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Anipryl (Selegiline)

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Product Info
What is Anipryl (Selegiline)?

Anipryl (selegiline), also known as L-Deprenyl, is a monoamine oxidase inhibitor (MAOI) that treats Cushing's Disease and Canine Cognitive Dysfunction Syndrome (senility). Anipryl requires a prescription from your veterinarian.



  • First and only FDA-approved drug used to control clinical signs associated with Canine Cognitive Dysfunction Syndrome
  • First and only product approved to control uncomplicated PDH (pituitary-dependent hyperadrenocorticism) Cushing's disease
How it Works:

Anipryl increases the concentration of a nervous system messenger chemical called dopamine. Higher levels of dopamine improve many cognitive processes. Treating Cushing's Disease has traditionally been centered on suppressing the adrenal gland's production and release of cortisone. However, this approach has a high potential for side effects. Selegiline has allowed for a new approach by suppressing the pituitary gland directly.


Because Anipryl belongs to a class of drugs called Monoamine Oxidase Inhibitors (MAOI) it should not be given with antidepressants such as Prozac. Do not use in pregnant or nursing animals. If any serious side effects occur (difficulty breathing, hives, agitation; swelling of the lips, tongue or face), stop giving Anipryl and seek emergency veterinary medical attention.

Brand Name:

Anipryl (Zoetis), Eldepryl (Somerset)

Generic Name:


What is the most important information I should know about Anipryl (Selegiline):

Anipryl is a prescription medication FDA approved for veterinary use in the treatment of Cushing's disease caused by a pituitary tumor in dogs. Anipryl is also used to treat canine cognitive dysfunction. The usual initial starting dose to treat Cushing's disease in dogs is 0.45 mg/pound given once a day in the morning. If no results within 2 months may increase to 0.9 mg/pound once a day. If still no response after one month of the increased dose, reevaluate the pet. The dose for canine cognitive dysfunction is 0.2-0.45 mg/pound. It may take up to one month or more to see improvement. Do not give more of this medication than is prescribed without consulting your veterinarian. Anipryl may cause drowsiness or dizziness.

What is Anipryl (Selegiline):

Anipryl, also known as L-deprenyl, is a monoamine oxidase inhibitor (MAOi) used in dogs for the treatment of Cushing's disease and canine cognitive dysfunction. It is not known specifically how Anipryl works. However, it is believed that Anipryl prevents the breakdown of dopamine. Anipryl may also be used for purposes other than those listed in this guide.

What should I discuss with my veterinarian before giving Anipryl (Selegiline) to my pet:

Anipryl should not be given if the pet is taking meperidine. Tell your veterinarian about any other medical conditions your pet has. Tell your veterinarian if your pet is pregnant or lactating.

How should this medication be given:

Give this medication exactly as directed by your veterinarian. Allow pet to drink plenty of water. If you do not understand the directions ask the pharmacist or veterinarian to explain them to you. Store Anipryl at room temperature away from moisture and heat. Keep this medication away from children and pets.

What happens if I miss giving a dose:

Give the missed dose as soon as you remember. However, if is almost time for the next regularly scheduled dose, skip the missed dose and take the next one as directed. Do not give a double dose of the medication.

What happens if I overdose the pet:

Seek emergency veterinary medical treatment. Symptoms of Anipryl overdose include excitement, irritability, nervousness, insomnia, dizziness, severe headache, hallucinations, weakness, sweating and seizures.

What should I avoid while giving Anipryl (Selegiline) to my pet:

Anipryl may cause dizziness or drowsiness. Do not give higher doses than those prescribed.

What are the possible side effects of Anipryl (Selegiline):

If any of the following serious side effects occur, stop giving Anipryl and seek emergency veterinary medical attention; an allergic reaction (difficulty breathing; swelling of the lips, tongue or face; hives), a severe headache, restlessness, agitation, or irritability, sweating, convulsions, uncontrollable or irregular movements. Other less serious side effects may occur. Continue giving Anipryl and talk to your veterinarian if your pet develops dizziness or drowsiness, nausea, abdominal pain or diarrhea, insomnia, mild confusion, agitation or anxiety, dry mouth. Other side effects may also occur. Talk to your veterinarian about any side effect that seems unusual or bothersome to the animal.

What other drugs will affect Anipryl (Selegiline):

Before giving Anipryl tell your veterinarian if your pet is also taking fluoxetine or meperidine. Talk to your veterinarian or pharmacist before giving any prescription or over the counter medicines.

Where can I get more information:

Your pharmacist has additional information about Anipryl written for health professionals that you may read.

How to Use
  • Anipryl is a prescription medication used in dogs for the treatment of Cushing's disease caused by a pituitary tumor.
  • Anipryl is also used in dogs to treat canine cognitive dysfunction.

Do not give more of this medication than is prescribed without consulting your veterinarian. Anipryl may cause drowsiness or dizziness.

Dogs: (when used for cognitive dysfunction)
All weights
The dose for canine cognitive dysfunction is 0.2mg-0.45mg per pound of body weight. It may take up to one month or more to see improvement
Dogs: (when used for Cushing's disease)
All weights
The usual starting dose to treat Cushing's disease is 0.45mg per pound of pet's body weight given once a day in the morning. If no result within two months, may increase to 0.9mg per pound of pet's body weight. If still no response after one month of the increased dose, reevaluate the pet
Do not use!
Do not use!

Should be stored at room temperature, away from moisture and heat.

Anipryl (Selegiline) 30:
Active Ingredient:
Selegiline Hydrochloride
30 mg
Customer Reviews
Anipryl is rated 4.5 out of 5 by 41.
Rated 5 out of 5 by from Anipryl has given our Lab two extra years--so far Our 11-year-old yellow Lab was standing in corners, digging out our closets, shredding paper (skipped the newspaper, went right to important mail), could not settle down at night--diagnosis was canine dysfunctional disorder. One 30-mg Anipryl daily brought her right back to a young dog personality. It did take a good 60 days to eliminate all the unwanted behaviors, but she was much happier right from the first pill. Her physical health is quite good--very surprised at that, as she is now 13 1/2. She's a happy, active senior. The cost is bit disappointing--about $100 per month--but my best friend and I had two more happy years together (and counting). I'm going to echo what others have said: we humans need our own pill, just like this, for our golden years.
Date published: 2017-09-25
Rated 5 out of 5 by from 180° Turn Within a Week Our 16 yo lab began exhibiting signs of dementia. She would get herself locked into a bathroom, lost in a corner, mildly aggressive, digging in trash, and lost her training. She accidently shut herself into a bedroom and she literally clawed her way out. We started her on a regiment of Anapril and within the first week she was a 5yo again looking to go bird hunting. We finally lost her 2 years later. Too bad it doesn't work as well in humans!!
Date published: 2017-07-19
Rated 5 out of 5 by from Anipryl worked almost immediately for my girl. Within 24 hours of having received her first dose of 15 mg, my girl was almost entirely back to normal. Within eight hours, she was briefly making eye contact and even wagging her tail at times. This medication worked for my girl who was recently diagnosed with canine cognitive dysfunction, and I'm thrilled to have her back. Her success with Anipryl may be due to the fact that it was prescribed and given so soon after seeing symypms of dementia or some other variable, but it most definitely works for her. As for my business transaction with 1-800-PetMeds, I was impressed with their services, and I will continue to use them for this medication and perhaps others as necessary. The order was shipped right away, and our other pooch enjoyed the doggy treat that they sent since Talli was too "out of it" at the time to even consider a hard treat. Thankfully, she was willing to take a Greenies pill pocket, hence her receiving her medication every day. The only downside to using this company was waiting for the pills to arrive (I was an emotional wreck seeing my girl in that condition), but that issue can easily be resolved with properly timing subsequent orders. If your best friend has CCD, this prescription is worth considering, and you'll likely save money by choosing 1-800-PetMeds.
Date published: 2017-04-21
Rated 5 out of 5 by from Excellent service My dog has been on Anipryl for 2 years and doing great after almost losing him. Our vet's receptionist has failed to order his meds numerous times. The speed of service from 1-800-petmeds was so appreciated!!!
Date published: 2017-01-11
Rated 5 out of 5 by from We got our dog back Our 11-year-old female Lab had all sorts of anxiety, was trying to build "nests" out of anything she could find, was pulling stuff out of closets and hiding in them, standing in corners, looking lost. Didn't answer to her name. We began to see some improvements on Anipryl right away, but it took a full four months on the 30 mg daily tablet to see a completely normal dog again. She's been on Anipryl for over a year, and this drug gave us more time with our otherwise very active and healthy dog, who looks and acts more like a 7-year-old than a 12-year-old. Everybody is happy. Try this for "old dog syndrome"; give it some time, you will be glad you waited it out.
Date published: 2016-12-22
Rated 5 out of 5 by from saved my dog 9 year old lab was running around all night, barking, out of his mind seemingly. Vet recommened ritalyin wasn't much help, saw all the reviews that matched my dog and gave this a try. Seemed to make a difference as early as one week, much less severe episodes. One month in now and he still gets them but they are a 2 on a scale of 10 versus a 9 before. This is the real deal for dementia in dogs.
Date published: 2016-04-08
Rated 5 out of 5 by from Effective in short amount of time We are amazed how active our 14 year old Shellie mix is since being on anipryl. She is more alert and runs with our other dog. At the beginning of this year she used to sleep all the time. Now she is awake almost all day long. Her incontinence of urine has subsided. She does occasionally regurgitate her saliva but not sure the cause of this.
Date published: 2014-08-09
Rated 5 out of 5 by from We are thankful for Anipryl! Our 15 yr. old mixed breed dog began to get confused when we would let her outside to use the bathroom. She would wander around and not come in when we called her. She began to use the bathroom in the house - during the night, and sometimes during the day (she had never done this in her lifetime!). She also began to whine and whimper a lot throughout the day - for no apparent reason. Our vet diagnosed dementia and recommended Anipryl. We have been very happy with the improvement!! She rarely uses the bathroom in the house. Her whining is much reduced. She is much like her old self. We are soooo thankful that this medicine has worked for her.
Date published: 2014-05-21
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I have a dog who has been on Anipryl for a week. She was making big improvements and acting more like herself. Then the last two days she has regressed to where she was before -- is it normal to have ups and downs like this while starting the medication?

Asked by: person
It is normal to see an adjustment period upon initiating a treatment regimen of Anipryl. Consult your veterinarian if you have concerns regarding it's efficacy.
Answered by: Lisa M
Date published: 2017-11-07

Can I Half this tablet ?

Asked by: Nancy
Hello Nancy, these tablets can be cut in half. I would recommend using a pill cutter to make it easier/more accurate.
Answered by: Roseanna Pharmacy Intern
Date published: 2017-04-12

Can I give this to her with her thyroid medicine soloxine?

Asked by: demo
Those two medications should be safe to take together.
Answered by: Ben B
Date published: 2017-03-01

Are the 30mg tabs scored in middle to cut in half?

Asked by: Ginger
Hello Ginger, These specific tablets are not scored down the middle. They can still be cut in half though. I would recommend using a pill cutter to make it easier/more accurate. Hope this helps.
Answered by: Trey W
Date published: 2017-02-27

I have a jack russell with ccd and was told to give her according to her bodyweight which is 12.2 pounds, however I only see 30mg I supposed to give her 5 everyone else giving their jack russell 30mg? Where is the option for 5mg tabs

Asked by: rebel
The dosage is 0.2-0.45mg per lb. Do not give your dog the 30mg tablet, especially if the directions say 5mg. In our stock we have the generic Anipryl (Selegiline) at 5 mg tablets. Consult your veterinarian for a new prescription.
Answered by: Ben B
Date published: 2017-02-23

What are the contraindications for Anipryl 

Asked by: Meme
Selegiline is contraindicated in patients with known hypersensitivity. In human patients, it is contraindicated in patients receiving meperidine and possibly other opiod drugs. The manufacturer cautions to perform appropriate diagnostic tests before initiating therapy. This should not be used to treat hyperadrenocorticism NOT of pituitary origin.
Answered by: Ben B
Date published: 2017-02-21

The generic drug of Anipryl is selegiline and is cheaper. Why should I buy Anipryl.

Asked by: MattyG
You may chose to purchase brand if your doctor indicates the brand is medically necessary for your pet, or the strength you need for your pet's dose is only available in the brand.
Answered by: S Duesler PharmD MBA
Date published: 2016-11-17

I'm going to be starting my lab mix on Anipryl. She is currently in Prozac. I will discontinue the Prozac, but is there a recommended waiting period between the 2 drugs?

Asked by: Rae J
Yes, you may want to wait a week before starting the Anipryl, as Prozac can stay in your system for about a week after discontinuation. However, Prozac should not be stopped immediately, and should instead be tapered off under your veterinarians supervision. Your vet would have more information on how to taper off of Prozac and how long you should wait before starting Anipryl.
Answered by: Christine
Date published: 2016-10-14
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