may occur, including vomiting. If your pet is experiencing loss of appetite, lethargy, or any other difference in behavior, contact your veterinarian. The FDA has received reports of adverse reactions in dogs receiving the drug Comfortis (spinosad) concurrently with high, extra-label doses of ivermectin. Dogs receiving extra-label doses of ivermectin to treat non-responsive demodectic mange and other conditions have developed signs of ivermectin toxicity. Ivermectin is an ingredient found in heartworm preventatives such as Heartgard Plus, Heartgard, Iverhart Plus and Ivomec. In cats, the most common adverse reaction recorded in clinical trials was vomiting. Other adverse reactions were: lethargy, decreased appetite, weight loss, and diarrhea. Use with caution with concomitant extra-label use of ivermectin.

Brand Name:

Comfortis (Lilly)

Generic Name:

Spinosad

What is Comfortis:

Comfortis is a chewable, synthetic beef flavored tablet (derived from pork protein and hydrolyzed soy) that is given to a dog or cat to kill fleas and prevent flea infestations for one month. Comfortis chewable tablets are for monthly use in dogs and puppies or cats and kittens 14 weeks of age and older.

What should I discuss with my veterinarian before giving Comfortis to my pet:

Tell your veterinarian if you are planning on breeding your pet. Tell your veterinarian if your dog or cat has a history of seizures (epilepsy).

What is the most important information I should know about Comfortis:

Comfortis is a prescription medication FDA approved for use in dogs and puppies and cats and kittens 14 weeks of age or older to kill fleas and prevent flea infestations for one month. Comfortis is available in a Yellow box for dogs 3.3 to 4.9 lbs and cats 2-4 lbs (90mg), Pink box for dogs 5 to 10 lbs and cats 4-6 lbs (140mg), Orange box for dogs 10.1 to 20 lbs and cats 6.1-12 lbs (270mg), Green box for dogs 20.1 to 40 lbs and cats 12.1-24 (560mg), Blue box for dogs 40.1 to 60 lbs (810mg), and Brown box for dogs 60.1 to 120 lbs (1620mg). Please note: Cats over 24 lbs should be administered the appropriate combination of tablets.

How should this medication be given:

Give Comfortis chewable tablets with food. Give Comfortis chewable tablets once a month. Comfortis chewable tablets may be chewed, offered in food, or administered like other tablet medications. If vomiting occurs within 1 hour of administration, redose the pet with another full dose. Store Comfortis at room temperature (68-77° F)

What should I avoid while giving Comfortis:

Your pet may maintain normal activities and interactions while being given Comfortis. The safe use of Comfortis in breeding, pregnant, or lactating cats and dogs has not been evaluated.

What are the possible side effects of Comfortis:

Side effects that may occur include vomiting. If vomiting occurs within one hour of administration, redose with another full dose. Other side effects may occur. Continue giving Comfortis chewable tablets and talk to your veterinarian if your pet experiences decreased appetite, lethargy or decreased activity, diarrhea, cough, increased thirst, vocalization, increased appetite, redness of the skin, hyperactivity and excessive salivation. Talk to your veterinarian about any side effect that seems unusual or especially bothersome to the pet.

What other drugs will affect Comfortis:

Talk to your veterinarian before giving any prescription or over the counter medications.

How to Use
Directions:
  • Comfortis is a prescription medication used in dogs to kill fleas and prevent flea infestations for 1 month.
  • Comfortis chewable tablets are beef flavored.
  • Comfortis can be given to dogs at least 14 weeks of age, weighing at least 3.3 lbs, and cats 14 weeks of age, weighing at least 2 lbs.
Tip:

If vomiting occurs within 1 hour of administration, redose the pet with another tablet.

Dosage:
Dogs/Puppies: (14 weeks of age or older)
Weight
Dosage
3.3-4.9 lbs (Yellow Box)
Give one 90mg chewable tablet by mouth once a month. Comfortis may be chewed, offered in food, or administered like other tablet medications
5-10 lbs (Pink Box)
Give one 140mg chewable tablet by mouth once a month. Comfortis may be chewed, offered in food, or administered like other tablet medications
10.1-20 lbs (Orange Box)
Give one 270mg chewable tablet by mouth once a month. Comfortis may be chewed, offered in food, or administered like other tablet medications
20.1-40 lbs (Green Box)
Give one 560mg chewable tablet by mouth once a month. Comfortis may be chewed, offered in food, or administered like other tablet medications
40.1-60 lbs (Blue Box)
Give one 810mg chewable tablet by mouth once a month. Comfortis may be chewed, offered in food, or administered like other tablet medications
60.1-120 lbs (Brown Box)
Give one 1620mg chewable tablet by mouth once a month. Comfortis may be chewed, offered in food, or administered like other tablet medications
Over 120 lbs
Give the appropriate combination of tablets
Cats/Kittens: (14 weeks of age or older)
Weight
Dosage
2-4 lbs (Yellow Box)
Give one 90mg chewable tablet by mouth once a month. Comfortis may be chewed, offered in food, or administered like other tablet medications
4-6 lbs (Pink Box)
Give one 140mg chewable tablet by mouth once a month. Comfortis may be chewed, offered in food, or administered like other tablet medications
6.1-12 lbs (Orange Box)
Give one 270mg chewable tablet by mouth once a month. Comfortis may be chewed, offered in food, or administered like other tablet medications
12.1-24* lbs (Green Box)
Give one 560mg chewable tablet by mouth once a month. Comfortis may be chewed, offered in food, or administered like other tablet medications
Horses:
Do not use!
Storage:

Store Comfortis at room temperature (68°-77° F).

Ingredients
Comfortis for Dogs: 3.3-4.9 lbs - Comfortis for Cats: 2-4 lbs (Yellow Box)
Active Ingredient
Amount
Spinosad
90 mg
Comfortis for Dogs: 5-10 lbs - Comfortis for Cats: 4-6 lbs (Pink Box)
Active Ingredient
Amount
Spinosad
140 mg
Comfortis for Dogs 10.1-20 lbs - Comfortis for Cats: 6.1-12 lbs (Orange Box)
Active Ingredient
Amount
Spinosad
270 mg
Comfortis for Dogs 20.1-40 lbs - Comfortis for Cats: 12.1-24 lbs (Green Box)
Active Ingredient
Amount
Spinosad
560 mg
Comfortis for Dogs 40.1-60 lbs (Blue Box)
Active Ingredient
Amount
Spinosad
810 mg
Comfortis for Dogs 60.1-120 lbs (Brown Box)
Active Ingredient
Amount
Spinosad
1,620 mg
Customer Reviews
Comfortis is rated 4.530537830446673 out of 5 by 1,097.
Rated 5 out of 5 by from Sparky Already Had A Flea Problem Sparky, my long haired chihuahua has had a flea problem since we've had him. We have fleas in our yard, our house, and it stays a constant mess. We fix one problem (like spraying our yard for example), and a stray dog comes around or a neighbor's dog, and we're back in the same boat. Sparky has struggled constantly with fleas. We bathe him, add normal flea treatments, even the flea collar. Nothing seemed to really work. What we have noticed is immediately his flea infestation went to unbearable to about 20 fleas in a matter of a week after taking just one dose. It sounds like a lot, but we were over our due dosage. 2 weeks, we've pulled off 3. Honestly, it's the best since we've had him. We responded to an ad back in 2014 where a lady could no longer care for Sparky, and she really didn't want to take him to a shelter. Her son was having seizures, and she was giving him very little attention caring for her child. Sparky had a flea problem then, and the normal meds just didn't work. The lady had 5 dogs that she re-homed. I am assuming that they all were struggling with fleas as well. The fleas were manageable as long as I kept his bed washed almost daily and bathed him regularly where I could hand pick the pests. My vet recommended Comfortis, and it worked amazingly! However, we don't live very close to our vet, and when we ran out, it wasn't available locally to us. We live almost 2 hours away, but he is such an incredible vet, it's worth the drive a few times a year for check ups. There is another local vet we can go to for emergencies, but they are so expensive for everything else! One visit to the local vet costs the same driving round trip to our vet, getting medication and even eating out and gasoline costs and we still bring home money. So we opted to try 1-800 Pet Meds in the hopes that next check up, we can be flea free! So excited so far at this option! We want to support our local vet, but until our next visit, at least we can rely on 1-800 Pet Meds!
Date published: 2016-09-13
Rated 1 out of 5 by from HORRIBLE! DOES NOT WORK! I have used this brand for the 1st and ONLY yime. I purchased a 3 months supply for all THREE of my dog from my (now ex) VET which was $60 more than here. After 2 months of dosing NOTHING!!! And my vet Dr. DARLAND in Festus MO refuses to do anything about it! Don't waste your time or money while your poor fur babies suffer unmecessarily.
Date published: 2016-09-07
Rated 4 out of 5 by from Working! Hi everyone! I have a colony of cats so you can imagine I spend hundreds of dollars on products to prevent an outbreak. I have been using frontline for the past 10 years and just had a flea infestation. I needed immediate solution. I was afraid that the side effects are going to be bad but I still wanted to get rid of these little suckers. The tablet has a weird smell but after crushing it and putting it in wet food did the magic. Only one of my cats did not eat it - I am still thinking of a solution. Non of them had any side effects by the away and the fleas are all dead! I am super releaved and already ordered the next shipment! Thank you!
Date published: 2016-09-04
Rated 5 out of 5 by from I love this!! I just gave this tablet to both my cats today at 1:15 it's now 3:40 pm and I've seen dead fleas falling off them. It works wonderful. Very happy with this product.
Date published: 2016-08-30
Rated 5 out of 5 by from Great pill, get the J-O-B done! I love this pill it works fast and last 30 plus day for my 5lb Yorkie. it kills fleas quick. when my dog is scratching and itching it drives me crazy so I can only imagine what my poor little dog is dealing with. Our vet had switched to another flea brand Trifiixis ....ugh! this flea med did not and would not last 30 days he was on it for 3 months and every time 2 weeks before the month ended here come the fleas. We our back on comfortis... the good stuff!
Date published: 2016-08-25
Rated 5 out of 5 by from Easy and effective! I wish I had known and done this instead of all the other treatments, baths, sprays, powders, and constant washing!!
Date published: 2016-08-16
Rated 1 out of 5 by from You dont know until youve spent the money Worked fine last year. Didn't work this year. It's very expensive and the tablet is huge. I had to split it and force it. No fun for man or beast.
Date published: 2016-07-30
Rated 5 out of 5 by from Fast results! I had my Corgi on Comfortis last year and had no fleas. This year I tried Frontline Plus because I didn't want to pay to get a vet exam in order to get the Comfortis for this year. Big mistake. Always had some fleas with the Frontline so after 2 months of dealing with this I got my dog back on Comfortis. I gave him a bath 2 hours after he got his first pill and I was shocked, not a single flea. It really does work fast. He is 13 years old and has a beautiful coat, no problems whatsoever with the product.
Date published: 2016-07-29
  • 2016-09-26T06:02CST
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  • clientName_1800petmeds
Q&A

I have a 10 lb cat and at 15 lb dog, can I buy one 12 pack and split it between the two of them or is it species specific? 

Asked by: Trent
You'll need a different strength for your cat and your dog. It's both weight and species specific.
Answered by: paulpharmacistintern
Date published: 2016-08-16

each pill last a month, correct? 

Asked by: Breanna
Yes each pill lasts a month.
Answered by: paulpharmacistintern
Date published: 2016-08-16

Can you give it to a dog that isn't on heartworm prevention?

Asked by: Shepard
Yes Comfortis can be given to a dog that isn't on a heartworm prevention medication.
Answered by: paulpharmacistintern
Date published: 2016-08-11

I have 3 cats- 2 big and 1 smaller that I need to treat for fleece. Do I need a seperate prescription for all 3? 

Asked by: Pina
Yes a seperate prescription would be needed so each dose can be tailored to each specific dog.
Answered by: paulpharmacistintern
Date published: 2016-08-10

Can you take a comfortis pill for  20-40 lb dog and split it in half an give the 2 pieces to 2 10-20 lb dogs

Asked by: TxGent
Talk to your veterinarian about splitting the chews. They may want to give you a new prescription for the right weight.
Answered by: paulpharmacistintern
Date published: 2016-08-09

My very pregnant momma dog got into this is it going to hurt her or the puppies

Asked by: Hoov90
The safe use of Comfortis in breeding, pregnant, or lactating cats and dogs has not been evaluated. Contact your veterinarian about how to proceed.
Answered by: paulpharmacistintern
Date published: 2016-08-09

Can you give comfortis for dogs 1620 mg to a cat

Asked by: roxy
Although Comfortis is both for cats and dogs, it'd be best to talk to your veterinarian to get an appropriate dose and prescription for your cat.
Answered by: paulpharmacistintern
Date published: 2016-08-09

Do you need a persciption from a veterinarian to buy comforts 

Asked by: Ronitta
Yes a prescription is needed for Comfortis.
Answered by: paulpharmacistintern
Date published: 2016-08-05
  • 2016-09-26T06:09CST
  • bvseo_cps, prod_bvqa, vn_cps_3.4.0
  • cp_1, bvpage1
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  • loc_en_US, sid_prod11039, PRD, sort_recentAnswersFirst
  • clientName_1800petmeds
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