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Comfortis

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Product Info
How to Use
Ingredients
Customer Reviews
Q&A
Product Info
What is Comfortis?

Comfortis is the first FDA-approved, chewable beef-flavored tablet that kills fleas and prevents flea infestations on dogs and cats for a full month. Comfortis for Dogs & Cats requires a prescription from your veterinarian.

For:

Dogs & Cats (14 weeks of age or older)

Benefits:
  • Starts killing fleas within 30 minutes
  • Lasts a full month
  • Kills fleas before they can lay eggs
  • Comes in a convenient chewable, beef-flavored tablet
  • Spinosad, the active ingredient in Comfortis, is environmentally friendly
How it Works:

Spinosad kills fleas by causing excitation of the insect's nervous system, leading to paralysis and rapid death.

Cautions:

Side effects may occur, including vomiting. If your pet is experiencing loss of appetite, lethargy, or any other difference in behavior, contact your veterinarian. The FDA has received reports of adverse reactions in dogs receiving the drug Comfortis (spinosad) concurrently with high, extra-label doses of ivermectin. Dogs receiving extra-label doses of ivermectin to treat non-responsive demodectic mange and other conditions have developed signs of ivermectin toxicity. Ivermectin is an ingredient found in heartworm preventatives such as Heartgard Plus, Heartgard, Iverhart Plus and Ivomec. In cats, the most common adverse reaction recorded in clinical trials was vomiting. Other adverse reactions were: lethargy, decreased appetite, weight loss, and diarrhea. Use with caution with concomitant extra-label use of ivermectin.

Brand Name:

Comfortis (Lilly)

Generic Name:

Spinosad

What is Comfortis:

Comfortis is a chewable, synthetic beef flavored tablet (derived from pork protein and hydrolyzed soy) that is given to a dog or cat to kill fleas and prevent flea infestations for one month. Comfortis chewable tablets are for monthly use in dogs and puppies or cats and kittens 14 weeks of age and older.

What should I discuss with my veterinarian before giving Comfortis to my pet:

Tell your veterinarian if you are planning on breeding your pet. Tell your veterinarian if your dog or cat has a history of seizures (epilepsy).

What is the most important information I should know about Comfortis:

Comfortis is a prescription medication FDA approved for use in dogs and puppies and cats and kittens 14 weeks of age or older to kill fleas and prevent flea infestations for one month. Comfortis is available in a Yellow box for dogs 3.3 to 4.9 lbs and cats 2-4 lbs (90mg), Pink box for dogs 5 to 10 lbs and cats 4-6 lbs (140mg), Orange box for dogs 10.1 to 20 lbs and cats 6.1-12 lbs (270mg), Green box for dogs 20.1 to 40 lbs and cats 12.1-24 (560mg), Blue box for dogs 40.1 to 60 lbs (810mg), and Brown box for dogs 60.1 to 120 lbs (1620mg). Please note: Cats over 24 lbs should be administered the appropriate combination of tablets.

How should this medication be given:

Give Comfortis chewable tablets with food. Give Comfortis chewable tablets once a month. Comfortis chewable tablets may be chewed, offered in food, or administered like other tablet medications. If vomiting occurs within 1 hour of administration, redose the pet with another full dose. Store Comfortis at room temperature (68-77° F)

What should I avoid while giving Comfortis:

Your pet may maintain normal activities and interactions while being given Comfortis. The safe use of Comfortis in breeding, pregnant, or lactating cats and dogs has not been evaluated.

What are the possible side effects of Comfortis:

Side effects that may occur include vomiting. If vomiting occurs within one hour of administration, redose with another full dose. Other side effects may occur. Continue giving Comfortis chewable tablets and talk to your veterinarian if your pet experiences decreased appetite, lethargy or decreased activity, diarrhea, cough, increased thirst, vocalization, increased appetite, redness of the skin, hyperactivity and excessive salivation. Talk to your veterinarian about any side effect that seems unusual or especially bothersome to the pet.

What other drugs will affect Comfortis:

Talk to your veterinarian before giving any prescription or over the counter medications.

How to Use
Directions:
  • Comfortis is a prescription medication used in dogs to kill fleas and prevent flea infestations for 1 month.
  • Comfortis chewable tablets are beef flavored.
  • Comfortis can be given to dogs at least 14 weeks of age, weighing at least 3.3 lbs, and cats 14 weeks of age, weighing at least 2 lbs.
Tip:

If vomiting occurs within 1 hour of administration, redose the pet with another tablet.

Dosage:
Dogs/Puppies: (14 weeks of age or older)
Weight
Dosage
3.3-4.9 lbs (Yellow Box)
Give one 90mg chewable tablet by mouth once a month. Comfortis may be chewed, offered in food, or administered like other tablet medications
5-10 lbs (Pink Box)
Give one 140mg chewable tablet by mouth once a month. Comfortis may be chewed, offered in food, or administered like other tablet medications
10.1-20 lbs (Orange Box)
Give one 270mg chewable tablet by mouth once a month. Comfortis may be chewed, offered in food, or administered like other tablet medications
20.1-40 lbs (Green Box)
Give one 560mg chewable tablet by mouth once a month. Comfortis may be chewed, offered in food, or administered like other tablet medications
40.1-60 lbs (Blue Box)
Give one 810mg chewable tablet by mouth once a month. Comfortis may be chewed, offered in food, or administered like other tablet medications
60.1-120 lbs (Brown Box)
Give one 1620mg chewable tablet by mouth once a month. Comfortis may be chewed, offered in food, or administered like other tablet medications
Over 120 lbs
Give the appropriate combination of tablets
Cats/Kittens: (14 weeks of age or older)
Weight
Dosage
2-4 lbs (Yellow Box)
Give one 90mg chewable tablet by mouth once a month. Comfortis may be chewed, offered in food, or administered like other tablet medications
4-6 lbs (Pink Box)
Give one 140mg chewable tablet by mouth once a month. Comfortis may be chewed, offered in food, or administered like other tablet medications
6.1-12 lbs (Orange Box)
Give one 270mg chewable tablet by mouth once a month. Comfortis may be chewed, offered in food, or administered like other tablet medications
12.1-24* lbs (Green Box)
Give one 560mg chewable tablet by mouth once a month. Comfortis may be chewed, offered in food, or administered like other tablet medications
Horses:
Do not use!
Storage:

Store Comfortis at room temperature (68°-77° F).

Ingredients
Comfortis for Dogs: 3.3-4.9 lbs - Comfortis for Cats: 2-4 lbs (Yellow Box)
Active Ingredient
Amount
Spinosad
90 mg
Comfortis for Dogs: 5-10 lbs - Comfortis for Cats: 4-6 lbs (Pink Box)
Active Ingredient
Amount
Spinosad
140 mg
Comfortis for Dogs 10.1-20 lbs - Comfortis for Cats: 6.1-12 lbs (Orange Box)
Active Ingredient
Amount
Spinosad
270 mg
Comfortis for Dogs 20.1-40 lbs - Comfortis for Cats: 12.1-24 lbs (Green Box)
Active Ingredient
Amount
Spinosad
560 mg
Comfortis for Dogs 40.1-60 lbs (Blue Box)
Active Ingredient
Amount
Spinosad
810 mg
Comfortis for Dogs 60.1-120 lbs (Brown Box)
Active Ingredient
Amount
Spinosad
1,620 mg
Customer Reviews
Comfortis is rated 4.5365 out of 5 by 1,083.
Rated 5 out of 5 by from Flea Free This product uses an insecticide that works as a systemic flea killer. Our cat is doing well and is free of fleas. For some cats the topical flea applications work well, but our cat had a skin reaction that made her hair fall out. She looked horrible. Comfortis is a good alternative and now her hair is growing back. I crumbled the pill into a can of her favorite canned pet food. Follow directions on the package for good results.
Date published: 2016-06-15
Rated 5 out of 5 by from Comfortis really works! I gave my pug his second dose about a week ago. I have not seen a single flea on him in over a month. I've tried other products which either didn't work or had unacceptable side effects. My parents also use Comfortis on their corgi and have had equally great results.
Date published: 2016-06-11
Rated 5 out of 5 by from No Skin Issues With This!!! English Bulldog This is the only product that I can give either of my English Bulldogs that doesn't make their hair fall out and sores on their skin!! We tried other products that have the "all in one pill" deal and the next day they started loosing clumps of hair!!! It was terrible! Comfortis is definitely the best thing for us!! No fleas and no problems!!
Date published: 2016-05-29
Rated 5 out of 5 by from Comfortis Chewable Tablets Our dog is approximately 70 lbs. She had a raw spot on her back near her tail from her biting at it. When you touched her or pet her she would dip down as if she had an itch. The vet prescribed her Comfortis by Elanco because he thought maybe she was allergic to fleas. We have never seen a flea on her or in the house but apparently he was right because she no longer bites her back, the raw spot is healed and she once again enjoys being petted. This was the 1620 Mg for 60-120 pound dogs.
Date published: 2016-05-28
Rated 5 out of 5 by from The best flea med Cats hate taking these, but you cannot deny the results! Fleas on the animal are gone within 24 hours. Any other fleas that jump on them and bite them die too. I have never used a flea med that is as effective since I began treating our cats with Comfortis a few years ago.
Date published: 2016-05-23
Rated 5 out of 5 by from Happy cats My vet put my cats on this last year. I had spent a fortune trying to get rid of the fleas. After giving the pills to my cats they were flea free within sn hour. Will start them back tomorrow. Great product an I highly recommend it.
Date published: 2016-05-11
Rated 5 out of 5 by from Great flea medicine! I brought this product for my cat who HATES topical flea medicine. I put the ground up pill in his food and he ate it, no problem. And I haven't seen any fleas.
Date published: 2016-04-29
Rated 5 out of 5 by from Works as soon as it says it does I didn't notice until an hour after I gave my dog the pull that there were little black dots all over the top of his coat. Then I realized they were fleas and they were definitely dead. This stuff is awesome. I will always buy this flea medicine from now on and it is well worth the money.
Date published: 2016-04-26
  • 2016-06-25T06:00CST
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Q&A

Do you start comfortis before fleas are seen

Asked by: mona
Comfortis is a once a month flea prevention that is given year round, please speak with your veterinarian and discuss if this medication is right for your pet.
Answered by: Pharmacy Manager
Date published: 2016-06-05

Will this product kill ticks on dogs?

Asked by: redboy
Comfortis is a chewable, synthetic beef flavored tablet that is given to a dog or cat to kill fleas and prevent flea infestations for one month. Comfortis is not effective against ticks. We do have Nexgard chewables available which is a brand new, revolutionary flea and tick preventative from the makers of Frontline®, the #1 choice of veterinarians. It's the first flea and tick killer of its kind because it comes in a yummy, beef-flavored soft chew that protects your dog from a flea and tick infestation for a full 30 days. You may click on the link below to view the Nexgard, Here is the link: http://www.1800petmeds.com/NexGard+Chewables-prod10356.html?q=nexgard
Answered by: Cherley Petmeds Pro
Date published: 2016-05-02

Are there any coupons I can use?

Asked by: alli98
TOP10 for 10% off your entire order, this offer cannot be combined with other coupon offers.
Answered by: Pharmacy Manager
Date published: 2016-05-20

Is comfortis good to use for tick infestation 

Asked by: Dee dub
Comfortis does not kill ticks or provide your pet protection from ticks. Comfortis is a flea preventative.
Answered by: Pharmacy Manager
Date published: 2016-05-02

How any pills in a 6 pack

Asked by: Benji
6 Pack includes 6 1 month doses.
Answered by: Laura PetMed Pro
Date published: 2016-05-30

Can comfortis be taken along with sentinel spectrum

Asked by: Connie
Yes. The flea control part of the Sentinel Spectrum works differently (sterilizes the flea eggs) than the Comfortis which will kill the fleas.
Answered by: SuzyCVT
Date published: 2016-01-10

Why is my dog still scratching?

We started Bella June on Comfortis but she is still scratching. She is a black lab. Is there certain dogs that this med isn't as effective on? Thanks
Asked by: Bella June
Have your vet check her for flea dermititis. One of our dogs has an allergic reaction to the bites that needed additional treatment. Your dog could have that.
Answered by: Riversmom
Date published: 2016-05-02

Selling Comfortis/Trifexis

How are you able to sell trifexis and comfortis when it supposed to be regulated by the Vet office?
Asked by: kellym
It is regulated by vets. PetMeds will confirm that your dog has a prescription from your vet when you order Rx meds.
Answered by: RSB
Date published: 2016-05-02
  • 2016-06-25T06:10CST
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