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Simparica TRIO - Trifexis
Call Us: 1-800-738-6337
Simparica TRIO
Trifexis
Kills Fleas checkmark checkmark
Repels Fleas X mark X mark
Kills Flea eggs and Larvae N/A checkmark
Kills Ticks checkmark X mark
Repels Ticks X mark X mark
Kills and/or Repels Mosquitoes X mark X mark
Prevents Heartworm checkmark checkmark
Other Parasites Information Protects against 5 types of ticks, roundworms, and hookworms Treats and controls hookworms, roundworms, and whipworms infections.
Waterproof (shampooing once a week can reduce effectiveness) N/A N/A
Safe for pregnant or nursing Pets The safe use of Simparica TRIO has not been evaluated in breeding, pregnant, or lactating dogs. Consult your veterinarian
How long does it take to work It starts to kill deer ticks within 8 hours, and fleas within 4 hours Starts to kill fleas within 30 minutes; kills 100% of fleas within 4 hours.
Taste liver-flavored chewable tablet Beef Flavor
Active Ingredient(s) Sarolaner, moxidectin, and pyrantel Spinosad/Milbemycin Oxime
RX Required checkmark checkmark
Dosage Monthly
Usage Simparica TRIO Usage Trifexis Usage
Video Video coming soon
Vet Review Coming soon An exciting and brand new product now available combines the main ingredient of Interceptor milbemycin with a powerful flea insecticide known as spinosad.  Given as a once monthly heartworm preventative, this product also will control and prevent whipworms, hookworms and roundworms, in addition to preventing heartworms. The additional ingredient spinosad allows effective flea and these internal parasite control all in one pill,  making it quite convenient for clients.  As with any pesticide rare digestive tract and neurological side effects may occur but this has not been a major problem in clinical trials. Since it is relatively new I will have to see how this product performs on the fleas but it seems to have excellent potential. I give this product an overall rating of a 5 with an ease of administration a 5 as well, taste a 5.
Our expert panel consists of licensed veterinarians and the knowledgeable staff of PetMed Express, Inc. d/b/a 1-800-PetMeds. Neither the Company nor any of its employees or consultants make any warranties, expressed or implied, or representations about the accuracy or completeness of the content or the content of any site or external sites. Likewise, no legal liability or responsibility is assumed for the accuracy or completeness of any information, or usefulness of products discussed. While every effort has been made to accurately represent the qualities and characteristics of each product, which for the most part were taken directly from the websites of the manufacturers, we are not responsible for any errors. The information presented is for educational purposes only and is intended to be a supplement to, and not a substitute for, the expertise and professional judgment of your veterinarian. The information is NOT to be used for diagnosis or treatment of your pet. You should always consult your own veterinarian for specific advice concerning the treatment of your pet. The information is not intended to cover all possible uses, directions, precautions, warnings, allergic reactions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for your pet. It is not a substitute for a veterinary exam, and it does not replace the need for services provided by your veterinarian. Note: Any trademarks are the property of their respective companies.

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