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Humulin N Insulin

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Q & A

What is Humulin N?

Humulin N insulin is a hormone used for the treatment of diabetes mellitus. It is a crystalline suspension of human insulin with protamine and zinc providing an immediate-acting insulin with a slower onset of of action and a longer duration of activity (up to 24 hours). Each vial contains 100 units/mL of insulin. It's used with U-100 insulin syringes (sold separately). Unopened vials of Humulin N should be stored in the refrigerator and can be used until the expiration date on the box of insulin. Once the vial of Humulin N is opened it may be kept at room temperature (below 86 degrees) or in the refrigerator. In either case, the opened vial should be discarded after 28 days.

To ensure proper temperature, it requires overnight shipping at an additional cost.

For: Dogs and Cats

Benefits:
•	Controls your pet's glucose levels
•	Improvement can be seen in a few days

How it works:
Insulin is a hormone that is naturally produced by the pancreas. When the body does not produce enough insulin, or when the insulin produced is not effective, it results in diabetes mellitus. Humulin N controls hyperglycemia in dogs with diabetes.

Cautions:
Do not switch from one type insulin to another unless under the directions of a veterinarian. Changing from one insulin to another may require an adjustment in the dose. Insulin requires refrigeration. Overnight shipping is required and additional shipping charges are applicable. Rarely, allergic reactions can occur. Seek emergency veterinary medical attention if your pet experiences hives, difficulty breathing, or swelling of the lips, tongue, or face.

More Information:

Brand Name
Humulin-N (Lilly)

Generic Name
NPH human Insulin

What is this medication used for:
Humulin N insulin is a hormone used for the treatment of diabetes mellitus.

Availability:
Humulin N insulin is a non-prescription (OTC) product available as 10 ml vials containing 100 units/ml (U-100).

How this medication should be used:
Humulin N insulin is not FDA approved for use in veterinary medicine; however, it is a commonly accepted practice for veterinarians to use this medication in dogs and cats. The dose of Humulin N insulin is determined by means of a blood glucose test. Doses can vary. In some instances Humulin N insulin may be given once a day and in other instances twice a day.

What are the side effects:
Side effects when using Humulin N insulin may include hypoglycemia (low blood sugar) with symptoms of weakness, tiredness, shaking, seizures or coma. Cats may appear immobile. Hyperglycemia (high blood sugar) has symptoms of increased thirst and urination, vomiting, change in gait or weakness. Allergic reaction may occur. Signs of an allergic reaction may include facial swelling, hives, scratching, sudden onset of diarrhea, vomiting, shock, seizures, or coma.

What special precautions are there:
Do not switch from one type insulin to another unless under the directions of a veterinarian. Changing from one insulin to another may require an adjustment in the dose. This medication should not be used in animals allergic to it. It is important to use the correct insulin syringe. 100 units/ml insulin (U-100) requires a 100 unit syringe. Humulin N insulin suspension should not be shaken but the bottle should be rolled between the hands to mix the vial. If a dose is missed, give the medication as soon as you remember. If it is almost time for the next dose, skip the one that was missed and give the next regularly scheduled dose. Do not give two doses at once. It is potentially less harmful to the pet to give too little insulin, than to give too much. Use caution when insulin is given with anabolic steroids (Winstrol V), beta blockers (propranolol), MAO inhibitors (selegiline), phenylbutazone, sulfinpyrasone, tetracycline or salicylates (aspirin) which can increase the risk of hypoglycemia. Use caution when given with glucocorticoids (prednisone), thyroid medications (levothyroxine), epinephrine, estrogen and progesterone combinations or diuretics (furosemide) which may increase the risk of hyperglycemia. Oral hypoglycemic agents such as glipizide may lower insulin requirements.

In the event of an overdose:
Contact your veterinarian or veterinary emergency room. Overdose of Humulin N insulin causes hypoglycemia. Symptoms include weakness, trembling, unresponsiveness, seizures, coma, and death. Feed the pet a normal meal or place a small amount of sugar water or Karo syrup on the gums. Do not treat an unresponsive pet.

How do I store this medication:
Unopened vials of Humulin N should be stored in the refrigerator and can be used until the expiration date on the box of insulin. Once the vial of Humulin N is opened it may be kept at room temperature (below 86 degrees) or in the refrigerator. In either case, the opened vial should be discarded after 28 days. Do not use Humulin N insulin if it has been frozen. Do not use Humulin N insulin past its expiration date. Keep this medication away from children and pets.

Directions:

•	Humulin N insulin is to help control blood glucose levels in diabetic pets.
•	Humulin N is available in 10 mL vials containing 100 units per mL.
•	Humulin N should be given using a U-100 insulin syringe only. Use of an insulin syringe other than a U-100 syringe will result in incorrect dosing.

Tip: Just prior to use, the vial should be mixed by gently rolling the vial between the palms of your hands 10 times.

Dosage:

Pet	Weight	Dosage
Dogs/Cats:	All weights	The dose of Humulin N insulin is determined by means of a blood glucose test. Doses can vary. In some instances Humulin N insulin may be given once a day and in other instances twice a day.
Horses:

Storage: Unopened vials of Humulin N should be stored in the refrigerator and can be used until the expiration date on the box of insulin. Once the vial of Humulin N is opened it may be kept at room temperature (below 86 degrees) or in the refrigerator. In either case, the opened vial should be discarded after 28 days.

Humulin N Insulin:

Active Ingredient (per mL)	Amount
NPH insulin	100 units
Nonmedicinal ingredients: dibasic sodium phosphate, glycerol, m-cresol, phenol, protamine sulfate and zinc. May contain: dimethicone, hydrochloric acid, and sodium hydroxide.

Humulin N Insulin 3.9 5 13 14

Toy Poodle is doing Great with Humulin N My Toy Poodle Kisses has been doing Great with this product. she was diagnosed with Diabetes in December 2010 and she had been loosing weight and having accidents and drinking more than usual. When I called the vet to bring her in they said it sounded like diabetes and spent all day testing her and a 2nd day trying to get her levels regulated. Kisses was put on the WD prescription food but was loosing alot of weight so I have put her on a wheat free food & I also cook her and my other poodle (Hershey) brown rice with either ground chicken/turkey and add there favorite veggie. Frozen french style green beans. Kisses went from being 13 lbs to just around 7 lbs in less than 2 months after diagnosis. Now she is right around 9 lbs and feeling/acting like a puppy again. Kisses gets 4 units 2x daily and really enjoy's getting her wheat free treat at the end. I love this product and thank my vet for getting the right meds for her the 1st time. 04/11/2012

Humulin N Insulin Old greyhound mix always had liver issues, been on supplements for years. Had frequent accidents in house. Did lots of tests. One day urine on floor was sticky and we realized it was diabetes. Well controlled with Humulin N Insulin. Expensive for a large dog, but worth it. 03/09/2012

12 yr old min pin Our 12 yr old min pin was just recently diag'd as a ketotic diabetic. Almost lost him, Humulin by far of two insulins attempted is the best. This dog is acting like a pup again, gained some of his weight back, and is on the go all of the time. Worth every dollar. 12/30/2011

Humulin for cats My chihuahua is doing great on Humulin but when my 8 yr old cat developed diabetis, my vet said humulin would not work well on the cat. Instead he prescribed Lantus. This was VERY expensive( over $125) AND the pharmacy tech told me to discard it after 28 days! checked with the vet and he said it would be fine to keep using, THe cat, who is doing great, is still on the first bottle from 9/14/10. still have 1/4 bottle left. will get a new one when this one hits experation date of 2/12/12. 10/26/2011

A life saver I have a mixed Terrier that weighs 25 lbs. that has been on "Humulin N" since April of 2005. He takes 9.5 units twice a day (4:30 am / 4:30 pm). His diet consists of Hill's WD dry food and I boil white chicken tenders to mix with his dry food. The chicken is boiled to get the fats out of it.....plus when he has the shakes from low sugar I carry an empty insulin test strip container filled with white Karo syrup to dip a piece of white chicken tender strip in to feed him (about 1-2 teaspoons full) along with the Hill's WD dry food. He has done very well on this insulin and the daily diet I have him on.....By keeping him on this strict diet and feeding him NOTHING ELSE but this I don't have to have his sugar checked unless he gets sick which is very rare. i also give him a "greenie" chewy every day for his teeth. It has been over 6.5 years since he was diagnosed with diabetes and "Buddy" is a happy and well adjusted dog. I hope this helps others who has a loving dog that is diabetic. Proper treatment is necessary because diabetes will cause cataracts which "Buddy' has. It is important to get them to eat as soon as possible after giving them insulin so their sugar does not drop low. (10/16/2011)...John B. 10/16/2011

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1 answer

My 8 lb. Malese is diebetic and is on Humilin N. She get 2 units after breakfast and 2 unirs after dinner.

The Pharmacy tells me that the 10 ML bottle is the only size I can get and it has to be renewed every 30 days. After 30 days I have used only 120 units. since the 10 ML bottle has 1000 units, that means I have to throw out the rest, at $70. - $75.00 a bottle. The Pharmacy tells me I cannot get anything smaller. I have seen a 3 ML bottle On Line, but how do I find out if I can use that one? Is it Lilly? I am a Senior and spending that amount on something I am going to toss in the trash really sucks.

1 month ago

MIMI

Answers

Hello, Yes the 3 ml vial has come on the
market in 2010....and it is exactly the same
thing...You certainly can use it.....It is by
Lilly....I believe the major drug chains are
carrying it.....Also , ask your vet about
the generic Humulin N....called Novolin N
....it may be less costly. The preservative
breaks down once the vial is open after
28 days.... thats why it is not recommended
as bacteria can then contaminate it....making
it unsafe as it may cause serious infections

1 month ago

Linda M 1800petmeds pharmacist

1 answer

Can I use Humulin on my cat?

1 month, 3 weeks ago

Michael

- Indianapolis

Answers

Top 10 Contributor

This may be prescribed for cats. Be sure to consult your vet for proper dosing.

1 month, 3 weeks ago

Laura, PetMed Pro

- Pompano Beach, Florida

1 answer

Can insulin soak threw the skin?

2 months ago

shellby

Answers

No, it can't.

3 weeks, 4 days ago

Rich, Pharmacy Intern

- Pompano Beach

2 answers

Does insulin vial have more than a 30 day shelf life if not opened?

Can I not purchase two vials at a time - open and use one - keeping the other sealed as a back up and then rotate it's use when the previous one has been all used up? Would save time going to pharmacy every month - plus have a safety supply in case the current vial was dropped and broken and pharmacy not open to get immediate replacement.

4 months, 2 weeks ago

Wayne L.

Answers

To prevent panic and disaster from a broken insulin bottle, take first 5 doses from bottle out in individual syringes. Leave in fridge. Order new bottle to arrived a few days before needed. If you break a bottle, you have at 2 day's worth of single dose syringes to get an emergency replacement. My vet and pharmacist confirmed that this is OK, as long as they are refrigerated and used within 30 days.

2 months ago

Mick

- California

Number One Contributor

Great question. Yes you can. The unopened vial can be kept until the expiration date on the box of insulin. Once the vial of Humulin N is opened it may be kept at room temperature (below 86 degrees) or in the refrigerator but in either case the opened vial should be discarded after 28 days.

4 months ago

Gary, Dir. of Pharmacy Services

1 answer

what is difference between humilin n and humilin u

5 months, 1 week ago

Anonymous

Answers

Number One Contributor

Humulin N, is a crystalline suspension of human insulin with protamine and zinc providing an immediate-acting insulin with a slower onset of of action and a longer duration of activity (up to 24 hours). Humulin U, which is no longer manufactured, was a crystalline suspension of human insulin with zinc providing a slower onset and a longer and less intense duration of activity (up to 28 hours).

5 months, 1 week ago

Gary, Dir. of Pharmacy Services

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This information sheet is for educational purposes only and is intended to be a supplement to, and not a substitute for, the expertise and professional judgment of your veterinarian. The information is NOT to be used for diagnosis or treatment of your pet. You should always consult your own veterinarian for specific advice concerning the treatment of your pet. The information is not intended to cover all possible uses, directions, precautions, warnings, allergic reactions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for your pet. It is not a substitute for a veterinary exam, and it does not replace the need for services provided by your veterinarian.
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