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Comfortis

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Product Info
How to Use
Ingredients
Customer Reviews
Q&A
Product Info
What is Comfortis?

Comfortis is the first FDA-approved, chewable beef-flavored tablet that kills fleas and prevents flea infestations on dogs and cats for a full month. Comfortis for Dogs & Cats requires a prescription from your veterinarian.

For:

Dogs & Cats (14 weeks of age or older)

Benefits:
  • Starts killing fleas within 30 minutes
  • Lasts a full month
  • Kills fleas before they can lay eggs
  • Comes in a convenient chewable, beef-flavored tablet
  • Spinosad, the active ingredient in Comfortis, is environmentally friendly
How it Works:

Spinosad kills fleas by causing excitation of the insect's nervous system, leading to paralysis and rapid death.

Cautions:

Side effects may occur, including vomiting. If your pet is experiencing loss of appetite, lethargy, or any other difference in behavior, contact your veterinarian. The FDA has received reports of adverse reactions in dogs receiving the drug Comfortis (spinosad) concurrently with high, extra-label doses of ivermectin. Dogs receiving extra-label doses of ivermectin to treat non-responsive demodectic mange and other conditions have developed signs of ivermectin toxicity. Ivermectin is an ingredient found in heartworm preventatives such as Heartgard Plus, Heartgard, Iverhart Plus and Ivomec. In cats, the most common adverse reaction recorded in clinical trials was vomiting. Other adverse reactions were: lethargy, decreased appetite, weight loss, and diarrhea. Use with caution with concomitant extra-label use of ivermectin.

Brand Name:

Comfortis (Elanco)

Generic Name:

Spinosad

What is Comfortis:

Comfortis is a chewable, synthetic beef flavored tablet (derived from pork protein and hydrolyzed soy) that is given to a dog or cat to kill fleas and prevent flea infestations for one month. Comfortis chewable tablets are for monthly use in dogs and puppies or cats and kittens 14 weeks of age and older.

What should I discuss with my veterinarian before giving Comfortis to my pet:

Tell your veterinarian if you are planning on breeding your pet. Tell your veterinarian if your dog or cat has a history of seizures (epilepsy).

What is the most important information I should know about Comfortis:

Comfortis is a prescription medication FDA approved for use in dogs and puppies and cats and kittens 14 weeks of age or older to kill fleas and prevent flea infestations for one month. Comfortis is available in a Pink box for dogs 5 to 10 lbs and cats 4-6 lbs (140 mg), Orange box for dogs 10.1 to 20 lbs and cats 6.1-12 lbs (270 mg), Green box for dogs 20.1 to 40 lbs and cats 12.1-24 (560 mg), Blue box for dogs 40.1 to 60 lbs (810 mg), and Brown box for dogs 60.1 to 120 lbs (1620 mg). Please note: Cats over 24 lbs should be administered the appropriate combination of tablets.

How should this medication be given:

Give Comfortis chewable tablets with food. Give Comfortis chewable tablets once a month. Comfortis chewable tablets may be chewed, offered in food, or administered like other tablet medications. If vomiting occurs within 1 hour of administration, redose the pet with another full dose. Store Comfortis at room temperature (68-77° F)

What should I avoid while giving Comfortis:

Your pet may maintain normal activities and interactions while being given Comfortis. The safe use of Comfortis in breeding, pregnant, or lactating cats and dogs has not been evaluated.

What are the possible side effects of Comfortis:

Side effects that may occur include vomiting. If vomiting occurs within one hour of administration, redose with another full dose. Other side effects may occur. Continue giving Comfortis chewable tablets and talk to your veterinarian if your pet experiences decreased appetite, lethargy or decreased activity, diarrhea, cough, increased thirst, vocalization, increased appetite, redness of the skin, hyperactivity and excessive salivation. Talk to your veterinarian about any side effect that seems unusual or especially bothersome to the pet.

What other drugs will affect Comfortis:

Talk to your veterinarian before giving any prescription or over the counter medications.

How to Use
Directions:
  • Comfortis is a prescription medication used in dogs and cats to kill fleas and prevent flea infestations for 1 month.
  • Comfortis chewable tablets are beef flavored.
  • Comfortis can be given to dogs at least 14 weeks of age, weighing at least 5 lbs, and cats 14 weeks of age, weighing at least 4 lbs.
Tip:

If vomiting occurs within 1 hour of administration, redose the pet with another tablet.

Dosage:
Dogs/Puppies: (14 weeks of age or older)
Weight
Dosage
5-10 lbs (Pink Box)
Give one 140 mg chewable tablet by mouth once a month. Comfortis may be chewed, offered in food, or administered like other tablet medications
10.1-20 lbs (Orange Box)
Give one 270 mg chewable tablet by mouth once a month. Comfortis may be chewed, offered in food, or administered like other tablet medications
20.1-40 lbs (Green Box)
Give one 560 mg chewable tablet by mouth once a month. Comfortis may be chewed, offered in food, or administered like other tablet medications
40.1-60 lbs (Blue Box)
Give one 810 mg chewable tablet by mouth once a month. Comfortis may be chewed, offered in food, or administered like other tablet medications
60.1-120 lbs (Brown Box)
Give one 1620 mg chewable tablet by mouth once a month. Comfortis may be chewed, offered in food, or administered like other tablet medications
Over 120 lbs
Give the appropriate combination of tablets
Cats/Kittens: (14 weeks of age or older)
Weight
Dosage
4-6 lbs (Pink Box)
Give one 140 mg chewable tablet by mouth once a month. Comfortis may be chewed, offered in food, or administered like other tablet medications
6.1-12 lbs (Orange Box)
Give one 270 mg chewable tablet by mouth once a month. Comfortis may be chewed, offered in food, or administered like other tablet medications
12.1-24* lbs (Green Box)
Give one 560 mg chewable tablet by mouth once a month. Comfortis may be chewed, offered in food, or administered like other tablet medications
Horses:
Do not use!
Storage:

Store Comfortis at room temperature (68°-77° F).

Ingredients
Comfortis for Dogs: 5-10 lbs - Comfortis for Cats: 4-6 lbs (Pink Box)
Active Ingredient
Amount
Spinosad
140 mg
Comfortis for Dogs 10.1-20 lbs - Comfortis for Cats: 6.1-12 lbs (Orange Box)
Active Ingredient
Amount
Spinosad
270 mg
Comfortis for Dogs 20.1-40 lbs - Comfortis for Cats: 12.1-24 lbs (Green Box)
Active Ingredient
Amount
Spinosad
560 mg
Comfortis for Dogs 40.1-60 lbs (Blue Box)
Active Ingredient
Amount
Spinosad
810 mg
Comfortis for Dogs 60.1-120 lbs (Brown Box)
Active Ingredient
Amount
Spinosad
1,620 mg
Customer Reviews
Comfortis is rated 4.5 out of 5 by 1124.
Rated 1 out of 5 by from Terrible for Cats We decided to give this a try for our cats, after flea problems persisted despite trying the numerous prescription topicals available. This was by far THE HARDEST medication I've ever had to give to my pets. The pills were HUGE so we first tried breaking it up into smaller pieces in wet food. They ate some but mostly ate around it. Next time we crushed it up into a powder and mixed into wet food. One cat ate it all, the other ate maybe half and then wouldn't have anything else to do with it. Several hours after giving the medications at least one of the cats had excessive vomiting and diarrhea throughout the house. I guess this should come as no surprise considering you're giving your pet a poison to ingest. It did help with the fleas to some extent but it's not worth the difficulty involved and how sick it makes your pet. We will definitely be going back to topicals and I DO NOT recommend this medication for cats. Period.
Date published: 2017-03-11
Rated 5 out of 5 by from Amazingly effective In January my 6-year-old DSH Gingi's flea allergy had gone out of control despite monthly treatments of Frontline or Revolution. He was licking himself bald and raw on his flanks. Vet recommended Comfortis for fleas and prescribed a two-week Prednisone steroid course for the inflammation. The oral Comfortis that apparently was tasty started to work quickly. The flea comb comes out clean now. The price is comparable with coupon to Revolution. No need to pay for expensive topical products with minimal results.
Date published: 2017-03-10
Rated 5 out of 5 by from Breaking it up to give losses effectiveness Effective flea control- Our Maltese came in contact with another dog who had fleas and our poor girl subsequently had a flea infestation. (Topical didn't help protect our girl.). The vet sent us home with Comfortis and within hours, the fleas died off. Breaking it apart loses its effectiveness- 5 years after the above mentioned situation, our girl was flea-free with monthly Comfortis. She'd always loved taking her comfortis wrapped in a Pill Pocket, the yummy type. However, she'd refused Pill Pocket all together after chemo treatment started last year. The only way we could get comfortis into her was to break it in pieces and hide it in, literally, an empty pill pocket (not the yummy type but the type that holds the medicine we humans are familiar with) the oncologist gave us and then wrap a layer of rice over it to mask any smell. We did this monthly for several months. During that time, flea infestation in our neighborhood and the areas we took our girl for walks were bad last fall. As a result, our girl took home fleas. Unfortunately, with the new method we were giving Comfortis, the fleas on our girl did not die immediately. They, however, did begin to slowly die, but it took days.
Date published: 2017-03-06
Rated 5 out of 5 by from This one works Dusty likes to hunt and patrols the neighborhood hoping to find a mouse. Exposed to fleas in lots of places.
Date published: 2017-02-24
Rated 4 out of 5 by from Only one that works! Charlie had some skin problems starting 5 year ago. It was due to topical flea meds. We started her on several other oral meds but problems persisted. Finally,we found Comfortis and within 2 months no fleas and skin was all clear. We cannot get this product locally any more so I tried PetMeds. I've used their services for everything else for years. They even send me a beautiful card when my fur baby Fella died! Love the product and very much appreciate the services of PetMeds,
Date published: 2017-02-23
Rated 3 out of 5 by from Kills fleas, huge disgusting pill! Comfortis works great on fleas, but it is so large I have to cut it in half. It smells so bad that my cat starts to avoid me, and now I have to try to get two pill pieces down her throat. I'm switching back to drops. I had hoped that this was a smaller pill or perhaps that it was flavored, but oh man is my cat disgusted with it. She spits it up and once it gets moist you can't easily get it down. I mixed a wet pill half into tuna but she wouldn't touch it.
Date published: 2017-02-11
Rated 5 out of 5 by from Immediate results! My Himalayan is very sensitive to flea bites and nothing else has worked. Within one hour of taking Comfortis the fleas were dropping off - dead! He's back to his same old self.
Date published: 2017-02-07
Rated 5 out of 5 by from Works great but has side effects Com fortis was suggested by our vet. It works very well, and works quickly. The only problem was a side effect-severe itching that lasted all night. But, I would use it again.
Date published: 2017-02-06
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Q&A

Do I need a prescription from the vet?

Asked by: Marje
Yes you do need a prescription for this product.
Answered by: Ben B
Date published: 2017-03-15

Can we just buy like 3 pills at a time ?

Asked by: Carolyn
Hello Carolyn, Sorry, we do not supply a 3 pack of this medication. It only comes in a 6 pack (6pills) or 12 pack, it is given once a month. There may be other products that work like this one in which you can buy less supply if you'd like. I would ask your Vet which product might be best. Hope this helps.
Answered by: Trey W
Date published: 2017-03-14

Does it work on multiple dogs? We have a 5 border collies and a Rottweiler. All super active, go everywhere with us dogs. I have done capstar 3 days straight, over- bombed the house, dawn dish soap baths and I still find them. How??

Asked by: Buzz88
This medication can be used for dogs of all different sizes and breeds. Be sure to wash everything during treatment. Discuss with veterinarian about further actions to take.
Answered by: Ben B
Date published: 2017-03-07

How long before it starts to work?

Asked by: Zeus
This is a monthly medication and it will begin killing fleas within 30 minutes after digestion. Hope this helps.
Answered by: Trey W
Date published: 2017-03-06

It's only been 2 weeks and my dog has fleas again. Can I give him another dose this soon?

Asked by: Missy
You should take the medication once a month. Consult with your veterinarian about your dogs new fleas.
Answered by: Ben B
Date published: 2017-03-06

My dog is over 120lbs how much do I give him and which do I buy? It seems to only go up to 120lbs.

Asked by: Patty8
You can still give this medication to dogs over 120lbs, you just have to use a combination of tablets to get the correct dose. So it will depend on how much your dog weighs. Lets say your dog weighs 150lbs. You can use 1 tablet of the brown box (60-120lbs) and 1 tablet of the green box (20-40lbs) to get the right dose for your dogs weight. Your veterinarian can also help with dosing if you get confused or if you want to see about other products possible. Hope this helps.
Answered by: Trey W
Date published: 2017-03-03

What is required for me to order comfortis? Prescription? Vet records?

Asked by: Reyna353
Yes, you would need a prescription from a Veterinarian in order to get Comfortis.
Answered by: Trey W
Date published: 2017-02-27

my english mastiff is 200lbs would i have to give him to pills?

Asked by: maria
Yes, you would have to give your dog 2 of the 60-120 pound tablets, but double check with your veterinarian just in case he/she is concerned about other issues that may be affected by that much Comfortis.
Answered by: SuzyCVT
Date published: 2017-03-02
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