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Activyl - Advantage II
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Activyl
Advantage II
Kills Fleas checkmark checkmark
Repels Fleas X mark X mark
Kills Flea eggs and Larvae checkmark checkmark
Kills Ticks X mark X mark
Repels Ticks X mark X mark
Kills and/or Repels Mosquitoes X mark X mark
Prevents Heartworm X mark X mark
Other Parasites Information NA Treats, Prevents, and Controls Lice Infestations
Waterproof (shampooing once a week can reduce effectiveness) checkmark checkmark
Safe for pregnant or nursing Pets X mark Consult your veterinarian
How long does it take to work Reapply Activyl every 30 days. Kills fleas in 12 hours
Taste Applied to skin Applied to Skin
Active Ingredient(s) indoxacarb Imidacloprid/Pyriproxyfen
RX Required X mark X mark
Dosage
Usage Activyl Usage Advantage II Usage
Video /images/products/video/petmeds-flea-preventative-advantage.flv
Vet Review Another recently available new topical flea preventative for dogs and cats. This new product works by being activated by only the flea's enzyme systems into a flea specific mechanism which paralyzes and kills the adult flea. The company claims that it does not get into the blood stream, but stays only in the superficial skin layers of the pet. Any adult fleas which come into contact with this product are quickly killed so that fleas do not have to actually bite the pet, which is tremendously helpful in those flea-allergic pets, where it only takes a few flea bites to set off an extensive itchy allergic reaction. Another wonderful benefit of this product is that it is waterproof, which is especially helpful in those active outside pets who are exposed to rain or like to swim. This effective product starts working within 12 hours of application, where over 90% of adult fleas are killed. Another excellent benefit of this product is that it also inhibits the development of flea eggs and larvae in the environment, which is a big bonus since much of the flea life cycle occurs in the home environment. While Activyl is very safe and effective for most pets, I have seen occasional rare reactions in sensitive pets, which most commonly is seen as irritation or excessive itchiness at the site of application. While the company says that it is odorless, some of my clients have said that they do sense an odor within the first several days of application, as well as leaving an occasional oily film for the first day or two following application. This film, however usually quickly disappears. The only other very rare reactions include digestive upset and/or drooling/neurological reactions, and certainly if a pet has any chronic digestive weaknesses or history of seizures, etc then the local veterinarian should be consulted before applying the product. I give this product an overall rating of 4, with an ease of use of 4. The non-greasy, non-odor formulation is a definite plus when used on sensitive patients, especially cats. I find that advantage kills fleas and larvae more quickly than some of the other products out there,  often resulting in quicker relief of flea allergy dermatitis symptoms in dogs and cats. Overall I have found it quite safe and have seen the fewest topical or rare systemic reactions in my practice over the years.  The main disadvantage I have found is that in heavy flea infestations that the efficacy may wear off in less than one month, necessitating some vets to recommend more frequent off label use of this product every few weeks.  It also does not control ticks as well on dogs and cats.  I find that advantage works most effectively when combined with good environmental flea control at home.
Our expert panel consists of licensed veterinarians and the knowledgeable staff of PetMed Express, Inc. d/b/a 1-800-PetMeds. Neither the Company nor any of its employees or consultants make any warranties, expressed or implied, or representations about the accuracy or completeness of the content or the content of any site or external sites. Likewise, no legal liability or responsibility is assumed for the accuracy or completeness of any information, or usefulness of products discussed. While every effort has been made to accurately represent the qualities and characteristics of each product, which for the most part were taken directly from the websites of the manufacturers, we are not responsible for any errors. The information presented is for educational purposes only and is intended to be a supplement to, and not a substitute for, the expertise and professional judgment of your veterinarian. The information is NOT to be used for diagnosis or treatment of your pet. You should always consult your own veterinarian for specific advice concerning the treatment of your pet. The information is not intended to cover all possible uses, directions, precautions, warnings, allergic reactions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for your pet. It is not a substitute for a veterinary exam, and it does not replace the need for services provided by your veterinarian. Note: Any trademarks are the property of their respective companies.

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