Lysodren

Lysodren (mitotane) is used by veterinarians to treat Cushing's Disease in dogs. Lysodren requires a prescription from your veterinarian, and is sold per tablet.

Dogs

• Effective treatment in most cases

Lysodren acts to suppress adrenal gland function by eroding the top layers of the adrenal gland that produce corticosteroid hormones, thereby reducing the production of cortisol.

Side effects include lethargy, weakness, and vomiting. If they occur, stop using the medication and contact your veterinarian. It should not be used in pregnant or nursing animals. Always wear disposable gloves when giving Lysodren to your pet and wash your hands after handling this medication. Pregnant women, or women trying to get pregnant should not handle this medication.

Lysodren (Bristol-Myers Squibb)

Mitotane

Lysodren, also known as o,p-DDD, is a medication used in dogs for the treatment of Cushing's disease (Hyperadrenocorticism). It is available by prescription as 500mg scored tablets. Use disposable gloves when handling this medication as it is cytotoxic to humans. Wash hands thoroughly if the tablet comes in contact with skin.

Lysodren is used in the treatment of Cushing's disease. Lysodren acts by suppressing adrenal gland function. Lysodren treatment involves two phases, a loading dose phase with higher doses for the first 1 or 2 weeks, then a maintenance dose phase. Lysodren may be used for purposes other than those listed in this medication guide.

Tell your veterinarian if your pet has ever had an allergic reaction to Lysodren. Tell your veterinarian if your pet is pregnant, or lactating. Tell your veterinarian if your pet has kidney or liver disease.

Give this medication exactly as directed by your veterinarian. If you do not understand the directions, ask your pharmacist or veterinarian to explain them to you. Your veterinarian will determine the exact dose to be given for the loading phase, and then the maintenance phase. The veterinarian may prescribe glucocorticoids such as prednisone for use in stressful situations such as travel, surgery, or illness. Store this medication at room temperature and protect from light. Keep out of the reach of children and pets.

Give the missed dose as soon as you remember. However, if it is almost time for the next regularly scheduled dose, skip the missed dose and give the next one as directed. Do not give a double dose of the medication.

In the event of overdose, contact your veterinarian or veterinary emergency room. Overdose of Lysodren can result in Addison's disease (hypoadrenocorticism), which can be life threatening. Symptoms of Addison's disease may include loss of appetite, vomiting, diarrhea, weakness, depression, drowsiness.

Always wear disposable gloves when giving Lysodren to your pet. If the tablet comes in contact with skin, wash thoroughly if the tablet comes in contact with skin. Pregnant women, or women trying to get pregnant should not handle this medication.

Side effects that may occur when using Lysodren include loss of appetite, nausea, vomiting, or diarrhea. Other side effects may also occur. Talk to your veterinarian about any side effect that seems unusual or bothersome to the animal.

Use caution when giving Lysodren with insulin, spironolactone (Aldactone), Phenobarbital, phenytoin (Dilantin), theophylline (Theo-Dur), warfarin (Coumadin), and drugs that affect the central nervous system, such as acepromazine (PromAce), and amitriptyline (Elavil). Talk to your veterinarian or pharmacist before using Lysodren with any prescription or over the counter medications, including vitamins, minerals and herbal supplements.

Your pharmacist has additional information about Lysodren written for health professionals that you may read.

Call your veterinarian for medical advice about any side effects to your pet. You may report side effects to the FDA at 1-800-FDA-1088.