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Ivermectin-Pyrantel - Generic to Heartgard Plus

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2. We verify your prescription and ship your order!
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26-50 lbs
51-100 lbs
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Product Info
How to Use
Customer Reviews
Product Info
What is Ivermectin-Pyrantel - Generic to Heartgard Plus?

Ivermectin/Pyrantel for dogs is a heartworm preventative that also controls roundworms and hookworms. Ivermectin/Pyrantel is a generic equivalent to Heartgard Plus, and requires a prescription from your veterinarian. It has the same active ingredients and is the same strength. Ivermectin/Pyrantel is considered to be the #1 generic heartworm preventative recommended by veterinarians.


Dogs (6 weeks of age or older and no weight requirement)

  • Tasty flavored chewable tablets
  • Easy to administer
  • Small, easy-to-chew tablet for smaller or finicky dogs
  • Given once a month
How it Works:

Ivermectin/Pyrantel is an anthelmintic (dewormer). The ingredient pyrantel pamoate is used to treat and control roundworms and hookworms in dogs.

Studies have indicated that certain dogs of the herding breeds are more sensitive to the effects of ivermectin administered at elevated dose levels due to the MDR1 gene. Dog breeds that may be affected include Australian Shepherd, Australian Shepherd Mini, Border Collie, Collie and English Shepherd.


Can cause sensitivities in herding dog breeds. Side effects of Ivermectin/Pyrantel are rare, but may include lethargy, limpness, salivation, shaking, diarrhea, decreased appetite, licking lips, and belching. Don't give your pet Ivermectin/Pyrantel if already giving a different heartworm medication. The safe use of this drug has not been evaluated in pregnant or lactating bitches.

Brand Name:

Iverhart Plus (Virbac), Tri-Heart Plus (Merck)

Generic Name:


What should I discuss with my veterinarian before giving Ivermectin/Pyrantel to my pet:

Tell your veterinarian if your pet has ever had an allergic reaction to the medication.

What is the most important information I should know about Ivermectin/Pyrantel:

Ivermectin/Pyrantel is a prescription medication available as flavored chewable tablets. The usual dose of Ivermectin/Pyrantel in dogs up to 25 pounds is 68mcg/57mg (Blue box), for dogs 26-50 pounds is 136mcg/114mg (Green box) and for dogs 51-100 lbs 272mcg/227mg (Brown box). Dogs over 100 lbs are given a combination of tablets.

How should this medication be given:

Give Ivermectin/Pyrantel exactly as directed by your veterinarian. If you do not understand the directions ask your pharmacist or veterinarian to explain them to you. Use with caution, Collies and other herding dog breeds have been known to have adverse reactions to ivermectin administered at elevated dose levels. Heartworm testing should be performed prior to the start of prevention therapy. If your pet is off Ivermectin/Pyrantel for 6 months or less, start the medication and test after 6 months since microfilaria, that take 6 months to mature, will result in a positive test result. Store Ivermectin/Pyrantel at room temperature. Do not remove the tablet from its wrapper until ready to give to your pet. Keep this medication away from children and pets. The safe use of this drug has not been evaluated in pregnant or lactating bitches.

What happens if I miss giving a dose:

Give the missed dose as soon as you remember. Do not give a double dose of the medication.

What should I avoid while giving Ivermectin/Pyrantel to my pet:

Because humans can contract hookworms from animals, it is important to maintain good personal hygiene. It is also important to eliminate fleas on your pet and in the household and to not feed your pet rodents. To prevent reinfection, daily cleanup of stools is recommended.

What are the possible side effects of Ivermectin/Pyrantel:

Side effects of Ivermectin/Pyrantel are rare at the recommended heartworm prevention dose. Higher doses in dogs may cause tremors, dilated pupils, loss of body weight, or death.

What other drugs will affect Ivermectin/Pyrantel:

Do not give Ivermectin/Pyrantel if your pet is already being given another heartworm medication.

How to Use
  • Give Ivermectin/Pyrantel Flavored Chewables once a month on the same day of each month year-round.
  • Ivermectin/Pyrantel Flavored Chewables can be given by hand, mixed intact with a small amount of food, or placed in the back of your dog's mouth for forced swallowing.
  • Watch your dog closely following dosing to be sure the entire dose has been swallowed. If it is not completely swallowed, give one more full recommended dose as soon as possible.

Do not remove the chewable from its wrapper until ready to give to your pet.

Dogs/Puppies: (6 weeks of age and older)
Up to 25 lbs
Give 1 chewable every month (Blue Box)
26-50 lbs
Give 1 chewable every month (Green Box)
51-100 lbs
Give 1 chewable every month (Brown Box)
Over 100 lbs
Give combination of chewables based on weight
Do not use!
Do not use!

Should be stored at room temperature.

Ivermectin/Pyrantel - Blue Box (Dogs up to 25 lbs):
Active Ingredients (per chewable tablet)
68 mcg
57 mg
Ivermectin/Pyrantel - Green Box (Dogs 26-50 lbs):
Active Ingredients (per chewable tablet)
136 mcg
114 mg
Ivermectin/Pyrantel - Brown Box (Dogs 51-100 lbs):
Active Ingredients (per chewable tablet)
272 mcg
227 mg
Customer Reviews
Ivermectin-Pyrantel - Generic to Heartgard Plus is rated 4.375 out of 5 by 936.
Rated 1 out of 5 by from Not Chewable!! Although the package says they're chewable, they are hard as a rock! They are about the size of a nickel and about twice as thick. I have a small dog and he wouldn't eat it. I had to break it in half and force it down his throat. Not recommended.
Date published: 2016-05-13
Rated 1 out of 5 by from Not a good replacment When I ordered this generic replacement I was under the impression that it was at least close to the competitor. Wrong. It is just a pill and not the chewy med that they compete against. My dog would not give the pill a second look even when submerged in chicken fat. Force feed only.
Date published: 2016-05-09
Rated 5 out of 5 by from My dog has been taken this about 2 years now. I have read the reviews and it seems there are alot of different opinions about the medicine. I have a positive review for the medicine because my dog has never had heartworm and he chews everything with no problem, thats why his name is Chewy. I also give it to him with lots of peanut butter on it.
Date published: 2016-05-09
Rated 3 out of 5 by from Blech! I purchased this because this site recommended it as a cheaper alternative to another product (love that about this site!!). Unfortunately it didn't work out. My dogs won't eat them. Not even if they are wrapped in cheese or slathered with peanut butter. I managed to get 2 of them to choke it down, but the 3rd was a no go. They advertise that this product is an "easy chew-able" "great tasting". I disagree. It is a hard, large (for my large dogs) pellet that is more crunchy than chew-able. I know because I stepped on an uneaten piece and it crumbled into powder.
Date published: 2016-05-03
Rated 1 out of 5 by from My Maltese gets sick from Tri -Heart Plus pill I have a Maltese and she does not like this pill have to hide it in her food. I just recently took her to vet because every time I give this to her she vomits and has diarrhea. I am now looking for something to replace it with.
Date published: 2016-04-19
Rated 5 out of 5 by from Why pay more? If the generic works as good as the name brand, why pay more? Heartgard Plus comes in a cube that is difficult for smaller dogs to chew on and eat Tri-Heart Plus is in smaller tablets that my Terriers can crust with no problems compared to Heartgard. And it still works just as well.
Date published: 2016-04-18
Rated 5 out of 5 by from So far so good I purchased this more recently and Cole is on his first dose. He seems to like the flavor (which is a huge plus).
Date published: 2016-04-16
Rated 1 out of 5 by from I returned this medication I wish I had looked at the reviews here before I ordered this. As others have stated, this pill is NOT really chewable, and my dog would NOT eat it. I called 1800petmeds and they credited me what I paid and are sending me regular Heart Guard Plus. Very good customer service!
Date published: 2016-04-15
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Do u have to have a prescription from a vet to order off this site

Asked by: jswift82
Prescriptions are required for any heartworm prevention, we highly encourage you to establish a new Vet, Client, Patient Relationship to ensure your pets health.
Answered by: Pharmacy Manager
Date published: 2016-04-17

What if my vet is no longer in business that's why I'm looking for a place to buy

Asked by: jswift82
This would be a great time to look for a new Veterinarian that will look after your pet's health. Before giving your pet Heartworm prevention they need to perform an updated Heartworm test to be certain your pet does not have heartworms. In the event the prevention is given to your pet and they are heartworm positive it can become extremely harmful to your pet without the proper medical supervision.
Answered by: Pharmacy Manager
Date published: 2016-04-16

Do you need a rx?

Asked by: edintroub
Yes, simply place the order online and our Pharmacy will contact your Pet's Veterinarian where they had their most recent Heart Worm test done. During the check out process we will ask for the information needed to contact the Veterinarian. If you have any further questions in regards to this process our customer care team is standing by to help. Thank you !
Answered by: Pharmacy Manager
Date published: 2016-03-12

Does Tri-Heart Plus have beef content? My dog is very sensitive to beef.

Asked by: REC73
Tri Heart Plus is a beef flavored chewable tablet. Your veterinarian can determine if it is an appropriate choice considering your pet's sensitivity.
Answered by: Lisa M
Date published: 2016-03-04


Asked by: TOBY
Interceptor Plus is currently unavailable through 1800PetMeds. I recommend that you contact your vet to see if he/she is carrying it.
Answered by: SuzyCVT
Date published: 2016-01-13

Perscription Queestion?

If my perscription is writen for Heartguard Plus Can I order the Tri Heart Plus with the Heart Guard Plus prescription because its the generic. Or does the prescription have to say tri heart plus.
Asked by: Anonymous
Call Petmeds and tell them what your prescription reads. They still have to verify it with your vet and you can tell them you want the generic and Petmeds will handle it for you.
Answered by: MarieC
Date published: 2016-03-28

Heartworm+ with a preventative?

I'm so confused. We recently adopted a dog that tested positive for heartworms. Our vet indicated that she be given Tri-Heart Plus (generic) for 3 months before she can be treated for the adult heartworms in hospital, and gave us the medication already to start. I've read in multiple articles, including the manufacturer's website, that the preventative should taken after the treatment, and could be dangerous if given before. I'm not sure if I'm misinterpreting what I'm reading, since I didn't misinterpret our vet's instructions. Has anyone have experience with this? There's nothing we wouldn't do for our pet. Thank you.
Asked by: OBXNC
The most current recommendations for the treatment of heartworm positive dogs has included initial treatment with Heartgard/Tri-Heart/whatever brand of ivermectin heartworm prevention. Yes, there is a small risk of a reaction at the initial dose which is why we administer and monitor the dog in our hospital for the day during this phase of treatment. But don't panic or think your vet is doing something totally inappropriate with this treatment.
Answered by: SuzyCVT
Date published: 2016-04-12

Heart worm med.

Is it ok to store heart worm med. in the refrigerator.
Asked by: Gene
The packaging states the medication should be stored at room temperature.
Answered by: SuzyCVT
Date published: 2015-11-21
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