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Advantage II

Starts $52.74 $37.77 
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Product Info
How to Use
Ingredients
Customer Reviews
Q&A
Product Info

What is Advantage II?

Advantage II is a monthly flea preventative for dogs and cats that offers comprehensive flea protection by killing adult fleas, larvae, and eggs. Plus, it kills fleas through contact, which means fleas don't have to bite your pet to die. Advantage II also treats, prevents, and controls lice on dogs. Advantage II does not kill ticks, so we recommend using the Preventic Tick Collar along with Advantage II (dogs only). Advantage II for small cats 5-9 lbs can also be used for ferrets weighing 1 lb or over and 10 weeks of age or older.

For:

Dogs (7+ weeks of age, weighing 3+ lbs), Cats (8+ weeks of age, weighing 2+ lbs), Ferrets (10+ weeks of age, weighing 1+ lbs)

Benefits:

  • Convenient, once-a-month application
  • Kills through contact - fleas don't have to bite to die
  • Kills fleas within 12 hours of application on cats and dogs
  • Kills fleas within 24 hours of application on ferrets
  • Kills all flea life stages including flea eggs and larvae to prevent infestation
  • Treats, prevents, and controls lice infestations (dogs only)
  • Safe and easy to apply
  • Waterproof - remains effective even if pet gets wet (use of a soap-free shampoo is recommended)

How does Advantage II work?

The first active ingredient is imidacloprid, which acts on the nervous system of the flea to cause paralysis and subsequent death. Within 12 hours of application on cats and dogs, 98-100 percent of fleas are dead. Advantage II Small Cat kills the existing fleas on ferrets within 24 hours. The second active ingredient, pyriproxyfen, is an insect growth regulator. Once a female flea lays her eggs, pyriproxyfen works to prevent the eggs from hatching, ending the flea life cycle. Also, the active ingredient in Advantage II kills through contact, which means that fleas don't have to bite your pet to die. Reinfesting fleas are killed with protection against further flea infestation lasting for up to 4 weeks. Pre-existing pupae in the environment may continue to emerge for 6 weeks or longer depending upon the climactic conditions.

Cautions:

Individual sensitivities, while rare, may occur after using any pesticide product for pets. If signs persist, or become severe, consult a veterinarian immediately. Do not get this product in your pet's eyes or mouth.

Brand Name:

Advantage II (Bayer)

What is the most important thing I should know about Advantage II?

The active ingredients in Advantage II are Imidacloprid (9.1%) and Pyriproxyfen (0.46%). Advantage II Kitten, Advantage II Small Cat and Advantage II Large Cat are once a month topical flea prevention and treatment for cats and kittens over 8 weeks or older. Advantage II Small Cat may also be used for ferrets weighing 1 lb or over and 10 weeks of age or older. Advantage II Small Dog, Advantage II Medium Dog, Advantage II Large Dog, and Advantage II Extra Large Dog are once a month topical flea prevention and treatment for dogs and puppies 4 lbs or more and 7 weeks or older. Advantage II kills all flea life stages. Advantage II kills fleas within 12 hours of application. Advantage II for Dogs also treats, prevents, and controls lice infestations. Advantage II is waterproof and fragrance free. Advantage II for cats or ferrets and Advantage II for dogs are non-prescription (OTC) products.

What should I discuss with my veterinarian before giving Advantage II to my pet?

Consult a veterinarian before using on medicated pets, if the pet is being given this product along with other pesticides, and debilitated, aged, pregnant or nursing pets.

How should Advantage II be applied?

Advantage II Kitten is available in 0.23 ml applicators for kittens 2-5 lbs (turquoise). Advantage II Small Cat is available in 0.4 ml applicators for cats 5-9 lbs or ferrets weighing 1 lb or over and 10 weeks of age or older (orange). Advantage II Large Cat is available in 0.8 ml applicators for cats 9 lbs & up (purple). Advantage II Small Dog is available in 0.4 ml applicators for dogs 3-10 lbs (green). Advantage II Medium Dog is available in 1.0 ml applicators for dogs 11-20 lbs (teal). Advantage II Large Dog is available in 2.5 ml applicators for dogs 21-55 lbs (red). Advantage II Extra Large Dog is available in 4.0 ml applicators for dogs over 55 lbs (blue). To apply, place the applicator tip through your pet's hair to the skin level. On cats and ferrets, apply to skin on neck at the base of the skull. For dogs up to 20 lbs, apply to skin on back between the shoulder blades. For dogs 21 lbs or over apply the contents of one tube to 3 or 4 spots along the skin on back from the shoulder to the tail. Do not get this product in the pet's eyes or mouth.

What are the potential side effects of Advantage II?

Individual sensitivities, while rare, may occur after using any pesticide product for pets. If signs persist, or become more severe, consult a veterinarian immediately.

What happens if I miss giving a dose of Advantage II?

If a dose is missed, apply the usual dose of Advantage II and resume a monthly dosing schedule.

What happens if I overdose my pet on Advantage II?

Contact your veterinarian or veterinary emergency room.

What should I avoid while giving Advantage II to my pet?

Advantage II is for external use on dogs and puppies 3 lbs or more and 7 weeks or older, cats and kittens 2 lbs or more and 8 weeks or older, or ferrets weighing 1 lb or over and 10 weeks of age or older. This product causes eye irritation in humans and is harmful if swallowed. Avoid contact with skin. Call poison control center if swallowed. If on skin, wash with plenty of soap and water. If in eyes, flush with plenty of water.

What other drugs will affect Advantage II?

Consult your veterinarian prior to giving this product along with other pesticides.

How to Use

Advantage II Directions:

  • Only use Advantage II on dogs/puppies over 3 lbs and over 7 weeks of age, cats/kittens over 2 lbs and over 8 weeks of age, and ferrets 1 lb or over and 10 weeks of age or older.
  • Apply Advantage II once a month every month.
  • For dogs up to 20 lbs, part the pet's hair between the shoulder blades until you can see the skin. Place the tip of the applicator on the skin and release all of the tube's contents on a single spot directly on the skin.
  • For dogs 21 lbs and over, apply entire contents of the tube evenly in 3 or 4 spots on the top of the back from the shoulder to the base of the tail. At each spot, part the hair until the skin is visible. Place the tip of the applicator on the skin and release a portion of the Advantage II solution directly on the skin. Do not apply an excessive amount of solution at any one spot that could cause some of the solution to run off the side of the dog.
  • For kittens, cats and ferrets, place the applicator tip through the cat's hair to the skin on the neck at the base of the skull and release all of the tube's contents on a single spot directly on the skin.
  • Use only one applicator per treatment.
Tip:

Under normal conditions Advantage II is effective for a month. However, in case of severe flea infestation, retreatment may be necessary earlier than four weeks. Do not re-treat cats or dogs more often than once every 7 days. For ferrets, do not retreat more often than every 14 days. After flea control is obtained, return to a monthly treatment.

Dosage:
Dogs/Puppies: (7+ weeks of age, weighing 3+ lbs)
Weight
Dosage
3-10 lbs
Apply contents of 1 applicator once a month (Green Box)
11-20 lbs
Apply contents of 1 applicator once a month (Teal Box)
21-55 lbs
Apply contents of 1 applicator once a month (Red Box)
Over 55 lbs
Apply contents of 1 applicator once a month (Blue Box)
Cats/Kittens: (8+ weeks of age, weighing 2+ lbs)
Ferrets: (10+ weeks of age, weighing 1+ lbs)
Weight
Dosage
2-5 lbs
Apply contents of 1 applicator once a month (Turquoise Box)
5-9 lbs
Apply contents of 1 applicator once a month (Orange Box)
9 lbs & up
Apply contents of 1 applicator once a month (Purple Box)
Ferrets 1+ lbs
Apply contents of 1 applicator once a month (Orange Box)
Horses:
Do not use!
Storage:

Store this product in a cool dry place. Do not store in the refrigerator. Do not reuse empty container. Do not contaminate water, food or feed by storage or disposal. To dispose of empty container place in trash or offer for recycling if available. If container is partly filled call local solid waste agency for disposal instructions. Never place unused product down any indoor or outdoor drain. Keep out of reach of children and pets.

Ingredients

Advantage II Ingredients:

Advantage II for Kittens 2-5 lbs (Kitten - Turquoise Box) (0.23 ml):
Active Ingredients
% By Weight
Imidacloprid
9.10%
Pyriproxyfen
0.46%
Other Ingredients (not specified)
90.44%
Advantage II for Cats 5- 9 lbs or Ferrets 1 lb or over and 10 weeks of age or older (Small Cat - Orange Box) (0.4 ml):
Active Ingredients
% By Weight
Imidacloprid
9.10%
Pyriproxyfen
0.46%
Other Ingredients (not specified)
90.44%
Advantage II for Cats Over 9 lbs (Large Cat - Purple Box) (0.8 ml):
Active Ingredients
% By Weight
Imidacloprid
9.10%
Pyriproxyfen
0.46%
Other Ingredients (not specified)
90.44%
Advantage II for Dogs 3-10 lbs (Small Dog - Green Box) (0.4 ml):
Active Ingredients
% By Weight
Imidacloprid
9.10%
Pyriproxyfen
0.46%
Other Ingredients (not specified)
90.44%
Advantage II for Dogs 11-20 lbs (Medium Dog - Teal Box) (1.0 ml):
Active Ingredients
% By Weight
Imidacloprid
9.10%
Pyriproxyfen
0.46%
Other Ingredients (not specified)
90.44%
Advantage II for Dogs 21-55 lbs (Large Dog - Red Box) (2.5 ml):
Active Ingredients
% By Weight
Imidacloprid
9.10%
Pyriproxyfen
0.46%
Other Ingredients (not specified)
90.44%
Advantage II for Dogs 55 lbs and Over (Extra Large Dog - Blue Box) (4.0 ml):
Active Ingredients
% By Weight
Imidacloprid
9.10%
Pyriproxyfen
0.46%
Other Ingredients (not specified)
90.44%
Customer Reviews
Advantage II is rated 4.2 out of 5 by 2845.
Rated 5 out of 5 by from Fastest shipping ever! This was my first purchase from 1800petmeds. They had a great sale going on their Advantage II flea products, so I purchased and chose the First Class 5-7 day shipping option. I didn't expect to receive it until the end of this week. Well, they shipped immediately, and I had the product by Tuesday! I thank you and my animals thank you, too!
Date published: 2017-03-14
Rated 1 out of 5 by from Wrong product This is the wrong product for my dog. I am so sadden by this
Date published: 2017-03-09
Rated 5 out of 5 by from Ease of Use I bought this brand because it seems to work on my cats. Easy to use, and I am done.
Date published: 2017-03-05
Rated 5 out of 5 by from Fantastic product I have been using Atvantage II for years....all my cars and home have been NO FLEA!
Date published: 2017-03-03
Rated 5 out of 5 by from Wonder Product All four of our cats Topaz, Gertie, Tig and Alley are flea free thanks to feline Advantage 11. We will never use anything else. No fleas in the house too. Since our cats all sleep on our beds this is very important. This is a great product.
Date published: 2017-02-28
Rated 5 out of 5 by from no itching ! We have used this countless times before and so far the product has not failed our cat Tazz . Great flea medication !
Date published: 2017-02-27
Rated 5 out of 5 by from Great product. I bought this product after I realized one of my cats had fleas and the other cat didn't. It worked quickly and worked great. I highly recommend this product to anyone who owns a cat or cats!
Date published: 2017-02-23
Rated 5 out of 5 by from Great product This is the best flea medication I have ever used! Amazing!!
Date published: 2017-02-20
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Q&A

I received my Advantage 11 today put it on my dog she is still scratching herself??

Asked by: Bella
The medication kills 98-100 percent of fleas within 12 hours. However the pet may still scratch as a result of the remaining fleas dying.
Answered by: Amy Petmed Pro
Date published: 2017-03-09

Can this be used while seristo is worn?

Asked by: Rebel 1
They are both flea preventatives and I would not recommend them together, unless otherwise recommended by your veterinarian.
Answered by: Ben B
Date published: 2017-03-03

Do you sell and ship to Canada? I'm not sure if there is a significant savings with the exchange, but if there is, I would order this to treat lice on my several dogs and foster dogs.

Asked by: LAstles
Yes, we sell and ship to Canada.
Answered by: Ben B
Date published: 2017-03-01

Is this pack for 1 month or is there a 6 months supply in the box? 

Asked by: GLow
6 applications
Answered by: Amy Petmed Pro
Date published: 2017-03-13

My cat is 9lb should I get the flea medicine for 5-9lb or the 9lb + ? 

Asked by: Jillk23
I would consult with your veterinarian on the appropriate dose for your cat.
Answered by: Ben B
Date published: 2017-03-13

Does this medicine kill more than fleas? Mites in the ears?

Asked by: Debbie
Hello Debbie, Thanks for your question. This medication works against fleas and lice when used on dogs. Its main purpose is flea protection, as it is a pesticide. If your pet has other problems other than fleas, I would ask your veterinarian to check your animal and determine what is best. Hope this helps. Thanks, PetMeds Intern
Answered by: Trey W
Date published: 2017-02-19

My cat is currently nine months old and weighs 8.8lbs. Can I get the 9+ pound advantage2 for him? 

Asked by: Natalie
I am very sorry, we can only advise to administer the medication the way the manufacturer intended, which is by weight class.
Answered by: Amy Petmed Pro
Date published: 2017-02-16

I have one cat that weighs 8 lbs and one that weight almost 10 lbs. I don't want to buy a large cat and small cat package. Can I use one for both cats?

Asked by: Sherri
I'm very sorry, we can only advise to use the medication the way the manufacturer intended, which is by weight class.
Answered by: Amy Petmed Pro
Date published: 2017-02-16
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