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Advantage II - Flea5X Plus - Generic to Frontline Plus - Revolution Plus
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Advantage II
Flea5X Plus - Generic to Frontline Plus
Revolution Plus
Kills Fleas checkmark checkmark checkmark
Repels Fleas X mark X mark X mark
Kills Flea eggs and Larvae checkmark checkmark Kills fleas before they lay eggs
Kills Ticks X mark checkmark checkmark
Repels Ticks X mark X mark X mark
Kills and/or Repels Mosquitoes X mark checkmark X mark
Prevents Heartworm X mark X mark checkmark
Other Parasites Information Treats, Prevents, and Controls Lice Infestations Eliminates infestations with chewing lice, aids in the control of sarcoptic mange infestation Treats and controls ear mites, roundworms, and hookworms.
Waterproof (shampooing once a week can reduce effectiveness) checkmark checkmark N/A
Safe for pregnant or nursing Pets Consult your veterinarian checkmark The safe use of Revolution Plus in pregnant, breeding or lactating cats has not been evaluated.
How long does it take to work Kills fleas in 12 hours Fast-acting protection that lasts up to 30 days Starts killing fleas within 6 hours
Taste Applied to Skin Applied to skin Applied to skin
Active Ingredient(s) Imidacloprid/Pyriproxyfen Fipronil/(S)-Methoprene Selamectin, Sarolaner
RX Required X mark X mark checkmark
Dosage
Usage Advantage II Usage Flea5X Plus - Generic to Frontline Plus Usage Revolution Plus Usage
Video /images/products/video/petmeds-flea-preventative-advantage.flv Coming soon. Video coming soon
Vet Review The non-greasy, non-odor formulation is a definite plus when used on sensitive patients, especially cats. I find that advantage kills fleas and larvae more quickly than some of the other products out there,  often resulting in quicker relief of flea allergy dermatitis symptoms in dogs and cats. Overall I have found it quite safe and have seen the fewest topical or rare systemic reactions in my practice over the years.  The main disadvantage I have found is that in heavy flea infestations that the efficacy may wear off in less than one month, necessitating some vets to recommend more frequent off label use of this product every few weeks.  It also does not control ticks as well on dogs and cats.  I find that advantage works most effectively when combined with good environmental flea control at home. 1800petmeds is very excited to now offer an economic and reliable alternative to the brand name Front line plus in the war against flea and tick infestations on dogs and cats. By storing itself in the oil glands of the skin, the ingredients self distribute through the hair follicles and provide protection against fleas, ticks and lice for up to a month. While most of the competitors' products kill only the adult fleas on pets, the two main ingredients in this product, fiprinil and methoprene, not only kill the adult fleas and ticks, but also eggs and larvae, which may represent up to 95% of the total flea population. Recent studies in dogs have shown that these ingredients together start killing fleas within 4 hours, and within 12 to 24 hours 100% of the fleas are killed. While many competitors' products require the fleas to bite the pet, Flea 5x kills on contact. Another wonderful advantage of using Flea 5x is that the product is water proof, and will not be washed away with bathing or swimming, as long as animal guardians wait until the product is completely absorbed into the oil glands, which usually takes 48 hours, before bathing the pet or allowing pet to swim. Veterinarians and guardians should also know that this product is safe to use in breeding, pregnant and lactating dogs and cats. However kittens and puppies should be at least 8 weeks of age before applying this product. Because fleas and ticks pose many health threats to both dogs and cats, including dangerous anemia, rickettsial diseases, flea allergy dermatitis, and tapeworms, it is important to have all pets on a comprehensive flea and tick control program such as Flea 5x. And with the reliable 1800petmeds brand name, animal guardians can confidently rely on the performance of this product as comparable to the brand name. I see very few disadvantages in using this product. Rarely there may be a mild contact dermatitis at the site of application, where occasional pets experience crusting and hair loss. Even less common are idiosyncratic digestive or neurologic upset in very sensitive patients. Any pet with a chronic health condition or prior sensitivity to chemicals or vaccination should have a thorough veterinary exam and evaluation before applying any topical or oral pesticide product. I also recommend that the application of products such as Flea 5x be done on a different day(preferably at least 7 days apart) from other parasite control products such as heartworm prevention or immune challenges such as vaccination. Occasionally clients may see more fleas on their pets after immediately applying Flea 5x plus, but this is just the dying off of the flea population, as they rise to the top of the coat. Because of the often presence of eggs in the environment before the application of this product, it may take a few months to kill the total population of fleas in the home, which is why I often suggest treating the home as well when starting pets on a product like flea 5x plus. While flea 5x does not repel fleas and ticks, I have not found any current products on the market effective with that in my experience and opinion. I give this product an overall rating of 4.5(on scale of 1-5) with the efficacy and ease of use of a 5. A significant limitation of the original revolution product for cats is that it did not cover any species of ticks, which is especially important in those cats who go outside and/or live with dogs where there is increased chance of tick borne infections such as Lyme disease, Ehrlichia and Anaplasmosis in dogs, not to mention the risk of tick born disease exposure in people whose cats bring ticks in to the home. With this new formulation clients get protection against 3 species of ticks. The American Heartworm Society has published that one in 4 cats diagnosed with heartworm disease are indoor only cats, so that especially in Southern, warmer clients, heartworm disease prevention may become as important in cats as dogs. And it takes only a few heartworms to cause significant disease in cats, who seem much more sensitive on exposure to this parasite than even dogs are. This versatile product not only kills fleas before they eggs, but gives additional 6 in 1 protection again ticks, round worms, hookworms, as well as ear mites. THe product is quite quick drying, easy to apply, and not messy or greasy like many other topical formulations. The only down side as to efficacy is in those cases where there is a severe flea infestation affecting multiple animals in a household, where I have found some of the other products a bit more effective in those cases in both dogs and cats, however the vast majority of flea infestations are easily taken care of with this product. Because of the addition of the Sarolamer ingredient for tick control, I would not use this product if there is any history of neurological disease or seizures in the cat. The only other rare side effect I have seen is lethargy and because of its easy to use formulation, only very rare contact sensitivity. With all this being said, I give this product an overall rating of a 4 out of 5 with an ease of application of 5.
Our expert panel consists of licensed veterinarians and the knowledgeable staff of PetMed Express, Inc. d/b/a 1-800-PetMeds. Neither the Company nor any of its employees or consultants make any warranties, expressed or implied, or representations about the accuracy or completeness of the content or the content of any site or external sites. Likewise, no legal liability or responsibility is assumed for the accuracy or completeness of any information, or usefulness of products discussed. While every effort has been made to accurately represent the qualities and characteristics of each product, which for the most part were taken directly from the websites of the manufacturers, we are not responsible for any errors. The information presented is for educational purposes only and is intended to be a supplement to, and not a substitute for, the expertise and professional judgment of your veterinarian. The information is NOT to be used for diagnosis or treatment of your pet. You should always consult your own veterinarian for specific advice concerning the treatment of your pet. The information is not intended to cover all possible uses, directions, precautions, warnings, allergic reactions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for your pet. It is not a substitute for a veterinary exam, and it does not replace the need for services provided by your veterinarian. Note: Any trademarks are the property of their respective companies.

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