4.9 out of 5 Customer Rating
Sentinel is rated 4.5 out of 5 by 919.
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Sentinel

4.9 out of 5 Customer Rating
Sentinel is rated 4.5 out of 5 by 919.
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Prescription Item Prescription Item Prescription Item
Starts at $48.09
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Reviews

Rated 1 out of 5 by from This review is for Medicine only! Petmeds C.S. :) This is only for the medicine. My dog is 12 years old and has been on a preventive for heartworms/flea/tick all her life. I set a schedule to never miss a dose. We have used Heartgard and Trifexis over years but I was recommended to try Sentinel 2 years ago to save on money but get same results. Well, found out recently that's not the case with this medicine!! After 12 years my dog just tested POSITIVE for Heartworms while on this medication! I thought everything was OK until we had the yearly test done. Not happy with this medicine,anymore!! I am, however, grateful to Petmeds for their customer service and help with getting reimbursed and payment for new Heartworm treatment.
Date published: 2019-01-02
Rated 5 out of 5 by from Multi purpose Have been using this for 7 years. Super effective! Peanut and Tinkerbell take it every month like it was a treat ❤️
Date published: 2019-01-02
Rated 5 out of 5 by from Multi purpose We have been using this product for many years now. Have never had any problems. It works great.
Date published: 2018-12-22
Rated 1 out of 5 by from Hookworm Positive while on Sentinel! My dog has been on Sentinel since he was a puppy and he is 8 years old now. I got a call from his Vet yesterday saying he tested positive for Hookworms. We will not be using Sentinel again!! Now I have to treat 3 other dogs as well for Hook Worms!!
Date published: 2018-11-22
Rated 5 out of 5 by from Sentinel I Lways use this brand ...I switched once and product was not healthy for my pets..sentinel as long as I own fur babies
Date published: 2018-11-08
Rated 5 out of 5 by from Sentinel works great! My Chewbacca and R2-D2 have always been on sentinel. I am very pleased with the product. Never had fleas and always get a good report on their blood work for heart worms. Chewbaca is 14 years old and is doing great other tha hearing and teeth loss. R2-D2 is six years old and so full of energy.
Date published: 2018-11-05
Rated 5 out of 5 by from Best for my fur babies Our girls Maddie and Gracie have only taken Sentinel. We have no issues never have.
Date published: 2018-11-02
Rated 5 out of 5 by from Bailey resounds well to Sentinel. Thank you, jay
Date published: 2018-10-22
Rated 5 out of 5 by from Amazing product Been using this product and takes care of multiple things of concern as well as the basic heart worm protection.
Date published: 2018-10-16
Rated 5 out of 5 by from Works Great I have always kept all my Shihtzus on Sentinel year round & it has ALWAYS protected them from heart worm and fleas, etc. My wonderful veterinarian does not carry it anymore so I have been purchasing it from PetMeds for a long time, and am so happy they sell it. And the quality is excellent and the price is good. I highly recommend.
Date published: 2018-10-12
Rated 5 out of 5 by from Working great. Our Sheltie has been on Sentinel for 6 years and we have never seen a flea or had any positive heart worm results from blood tests. The pill does not upset her stomach and so far seems to be working well. PetMeds ships quickly and we use them all the time for Sentinel orders.
Date published: 2018-09-28
Rated 5 out of 5 by from Our chosen Heart Worm preventative Medicine Sentinel is my Veterinarian preferred Heart Worm preventative medicine. For sure it keeps my pups healthy.
Date published: 2018-09-02
Rated 4 out of 5 by from The Right Combination My smooth Collie, Bob, is on Sentinel because he has the MRD1 gene mutation. Also, as a herding breed, he should avoid Ivermectin. Since he takes Sentinel in combination with another flea and tick preventive, we give him a slightly lower, vet approved dose of the second med. This seems to be safe and effective.
Date published: 2018-08-29
Rated 5 out of 5 by from No fleas no parasites Rudy is my third dog on Sentinel. All have done well, and our home has never had a flea problem! My dogs are indoors, outdoors, and sleep in our beds. I like the flea control of Sentinel without external chemicals, and I like that it has been used for a long time- has a solid reputation after years of use. My dogs have never tested positive for parasites or worms. Sentinel is good solid flea infestation protection with a well-deserved vet recommended reputation.
Date published: 2018-08-24
Rated 5 out of 5 by from Great product..covers my two pugs from fleas and heart worm. No side affects most important. Thank you pet meds for always delivering so fast.
Date published: 2018-08-10
Rated 5 out of 5 by from Completely satisfied! Our Veterinarian recommended Sentinel for our Darcie when she was little. She is 5 years old now and has been taking it regularly since then. She has had no problems with it and we can get it for less by ordering. Actually, we get it faster, too!
Date published: 2018-08-03
Rated 1 out of 5 by from Disappointed Pet meds in general gets 5 stars, great customer service and sends my pup a treat every time. I have to give this product one star, I bought this product a few weeks ago, I was apprehensive because I’ve never used it before, but it’s the only Heartworm preventive my Pup can take because of the MRD1 gene Mutation. Everything seemed to be working well but just found out my dog has hookworms.
Date published: 2018-07-26
Rated 5 out of 5 by from Great product Sentinel is a great product. Happy that I purchased it from petmeds at a good price.
Date published: 2018-07-22
Rated 5 out of 5 by from Good product. I have used Sentinel for years and it's a great product, and affordable. The one they are pushing now cost way too much, and I don't think it even covers everything that Sentinel covers.
Date published: 2018-07-17
Rated 5 out of 5 by from Great product We love ordering from PetMed. The prices are great, delivery fast, and the shipping is free when we order the Sentinel. It’s a wonderful product and it not only prevents heartworm, it works on fleas, too.
Date published: 2018-07-05
Rated 5 out of 5 by from My Pup Thinks It's A Treat! My dog loves these, every time I give him one he think it's a treat. He's been on it for about 6 months non-stop, there has been no issues. Better than ordering from the vet... as I pay the same price (at the vet) for only 3 months... where here I pay the SAME price, BUT FOR 6 months! Love this website.
Date published: 2018-07-03
Rated 5 out of 5 by from Atra has been on sentinal for the last five years its an awesome product. Very pleased. And Atra loves 1 800 petmeds. Send her a treat with every order
Date published: 2018-07-02
Rated 5 out of 5 by from Great! My dog had no problem so far with Sentinel.
Date published: 2018-06-27
Rated 5 out of 5 by from Sentinel We Trust Sentinel with our dogs it's a good safe product unlike some of the other products out there
Date published: 2018-06-26
Rated 1 out of 5 by from Doesn’t work My dog just came back positive for hookworm but we use sentinel year round and never missed a dose...
Date published: 2018-06-26
Rated 5 out of 5 by from Great Price & Great Service I bought this from 1 800 Pet Meds without any hassle and quick delivery at the best price.
Date published: 2018-06-22
Rated 5 out of 5 by from No Heart worms or Fleas This is my third dog that has received the Sentinel product. I haven't noticed any problems and the dogs get good check ups when they see the vet.
Date published: 2018-06-19
Rated 5 out of 5 by from Great service I am extremely happy with the pricing..convience of ordering on line knowing exactly when merchandise will arrive and prompt service
Date published: 2018-06-12
Rated 5 out of 5 by from does the job Never fails. It prevents fleas and heart worms
Date published: 2018-06-06
Rated 5 out of 5 by from Great check ups due to sentinel Nichol has been on this med for at least two years and every check up is great. Always negative which is great for no worms and no parasites. She is a happy Pekingese.
Date published: 2018-06-04
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Questions

it has been 49 days since I last gave my dog his Sentinel... Can I give him now without getting a heartworm test first?

Asked by: Chris
Thank you for your question. If a dose is missed and a 30-day interval between dosing is exceeded, administer Sentinel immediately and resume the monthly dosing schedule.
Answered by: Crystal RPTechnician
Date published: 2018-09-12

Can I use this along with nextguard for my dog?

Asked by: Nicole
Yes. It is safe to use Sentinel in conjunction with Nexgard.
Answered by: Cherley Petmeds Pro
Date published: 2018-06-06

My dog will not chew any flavored tab, He is picky about what treat or food he will eat in any given day, He obviously is a very picky eater, and eats a full meal maybe 1 time every 36 hours. Will this be effective. BTW he is a 16 lb shih tsu.

Asked by: Maxwill the picky one
The dog needs to eat the pill to be effective. If your dog will not eat/ chew the pill with food I wold suggest going to abtopical product instead .
Answered by: Jackie113
Date published: 2018-09-12

Rufus weighs 29 lbs. I just bought him the up to 25 pounds and gave him this medicine 2 weeks ago. I just found fleas and eggs on him. Is it because his weight is over 25 lbs?

Asked by: bros
Yes. Our pharmacy recommends giving this product within your furry babies weight range for guaranteed coverage.
Answered by: Cherley Petmeds Pro
Date published: 2018-07-22

Do you need a RX from the Vet?

Asked by: jan1
Our pharmacy can contact your veterinarian to obtain the prescription for you prior to shipment.
Answered by: Cherley Petmeds Pro
Date published: 2018-07-22

Is the medication effective if it is slightly out of date and or does the medication get stronger after It expires

Asked by: Big boy
Thank you for your question. It is not recommended to give your pet expired medication. The medication loses its effectiveness after it becomes expired and may not work for your pet.
Answered by: Crystal RPTechnician
Date published: 2018-09-12

My current Green box says 8.1 to 25 lbs, this box says 11-25 lbs. Why?

Asked by: ScottD
Thank you for your question. The Sentinel is sold in the following doses 2-10lbs, 11-25lbs , 26-50lbs and 51-100lbs. We also offer Sentinel Spectrum which is available 2-8lbs, 8.25lbs. 25-50 and 50-100lbs. With the Sentinel Spectrum the green box is 8.1-25lbs. The difference between the two products are Sentinel is a flavored tablet preventive that guards against heartworms, adult roundworms, adult hookworms, whipworms, and prevents the development of flea eggs. Sentinel Spectrum is beef-flavored chewable that prevents heartworms and prevents and controls fleas. Each chew also treats and controls whipworms, hookworms, roundworms and tapeworms.
Answered by: Crystal RPTechnician
Date published: 2018-07-22

We have a 5month old McNabb German Shepard mix he's around 50-60 lbs how much does it cost for one pill a month because he's still growing

Asked by: Kendra
Thank you for your question. Yes we do in certain circumstances such as the one mentioned. Please call us at 1-800-738-6337for pricing information.
Answered by: Crystal RPTechnician
Date published: 2018-05-03

What is the country of origin for manufacture?

Asked by: eddie64
Thank you for your question. This product is made by Virbac in which their corporate headquarters is Fort Worth TX.
Answered by: Crystal RPTechnician
Date published: 2018-07-22

I have a 10 lb puppy that will grow substantially every month. Can I buy the 02-10 tablets and give him two the next month?

Asked by: Cathy
Administering the correct size tablet is always recommended. You may order single doses by calling us at 1-800-738-6337.
Answered by: Lisa M
Date published: 2018-07-22

What does the Sentinel brown box the PILL look like

Asked by: Toni
Thank you for your question. The Sentinel brown box is for dogs 2-10lbs. A visual of the tablet is available on our website when viewing the product.
Answered by: Crystal RPTechnician
Date published: 2018-03-20

Does the puppy pill kill grown roundworms that are already exists in the stomach?

Asked by: Melody
Thank you for your question. The Sentinel treats and control roundworms.
Answered by: Crystal RPTechnician
Date published: 2018-07-22

Can this be safely given along with bravecto (kills fleas and ticks)? Our two dogs are one Sheltie/Beagle mix and one American Eskimo. We are concerned with the Sheltie mix due to the mdr1 potential interaction.

Asked by: Elle
Thank you for your question. Bravecto and Sentinel may be used concurrently.
Answered by: Crystal RPTechnician
Date published: 2018-06-12

Does Sentinal protect against ticks? Thank you.

Asked by: Polly
Sentinel is the only monthly oral preventive that guards against heartworms, adult roundworms, adult hookworms, whipworms, and prevents the development of flea eggs. It does not protect against ticks.
Answered by: Lisa M
Date published: 2018-07-22

I took my dog to our local animal shelter for a heartworm test. He tested negative. Can I get his heartworm prevention with it.

Asked by: Rhonda
Thank you for your question. We can accept the prescription directly from your veterinarian via email, phone or fax. Otherwise you are welcome to mail in the original written prescription to us. We cannot use the test results in lieu of the actual prescription or prescription authorization.
Answered by: Crystal RPTechnician
Date published: 2018-03-11

If I have a 60 pound dog and a 30 pound dog, can I give the smaller dog half of the larger dose pill instead of buying two separate boxes?

Asked by: Jess
Jess, I have always done this with my dogs and vet said it was fine 
Answered by: CindyP
Date published: 2018-07-22

How do I buy multiple packs of sentinel for 2 different dogs

Asked by: Captrad824
Thank you for your question. The Sentinel is sold in a 6 or 12 pack and dosage is based on your pets weight. You can only list one pet per prescription. You may place the order online or by calling us a 1-800-738-6337.
Answered by: Crystal RPTechnician
Date published: 2018-07-22

Side effects?

Asked by: Paco
Thank you for your question. Side effects are rare, though some pets may exhibit vomiting, depression, drowsiness, itching, hives, loss of appetite, diarrhea, or seizures, hyper salivation, and weakness. If these or other symptoms develop contact your veterinarian.
Answered by: Crystal RPTechnician
Date published: 2018-07-22

Can brevecto for flea and ticks be given along with sentinel? 

Asked by: June
Bravecto and Sentinel may be used concurrently.
Answered by: Lisa M
Date published: 2018-07-22

My dog has been on Sentinel for over a year and has not missed dose. I asked my vet for another years worth and they want to test my dog even though they haven't missed a dose. Do I have to get my dog retested?

Asked by: JTTaz
Most veterinarians require an annual heartworm test even if your pet has continuously been on prevention year round.
Answered by: Lisa M
Date published: 2018-07-22

Is this safe for a dog on phenobarbital (seizure medication )?

Asked by: Ebonfanti30
There is no drug interaction between phenobarbital and Sentinel. Your veterinarian will determine if Sentinel is appropriate for your specific pet.
Answered by: Lisa M
Date published: 2018-07-22

I have two dogs that weight the same. Can I buy 1 six month supply and use both for them? (Meaning I will only get a total of 3 months supply). Or do I need to buy two 6 months prescription?

Asked by: Larae711
Most veterinarians recommend a separate prescription for each pet. Consult your veterinarian for his or her opinion.
Answered by: Lisa M
Date published: 2018-07-22

Do I need a perscriptson for flea medicine

Asked by: Davida
Thank you for your question. Sentinel guards against heartworms, adult roundworms, adult hookworms, whipworms, and prevents the development of flea eggs. Sentinel requires a prescription from your veterinarian.
Answered by: Crystal RPTechnician
Date published: 2018-07-22

I ordered the sentinel 2-10 pound (2 packs of 6) what if my dog goes over 10 pounds will the medication be good?

Asked by: Tiffany
Since you weren't happy with the proper answer, if your dog goes over 10 pounds, to be fully protected, you would have to give 2 & 1/2 tablets each month of the size you purchased.
Answered by: SuzyCVT
Date published: 2018-07-22

Will Sentinel or 1-800 PetMeds reimburse for medical expenses if your dogs gets whipworm after months of giving them sentinel?

Asked by: Golden
Thank you for your question. We back all of our products with our "100% Happy Guarantee.  You're 100% happy or your money back!" 
Answered by: Crystal RPTechnician
Date published: 2018-07-22

Is it safe to give my dogs Sentinel while they are wearing the Sorresto collar? I want to ensure they are safe to use in conjunction with one another. Thank you

Asked by: Kelbel
Yes, Sentinel may be safely administered while using a Seresto collar.
Answered by: Lisa M
Date published: 2018-07-22

Can I give Advantage 11 for fleas to my dog and this Sentinel for heartworms at the same time....each once a month?

Asked by: Alice
There is no contraindication between Advantage II and Sentinel. They may be administered together.
Answered by: Lisa M
Date published: 2018-07-22

I have a MDR1 sensitive dog...is Sentinel safe for her?

Asked by: Oceangal
Yes, Sentinel is safe for use in MDR1 sensitive dogs.
Answered by: SuzyCVT
Date published: 2018-07-22

Do I need to have a prescription from my vet in order to get heartworm pills for my dog from you? In the past I've been getting them directly from the vet.

Asked by: Dian
Yes, a prescription is required for all heartworm preventatives.
Answered by: Lisa M
Date published: 2018-01-19

I have been packing to move and discovered that I forgot to give my dog his tablet at the beginning of this month. We are halfway through Sept., should I cut a table in half and give to him now?

Asked by: Chris
Please give your pet a whole tablet now and continue to give the next subsequent doses every 30 days from the new date. Contact your new veterinarian in your area about what happened as the vet may likely order a heartworm test 6 months from now.
Answered by: Lilli Pharmacist
Date published: 2017-09-19
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What is Sentinel?

Sentinel is the only monthly oral preventive that guards against heartworms, adult roundworms, adult hookworms, whipworms, and prevents the development of flea eggs. Sentinel requires a prescription from your veterinarian.

For:

Dogs and Puppies (4+ weeks of age, weighing 2+ lbs)

Benefits:

  • Comes in palatable flavored tabs
  • Easy to administer just once a month

How does Sentinel work?

Milbemycin oxime eliminates the tissue stage of heartworm larvae and the adult stage of hookworm, roundworm, and whipworm infestations. Lufenuron, the other active ingredient, is an insect development inhibitor that breaks the flea life cycle by inhibiting egg development. Lufenuron prevents most flea eggs from hatching or maturing into adults and thus prevents and controls flea populations by breaking the life cycle.

Cautions:

Side effects are rare, though some pets may exhibit vomiting, depression, drowsiness, itching, hives, loss of appetite, diarrhea, or seizures, hypersalivation, and weakness. If these or other symptoms develop contact your veterinarian. It's important to maintain good personal hygiene, since humans can contract hookworms and roundworms. It's also important to eliminate fleas and to not feed your pet rodents or uncooked meat or fish. To prevent re-infection, clean up stools on a daily basis. Consult your veterinarian for pregnant or lactating dogs.

Brand Name:

Sentinel (Merck)

Generic Name:

Milbemycin Oxime (mil-beh-my-sin ox-eem) and Lufenuron (lew-fen-your-on)

What is the most important information I should know about Sentinel?

Sentinel is a prescription medication FDA-approved for use in dogs. Sentinel is available as artificial beef flavored (derived from pork and soy protein) chewable tablets. This medication should be given once a month year-round.

What should I discuss with my veterinarian before giving Sentinel to my pet?

Tell your veterinarian if your pet has ever had an allergic reaction to the medication.

How should Sentinel be given?

Give Sentinel exactly as directed by your veterinarian. If you do not understand the directions ask your pharmacist or veterinarian to explain them to you. The usual dose of Sentinel for dogs 2 to 10 pounds is 1 Flavor Tab every month (Brown Box), 11 to 25 pounds is 1 Flavor Tab every month (Green Box), 26 to 50 pounds is 1 Flavor Tab every month (Yellow Box) and 51 to 100 pounds is 1 Flavor Tab every month (White Box). For dogs over 100 pounds give the appropriate combination of tablets. To ensure adequate absorption, always administer Sentinel to dogs immediately after or in conjunction with a normal meal. Heartworm testing should be performed prior to the start of prevention therapy. If your pet is off Sentinel for 6 months or less, re-start the medication and test after 6 months since microfilaria, that take 6 months to mature, will result in a positive test result. Store Sentinel in a dry place at controlled room temperature, between 59-77F (15-25 C). Do not remove the tablet from its wrapper until ready to give the medicine. Keep this medication away from children and pets. Consult your veterinarian for pregnant or lactating dogs.

What are the possible side effects of Sentinel?

Side effects of Sentinel are rare although some pets may exhibit vomiting, depression, drowsiness, itching, hives, loss of appetite, diarrhea, or seizures, hypersalivation, and weakness. If these or other symptoms develop contact your veterinarian.

What happens if I miss giving a dose of Sentinel?

If a dose is missed and a 30-day interval between dosing is exceeded, administer Sentinel immediately and resume the monthly dosing schedule. If Sentinel replaces daily diethylcarbamazine (DEC) for heartworm prevention, the first dose must be given within 30 days after the last dose of DEC.

What happens if I overdose my pet on Sentinel?

Contact your veterinarian immediately.

What should I avoid while giving Sentinel to my pet?

Because humans can contract hookworms and roundworms from pets, it is important to maintain good personal hygiene. It is also important to eliminate fleas on your pet and in the household.

What other drugs will affect Sentinel?

While Sentinel is safe to use in dogs at risk for MDRI-allele mutation (Australian Shepherds, Collies, Shelties, etc.), unless tested normal, caution is advised if your pet is also being given amiodarone (Cordarone), azole antifungals such as ketoconazole, carvedilol (Coreg), cyclosporine (Atopica), diltiazem (Cardizem), erythromycin (Ery-Tabs) or clarithromycin (Biaxin), quinidine, spironolactone (Aldactone), tamoxifen, and verapamil (Calan). Do not give Sentinel to your pet if already giving an alternate heartworm medication.

Sentinel Directions:

  • Give Sentinel Flavor Tabs once a month on the same day of each month year-round.
  • Sentinel Flavor Tabs is for use in dogs only. Do not give to cats.
  • Watch your dog closely following dosing to be sure the entire dose has been swallowed. If it is not completely swallowed, give one more full recommended dose as soon as possible.
  • To ensure adequate absorption, always administer Sentinel to dogs immediately after or in conjunction with a normal meal.
  • Sentinel has no effect on adult fleas, but controls flea populations by breaking the flea life cycle at the egg stage.
  • To speed control of flea infestation, products that kill adult fleas like Capstar Flea Treatment Tablets may be used temporarily with Sentinel depending on the severity of the infestation.
  • Treatment may begin at any time of the year.
  • It is important to treat all dogs in the household for fleas. Cats in the same household should be treated with approved products for heartworm prevention for cats.
Tip:

Do not remove Sentinel from its wrapper until ready to give to your pet.

Sentinel Dosage for Dogs/puppies: (4+ weeks of age, weighing 2+ lbs)

Dogs/puppies: (4+ weeks of age, weighing 2+ lbs)
WeightDosage
2-10 lbsGive 1 Flavor Tab every month (Brown Box)
11-25 lbsGive 1 Flavor Tab every month (Green Box)
26-50 lbsGive 1 Flavor Tab every month (Yellow Box)
51-100 lbsGive 1 Flavor Tab every month (White Box)
Over 100 lbsGive combination of Flavor Tabs based on weight
Sentinel Dosage for Cats:
Cats
Do not use!
Sentinel Dosage for Horses:
Horses
Do not use!

Storage:

Should be stored at room temperature between 59° and 77° F.

Sentinel for Dogs Ingredients:

Sentinel Brown for Dogs 2-10 lbs:
Active Ingredient (per tablet)Amount
Milbemycin Oxime2.3 mg
Lufenuron46 mg
Sentinel Green for Dogs 11-25 lbs:
Active Ingredient (per tablet)Amount
Milbemycin Oxime5.75 mg
Lufenuron115 mg
Sentinel Yellow for Dogs 26-50 lbs:
Active Ingredient (per tablet)Amount
Milbemycin Oxime11.5 mg
Lufenuron230 mg
Sentinel White for Dogs 51-100 lbs:
Active Ingredient (per tablet)Amount
Milbemycin Oxime23 mg
Lufenuron460 mg

What is Sentinel?

Sentinel is the only monthly oral preventive that guards against heartworms, adult roundworms, adult hookworms, whipworms, and prevents the development of flea eggs. Sentinel requires a prescription from your veterinarian.

For:

Dogs and Puppies (4+ weeks of age, weighing 2+ lbs)

Benefits:

  • Comes in palatable flavored tabs
  • Easy to administer just once a month

How does Sentinel work?

Milbemycin oxime eliminates the tissue stage of heartworm larvae and the adult stage of hookworm, roundworm, and whipworm infestations. Lufenuron, the other active ingredient, is an insect development inhibitor that breaks the flea life cycle by inhibiting egg development. Lufenuron prevents most flea eggs from hatching or maturing into adults and thus prevents and controls flea populations by breaking the life cycle.

Cautions:

Side effects are rare, though some pets may exhibit vomiting, depression, drowsiness, itching, hives, loss of appetite, diarrhea, or seizures, hypersalivation, and weakness. If these or other symptoms develop contact your veterinarian. It's important to maintain good personal hygiene, since humans can contract hookworms and roundworms. It's also important to eliminate fleas and to not feed your pet rodents or uncooked meat or fish. To prevent re-infection, clean up stools on a daily basis. Consult your veterinarian for pregnant or lactating dogs.

Brand Name:

Sentinel (Merck)

Generic Name:

Milbemycin Oxime (mil-beh-my-sin ox-eem) and Lufenuron (lew-fen-your-on)

What is the most important information I should know about Sentinel?

Sentinel is a prescription medication FDA-approved for use in dogs. Sentinel is available as artificial beef flavored (derived from pork and soy protein) chewable tablets. This medication should be given once a month year-round.

What should I discuss with my veterinarian before giving Sentinel to my pet?

Tell your veterinarian if your pet has ever had an allergic reaction to the medication.

How should Sentinel be given?

Give Sentinel exactly as directed by your veterinarian. If you do not understand the directions ask your pharmacist or veterinarian to explain them to you. The usual dose of Sentinel for dogs 2 to 10 pounds is 1 Flavor Tab every month (Brown Box), 11 to 25 pounds is 1 Flavor Tab every month (Green Box), 26 to 50 pounds is 1 Flavor Tab every month (Yellow Box) and 51 to 100 pounds is 1 Flavor Tab every month (White Box). For dogs over 100 pounds give the appropriate combination of tablets. To ensure adequate absorption, always administer Sentinel to dogs immediately after or in conjunction with a normal meal. Heartworm testing should be performed prior to the start of prevention therapy. If your pet is off Sentinel for 6 months or less, re-start the medication and test after 6 months since microfilaria, that take 6 months to mature, will result in a positive test result. Store Sentinel in a dry place at controlled room temperature, between 59-77F (15-25 C). Do not remove the tablet from its wrapper until ready to give the medicine. Keep this medication away from children and pets. Consult your veterinarian for pregnant or lactating dogs.

What are the possible side effects of Sentinel?

Side effects of Sentinel are rare although some pets may exhibit vomiting, depression, drowsiness, itching, hives, loss of appetite, diarrhea, or seizures, hypersalivation, and weakness. If these or other symptoms develop contact your veterinarian.

What happens if I miss giving a dose of Sentinel?

If a dose is missed and a 30-day interval between dosing is exceeded, administer Sentinel immediately and resume the monthly dosing schedule. If Sentinel replaces daily diethylcarbamazine (DEC) for heartworm prevention, the first dose must be given within 30 days after the last dose of DEC.

What happens if I overdose my pet on Sentinel?

Contact your veterinarian immediately.

What should I avoid while giving Sentinel to my pet?

Because humans can contract hookworms and roundworms from pets, it is important to maintain good personal hygiene. It is also important to eliminate fleas on your pet and in the household.

What other drugs will affect Sentinel?

While Sentinel is safe to use in dogs at risk for MDRI-allele mutation (Australian Shepherds, Collies, Shelties, etc.), unless tested normal, caution is advised if your pet is also being given amiodarone (Cordarone), azole antifungals such as ketoconazole, carvedilol (Coreg), cyclosporine (Atopica), diltiazem (Cardizem), erythromycin (Ery-Tabs) or clarithromycin (Biaxin), quinidine, spironolactone (Aldactone), tamoxifen, and verapamil (Calan). Do not give Sentinel to your pet if already giving an alternate heartworm medication.

Sentinel Directions:

  • Give Sentinel Flavor Tabs once a month on the same day of each month year-round.
  • Sentinel Flavor Tabs is for use in dogs only. Do not give to cats.
  • Watch your dog closely following dosing to be sure the entire dose has been swallowed. If it is not completely swallowed, give one more full recommended dose as soon as possible.
  • To ensure adequate absorption, always administer Sentinel to dogs immediately after or in conjunction with a normal meal.
  • Sentinel has no effect on adult fleas, but controls flea populations by breaking the flea life cycle at the egg stage.
  • To speed control of flea infestation, products that kill adult fleas like Capstar Flea Treatment Tablets may be used temporarily with Sentinel depending on the severity of the infestation.
  • Treatment may begin at any time of the year.
  • It is important to treat all dogs in the household for fleas. Cats in the same household should be treated with approved products for heartworm prevention for cats.
Tip:

Do not remove Sentinel from its wrapper until ready to give to your pet.

Sentinel Dosage for Dogs/puppies: (4+ weeks of age, weighing 2+ lbs)

Dogs/puppies: (4+ weeks of age, weighing 2+ lbs)
WeightDosage
2-10 lbsGive 1 Flavor Tab every month (Brown Box)
11-25 lbsGive 1 Flavor Tab every month (Green Box)
26-50 lbsGive 1 Flavor Tab every month (Yellow Box)
51-100 lbsGive 1 Flavor Tab every month (White Box)
Over 100 lbsGive combination of Flavor Tabs based on weight
Sentinel Dosage for Cats:
Cats
Do not use!
Sentinel Dosage for Horses:
Horses
Do not use!

Storage:

Should be stored at room temperature between 59° and 77° F.

Sentinel for Dogs Ingredients:

Sentinel Brown for Dogs 2-10 lbs:
Active Ingredient (per tablet)Amount
Milbemycin Oxime2.3 mg
Lufenuron46 mg
Sentinel Green for Dogs 11-25 lbs:
Active Ingredient (per tablet)Amount
Milbemycin Oxime5.75 mg
Lufenuron115 mg
Sentinel Yellow for Dogs 26-50 lbs:
Active Ingredient (per tablet)Amount
Milbemycin Oxime11.5 mg
Lufenuron230 mg
Sentinel White for Dogs 51-100 lbs:
Active Ingredient (per tablet)Amount
Milbemycin Oxime23 mg
Lufenuron460 mg

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