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Product Info
How to Use
Customer Reviews
Product Info
What is Proin?

Proin is an aid in the management of urinary incontinence in dogs. Proin requires a prescription from your veterinarian, and is considered a controlled substance in Arkansas, Iowa, Louisiana and Oregon.

Proin is unavailable to be shipped to Arkansas, Iowa, Louisiana, Oregon or Internationally.



  • Is a supplement for urinary incontinence in dogs
  • Ensures sustained phenylpropanolamine levels in the blood stream and may help reduce the conditions often associated with high levels of phenylpropanolamine such as: decreased appetite, changes in heart rate, increased blood pressure, hyperexcitability
How it Works:

Proin contains the active ingredient phenylpropanolamine, an adrenergic agent that works by tightening the bladder sphincter muscle, which helps to control urine leakage.


Don't give Proin with ephedrine or epinephrine, and don't give it within two weeks of using a MAOi, such as Anipryl, selegiline or a Preventic Collar. Possible side effects can occur, including restlessness, or loss of appetite, difficulty breathing, hives, and swelling of the lips, tongue, or face. If these or any other side effects occur, contact your veterinarian immediately. Proin is unavailable to be shipped to Arkansas, Iowa, Louisiana, Oregon or Internationally.

Brand Name:

Proin (PRN Pharmacal)

Generic Name:


What is the most important information I should know about Proin:

Proin is a prescription medication for veterinary use in dogs. Proin is available as 25mg, 50mg and 75mg chewable, liver flavor tablets. Proin may cause restlessness, irritability, or loss of appetite.

What is Proin:

Proin is an adrenergic agent used as a supplemental product for urinary incontinence in dogs. Proin may also be used for purposes other than those listed in this guide.

What should I discuss with my veterinarian before giving Proin to my pet:

Tell your veterinarian if your pet has ever had an allergic reaction to this medication. Tell your veterinarian if your pet has glaucoma, hyperthyroid disease, diabetes, heart problems or high blood pressure. Tell your veterinarian if your pet is pregnant or lactating.

How should this medication be given:

The usual dose for dogs is 0.4-0.8mg/pound every 12 hours. Give Proin exactly as directed by the veterinarian. If you do not understand the directions ask the pharmacist or veterinarian to explain them to you. Store Proin at room temperature away from moisture and heat. Keep this medication away from children and pets. 

What happens if I miss giving a dose:

Give the missed dose as soon as you remember during the same day. However, if you don't remember until the next day, skip the dose you missed and give only the next regularly scheduled dose. Do not give a double dose of the medication.

What happens if I overdose the pet:

Seek emergency veterinary medical treatment. Symptoms of overdose may include increased blood pressure, increased heart rate, seizures or coma.

What should I avoid while giving Proin to my pet:

Do not give Proin with ephedrine or epinephrine and do not give within 2 weeks of using an MAOi such as selegiline or Preventic Collar.

What are the possible side effects of Proin:

Stop giving Proin and contact your veterinarian immediately if your pet has an allergic reaction (difficulty breathing; swelling of the lips, tongue, face; and hives). Other side effects that may occur include restlessness, irritability, increased heart rate, increased blood pressure and loss of appetite. Continue to give the medication and contact your veterinarian. Other less serious side effects may occur. Contact your veterinarian about any side effects that seem bothersome.

What other drugs will affect Proin:

Before giving Proin, tell your veterinarian if your pet is being given digoxin, NSAIDs such as aspirin or Rimadyl, tricyclic antidepressants such as clomipramine, and beta blockers such as atenolol, or any other prescription or over the counter medications. 

Where can I get more information:

Your pharmacist has additional information about Proin written for health professionals that you may read.

How to Use
  • Proin liver flavored chewable tablets are available by prescription for use in dogs to treat urinary incontinence.
  • Proin may cause restlessness, irritability, or loss of appetite.
  • Tell your veterinarian about any other medication you may be giving your pet.

Give this medication exactly as directed by your veterinarian. Do not exceed 1.8mg/lb per day. The medication may be given with food.

All weights
The usual dose for dogs is 0.4-0.8mg/pound every 12 hours.
Do not use!
Do not use!

Should be stored at room temperature away from moisture and heat. Keep this medication away from children and pets.

Proin Chewable Flavor Tabs 25 mg:
Active Ingredients
25 mg
Proin Chewable Flavor Tabs 50 mg:
Active Ingredients
50 mg
Proin Chewable Flavor Tabs 75 mg:
Active Ingredients
75 mg
Customer Reviews
Proin is rated 4.651515151515151 out of 5 by 594.
Rated 5 out of 5 by from Thank you 1-800-Petmeds I was purchasing Proin through my Vet for a few years - not through my current vet. The price sored in recent years. I found it difficult to keep up with the price. I finally found a vet that would write a script for it and I could save big money at 1-800-Petmeds. It has made the world of difference and it works like a charm for my girl. I'm thrilled!
Date published: 2016-09-05
Rated 4 out of 5 by from My tammy has been on for one year,works well!! No side effects that I've seen.
Date published: 2016-09-03
Rated 5 out of 5 by from I'm sorry to read that some dogs suffer adverse effects from the medication. I have had three female dogs since 1984. All of them eventually need Proin and remained on it for the length of their lives with no side effects. With my second dog, I discovered that half the dose was all that was needed. I never had to increase it over the years. So with my current dog, Caterina, I tried the same thing and the 1/2 dose is perfect. (My vet was aware of the decreased dosage both times). I just adopted another dog, also a female. Time will tell if she will need Proin in her future. I am confident that if so, she will have the same experience as my other girls.
Date published: 2016-08-29
Rated 5 out of 5 by from Very pleased with how Proin has worked for Harlie. And even more pleased with how awesome Petmeds has been serving us!
Date published: 2016-08-29
Rated 5 out of 5 by from Proin works amazingly! Our female, spayed, GS developed early onset incontinence. After ruling out a bladder infection, our vet suggested Proin. Within 2 days, she had no more leaking. Proin has worked amazingly for her!
Date published: 2016-08-20
Rated 5 out of 5 by from Fast Acting and Effective! A few months ago my 13-year old girl started leaking and having accidents. She was ashamed and upset and it felt like she aged very rapidly since she became less active. Within a day of starting Proin, the accidents were over. She was happy and active again and seemed much younger. It's been a few months and it's still working. We're all very happy!
Date published: 2016-08-05
Rated 5 out of 5 by from Finally allowed in the house again Chocolate has had this problem for a long time. With pronin she is no longer leaking. She is no longer stinky. And she gets to come inside which she loves. Finally the price is less than half that of my local vet!!
Date published: 2016-08-02
Rated 5 out of 5 by from 100% Perfection Easy to order and quick to receive. None of the pills were broken!!! I use order the pills from the Vet and they would be broken - asked for replacement and was challenged.
Date published: 2016-07-05
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Is there a liquid form of ProIn

My dog is 16 yrs old and I have literally tried everything including steak to give her the proin, she will spit it out everytime, I am at my wits end and because of this she has to wear a diaper at night
Asked by: shelby
I use this for my girl and so far what works best for her is just dipping it in a big glob of peanut butter and she has never spit it out ever .
Answered by: Manderz
Date published: 2016-09-14

I have a written Rx for this item, how Domingo about ordering? Can I email copy of Rx?

Asked by: Boo1
Prescriptions cannot be emailed by law. Please mail the written prescription to the following address: 1800PetMeds 1441 SW 29 Avenue Pompano Beach, FL 33069
Answered by: Lisa M
Date published: 2016-03-08

breaking Proin 50 tablets

Should you wear gloves when breaking these tablets? Is is possible for the powder to be absorbed through the skin and thus create human health issues?
Asked by: Marty
I never do. Just use a knife to split it.
Answered by: Bort
Date published: 2015-12-23

Proin prescription in Arizona

Is this basically saying if I ask the vet for a prescription for Proin they have to do it? Is 1800petmeds considered a dispensing veterinarian? Arizona Administrative Code R3-11-801. Notification That Prescription-only Drugs Or Controlled Substances May Be Available At A Pharmacy A. A dispensing veterinarian shall notify an animal owner that some prescription-only drugs and controlled substances may be available at a pharmacy by: 1. Stating the availability at or before the time of dispensing; 2. Posting a written statement that is visible to the animal owner; or 3. Providing the animal owner with written notification. B. A dispensing veterinarian may provide a written prescription to the animal owner if requested by an animal owner.
Asked by: bluenose
Proin is a prescription medication that may be prescribed by your veterinarian if the veterinarian feels your pet's diagnosis will benefit from the medication. It is to the disgression of your veterinarian to prescribe the medication and they are not obligated to approve the medication. Our company is a registered pharmacy that has dispensing priviledges in all 50 states and is not a veterinarian's office. We can dispense Proin only if we have received the approval from a licensed veterinarian to do so.
Answered by: Lilli Pharmacist
Date published: 2015-09-22

Teacup Yorkie 3.5 lbs, Can use Proin?

I have Yorkie 12 years old, his weight only 3.5 lbs, can use the Proin, if yes, please let me know how to take?
Asked by: Lydia
The dose would be determined by your vet. Please consult your veterinarian.
Answered by: Stephanie Duesler, Pharm. D, MBA
Date published: 2015-08-28

will Proin be effective with leakage from Nuero Myolopathy

My dog is 60 # and is becoming more incontenent as his disease progresses. Is this something Proin can help or is it for other causes?
Asked by: Stryder's mom
Its possible that Proin may help. Please discuss with your veterinarian. Good luck to you,
Answered by: Linda M 1800petmeds pharmacist
Date published: 2015-07-26

what if my dog wont eat it?

is it ok to grind the pill down and mix with his food? he wont eat even pieces, even if hidden in his food.
Asked by: CG
I have given it to my dog in his food with hot water, wait a few minutes and then crush the pill with a fork. My dog licked the bowl clean. Good luck!
Answered by: Doglover37
Date published: 2015-07-15

can I order Proin 50 from you without going thru my vet

Asked by: Larry
No, you need a prescription from your veternarian.
Answered by: sport
Date published: 2015-06-28
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