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Simple once-a-month tablet that:
  • Kills fleas
  • Prevents heartworm disease
  • Treats & controls adult hookworms, roundworms & whipworms


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      Product Info   How to use   Ingredients   Customer Reviews   Q & A  

    What is Trifexis?

    Trifexis is a chewable tablet that kills fleas and prevents infestations, protects against heartworms, and treats and controls adult hookworm, roundworm, and whipworm infections. Trifexis requires a prescription from your veterinarian.
    For: Dogs (8 weeks of age and older and weighing at least 5 lbs)
    Begins killing biting fleas within 30 minutes
    Kills fleas before they can lay eggs
    Prevents heartworm disease
    Treats and controls roundworms, hookworms, and whipworms
    Artificial beef flavor made from pork liver and hydrolyzed soy
    Easy to administer chewable tablet

    How it works:
    Spinosad, an active ingredient in Trifexis, starts to work within 30 minutes to kill fleas and has been proven to kill 100% of all biting fleas within 4 hours. Trifexis also kills flea eggs before they can mature, which helps to end the flea life cycle. Trifexis prevents heartworm disease by killing microfilariae and larvae from maturing into adult heartworms.

    Serious adverse reactions have been reported following concomitant extra-label use of ivermectin with spinosad alone, one of the components of Trifexis chewable tablets. Use with caution in breeding females. The safe use of Trifexis in breeding males has not been evaluated. Use with caution in dogs with pre-existing epilepsy. Puppies less than 14 weeks of age may experience a higher rate of vomiting. Consult your veterinarian for pregnant or lactating dogs.

    More Information:
    Brand Name
    Trifexis (Elanco Animal Health)
    Generic Name
    Spinosad and Milbemycin oxime
    What is the most important information I should know about Trifexis: Trifexis is a prescription medication FDA approved for use in dogs 8 weeks of age or older and 5 lbs of body weight or more. Trifexis contains spinosad and milbemycin oxime and is indicated for the prevention of heartworm disease. Trifexis kills fleas and is indicated for the prevention and treatment of flea infestations, and the treatment and control of adult hookworm, adult roundworm, and adult whipworm infections. Trifexis is available in a pink box for dogs 5 to 10 lbs (140mg/2.3mg)), Orange box for dogs 10.1 to 20 lbs (270mg/4.5mg), Green box for dogs 20.1 to 40 lbs (560mg/9.3mg), Blue box for dogs 40.1 to 60 lbs (810mg/13.5mg), and Brown box for dogs 60.1 to 120 lbs (1620mg/27mg). For dogs over 120 lbs give the appropriate combination of tablets.

    What is Trifexis: Trifexis is a chewable, beef flavored tablet that is made out of pork liver and hydrolyzed soy and given to your dog once month to prevent heartworm, to prevent and treat flea infestations, and to treat and control adult hookworm, roundworm, and whipworm infections. Trifexis chewable tablets are for monthly use in dogs and puppies 8 weeks of age and older and 5 lbs of body weight or more.

    What should I discuss with my veterinarian before giving Trifexis to my pet: Tell your veterinarian if you are planning on breeding your pet. Tell your veterinarian if your dog has a history of seizures (epilepsy).

    How should this medication be given: Give Trifexis chewable tablets with food. Give Trifexis chewable tablets once a month. Trifexis chewable tablets may be chewed, offered in food, or administered like other tablet medications. If vomiting occurs within 1 hour of administration, redose the pet with another full dose. Store Trifexis at room temperature (68-77į F). Consult your veterinarian for pregnant or lactating dogs.

    What happens if I miss a dose: Give the missed dose with food as soon as you remember and resume a monthly dosing schedule.

    What happens if I overdose the pet: Overdose of this medication is unlikely. However, if an overdose is suspected, contact your veterinarian or veterinary emergency room. Symptoms of overdose that may occur include vomiting.

    What should I avoid while giving Trifexis: Your pet may maintain normal activities and interactions while being given Trifexis. The safe use of Trifexis chewable tablets in male dogs intended for breeding has not been established.

    What are the possible side effects of Trifexis: Side effects that may occur include vomiting. If vomiting occurs within one hour of administration, redose with another full dose. Other side effects may occur. Continue giving Trifexis chewable tablets and talk to your veterinarian if your pet experiences decreased appetite, lethargy or decreased activity, diarrhea, cough, increased thirst, vocalization, increased appetite, redness of the skin, hyperactivity and excessive salivation. Talk to your veterinarian about any side effect that seems unusual or especially bothersome to the pet.

    What other drugs will affect Trifexis: Talk to your veterinarian before giving any prescription or over the counter medications.

    Where can I get more information: Your pharmacist has additional information about Trifexis written for health professionals that you may read.


    Please view the chart below for the correct dosage of Trifexis for your dog.
    Tip: Trifexis does not protect against ticks. To help control ticks, try the Preventic Tick Collar.
    Pet Weight Dosage
    (Over 8 weeks of age)
    5 - 10 lbs Give one tablet (Pink label box)
    10.1 - 20 lbs Give one tablet (Orange label box)
    20.1 - 40 lbs Give one tablet (Green label box)
    40.1 - 60 lbs Give one tablet (Blue label box)
    60.1 - 120 lbs Give one tablet (Brown label box)
    Over 120 lbs Administer the appropriate combination of tablets
    Storage: Should be stored at room temperature. Keep away from pets and children.
    Trifexis for Dogs 5 to 10 lbs:
    Active Ingredients per tablet Amount
    Spinosad 140 mg
    Milbemycin oxime 2.3 mg

    Trifexis for Dogs 10.1 to 20 lbs:
    Active Ingredients per tablet Amount
    Spinosad 270 mg
    Milbemycin oxime 4.5 mg

    Trifexis for Dogs 20.1 to 40 lbs:
    Active Ingredients per tablet Amount
    Spinosad 560 mg
    Milbemycin oxime 9.3 mg

    Trifexis for Dogs 40.1 to 60 lbs:
    Active Ingredients per tablet Amount
    Spinosad 810 mg
    Milbemycin oxime 13.5 mg

    Trifexis for Dogs 60.1 to 120 lbs:
    Active Ingredients per tablet Amount
    Spinosad 1620 mg
    Milbemycin oxime 27 mg

    Trifexis 3.7 5 365 369
    Works but allergic reaction I tried this because my mother-in-law was referred from her vet to give it to her dog and she told me to get it for my dog also. Yes, it does work great at killing and keeping away the fleas. BUT... both of are dogs had allergic reactions to the medicine. Hers more so than mine. My little one is broke out all over now from a allergic reaction to her skin from it. I know it is from the medicine and not fleas because we haven't had them since September. It did not start until I gave her the pill about a week or so ago. Now have to go to the vet to get her a shot to keep the itching and swelling down. If you are considering this for your dog, please please please go over it very well with your veterinarian to make sure this is the right medicine for him or her. 01/02/2014
    sticktight fleas I bought this product from my vet as I liked the idea of all in one. However a couple of weeks after taking the first dose our golden mix started chewing and licking her tummy and the inside of her leg. She had little red spots on her which became inflamed due to her constant chewing. I took her in to see the vet and told him that the only change was to the trifexis. He treated her and the next month it returned again. Another vet noticed a sticktight flea in the inflamed area. Not sure where she picked up this flea (bird/chicken flea,) but they burry in the skin like a tick. Called the trifexis company and they do not cover that type of flea. I will now have to go back to the topical and heartworm separately to make sure our dogs do not get this nasty sticktight flea. 12/26/2013
    urination? I have 3 frenchies and this product is awesome. However, my female urinated in her sleep for a few nights after giving it to her. She did it 3 out of the 4 months given to her. Anyone else have this issue? I don't know if its related but wanted to ask. She has never done that before and it happened about 3 nights after being given (for each night). Maybe just a coincidence? I thought she slept extra heavy ? 12/21/2013
    Love its 2 pills in one We had been using different products for fleas and heartworm. The pill is large and we break it up and serve it with some peanut butter. 12/07/2013
    works great My Welsh Corgi will NOT eat this pill! I have mixed it with everything: beef, chicken, lunchmeat, but every time he would separate the pill and spit it out. I bought a mortar and pestle to crush the pill and then soak it up with lunch meat and he readily gobbles it down. 12/01/2013
    Great product My dog is extremely allergic to flea bites. The popular topical products work by killing the fleas AFTER they bite, this caused major problems for my Irish Setter. This product gets rid of the fleas without the biting and the results are immediate. Give with food as directed and see the results within 30 minutes. Pretty amazing and worth the additional cost. Finally some relief for our fury family member. 11/26/2013
    Give Trifexis on a FULL stomach We gave our Shih-Tzu Trifexis and she threw up all over the place. We took her to the Vet and it was stressed to us to not give her the pill on an empty stomach. A lot like human pills, many of them you shouldn't take on an empty stomach. So, please always give your dog Trifexis on a full stomach. 11/10/2013
    12 lb silver yorky male 1 yr old works well with little to no side effects that I can tell. We have Been using it for 6 months. no fles or heart worms / worms period $104 for 6 month supply 11/06/2013
    Trifexis is a Failure ! I'm sorry to have to say that Trfexis does not work well on getting rid of fleas. My 2 year old German Shepherd had been on Frontine plus and I noticed fleas on her 22 days after applying it. So, I applied Advantix II and a week later I still had fleas. I re-applied Advantix II and still I have fleas. One week later I gave my dog Trifexis and I still have fleas. One week later I added Advantix II again and finally no fleas. It appears to take at least two separate products in order to get rid of fleas these days. 11/03/2013
    Love It I have all 3 of my dogs on this product. It works great. I live out in the middle of the woods and my dogs used to always have fleas and ticks. But since i made the switch it works great. 10/27/2013
    Great Product We started off using Sentinel which works great. But we noticed that fleas were not dying, so we switched to Trifexis. For starters, our dogs will take any pill you give asking about taste is not relevant and if my dog could talk, I might have to ask them. This products kills Within an hour. Never had an issue, great product. 10/02/2013
    Great Product I use this with all three of my Rottweilers. I did discontinue with my female while she was nursing. My 6 month old pups (65+pounds) and our female tolerate it well. They will not chew it, but swallow easily wrapped in cheese! I'm sure they would eat it if it was peanut butter flavored! 09/28/2013
    Not one flea! Have been using this almost a year and never have had a flea on our cockapoo. Vet said to give with a little cheese before eating and have had no problems. We winter in Florida where fleas are everywhere and this product is amazing, worth the cost. Highly recommend. 09/20/2013
    Good-careful reading... Trifexis is good for overall protection. Sure, it does not cover everything under the sun but it is not intended to. Any pet owner who keeps their dog/cat in good condition should not have any significant issues with this product. BTW-Don't read too much into a previous reviewer's endorsement of "Iverhart Max" as this is a generic for Heartguard . As we all know, those products have nothing to do with flea prevention... 09/14/2013
    Been using for 2.5 years I've been using Trifexis as my flea prevention. My Peke will be 3 y/o next month and hasn't had an issue. I did split the pill when he was growing and his weight averaged between 9.9 and 10.5 pounds. I spoke with my vet about splitting the pill for the 10.1-20 lb dog. I was comfortable doing it knowing that I may have to give it earlier than 4 weeks. My Peke is now 12 lbs and I gave him the whole pill for the first time - split into 2 doses, one in the am and the other half in the pm. No issues at all. No vomiting (he takes with food) and no lethargy). I would recommend this medication. 09/14/2013
    I switched my pug to trifexis and after about 2 months she began getting bumps on her ears. I took her to the vet- he put her on antibiotics but wasn't 100% sure what the bumps were. I asked if it could have been a side effect from the trifexis since that was the only thing I could think of that had changed for her and he assured me it was not. He said if the antibiotics did not work they would biopsy the bumps. I used the antibiotics and the bumps did not go away. I decided to not continue with the trifexis just to see what happens. I went back to her old flea prevention medicine and the bumps began to get smaller after the first month and then were completely gone by the 2nd month. I was skeptical with using the product because I did see mixed reviews but my vet assured me it was safe. I would definitely not recommend this product. 09/08/2013
    still gets hookworm My dog Abby is a 50lb Lab mix who likes to scavenge on walks. I give her Trifexis monthly for heartworm and other intestinal parasites, but she still gets hookworm infections which should be covered by Trifexis. This is the 2nd time in 5 months I have to treat her with another medication to eliminate the hookworms, even though Trifexis should take care of them. She does not eliminate in our yard, so is not getting re-infected from there. Also, the vet tells me that the Trifexis manufacturer will reimburse me for the additional treatment for hookworm, but they denied me the last time. So, bottom line, please be sure to continue with fecal tests on a regular basis if you see something is different in your dog's feces. 09/03/2013
    Love Trifexis I use this on my German Shepherds. I love it. It is a grate all in one pill. I love how not only a heart-worm preventative, but fleas and even intestinal worms including Whipworm. Not too many meds take care of whipworm. My dogs have nice sold stools with it. No vomiting and no diarrhea. Use it for my older German Shepherds and my German Shepherd puppy since she was 3 months and all have done well. My one male has a sensitive stomach (10 years old) and even he has not had any issues with it. The only problem I have is I can not get any of them to eat it in their food or other wise so, I do have to make them swallow it. I break the big ones up for them to swallow. I make sure they eat some food 1st so I know they have food in their stomach. I started using Trifexis last year. Does anyone know for sure if it is safe on females before, during and after they have pups. I have not used it at that time. I know they do not know about the males and ask vet for females. But I would really want to know for the future and also for some of my friends. If anything, I will use another product just for that time then back to this one as I really like this one. 08/29/2013
    great med----but...... my Peke does excellent on this medication. works as advertised. the but...... is that I get mine from my vet and always pay 10-20 dollars LESS that the price here...with taxes!! 08/23/2013
    Great Product I have always given my two small indoor dogs Frontline Plus along with heartworm preventative. I have never had issues with fleas or ticks. I now live in NC and fleas here must be bad. For the first time I began finding fleas on my dogs. I sprayed our home, bathed my dogs every other day with flea shampoo, used flea traps, vacuumed, washed their beds and blankets. Finally, after watching my poor dogs itch and suffer I decided to go to the vet to try Triflexis since Frontline Plus wasn't working anymore. My dogs did not get sick. I also used the Seresto collar as back up to kill ticks but also fleas. No more fleas! I am so happy. Buy Triflexis and Seresto collar from 1800pedmeds not your vet (too expensive). Both Triflexis and Seresto have rebates. 08/11/2013
    Unbelievably Great Best thing ever, I will be keeping my Dogs on these Meds no if ands or buts, Not only does it give me the peace of mind knowing they are protected from Heartworms, But the fact that they dont have ANY FLEAS at all is wonderful I am in awe of this product and am recommending it to any one that asks... And I also Never got any vomiting from either of my dogs, A little bit of info tho, because my guys are so tiny, the vet suggested giving half the tablet every two weeks instead of once a month and this is working out just great for us 08/11/2013
    Great product I have had my Allie (58lbs.) on Trifexis for 2 months now and she is doing very well. She did not experience and side effects while on this medication. She had absolutely no problem eating it and did not spit it out. We made sure to give it to her on a full stomach, so she ate some of her dry food and a couple hot dogs. I'm so happy this medication has worked for her. 08/10/2013
    Needs to be favored This medication does the job. It does cause one of my dogs to vomit every other time or so. The pills needs to be favored, it smells like poison and it is difficult to get the dogs to take it. 08/09/2013
    Won't Eat It The product works, however it is a nightmare trying to get my dog to swallow this pill. My dog is a lab who loves food and eats everything. Previously we used Sentinel for heartworm. My dog loved that pill and would eat it out of my hand. We switched to Trifexis and my dog refuses to eat it. Spits it out every time. I end up having to cut the pill in small pieces and hid it in banana slices or avocado. They need to add a flavor so dogs will eat it. 08/07/2013
    Great Product I have Malteeses, they all use this product for constant protection against fleas and parasites...We live in Florida which is mostly sand, which house fleas and eggs..We have had an infestation of fleas and we used every product to get rid off and prevent and nothing really worked as good as Trifexis...We got it under control and able to prevent future infestations. 08/06/2013
    Works amazing for fleas Our Australian Shepherd has been on Trifexis for about 10 months. About 2 months ago we got a new 1 year old Border Collie mix. We DID NOT put her on Trifexis. Here we are, 2 months later and just discovered our new dog has fleas - and I mean a MAJOR infestation! And our original dog on Trifexis that plays & sleeps with her all day? Not a single flea could be found. You don't get better proof than that this stuff works! My dog will not eat it if presented alone, but wrapped in a little slice of ham he has no problem. Going to get this for the 2nd dog tomorrow. 08/05/2013
    What the Vet forgets to tell you! I had been using this product for over a year and loved it. I thought wow no fleas, no ticks, and is kills all the worms I really need to worry about. Well, not so fast.....I was told at the vet it did kill ticks! Which it does not if you read the label but I trusted my VET! Also, after bringing a new puppy into the house and starting her on it after she reached six months old, we were discustingly surprised when she came down with a terrible case of tapeworms and yes after questioning the Vet he desided to tell me that it doesn't kill them either. This medication is far to expensive to have to buy supplimental medications to full in the gaps. I am trying Iverhart Max and we will see if it has any negitive effects to speak about. I can already say that at $4.50 a pill...I already give it more stars then Trifexis! 07/23/2013
    Failed to prevent roundworms My 2 year old beagle has been using this product for 18 months. He never experienced any negative reactions and it has worked to prevent Heartworm and fleas. Unfortunately my family recently got a new puppy and our older dog got roundworms from him. I am disappointed that this product has failed too prevent parasites like advertised. I will be switching my dog to Heart guard after his worming treatment is over. 07/18/2013
    Ticks Works fine but does NOT repel ticks.Not purchasing again.You would think the Vet would have told us about not repelling ticks. 07/17/2013
    Great Med I have a Lab Mix, and this is her fifth month on this medication and for us it works great. I'm reading the reviews of pet owners whose dogs had severe reactions to this medication and I want to mention that it doesn't happen to every dog, my 18 month old lab has had no noticable problems with this medication. And to whoever was angry about pulling ticks off their dog i feel i should point out that the box and the descriptions here all say absolutely nothing about treating ticks, and the box actually says not for the treatment or prevention of tick infestations. I live in an area known for its ticks and fleas, and we tried everything frontline, advantage, advantix all of them, the only thing that has successfully gotten rid of our flea problem is this medication its awesome. 07/15/2013
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    213 Questions · 322 Answers

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    for a dog under 20lbs?
    2 weeks, 3 days ago
    Answer this question


    1 week, 5 days ago
    Linda M 1800petmeds pharmacist
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    You can purchase 3 individual tablets of the Trifexis.
    1 week, 5 days ago
    Kelly P
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    in the commercial and in the description it states that the product kills fleas, heart worms, etc but does not state whether it kills flea EGGS as well.
    3 weeks, 2 days ago
    yonkers ny
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    1 week ago
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    Thank you for your question. No, this does not kill the flea eggs. Trifexis kills the adult fleas before they can lay any eggs.
    3 weeks, 1 day ago
    Maureen PetMeds Pro
    Pompano Beach, FL
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    4 weeks, 1 day ago
    Answer this question


    Yes you can bathe your dog, the shampoo will not interfere with the treatment.
    4 weeks ago
    Pompano beach
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    1 month, 1 week ago
    Answer this question


    Trifexis offers both heartworm prevention adn flea control, so the k-9 advantix should not be needed.
    1 month ago
    Kelly P
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    Will Trifexis harm cats if given to dogs living in the same household?
    1 month, 1 week ago
    Answer this question


    There should not be a problem giving Trifexis to your dogs when around cats.
    1 month, 1 week ago
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    This information sheet is for educational purposes only and is intended to be a supplement to, and not a substitute for, the expertise and professional judgment of your veterinarian. The information is NOT to be used for diagnosis or treatment of your pet. You should always consult your own veterinarian for specific advice concerning the treatment of your pet. The information is not intended to cover all possible uses, directions, precautions, warnings, allergic reactions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for your pet. It is not a substitute for a veterinary exam, and it does not replace the need for services provided by your veterinarian.
    Note: Any trademarks are the property of their respective companies.
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