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Simple once-a-month tablet that:
  • Kills fleas
  • Prevents heartworm disease
  • Treats & controls adult hookworms, roundworms & whipworms


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      Product Info   How to use   Ingredients   Customer Reviews   Q & A  

    What is Trifexis?

    Trifexis is a chewable tablet that kills fleas and prevents infestations, protects against heartworms, and treats and controls adult hookworm, roundworm, and whipworm infections. Trifexis requires a prescription from your veterinarian.
    For: Dogs (8 weeks of age and older and weighing at least 5 lbs)
    Begins killing biting fleas within 30 minutes
    Kills fleas before they can lay eggs
    Prevents heartworm disease
    Treats and controls roundworms, hookworms, and whipworms
    Artificial beef flavor made from pork liver and hydrolyzed soy
    Easy to administer chewable tablet

    How it works:
    Spinosad, an active ingredient in Trifexis, starts to work within 30 minutes to kill fleas and has been proven to kill 100% of all biting fleas within 4 hours. Trifexis also kills flea eggs before they can mature, which helps to end the flea life cycle. Trifexis prevents heartworm disease by killing microfilariae and larvae from maturing into adult heartworms.

    Serious adverse reactions have been reported following concomitant extra-label use of ivermectin with spinosad alone, one of the components of Trifexis chewable tablets. Use with caution in breeding females. The safe use of Trifexis in breeding males has not been evaluated. Use with caution in dogs with pre-existing epilepsy. Puppies less than 14 weeks of age may experience a higher rate of vomiting. Consult your veterinarian for pregnant or lactating dogs.

    More Information:
    Brand Name
    Trifexis (Elanco Animal Health)
    Generic Name
    Spinosad and Milbemycin oxime
    What is the most important information I should know about Trifexis: Trifexis is a prescription medication FDA approved for use in dogs 8 weeks of age or older and 5 lbs of body weight or more. Trifexis contains spinosad and milbemycin oxime and is indicated for the prevention of heartworm disease. Trifexis kills fleas and is indicated for the prevention and treatment of flea infestations, and the treatment and control of adult hookworm, adult roundworm, and adult whipworm infections. Trifexis is available in a pink box for dogs 5 to 10 lbs (140mg/2.3mg)), Orange box for dogs 10.1 to 20 lbs (270mg/4.5mg), Green box for dogs 20.1 to 40 lbs (560mg/9.3mg), Blue box for dogs 40.1 to 60 lbs (810mg/13.5mg), and Brown box for dogs 60.1 to 120 lbs (1620mg/27mg). For dogs over 120 lbs give the appropriate combination of tablets.

    What is Trifexis: Trifexis is a chewable, beef flavored tablet that is made out of pork liver and hydrolyzed soy and given to your dog once month to prevent heartworm, to prevent and treat flea infestations, and to treat and control adult hookworm, roundworm, and whipworm infections. Trifexis chewable tablets are for monthly use in dogs and puppies 8 weeks of age and older and 5 lbs of body weight or more.

    What should I discuss with my veterinarian before giving Trifexis to my pet: Tell your veterinarian if you are planning on breeding your pet. Tell your veterinarian if your dog has a history of seizures (epilepsy).

    How should this medication be given: Give Trifexis chewable tablets with food. Give Trifexis chewable tablets once a month. Trifexis chewable tablets may be chewed, offered in food, or administered like other tablet medications. If vomiting occurs within 1 hour of administration, redose the pet with another full dose. Store Trifexis at room temperature (68-77į F). Consult your veterinarian for pregnant or lactating dogs.

    What happens if I miss a dose: Give the missed dose with food as soon as you remember and resume a monthly dosing schedule.

    What happens if I overdose the pet: Overdose of this medication is unlikely. However, if an overdose is suspected, contact your veterinarian or veterinary emergency room. Symptoms of overdose that may occur include vomiting.

    What should I avoid while giving Trifexis: Your pet may maintain normal activities and interactions while being given Trifexis. The safe use of Trifexis chewable tablets in male dogs intended for breeding has not been established.

    What are the possible side effects of Trifexis: Side effects that may occur include vomiting. If vomiting occurs within one hour of administration, redose with another full dose. Other side effects may occur. Continue giving Trifexis chewable tablets and talk to your veterinarian if your pet experiences decreased appetite, lethargy or decreased activity, diarrhea, cough, increased thirst, vocalization, increased appetite, redness of the skin, hyperactivity and excessive salivation. Talk to your veterinarian about any side effect that seems unusual or especially bothersome to the pet.

    What other drugs will affect Trifexis: Talk to your veterinarian before giving any prescription or over the counter medications.

    Where can I get more information: Your pharmacist has additional information about Trifexis written for health professionals that you may read.


    Please view the chart below for the correct dosage of Trifexis for your dog.
    Tip: Trifexis does not protect against ticks. To help control ticks, try the Preventic Tick Collar.
    Pet Weight Dosage
    (Over 8 weeks of age)
    5 - 10 lbs Give one tablet (Pink label box)
    10.1 - 20 lbs Give one tablet (Orange label box)
    20.1 - 40 lbs Give one tablet (Green label box)
    40.1 - 60 lbs Give one tablet (Blue label box)
    60.1 - 120 lbs Give one tablet (Brown label box)
    Over 120 lbs Administer the appropriate combination of tablets
    Storage: Should be stored at room temperature. Keep away from pets and children.
    Trifexis for Dogs 5 to 10 lbs:
    Active Ingredients per tablet Amount
    Spinosad 140 mg
    Milbemycin oxime 2.3 mg

    Trifexis for Dogs 10.1 to 20 lbs:
    Active Ingredients per tablet Amount
    Spinosad 270 mg
    Milbemycin oxime 4.5 mg

    Trifexis for Dogs 20.1 to 40 lbs:
    Active Ingredients per tablet Amount
    Spinosad 560 mg
    Milbemycin oxime 9.3 mg

    Trifexis for Dogs 40.1 to 60 lbs:
    Active Ingredients per tablet Amount
    Spinosad 810 mg
    Milbemycin oxime 13.5 mg

    Trifexis for Dogs 60.1 to 120 lbs:
    Active Ingredients per tablet Amount
    Spinosad 1620 mg
    Milbemycin oxime 27 mg

    Trifexis 3.7 5 383 387
    Great product I have been giving my American Bulldog Trifexis for a year and a half and am glad my vet recommended it. We had been using another heartworm med that required the use of topical flea and tick protection so the all in one aspect is great. My dog refused to eat the tablets even though I told him they had a nice beefy flavor. Smothering the tablet in peanut butter worked a few times, but he started licking it clean and spitting it out. I checked with the vet who told me that swallowing it whole would be okay, so now I give it like a pill, with no ill effects. 04/21/2014
    Love It Love this product because Jojo has very sensitive skin. Uses to use the topical product each month and it would drive him crazy scratching and scratching. It drove me crazy watching him suffer itching and itching. With Trifexis, he ate the tablet with no problems and he did not have a bad reaction and no flees. 04/19/2014
    feed before you give. thank goodness a product that prevents fleas and heartworms. i put a pill under some food, soft in a bowl and dog eats food and apparently loves pill. seems to like crunching it on back teeth. good stuff. 04/18/2014
    Great Product Moved to LA about a year ago from Vegas. Vegas was too hot for fleas and mosquitoes. I didn't even think about it when I moved here. So first couple weeks after we arrive, fleas are everywhere!!! Tried everything topical and they just weren't working. Even cleaned my house every day, washed everything, couldn't keep the dang things out. The vet recommended Trifexis & BAM immediately they stopped scratching & the fleas stopped feeding off me too. (the dogs sleep in the bed). We haven't had any problems with side effects. I was worried since my girl dog has a really sensitive stomach. I give them the pill after dinner, which I include a little bit of wet food. They take it with no problem, they think it's a treat. Been using it for almost a year and neither dog has shown any side effects. Maybe just extra thirsty and extra trips outside, but that's normal. 04/14/2014
    Trifexis works better than any other! I have a 3 year old pit bull and he has very sensitive skin. Mosquitos and fleas would make him break out all over before he started taking Trifexis. Since he's been using Trifexis (about 2 years), bugs stay away from him. Only downside is that I have to cut up the pill into 1/4 and give it to him in lots of peanut butter or he won't eat it. He does not have any side effects after he takes this pill. 03/31/2014
    Seems to cause trouble for some I switched from Sentinel to Trifexis because we got it free from a relative who worked at a vet. We gave it to our dog (6-yr old lab mix) at the beginning of the month. Three weeks later, our dog got diarrhea and a couple days after that vomited while at home. After taking him to the vet, bloodwork came back for him being positive for roundworm. I can't say for a fact that Trifexis was the cause of all that, but after seeing some reviews on Trifexis (including here on 1800petmeds) about nausea, vomiting and diarrhea for some dogs (although nothing about roundworm), I've quickly decided to go back to Sentinel for treatments. If you do choose Trifexis, just monitor your dog and know ahead of time the possible side effects. 03/30/2014
    It WORKS! I've been through it with him. Fleas, the scratching, the gnawing, persistent flea dirt , I finally cornered the vet, FIND SOMETHING THAT WILL WORK! Trifexis has done it. I cant say it's inexpensive, he's a big boy it takes double for him. But he is protected. No more fleas, scratching, gnawing, chasing his tail to get to them. This Mama is happy- 03/14/2014
    great results I have used Trifexus for over a year now for my Malamute 96 lbs and my male German Shepard 1 1/2 years old have hav e had no problems with fleas or anything else and they get a HEALTHY report from the Vet on their annual visits. I strongly recommend it. 03/12/2014
    Works great but horrible smell! We have two lab/shepherd mix, that are our children. Our Vet discontinued offering Sentinel and now only offers Trifexis. The pills smell horrible!! Our dogs refuse to take them, we've tried peanut butter, beef and chicken, but they can smell the chemicals in the pills, if we can smell it surely THEY can. We have to split the pills in half and shove them down their throats, not a very pleasant experience for our 15-year old. Going to see if our Vet will give us a prescription for Sentinel. 03/11/2014
    I noticed my dog would just lay around for 2 days after her med. (trifexis). Seemed like she was not feeling good at all. One day I had the news on tv and the were discussing the side affects of trifexis. The report was some dogs had died due to the meds. So anyway I took my dog off it. Now I am so confused as what to do. I have read good reviews but also bads ones. 03/09/2014
    My dog hates this I have tried month after month to give this to my mini poodle. I can't hide it in anything: cheese, peanut butter, steak, nothing. This stuff smells horrible and the pill is so large. I am telling my vet I refuse to keep shoving this down my dog's throat. I'll find something else or find another vet. 02/24/2014
    Side effects Be very watchful of dog when first starting and each month after you give. I have two dogs both same age and one dog suffered seizure. When taking walk he just stopped walking and fell over. Quite frightening as I had to carry him home and in about 1/2 hour he was fine. Did not think it was Trifexis. Then the next month again it happened. so please be aware as the side effects can happen. Other dog is fine and product works so owners just need to be watchful 02/23/2014
    Not so good Going back to Heartguard. 02/16/2014
    Horrible Taste I have been using Trifexis for years but every month it is a terrible battle to try and get her to take the tablet. I don't blame her either. The tablet smells terrible!! It's supposed to be chewable but my dog runs from it. She won't take it. I've tried mixing it with peanut butter, cheese, her favorite food, etc. I've tried breaking it down into a powder and mixing it so she can't see it. But she still smells it!! She absolutely hates this pill. Why anyone would invent a necessary product that does not both smell and taste delicious to a dog is beyond me. That should be the #1 test that it has to pass in the Quality Assurance cycle. Well, maybe #2 if effectiveness is #1. Anyway, she hates this pill. I have tried everything. I don't blame her because to be honest it smells terrible even to me. I get it on my fingers and it's disgusting. So now both my dog and I both dread Trifexis day. So I'm looking around at other options now. Has to be something as effective but better tasting. 02/13/2014
    I was using topical for fleas and ticks and no matter which one I used the fleas seemed to be immune to all of the topicals. After switching to Trifexis after the second dose I have not had any fleas on my dog or in the house. I will use Trifexis. Had no problems with vomiting usually give with a piece of cheese. 02/12/2014
    Stop the vomitt Trifexis is a great product. I wanted to try again. It was suggested to me that I give a small can of wet dog food with the Trifexis. It worked like a charm. I am lucky to have a vet assistant (actually 2 of them) as very close friends. They sure gave me great advice. Glad I actually listened for once. (LOL) 02/02/2014
    Fantastic Product I have a 92 lb Boxer. I made sure I fed her first then I broke the tablet in half and smothered it in peanut butter. She ate the whole thing. Within the hour she stopped scratching and hasn't scratched since. It has been 3 weeks so far. Only thing, she did vomit once within a 24 hour period but has been fine since. I highly recommend this product. Some people complain the pill is too big, but I've given my dog biscuits bigger than this tablet. As I said, I broke it in half and put peanut butter on it. She loved it. And, no more fleas!!!!! 01/22/2014
    It works great, but... I have not encountered a single problem with this product and I have been using it on all three of my dogs for the past six months... Except my dogs HATE the taste. I have to shove it down their throats. Other than that, it's a great all-in-one product and I will continue to use it as well as recommend it to all my fellow pet lovers! 01/10/2014
    Works but allergic reaction I tried this because my mother-in-law was referred from her vet to give it to her dog and she told me to get it for my dog also. Yes, it does work great at killing and keeping away the fleas. BUT... both of are dogs had allergic reactions to the medicine. Hers more so than mine. My little one is broke out all over now from a allergic reaction to her skin from it. I know it is from the medicine and not fleas because we haven't had them since September. It did not start until I gave her the pill about a week or so ago. Now have to go to the vet to get her a shot to keep the itching and swelling down. If you are considering this for your dog, please please please go over it very well with your veterinarian to make sure this is the right medicine for him or her. 01/02/2014
    sticktight fleas I bought this product from my vet as I liked the idea of all in one. However a couple of weeks after taking the first dose our golden mix started chewing and licking her tummy and the inside of her leg. She had little red spots on her which became inflamed due to her constant chewing. I took her in to see the vet and told him that the only change was to the trifexis. He treated her and the next month it returned again. Another vet noticed a sticktight flea in the inflamed area. Not sure where she picked up this flea (bird/chicken flea,) but they burry in the skin like a tick. Called the trifexis company and they do not cover that type of flea. I will now have to go back to the topical and heartworm separately to make sure our dogs do not get this nasty sticktight flea. 12/26/2013
    urination? I have 3 frenchies and this product is awesome. However, my female urinated in her sleep for a few nights after giving it to her. She did it 3 out of the 4 months given to her. Anyone else have this issue? I don't know if its related but wanted to ask. She has never done that before and it happened about 3 nights after being given (for each night). Maybe just a coincidence? I thought she slept extra heavy ? 12/21/2013
    Love its 2 pills in one We had been using different products for fleas and heartworm. The pill is large and we break it up and serve it with some peanut butter. 12/07/2013
    works great My Welsh Corgi will NOT eat this pill! I have mixed it with everything: beef, chicken, lunchmeat, but every time he would separate the pill and spit it out. I bought a mortar and pestle to crush the pill and then soak it up with lunch meat and he readily gobbles it down. 12/01/2013
    Great product My dog is extremely allergic to flea bites. The popular topical products work by killing the fleas AFTER they bite, this caused major problems for my Irish Setter. This product gets rid of the fleas without the biting and the results are immediate. Give with food as directed and see the results within 30 minutes. Pretty amazing and worth the additional cost. Finally some relief for our fury family member. 11/26/2013
    Give Trifexis on a FULL stomach We gave our Shih-Tzu Trifexis and she threw up all over the place. We took her to the Vet and it was stressed to us to not give her the pill on an empty stomach. A lot like human pills, many of them you shouldn't take on an empty stomach. So, please always give your dog Trifexis on a full stomach. 11/10/2013
    12 lb silver yorky male 1 yr old works well with little to no side effects that I can tell. We have Been using it for 6 months. no fles or heart worms / worms period $104 for 6 month supply 11/06/2013
    Trifexis is a Failure ! I'm sorry to have to say that Trfexis does not work well on getting rid of fleas. My 2 year old German Shepherd had been on Frontine plus and I noticed fleas on her 22 days after applying it. So, I applied Advantix II and a week later I still had fleas. I re-applied Advantix II and still I have fleas. One week later I gave my dog Trifexis and I still have fleas. One week later I added Advantix II again and finally no fleas. It appears to take at least two separate products in order to get rid of fleas these days. 11/03/2013
    Love It I have all 3 of my dogs on this product. It works great. I live out in the middle of the woods and my dogs used to always have fleas and ticks. But since i made the switch it works great. 10/27/2013
    Great Product We started off using Sentinel which works great. But we noticed that fleas were not dying, so we switched to Trifexis. For starters, our dogs will take any pill you give asking about taste is not relevant and if my dog could talk, I might have to ask them. This products kills Within an hour. Never had an issue, great product. 10/02/2013
    Great Product I use this with all three of my Rottweilers. I did discontinue with my female while she was nursing. My 6 month old pups (65+pounds) and our female tolerate it well. They will not chew it, but swallow easily wrapped in cheese! I'm sure they would eat it if it was peanut butter flavored! 09/28/2013
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    220 Questions · 335 Answers

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    Talk to other pet lovers about this product.

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    My dog is 11 lbs in weight, and in good health. Sentinel was suggested at an early age. How is Trifexis different ? She is 5yrs. old (15).
    5 days ago
    Answer this question
    1 week ago
    Answer this question


    Thank you for your question. No, this medication does not kill lice.
    6 days ago
    Maureen PetMeds Pro
    Pompano Beach, FL
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    Thanks for Voting
    My dog is currently and has been about 42 pounds. Can she have the 20 to 40 tablet or do we continue with the 40 to 60
    She is full grown . I am currently buy single dose from the vet so really don't know what dose she is getting
    4 weeks, 2 days ago
    Answer this question


    continue with the 40 to 60 lb size
    4 weeks ago
    Linda M 1800petmeds pharmacist
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    1 answer


    This would be my first time ordering. My dogs have been on Trifexus and I want to find a less expensive supplier other than my dog's Vet.
    Do I need a prescription to order?
    1 month ago
    Answer this question


    Trifexis does require a prescription.
    2 weeks ago
    Stephanie Duesler, Pharm. D, MBA
    Vote as Best Answer
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    Our 12-year old Golden Retriever is here in Mexico with us and I think he has mange. The prescribed cure is mite relief but that seems to come with flea control products.
    He's already on monthly Trifexis, that has flea control. So how do I treat his mange when the products for mites also treat fleas and he's already being treated for fleas? I don't want to overmedicate him. Please help as we are all miserable.
    2 months, 1 week ago
    Currently in Mexico
    Answer this question


    Speak to your veterinarian to determine the most appropriate treatment for your pet. Different products can be used to treat mange.
    2 months, 1 week ago
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    This information sheet is for educational purposes only and is intended to be a supplement to, and not a substitute for, the expertise and professional judgment of your veterinarian. The information is NOT to be used for diagnosis or treatment of your pet. You should always consult your own veterinarian for specific advice concerning the treatment of your pet. The information is not intended to cover all possible uses, directions, precautions, warnings, allergic reactions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for your pet. It is not a substitute for a veterinary exam, and it does not replace the need for services provided by your veterinarian.
    Note: Any trademarks are the property of their respective companies.
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