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Ivermectin-Pyrantel - Generic to Heartgard Plus

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01-25 lbs
26-50 lbs
51-100 lbs
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Product Info
How to Use
Customer Reviews
Product Info
What is Ivermectin-Pyrantel - Generic to Heartgard Plus?

Ivermectin/Pyrantel for dogs is a heartworm preventative that also controls roundworms and hookworms. Ivermectin/Pyrantel is a generic equivalent to Heartgard Plus, and requires a prescription from your veterinarian. It has the same active ingredients and is the same strength. Ivermectin/Pyrantel is considered to be the #1 generic heartworm preventative recommended by veterinarians.


Dogs (6 weeks of age or older and no weight requirement)

  • Tasty flavored chewable tablets
  • Easy to administer
  • Small, easy-to-chew tablet for smaller or finicky dogs
  • Given once a month
How it Works:

Ivermectin/Pyrantel is an anthelmintic (dewormer). The ingredient pyrantel pamoate is used to treat and control roundworms and hookworms in dogs.

Studies have indicated that certain dogs of the herding breeds are more sensitive to the effects of ivermectin administered at elevated dose levels due to the MDR1 gene. Dog breeds that may be affected include Australian Shepherd, Australian Shepherd Mini, Border Collie, Collie and English Shepherd.


Can cause sensitivities in herding dog breeds. Side effects of Ivermectin/Pyrantel are rare, but may include lethargy, limpness, salivation, shaking, diarrhea, decreased appetite, licking lips, and belching. Don't give your pet Ivermectin/Pyrantel if already giving a different heartworm medication. The safe use of this drug has not been evaluated in pregnant or lactating bitches.

Brand Name:

Iverhart Plus (Virbac), Tri-Heart Plus (Merck)

Generic Name:


What should I discuss with my veterinarian before giving Ivermectin/Pyrantel to my pet:

Tell your veterinarian if your pet has ever had an allergic reaction to the medication.

What is the most important information I should know about Ivermectin/Pyrantel:

Ivermectin/Pyrantel is a prescription medication available as flavored chewable tablets. The usual dose of Ivermectin/Pyrantel in dogs up to 25 pounds is 68mcg/57mg (Blue box), for dogs 26-50 pounds is 136mcg/114mg (Green box) and for dogs 51-100 lbs 272mcg/227mg (Brown box). Dogs over 100 lbs are given a combination of tablets.

How should this medication be given:

Give Ivermectin/Pyrantel exactly as directed by your veterinarian. If you do not understand the directions ask your pharmacist or veterinarian to explain them to you. Use with caution, Collies and other herding dog breeds have been known to have adverse reactions to ivermectin administered at elevated dose levels. Heartworm testing should be performed prior to the start of prevention therapy. If your pet is off Ivermectin/Pyrantel for 6 months or less, start the medication and test after 6 months since microfilaria, that take 6 months to mature, will result in a positive test result. Store Ivermectin/Pyrantel at room temperature. Do not remove the tablet from its wrapper until ready to give to your pet. Keep this medication away from children and pets. The safe use of this drug has not been evaluated in pregnant or lactating bitches.

What happens if I miss giving a dose:

Give the missed dose as soon as you remember. Do not give a double dose of the medication.

What should I avoid while giving Ivermectin/Pyrantel to my pet:

Because humans can contract hookworms from animals, it is important to maintain good personal hygiene. It is also important to eliminate fleas on your pet and in the household and to not feed your pet rodents. To prevent reinfection, daily cleanup of stools is recommended.

What are the possible side effects of Ivermectin/Pyrantel:

Side effects of Ivermectin/Pyrantel are rare at the recommended heartworm prevention dose. Higher doses in dogs may cause tremors, dilated pupils, loss of body weight, or death.

What other drugs will affect Ivermectin/Pyrantel:

Do not give Ivermectin/Pyrantel if your pet is already being given another heartworm medication.

How to Use
  • Give Ivermectin/Pyrantel Flavored Chewables once a month on the same day of each month year-round.
  • Ivermectin/Pyrantel Flavored Chewables can be given by hand, mixed intact with a small amount of food, or placed in the back of your dog's mouth for forced swallowing.
  • Watch your dog closely following dosing to be sure the entire dose has been swallowed. If it is not completely swallowed, give one more full recommended dose as soon as possible.

Do not remove the chewable from its wrapper until ready to give to your pet.

Dogs/Puppies: (6 weeks of age and older)
Up to 25 lbs
Give 1 chewable every month (Blue Box)
26-50 lbs
Give 1 chewable every month (Green Box)
51-100 lbs
Give 1 chewable every month (Brown Box)
Over 100 lbs
Give combination of chewables based on weight
Do not use!
Do not use!

Should be stored at room temperature.

Ivermectin/Pyrantel - Blue Box (Dogs up to 25 lbs):
Active Ingredients (per chewable tablet)
68 mcg
57 mg
Ivermectin/Pyrantel - Green Box (Dogs 26-50 lbs):
Active Ingredients (per chewable tablet)
136 mcg
114 mg
Ivermectin/Pyrantel - Brown Box (Dogs 51-100 lbs):
Active Ingredients (per chewable tablet)
272 mcg
227 mg
Customer Reviews
Ivermectin-Pyrantel - Generic to Heartgard Plus is rated 4.365904365904366 out of 5 by 962.
Rated 1 out of 5 by from Ivermectin This pill is HUGE !!!! I wouldn't be able to swallow this pill myself much less my little Yorkie !!!! Very disappointed in it, and yes, I break it into 4 pieces to get her to take it. It also makes her sick. It's too bad that what I was ordering from PetMeds quit selling it.
Date published: 2016-08-25
Rated 3 out of 5 by from Big, pungent tablet Great price, but it's a pill in itself to get my dog to take her dose. My dog gets the medium-sized dose of this pill, and it is noticeably bigger than the non-generic pills, and also a bit more pungent. Not only can she not swallow the pill as-is, but she hates the taste and smell so it can't be simply mixed in with food, and she easily picks it out via texture and scent if it's mixed in a meal. Cutting in half just made her choke on the hard edge. If anyone else has this issue, to get her to eat it, I ground it up into basically a powder so she couldn't pick out the bits, and mixed that up with an already cooked egg and pumpkin puree so she couldn't smell it and suspect what I was giving her.
Date published: 2016-08-16
Rated 5 out of 5 by from Great product Tried this for my Husky pup. So far so good, and a good price too!
Date published: 2016-08-11
Rated 5 out of 5 by from Does the job I usually buy heartguard plus. We have 10 dogs. Dogs range from 23&84 lbs. 9/10 take heart guard plus. 6/4 took the tri heart. Id buy it again. Saved me a few bucks and it'll do the job just the same.
Date published: 2016-08-09
Rated 5 out of 5 by from My dog loves it I've tried several heart worm meds for my dog and all made him sick to his stomach. This one doesn't and we are both relieved.
Date published: 2016-08-01
Rated 5 out of 5 by from Different The tablet is described as chewable,but the dog has to want to chew it, for that to be effective and true. It does not have the texture of Heart guard,but it can be crushed easily and put into something delectable,such as ricotta cheese. Ivy ate it up!
Date published: 2016-07-28
Rated 5 out of 5 by from Love it!! These are hard and not soft like the Heartgard, but my dogs will eat anything so I figured I would give it a try. They love it. They think it is their monthly treat. My smaller dog was a stray that we took in and she tested positive for heartworms when we first took her in. Since the treatment is expensive our vet told us that we try doing a slow kill and to continue giving her heartworm treatments every month. She said sometimes that would slow kill them and to see if that would work. It took 8 months, but it worked. I was worried using the off brand, but it worked very well. Just took her back for a checkup and she tested negative for heartworms and our other dog has never had any problems. As long as your dog can chew the pills I highly recommend these. They work great and it saves money, especially if you have multiple pets.
Date published: 2016-07-22
Rated 4 out of 5 by from It's ok The pills are pretty hard & Ellie kept spitting it out, it's also big, but I kept giving it back & she did eat it. That's good because I hate paying full price for any meds!
Date published: 2016-07-20
  • 2016-08-28T06:04CST
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My dog is 4 years old should I still give him heart worm meds?

Asked by: amarie
It is applicable at any age after 6 weeks old. It is best to continue medication though to prevent worms.
Answered by: paulpharmacistintern
Date published: 2016-08-12

Is this safe for border collies

Asked by: Ktpj1989
It has been shown that certain dogs such as Border Collies could be sensitive to the effects of ivermectin. Talk to your veterinarian about that possibility before using this medication.
Answered by: paulpharmacistintern
Date published: 2016-08-04

Do I need a RX for heartworm meds

Asked by: tiara
Yes a prescription is needed for heartworm medication.
Answered by: paulpharmacistintern
Date published: 2016-08-04

Do I need a vets prescription for this product?

Asked by: Ana K
Yes a prescription is required for Ivermectin-Pyrantel.
Answered by: paulpharmacistintern
Date published: 2016-08-03

Do I have to have a perscription????

Asked by: Marleen
Yes a prescription is needed.
Answered by: paulpharmacistintern
Date published: 2016-08-03

Where is this manufactured?  Where is it shipped from?

Asked by: Twiggy Z
This product is manufactured in U.S.A. and ships from Florida.
Answered by: Cherley Petmeds Pro
Date published: 2016-06-14

Do u have to have a prescription from a vet to order off this site

Asked by: jswift82
Prescriptions are required for any heartworm prevention, we highly encourage you to establish a new Vet, Client, Patient Relationship to ensure your pets health.
Answered by: Pharmacy Manager
Date published: 2016-04-17

What if my vet is no longer in business that's why I'm looking for a place to buy

Asked by: jswift82
This would be a great time to look for a new Veterinarian that will look after your pet's health. Before giving your pet Heartworm prevention they need to perform an updated Heartworm test to be certain your pet does not have heartworms. In the event the prevention is given to your pet and they are heartworm positive it can become extremely harmful to your pet without the proper medical supervision.
Answered by: Pharmacy Manager
Date published: 2016-04-16
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