My Account
Errors:

Advantage II

Starts $53.74 $38.69 
Ships in one business day or less
1
Select Pet's Weight:
Dog
03-10 lbs
11-20 lbs
21-55 lbs
55 lbs & up
Cat
02-05 lbs
05-09 lbs
09 lbs & up
2
Select a Supply:
4 pack
$53.74
$42.99
$38.69
Price w/coupon TOP10
6 pack
$76.85
$61.48
$55.33
Price w/coupon TOP10
Free Shipping
Save $2 over 4 pk
12 pack
$148.70
$118.96
$107.06
Price w/coupon TOP10
Free Shipping
Save $9 over 4 pk
Starts $53.74 $38.69 
Ships in one business day or less
Please select all product options.
3
Select a Quantity:
Quantity
Please select all product options.
Product Info
How to Use
Ingredients
Customer Reviews
Q&A
Product Info
What is Advantage II?

Advantage II is a monthly flea preventative for dogs and cats that offers comprehensive flea protection by killing adult fleas, larvae, and eggs. Plus, it kills fleas through contact, which means fleas don't have to bite your pet to die. Advantage II also treats, prevents, and controls lice on dogs. Advantage II does not kill ticks, so we recommend using the Preventic Tick Collar along with Advantage II (dogs only).

For:

Dogs (3 lbs or over and 7 weeks of age or older), Cats (2 lbs or over and 8 weeks of age or older)

Benefits:
  • Kills fleas within 12 hours of application
  • Kills all flea life stages including flea eggs and larvae to prevent infestation
  • Treats, prevents, and controls lice infestations (dogs only)
  • Safe and easy to apply
  • Waterproof remains effective even if pet gets wet
How it Works:

The first active ingredient is imidacloprid, which acts on the nervous system of the flea to cause paralysis and subsequent death. Within 12 hours of application, 98-100 percent of fleas are dead. The second active ingredient, pyriproxyfen, is an insect growth regulator. Once a female flea lays her eggs, pyriproxyfen works to prevent the eggs from hatching, ending the flea life cycle. Also, the active ingredient in Advantage II kills through contact, which means that fleas don't have to bite your pet to die.

Cautions:

Individual sensitivities, while rare, may occur after using any pesticide product for pets. If signs persist, or become severe, consult a veterinarian immediately. Do not get this product in your pet's eyes or mouth.

Brand Name:

Advantage II (Bayer)

Active Ingredient(s):

Imidacloprid (9.1%), Pyriproxyfen (0.46%) Other ingredients (90.44%)

What is this product used for:

Advantage II Kitten, Advantage II Small Cat and Advantage II Large Cat are once a month topical flea prevention and treatment for cats and kittens over 8 weeks or older. Advantage II Small Dog, Advantage II Medium Dog, Advantage II Large Dog, and Advantage II Extra Large Dog are once a month topical flea prevention and treatment for dogs and puppies 4 lbs or more and 7 weeks or older. Advantage II kills all flea life stages. Advantage II kills fleas within 12 hours of application. Advantage II for Dogs also treats, prevents, and controls lice infestations. Advantage II is waterproof and fragrance free.

Availability:

Advantage II for cats and Advantage II for dogs are non-prescription (OTC) products.

How this product should be used:

Advantage II Kitten is available in 0.23 ml applicators for kittens 2-5 lbs (turquoise). Advantage II Small Cat is available in 0.4 ml applicators for cats 5-9 lbs (orange). Advantage II Large Cat is available in 0.8 ml applicators for cats 9 lbs & up (purple). Advantage II Small Dog is available in 0.4 ml applicators for dogs 3-10 lbs (green). Advantage II Medium Dog is available in 1.0 ml applicators for dogs 11-20 lbs (teal). Advantage II Large Dog is available in 2.5 ml applicators for dogs 21-55 lbs (red). Advantage II Extra Large Dog is available in 4.0 ml applicators for dogs over 55 lbs (blue). To apply, place the applicator tip through your pet's hair to the skin level. On cats, apply to skin on neck at the base of the skull. For dogs up to 20 lbs, apply to skin on back between the shoulder blades. For dogs 21 lbs or over apply the contents of one tube to 3 or 4 spots along the skin on back from the shoulder to the tail. Do not get this product in the pet's eyes or mouth.

What are the side effects:

Individual sensitivities, while rare, may occur after using any pesticide product for pets. If signs persist, or become more severe, consult a veterinarian immediately.

What special precautions are there:

Advantage II is for external use on dogs and puppies 3 lbs or more and 7 weeks or older and cats and kittens 2 lbs or more and 8 weeks or older. Consult a veterinarian before using on medicated animals, if the animal is being given this product along with other pesticides, and debilitated, aged, pregnant or nursing animals. This product causes eye irritation in humans and is harmful if swallowed. Avoid contact with skin. Call poison control center if swallowed. If on skin, wash with plenty of soap and water. If in eyes, flush with plenty of water.

In the event of overdose:

Contact your veterinarian or veterinary emergency room.

How should I store this product:

Store this product in a cool dry place. Do not store in the refrigerator. Do not reuse empty container. Do not contaminate water, food or feed by storage or disposal. To dispose of empty container place in trash or offer for recycling if available. If container is partly filled call local solid waste agency for disposal instructions. Never place unused product down any indoor or outdoor drain. Keep out of reach of children and pets.

How to Use
Directions:
  • Only use Advantage II on dogs/puppies over 3 lbs and over 7 weeks of age, and cats/kittens over 2 lbs and over 8 weeks of age.
  • Apply Advantage II once a month every month.
  • For dogs up to 20 lbs, part the pet's hair between the shoulder blades until you can see the skin. Place the tip of the applicator on the skin and release all of the tube's contents on a single spot directly on the skin.
  • For dogs 21 lbs and over, apply entire contents of the tube evenly in 3 or 4 spots on the top of the back from the shoulder to the base of the tail. At each spot, part the hair until the skin is visible. Place the tip of the applicator on the skin and release a portion of the Advantage II solution directly on the skin. Do not apply an excessive amount of solution at any one spot that could cause some of the solution to run off the side of the dog.
  • For kittens and cats, place the applicator tip through the cat's hair to the skin on the neck at the base of the skull and release all of the tube's contents on a single spot directly on the skin.
  • Use only one applicator per treatment.
Tip:

Under normal conditions Advantage II is effective for a month. However, in case of severe flea infestation, retreatment may be necessary earlier than four weeks. Do not re-treat more often than once every seven days. After flea control is obtained, return to a monthly treatment.

Dosage:
Dogs/Puppies: (7 weeks of age or older)
Weight
Dosage
3-10 lbs
Apply contents of 1 applicator once a month (Green Box)
11-20 lbs
Apply contents of 1 applicator once a month (Teal Box)
21-55 lbs
Apply contents of 1 applicator once a month (Red Box)
Over 55 lbs
Apply contents of 1 applicator once a month (Blue Box)
Kittens: (8 weeks of age or older)
Weight
Dosage
2-5 lbs
Apply contents of 1 applicator once a month (Turquoise Box)
Cats: (8 weeks of age or older)
Weight
Dosage
5-9 lbs
Apply contents of 1 applicator once a month (Orange Box)
9 lbs & up
Apply contents of 1 applicator once a month (Purple Box)
Horses:
Do not use!
Storage:

Should be stored in a cool dry place. Do not refrigerate.

Ingredients
Advantage II for Kittens 2-5 lbs (Kitten - Turquoise Box) (0.23 mL):
Active Ingredients
% By Weight
Imidacloprid
9.10%
Pyriproxyfen
0.46%
Other Ingredients (not specified)
90.44%
Advantage II for Cats 5 to 9 lbs (Small Cat - Orange Box) (0.4 mL):
Active Ingredients
% By Weight
Imidacloprid
9.10%
Pyriproxyfen
0.46%
Other Ingredients (not specified)
90.44%
Advantage II for Cats Over 9 lbs (Large Cat - Purple Box) (0.8 mL):
Active Ingredients
% By Weight
Imidacloprid
9.10%
Pyriproxyfen
0.46%
Other Ingredients (not specified)
90.44%
Advantage II for Dogs 3 to 10 lbs (Small Dog - Green Box) (0.4 mL):
Active Ingredients
% By Weight
Imidacloprid
9.10%
Pyriproxyfen
0.46%
Other Ingredients (not specified)
90.44%
Advantage II for Dogs 11 to 20 lbs (Medium Dog - Teal Box) (1.0 mL):
Active Ingredients
% By Weight
Imidacloprid
9.10%
Pyriproxyfen
0.46%
Other Ingredients (not specified)
90.44%
Advantage II for Dogs 21 to 55 lbs (Large Dog - Red Box) (2.5 mL):
Active Ingredients
% By Weight
Imidacloprid
9.10%
Pyriproxyfen
0.46%
Other Ingredients (not specified)
90.44%
Advantage II for Dogs 55 lbs and Over (Extra Large Dog - Blue Box) (4.0 mL):
Active Ingredients
% By Weight
Imidacloprid
9.10%
Pyriproxyfen
0.46%
Other Ingredients (not specified)
90.44%
Customer Reviews
Advantage II is rated 4.216 out of 5 by 2,968.
Rated 4 out of 5 by from Awesome product Have had more success with advantage II from 1800 pet meds than with Frontline bought from farm supply in my local county
Date published: 2016-03-23
Rated 5 out of 5 by from The only medicine that kills fleas fast I have tried many other flea medicines before and none of them help. We have multiple cats and unfortunately got an infestation of fleas last summer. I couldn't walk into my bedroom without having 5 or 6 jump onto my legs. Not to mention my cat was terrified of jumping on the floor because they swarmed her. I tried bug bombs, and frontline plus, flea collars, and nothing worked. Until i got advantage and it killed nearly all of them within a week and stopped the infestation. I still had to vacuum and sanitize everything but it works great and you see results fast. Frontline didn't even keep the fleas off of my cat. It only killed the ones that were on her the day i treated her. The next day they were still biting her. Also 1800petmeds is the best place to buy this product otherwise it gets really expensive other places.
Date published: 2016-03-17
Rated 5 out of 5 by from It works! I like this product for my cats because it works better than the popular, leading brand. It seems to be stronger and work longer.
Date published: 2016-03-13
Rated 5 out of 5 by from Good stuff Advantage II does what it's supposed to do.....which is it takes care of fleas. About a year ago the scent was reformulated and it now doesn't smell as strong as it used to.
Date published: 2016-03-11
Rated 5 out of 5 by from Excellent Price! I shopped around at some local and very popular pet supply stores before buying from 1800Petmeds. The prices at the other stores was $25 dollars more than 1800petmeds, I don't know about you but I certainly don't want to pay more for any thing. I highly recommend this site and will be placing another order in the very near future.
Date published: 2016-03-10
Rated 5 out of 5 by from Exceptional results! I have indoor-only cats. Somehow, in my apartment, we keep getting fleas anyway. I tried Frontline because it is a known product, but my largest cat had a skin reaction to it. This time around, I tried Advantage II. My big boy FINALLY stopped biting his front legs, can allow me to pet him without feeling those biting critters, and has had no skin reaction whatsoever. I bought several so I can treat all the cats again the next few months, washed everything I could, and treated the carpets with Precor Plus. So far, it's been 2 weeks and no sign of flea dirt or excessive scratching. I love this stuff!
Date published: 2016-02-24
Rated 4 out of 5 by from On second dose and still seeing some fleas Not sure why I'm still seeing some fleas after 2 month of use. They are mostly all gone but I just saw one on him. I figured the cycle would be finished after 2 months. I'm going to continue to use it hoping it will finally break the cycle after another month. I did see one 2 weeks ago but it was half dead and easy to get and flush. The one tonight was fast and got away.Product has great reviews.
Date published: 2016-02-14
Rated 5 out of 5 by from Advantage II surely has an advantage against those I have ordered this several times over the years. Simply, it works, killing fleas, eggs, larvae. It is just the ticket for your loved ones, because they are not like family, they are family. They don't ask for much. I wish I could save them all, but I can't, so I do what I CAN.
Date published: 2016-02-05
  • 2016-03-25T06:02CST
  • bvseo_cps, prod_bvrr, vn_cps_3.2.0
  • cp_1, bvpage1
  • co_hasreviews, tv_32, tr_2,936
  • loc_en_US, sid_prod10433, PRD, sort_mostRecent
  • clientName_1800petmeds
Q&A

What age can I start using advantage on a dog

Asked by: Sammie
This product is safe for dogs 3 lbs or over and 7 weeks of age or older..
Answered by: Cherley Petmeds Pro
Date published: 2016-03-24

I have a 30ish lb male (coon,Bob mix )will this work for him? His sister is also larger than most cats coming in about 15lbs. Both are healthy but on the older side so getting the  correct dose is really important to me. 

Asked by: Jlee
The Advantage II is formulated for cats up to 18 pounds. Since your furry baby is 30 lbs or more, you may give him/her two doses of the 9-18 lbs dose and give one of the 9-18 lbs dose to the 15 pounder.
Answered by: Cherley Petmeds Pro
Date published: 2016-03-22

Can you use advantage 2 for dogs on a cat

Asked by: Helpful answers
Advantage II for dogs is not recommended for cats.
Answered by: Cherley Petmeds Pro
Date published: 2016-03-20

 how can a topical for 55+lbs treat dogs treat my dogs that are 120 and 160lbs? That's a lot more dog then 55lbs

Asked by: edward
The extra large dose for dogs 55 lbs and over covers pets up to 200 lbs.
Answered by: Cherley Petmeds Pro
Date published: 2016-03-17

Can chiwawa take this product if she is on sentinol

Asked by: andrea
Yes, it is safe to combine the Advantage II with the Sentinel.
Answered by: Cherley Petmeds Pro
Date published: 2016-03-13

Do you need a prescription?

Asked by: Tgood
No, Advantage II is over the counter.
Answered by: Cherley Petmeds Pro
Date published: 2016-03-14

Is there a generic for this?

Asked by: Gemma
Unfortunately, we do not have a generic brand available for Advantage II. However, we do have a generic available for Frontline Plus which is called Flea5x Plus. Here is the link: http://www.1800petmeds.com/productw.jsp?id=prod11480&sku=11480
Answered by: Cherley Petmeds Pro
Date published: 2016-02-28

Where is my STACK2 for my purchase?

Asked by: Kate
Perhaps the Stack5 code was not entered at checkout. Please call us at 1-800-738-6337 or email us at customerservice@1800petmeds.com so we can take care of this for you.
Answered by: Cherley Petmeds Pro
Date published: 2016-02-25
  • 2016-03-25T06:09CST
  • bvseo_cps, prod_bvqa, vn_cps_3.2.0
  • cp_1, bvpage1
  • co_hasquestionsanswers, tq_797
  • loc_en_US, sid_prod10433, PRD, sort_recentAnswersFirst
  • clientName_1800petmeds
Close
Live Chat Share Website Feedback
Name:
Email:
Phone:
Feedback: