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Frontline Plus - Frontline Top Spot
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Frontline Plus
Frontline Top Spot
Kills Fleas checkmark checkmark
Repels Fleas X mark X mark
Kills Flea eggs and Larvae checkmark X mark
Kills Ticks checkmark checkmark
Repels Ticks X mark X mark
Kills and/or Repels Mosquitoes checkmark checkmark
Prevents Heartworm X mark X mark
Other Parasites Information Eliminates infestations with chewing lice, aids in the control of sarcoptic mange infestation Kills chewing lice in dog and puppies and controls mites that may cause sarcoptic mange.
Waterproof (shampooing once a week can reduce effectiveness) checkmark checkmark
Safe for pregnant or nursing Pets checkmark checkmark
How long does it take to work Kills Fleas within 12 hours and Ticks within 48 hours Kills Fleas within 12 hours of contact and Ticks within 48 hours of contact.
Taste Applied to Skin Applied To Skin
Active Ingredient(s) Fipronil/(S)-Methoprene Fipronil
RX Required X mark X mark
Dosage
Usage Frontline Plus Usage Frontline Top Spot Usage
Video /images/products/video/petmeds-flea-preventative-frontline-plus.flv /images/products/video/petmeds-flea-medicine-frontline-topspot.flv
Vet Review I find that the effective combination of an ingredient like fipronil, along with the insect growth regulator methoprene, provides the best spectrum of activity and protection against all stages of the flea life cycle from egg through larval stage on to adult. Because of these two main ingredients and their method of action, I find that clients don't have to treat the environment as much. I find that this product tends to be safer in smaller breed animals when compared to its competition. I find its tick efficacy quite good. The fact that it is waterproof also allows clients, whose pets swim frequently, to confidently use this product during the swimming months. I also find that this product works the longest for fleas, while some of the competitive products have to be reapplied before the end of the month. The lack of label efficacy against mosquitoes and flies, as well as the fact that this product does not repel fleas or ticks are the two main disadvantages. As with any insecticidal products, I find that every pet is an individual, in terms of which of the products works best on them. When I am dealing with more of a flea issue in a patient, this is the product I will likely reach for first. One of my favorite and most widely prescribed flea and tick control products in practice front line top spot offers not only the ease of application in one spot, where it collects in the hair follicles and skin oils and gradually released over the month, but also a wide area of safety in most pets, including breeding, pregnant and lactating dogs. .   It will kill adult fleas and larvae by selectively affecting the parasite's nervous system.  Efficacy against  flea eggs is variable  in my experience and opinion.   It will also kill chewing lice and some veterinarians, including myself have seen it work to help control demodectic mange and ear mites, although it is it not approved for use for these uses.   This versatile product will also kill all stages of various ticks including brown dog ticks, american dog ticks, lone star ticks and deer ticks.   I have also used it to control  sarcoptic mange infestations in dogs, but will often go to topical revolution first in sarcoptic mange or ivermectin as my first choices for scabies.   In general I find that fleas and ticks are generally killed before they have the chance to transmit diseases in patients, usually being close to 100% effective within 24 to 48 hours. The formulation is water proof so it is certainly appropriate to use in those outdoor dogs who love to swim.   I have only seen occasional/rare side effects at the sight of application, and even more rare systemic reactions like digestive upset or neurological reactions or blood disorders in extremely sensitive pets.   However these reactions are rare in my experience.  In geriatric patients or sick patients or those with chronic disease it is important to consult with your veterinarian before applying this or any other topical flea and tick product.
Our expert panel consists of licensed veterinarians and the knowledgeable staff of PetMed Express, Inc. d/b/a 1-800-PetMeds. Neither the Company nor any of its employees or consultants make any warranties, expressed or implied, or representations about the accuracy or completeness of the content or the content of any site or external sites. Likewise, no legal liability or responsibility is assumed for the accuracy or completeness of any information, or usefulness of products discussed. While every effort has been made to accurately represent the qualities and characteristics of each product, which for the most part were taken directly from the websites of the manufacturers, we are not responsible for any errors. The information presented is for educational purposes only and is intended to be a supplement to, and not a substitute for, the expertise and professional judgment of your veterinarian. The information is NOT to be used for diagnosis or treatment of your pet. You should always consult your own veterinarian for specific advice concerning the treatment of your pet. The information is not intended to cover all possible uses, directions, precautions, warnings, allergic reactions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for your pet. It is not a substitute for a veterinary exam, and it does not replace the need for services provided by your veterinarian. Note: Any trademarks are the property of their respective companies.

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