What is Anipryl?
Anipryl (selegiline), also known as L-Deprenyl, is a monoamine oxidase inhibitor (MAOI) that treats Cushing's Disease and Canine Cognitive Dysfunction Syndrome (senility). Anipryl requires a prescription from your veterinarian.
- First and only FDA-approved drug used to control clinical signs associated with Canine Cognitive Dysfunction Syndrome
- First and only product approved to control uncomplicated PDH (pituitary-dependent hyperadrenocorticism) Cushing's disease
How it Works:
Anipryl increases the concentration of a nervous system messenger chemical called dopamine. Higher levels of dopamine improve many cognitive processes. Treating Cushing's Disease has traditionally been centered on suppressing the adrenal gland's production and release of cortisone. However, this approach has a high potential for side effects. Selegiline has allowed for a new approach by suppressing the pituitary gland directly.
Because Anipryl belongs to a class of drugs called Monoamine Oxidase Inhibitors (MAOI) it should not be given with antidepressants such as Prozac. Do not use in pregnant or nursing animals. If any serious side effects occur (difficulty breathing, hives, agitation; swelling of the lips, tongue or face), stop giving Anipryl and seek emergency veterinary medical attention.
Anipryl (Zoetis), Eldepryl (Somerset)
What is the most important information I should know about Anipryl:
Anipryl is a prescription medication FDA approved for veterinary use in the treatment of Cushing's disease caused by a pituitary tumor in dogs. Anipryl is also used to treat canine cognitive dysfunction. The usual initial starting dose to treat Cushing's disease in dogs is 0.45 mg/pound given once a day in the morning. If no results within 2 months may increase to 0.9 mg/pound once a day. If still no response after one month of the increased dose, reevaluate the pet. The dose for canine cognitive dysfunction is 0.2-0.45 mg/pound. It may take up to one month or more to see improvement. Do not give more of this medication than is prescribed without consulting your veterinarian. Anipryl may cause drowsiness or dizziness.
What is Anipryl:
Anipryl, also known as L-deprenyl, is a monoamine oxidase inhibitor (MAOi) used in dogs for the treatment of Cushing's disease and canine cognitive dysfunction. It is not known specifically how Anipryl works. However, it is believed that Anipryl prevents the breakdown of dopamine. Anipryl may also be used for purposes other than those listed in this guide.
What should I discuss with my veterinarian before giving Anipryl to my pet:
Anipryl should not be given if the pet is taking meperidine. Tell your veterinarian about any other medical conditions your pet has. Tell your veterinarian if your pet is pregnant or lactating.
How should this medication be given:
Give this medication exactly as directed by your veterinarian. Allow pet to drink plenty of water. If you do not understand the directions ask the pharmacist or veterinarian to explain them to you. Store Anipryl at room temperature away from moisture and heat. Keep this medication away from children and pets.
What happens if I miss giving a dose:
Give the missed dose as soon as you remember. However, if is almost time for the next regularly scheduled dose, skip the missed dose and take the next one as directed. Do not give a double dose of the medication.
What happens if I overdose the pet:
Seek emergency veterinary medical treatment. Symptoms of Anipryl overdose include excitement, irritability, nervousness, insomnia, dizziness, severe headache, hallucinations, weakness, sweating and seizures.
What should I avoid while giving Anipryl to my pet:
Anipryl may cause dizziness or drowsiness. Do not give higher doses than those prescribed.
What are the possible side effects of Anipryl:
If any of the following serious side effects occur, stop giving Anipryl and seek emergency veterinary medical attention; an allergic reaction (difficulty breathing; swelling of the lips, tongue or face; hives), a severe headache, restlessness, agitation, or irritability, sweating, convulsions, uncontrollable or irregular movements. Other less serious side effects may occur. Continue giving Anipryl and talk to your veterinarian if your pet develops dizziness or drowsiness, nausea, abdominal pain or diarrhea, insomnia, mild confusion, agitation or anxiety, dry mouth. Other side effects may also occur. Talk to your veterinarian about any side effect that seems unusual or bothersome to the animal.
What other drugs will affect Anipryl:
Before giving Anipryl tell your veterinarian if your pet is also taking fluoxetine or meperidine. Talk to your veterinarian or pharmacist before giving any prescription or over the counter medicines.
Where can I get more information:
Your pharmacist has additional information about Anipryl written for health professionals that you may read.
- Anipryl is a prescription medication used in dogs for the treatment of Cushing's disease caused by a pituitary tumor.
- Anipryl is also used in dogs to treat canine cognitive dysfunction.
Do not give more of this medication than is prescribed without consulting your veterinarian. Anipryl may cause drowsiness or dizziness.
Dogs: (when used for cognitive dysfunction)
The dose for canine cognitive dysfunction is 0.2mg-0.45mg per pound of body weight. It may take up to one month or more to see improvement
Dogs: (when used for Cushing's disease)
The usual starting dose to treat Cushing's disease is 0.45mg per pound of pet's body weight given once a day in the morning. If no result within two months, may increase to 0.9mg per pound of pet's body weight. If still no response after one month of the increased dose, reevaluate the pet
Should be stored at room temperature, away from moisture and heat.
Anipryl is rated
Rated 5 out of
My dog has been on Anipryl for 2 years and doing great after almost losing him. Our vet's receptionist has failed to order his meds numerous times. The speed of service from 1-800-petmeds was so appreciated!!!
Date published: 2017-01-11
Rated 5 out of
We got our dog back
Our 11-year-old female Lab had all sorts of anxiety, was trying to build "nests" out of anything she could find, was pulling stuff out of closets and hiding in them, standing in corners, looking lost. Didn't answer to her name. We began to see some improvements on Anipryl right away, but it took a full four months on the 30 mg daily tablet to see a completely normal dog again. She's been on Anipryl for over a year, and this drug gave us more time with our otherwise very active and healthy dog, who looks and acts more like a 7-year-old than a 12-year-old. Everybody is happy. Try this for "old dog syndrome"; give it some time, you will be glad you waited it out.
Date published: 2016-12-22
Rated 5 out of
saved my dog
9 year old lab was running around all night, barking, out of his mind seemingly. Vet recommened ritalyin wasn't much help, saw all the reviews that matched my dog and gave this a try. Seemed to make a difference as early as one week, much less severe episodes. One month in now and he still gets them but they are a 2 on a scale of 10 versus a 9 before. This is the real deal for dementia in dogs.
Date published: 2016-04-08
Rated 5 out of
Effective in short amount of time
We are amazed how active our 14 year old Shellie mix is since being on anipryl. She is more alert and runs with our other dog. At the beginning of this year she used to sleep all the time. Now she is awake almost all day long. Her incontinence of urine has subsided. She does occasionally regurgitate her saliva but not sure the cause of this.
Date published: 2014-08-09
Rated 5 out of
We are thankful for Anipryl!
Our 15 yr. old mixed breed dog began to get confused when we would let her outside to use the bathroom. She would wander around and not come in when we called her. She began to use the bathroom in the house - during the night, and sometimes during the day (she had never done this in her lifetime!). She also began to whine and whimper a lot throughout the day - for no apparent reason. Our vet diagnosed dementia and recommended Anipryl. We have been very happy with the improvement!! She rarely uses the bathroom in the house. Her whining is much reduced. She is much like her old self. We are soooo thankful that this medicine has worked for her.
Date published: 2014-05-21
Rated 2 out of
Anipryl for Cog. Dysfunction
My 17 year old Jack Russell has been on Anipryl for dementia for 2 months now. Previously he was so disoriented he would walk into his food or water dish and get stuck there whining until someone rescued him. He would also get stuck in corners and bark for help - not remembering how to back up or get free. After about a week on Anipryl he stopped walking into his dishes and getting stuck in corners. He will still walk up against corners but after a while he'll turn his head and move along. I have not seen any change in his disposition. He is still pretty low energy and no interest in toys or people like he used to exhibit when he was younger. He also doesn't run around or wag his tail as some other reviewers have noted (unfortunately). However, we are keeping him on Anipryl as it keeps him from getting stuck and waking us up at night. He also seems to rest better at night (somewhat). So although it has not been a miracle drug for us we have seen some improvement - enough to keep our dog with us for a while longer. We were at the point prior to Anipryl that we were going to have to euthanize him as neither the dog nor the humans in our house could get any sleep at night. If you are having severe issues with dementia this is worth a try.
Date published: 2014-03-10
Rated 5 out of
my 18 yr old male cairn
Had come to the point of just staring at the wall most of the time. The first 2 weeks on this great drug brought him back AND he was also walking and reacting like his old self. He's still with me! going on 19!
Date published: 2013-09-04
Rated 5 out of
Good for my best friend and me
15 yr old Cairn Terrier diagnosed with SDS after 6 months of little to no sleep at night for both of us; He was put on 15mg of anipryl a day and after 1 month he is back to normal and we both get a good nights sleep.
Date published: 2013-01-11