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Ivermectin-Pyrantel - Generic to Heartgard Plus

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1. We'll ask for your vet's info during checkout.
2. We verify your prescription and ship your order!
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01-25 lbs
26-50 lbs
51-100 lbs
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Product Info
How to Use
Customer Reviews
Product Info
What is Ivermectin-Pyrantel - Generic to Heartgard Plus?

Ivermectin/Pyrantel for dogs is a heartworm preventative that also controls roundworms and hookworms. Ivermectin/Pyrantel is a generic equivalent to Heartgard Plus, and requires a prescription from your veterinarian. It has the same active ingredients and is the same strength. Ivermectin/Pyrantel is considered to be the #1 generic heartworm preventative recommended by veterinarians.


Dogs (6 weeks of age or older and no weight requirement)

  • Tasty flavored chewable tablets
  • Easy to administer
  • Small, easy-to-chew tablet for smaller or finicky dogs
  • Given once a month
How it Works:

Ivermectin/Pyrantel is an anthelmintic (dewormer). The ingredient pyrantel pamoate is used to treat and control roundworms and hookworms in dogs.

Studies have indicated that certain dogs of the herding breeds are more sensitive to the effects of ivermectin administered at elevated dose levels due to the MDR1 gene. Dog breeds that may be affected include Australian Shepherd, Australian Shepherd Mini, Border Collie, Collie and English Shepherd.


Can cause sensitivities in herding dog breeds. Side effects of Ivermectin/Pyrantel are rare, but may include lethargy, limpness, salivation, shaking, diarrhea, decreased appetite, licking lips, and belching. Don't give your pet Ivermectin/Pyrantel if already giving a different heartworm medication. The safe use of this drug has not been evaluated in pregnant or lactating bitches.

Brand Name:

Iverhart Plus (Virbac), Tri-Heart Plus (Merck)

Generic Name:


What should I discuss with my veterinarian before giving Ivermectin/Pyrantel to my pet:

Tell your veterinarian if your pet has ever had an allergic reaction to the medication.

What is the most important information I should know about Ivermectin/Pyrantel:

Ivermectin/Pyrantel is a prescription medication available as flavored chewable tablets. The usual dose of Ivermectin/Pyrantel in dogs up to 25 pounds is 68mcg/57mg (Blue box), for dogs 26-50 pounds is 136mcg/114mg (Green box) and for dogs 51-100 lbs 272mcg/227mg (Brown box). Dogs over 100 lbs are given a combination of tablets.

How should this medication be given:

Give Ivermectin/Pyrantel exactly as directed by your veterinarian. If you do not understand the directions ask your pharmacist or veterinarian to explain them to you. Use with caution, Collies and other herding dog breeds have been known to have adverse reactions to ivermectin administered at elevated dose levels. Heartworm testing should be performed prior to the start of prevention therapy. If your pet is off Ivermectin/Pyrantel for 6 months or less, start the medication and test after 6 months since microfilaria, that take 6 months to mature, will result in a positive test result. Store Ivermectin/Pyrantel at room temperature. Do not remove the tablet from its wrapper until ready to give to your pet. Keep this medication away from children and pets. The safe use of this drug has not been evaluated in pregnant or lactating bitches.

What happens if I miss giving a dose:

Give the missed dose as soon as you remember. Do not give a double dose of the medication.

What should I avoid while giving Ivermectin/Pyrantel to my pet:

Because humans can contract hookworms from animals, it is important to maintain good personal hygiene. It is also important to eliminate fleas on your pet and in the household and to not feed your pet rodents. To prevent reinfection, daily cleanup of stools is recommended.

What are the possible side effects of Ivermectin/Pyrantel:

Side effects of Ivermectin/Pyrantel are rare at the recommended heartworm prevention dose. Higher doses in dogs may cause tremors, dilated pupils, loss of body weight, or death.

What other drugs will affect Ivermectin/Pyrantel:

Do not give Ivermectin/Pyrantel if your pet is already being given another heartworm medication.

How to Use
  • Give Ivermectin/Pyrantel Flavored Chewables once a month on the same day of each month year-round.
  • Ivermectin/Pyrantel Flavored Chewables can be given by hand, mixed intact with a small amount of food, or placed in the back of your dog's mouth for forced swallowing.
  • Watch your dog closely following dosing to be sure the entire dose has been swallowed. If it is not completely swallowed, give one more full recommended dose as soon as possible.

Do not remove the chewable from its wrapper until ready to give to your pet.

Dogs/Puppies: (6 weeks of age and older)
Up to 25 lbs
Give 1 chewable every month (Blue Box)
26-50 lbs
Give 1 chewable every month (Green Box)
51-100 lbs
Give 1 chewable every month (Brown Box)
Over 100 lbs
Give combination of chewables based on weight
Do not use!
Do not use!

Should be stored at room temperature.

Ivermectin/Pyrantel - Blue Box (Dogs up to 25 lbs):
Active Ingredients (per chewable tablet)
68 mcg
57 mg
Ivermectin/Pyrantel - Green Box (Dogs 26-50 lbs):
Active Ingredients (per chewable tablet)
136 mcg
114 mg
Ivermectin/Pyrantel - Brown Box (Dogs 51-100 lbs):
Active Ingredients (per chewable tablet)
272 mcg
227 mg
Customer Reviews
Ivermectin-Pyrantel - Generic to Heartgard Plus is rated 4.367539267015707 out of 5 by 955.
Rated 5 out of 5 by from Love it!! These are hard and not soft like the Heartgard, but my dogs will eat anything so I figured I would give it a try. They love it. They think it is their monthly treat. My smaller dog was a stray that we took in and she tested positive for heartworms when we first took her in. Since the treatment is expensive our vet told us that we try doing a slow kill and to continue giving her heartworm treatments every month. She said sometimes that would slow kill them and to see if that would work. It took 8 months, but it worked. I was worried using the off brand, but it worked very well. Just took her back for a checkup and she tested negative for heartworms and our other dog has never had any problems. As long as your dog can chew the pills I highly recommend these. They work great and it saves money, especially if you have multiple pets.
Date published: 2016-07-22
Rated 4 out of 5 by from It's ok The pills are pretty hard & Ellie kept spitting it out, it's also big, but I kept giving it back & she did eat it. That's good because I hate paying full price for any meds!
Date published: 2016-07-20
Rated 5 out of 5 by from Great product, great service Originally, we received this medicine from our vet then we did some googling and learned we could save $40 per year by just ordering it online. Ordered on a Monday and received it on Thursday.
Date published: 2016-07-18
Rated 5 out of 5 by from Great prices, and fast shipping! I loved this product. My two dogs took it with no problems. Price is great, and shipping was very fast.
Date published: 2016-07-09
Rated 5 out of 5 by from Great deal ! Why spent so much on name brand when the generic one is just as good. I've been using this product for two years and I'm completely satisfied with it
Date published: 2016-07-09
Rated 1 out of 5 by from not for little dogs These pills are so hard you can't even crush them. I have to dissolve them in water (which takes days) and try to mix it with her food. It's hard enough for her to eat a little biscuit with her little teeth. It's not worth the trouble, I'll go back to Heartgard even though they cost more
Date published: 2016-07-06
Rated 4 out of 5 by from Good generic from what we can tell We started Goomba, an American Staffy, on Heartguard and went through a 6 month program. Not wanting to spend more money on crazy vet markups, we went for the generics. The pill is a little bigger and harder than the Heartguard. But if you wrap it in cheese, it goes down without a problem. No ill effects that we can tell. Hopefully it will continue to provide adequate protection. And as with all heartworm medication, it is never a guarantee it will protect, especially if they already have it.
Date published: 2016-07-05
Rated 5 out of 5 by from Amazing I actually prefer this to Heartguard. Not only is it cheaper, but it was more effective for my dog. He enjoys taking it, and having 6 and 12 month options make it super convenient for monthly doses. Will definitely begin giving it to my new puppy as well, once old enough. If you're on the fence about this, get it! You won't be disappointed.
Date published: 2016-06-21
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Where is this manufactured?  Where is it shipped from?

Asked by: Twiggy Z
This product is manufactured in U.S.A. and ships from Florida.
Answered by: Cherley Petmeds Pro
Date published: 2016-06-14

Do u have to have a prescription from a vet to order off this site

Asked by: jswift82
Prescriptions are required for any heartworm prevention, we highly encourage you to establish a new Vet, Client, Patient Relationship to ensure your pets health.
Answered by: Pharmacy Manager
Date published: 2016-04-17

What if my vet is no longer in business that's why I'm looking for a place to buy

Asked by: jswift82
This would be a great time to look for a new Veterinarian that will look after your pet's health. Before giving your pet Heartworm prevention they need to perform an updated Heartworm test to be certain your pet does not have heartworms. In the event the prevention is given to your pet and they are heartworm positive it can become extremely harmful to your pet without the proper medical supervision.
Answered by: Pharmacy Manager
Date published: 2016-04-16

Do you need a rx?

Asked by: edintroub
Yes, simply place the order online and our Pharmacy will contact your Pet's Veterinarian where they had their most recent Heart Worm test done. During the check out process we will ask for the information needed to contact the Veterinarian. If you have any further questions in regards to this process our customer care team is standing by to help. Thank you !
Answered by: Pharmacy Manager
Date published: 2016-03-12

Does Tri-Heart Plus have beef content? My dog is very sensitive to beef.

Asked by: REC73
Tri Heart Plus is a beef flavored chewable tablet. Your veterinarian can determine if it is an appropriate choice considering your pet's sensitivity.
Answered by: Lisa M
Date published: 2016-03-04


Asked by: TOBY
Interceptor Plus is currently unavailable through 1800PetMeds. I recommend that you contact your vet to see if he/she is carrying it.
Answered by: SuzyCVT
Date published: 2016-07-21

Perscription Queestion?

If my perscription is writen for Heartguard Plus Can I order the Tri Heart Plus with the Heart Guard Plus prescription because its the generic. Or does the prescription have to say tri heart plus.
Asked by: Jmorter23
Call Petmeds and tell them what your prescription reads. They still have to verify it with your vet and you can tell them you want the generic and Petmeds will handle it for you.
Answered by: MarieC
Date published: 2016-01-11

Heartworm+ with a preventative?

I'm so confused. We recently adopted a dog that tested positive for heartworms. Our vet indicated that she be given Tri-Heart Plus (generic) for 3 months before she can be treated for the adult heartworms in hospital, and gave us the medication already to start. I've read in multiple articles, including the manufacturer's website, that the preventative should taken after the treatment, and could be dangerous if given before. I'm not sure if I'm misinterpreting what I'm reading, since I didn't misinterpret our vet's instructions. Has anyone have experience with this? There's nothing we wouldn't do for our pet. Thank you.
Asked by: OBXNC
The most current recommendations for the treatment of heartworm positive dogs has included initial treatment with Heartgard/Tri-Heart/whatever brand of ivermectin heartworm prevention. Yes, there is a small risk of a reaction at the initial dose which is why we administer and monitor the dog in our hospital for the day during this phase of treatment. But don't panic or think your vet is doing something totally inappropriate with this treatment.
Answered by: SuzyCVT
Date published: 2016-01-10
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