Compare

Frontline Plus - Seresto - Trifexis
Call Us: 1-800-738-6337
Frontline Plus
Seresto
Trifexis
Kills Fleas checkmark checkmark checkmark
Repels Fleas X mark checkmark X mark
Kills Flea eggs and Larvae checkmark checkmark checkmark
Kills Ticks checkmark checkmark X mark
Repels Ticks X mark checkmark X mark
Kills and/or Repels Mosquitoes checkmark X mark X mark
Prevents Heartworm X mark X mark checkmark
Other Parasites Information Eliminates infestations with chewing lice, aids in the control of sarcoptic mange infestation Kills biting lice plus aids in the treatment & control of sarcoptic mange on dogs. Treats and controls hookworms, roundworms, and whipworms infections.
Waterproof (shampooing once a week can reduce effectiveness) checkmark checkmark N/A
Safe for pregnant or nursing Pets checkmark Consult veterinarian before use. Consult your veterinarian
How long does it take to work Kills Fleas within 12 hours and Ticks within 48 hours Kills fleas within 24 hours, and reinfesting fleas are killed in 2 hours. Reinfesting ticks are repelled and/or killed in 6 hours. Starts to kill fleas within 30 minutes; kills 100% of fleas within 4 hours.
Taste Applied to Skin Collar Beef Flavor
Active Ingredient(s) Fipronil/(S)-Methoprene Flumethrin, Imidacloprid Spinosad/Milbemycin Oxime
RX Required X mark X mark checkmark
Dosage
Usage Frontline Plus Usage Seresto Usage Trifexis Usage
Video /images/products/video/petmeds-flea-preventative-frontline-plus.flv
Vet Review I find that the effective combination of an ingredient like fipronil, along with the insect growth regulator methoprene, provides the best spectrum of activity and protection against all stages of the flea life cycle from egg through larval stage on to adult. Because of these two main ingredients and their method of action, I find that clients don't have to treat the environment as much. I find that this product tends to be safer in smaller breed animals when compared to its competition. I find its tick efficacy quite good. The fact that it is waterproof also allows clients, whose pets swim frequently, to confidently use this product during the swimming months. I also find that this product works the longest for fleas, while some of the competitive products have to be reapplied before the end of the month. The lack of label efficacy against mosquitoes and flies, as well as the fact that this product does not repel fleas or ticks are the two main disadvantages. As with any insecticidal products, I find that every pet is an individual, in terms of which of the products works best on them. When I am dealing with more of a flea issue in a patient, this is the product I will likely reach for first. In recent years, the company Bayer has developed a revolutionary flea/tick collar for both dogs and cats that is highly effective, especially in flea control, as well as providing moderately effective tick control. The most exciting aspect of this product is that it provides BOTH repelling and killing of fleas and ticks for up to 8 months!! While it is somewhat expensive, it is actually cheaper than purchasing 8 months of Revolution, Advantage or Frontline. In many areas of the country, this protection will last the entire flea and tick season, by just properly applying the collar. Another major advantage over collars developed in prior years (i.e. Preventic collar) is that Seresto is water resistant, and can be worn with confidence, even by dogs who frequently swim. The collar also has no odor, as well as a powdery, soft feel, in addition to leaving no greasy topical residue, like many of the other topical flea and tick products available. The collar is safe if chewed and/or even eaten by the pet, which was a problem with the old Amitraz based collars such as the Preventic collar. The Bayer company has also made it radioopaque, in case an overzealous pet did ingest the collar, so as to allow radiographic tracing and/or location should it possibly get caught up in the intestinal tract. The collar also has unique technology, in that the release of the active ingredients is triggered by friction of the movement of the pet's hair and body heat. The cat collar even has a break-away apparatus to allow for the pet to safely detach from the collar should it get caught on something outside. The reflectors on the dog product also allow the dog to be seen during the hours of darkness. While the collar is very safe for most pets, I have occasionally and rarely seen reactions in sensitive, geriatric or chronically ill pets. These typically involve transient itching, redness and hair loss at the site of adherence to the skin. While most of the time this will resolve on its own in a week or two, occasionally pets will develop enough irritation where the collar may need to be removed. The major rare systemic reactions seen in sensitive pets are mild lethargy and decrease in energy, but even more rare is the development of neurological symptoms, including weakness and/or seizures. I don't recommend that it be used in pets with a history of seizures and/or neurological sensitivity or reactions. While it is amazing for killing and repelling all stages of the flea life cycle quite quickly, it can sometimes take up to several days for the maximal effects to be seen with tick control and prevention. I, therefore, give this product an overall rating of a 4 out of 5, with an ease of compliance and efficacy of a 4.5 out of 5. An exciting and brand new product now available combines the main ingredient of Interceptor milbemycin with a powerful flea insecticide known as spinosad.  Given as a once monthly heartworm preventative, this product also will control and prevent whipworms, hookworms and roundworms, in addition to preventing heartworms. The additional ingredient spinosad allows effective flea and these internal parasite control all in one pill,  making it quite convenient for clients.  As with any pesticide rare digestive tract and neurological side effects may occur but this has not been a major problem in clinical trials. Since it is relatively new I will have to see how this product performs on the fleas but it seems to have excellent potential. I give this product an overall rating of a 5 with an ease of administration a 5 as well, taste a 5.
Our expert panel consists of licensed veterinarians and the knowledgeable staff of PetMed Express, Inc. d/b/a 1-800-PetMeds. Neither the Company nor any of its employees or consultants make any warranties, expressed or implied, or representations about the accuracy or completeness of the content or the content of any site or external sites. Likewise, no legal liability or responsibility is assumed for the accuracy or completeness of any information, or usefulness of products discussed. While every effort has been made to accurately represent the qualities and characteristics of each product, which for the most part were taken directly from the websites of the manufacturers, we are not responsible for any errors. The information presented is for educational purposes only and is intended to be a supplement to, and not a substitute for, the expertise and professional judgment of your veterinarian. The information is NOT to be used for diagnosis or treatment of your pet. You should always consult your own veterinarian for specific advice concerning the treatment of your pet. The information is not intended to cover all possible uses, directions, precautions, warnings, allergic reactions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for your pet. It is not a substitute for a veterinary exam, and it does not replace the need for services provided by your veterinarian. Note: Any trademarks are the property of their respective companies.

Most Recent Comparisons

Previous Month October 2020
Sun Mon Tue Wed Thu Fri Sat
1 2 3
4 5 6 7 8 9 10
11 12 13 14 15 16 17
18 19 20 21 22 23 24
25 26 27 28 29 30 31