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Heartgard Plus Chewables

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1. We'll ask for your vet's info during checkout.
2. We verify your prescription and ship your order!
Starts $44.99 $32.39 
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01-25 lbs
26-50 lbs
51-100 lbs
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Product Info
How to Use
Customer Reviews
Product Info
What is Heartgard Plus Chewables?

Heartgard Plus is a real-beef chewable tablet for dogs that provides protection against heartworms, and treats and controls roundworms and hookworms. Heartgard Plus is given monthly and requires a prescription from your veterinarian.


Dogs (6 weeks of age or older and no weight requirement)

  • Considered the most tasty heartworm chewable tablet (beef flavor)
  • Effectively controls heartworms, roundworms & hookworms
  • Only given once a month
How it Works:

Heartgard Plus contains ivermectin, a broad-spectrum antiparasitic medication used to prevent heartworms. Heartgard Plus also contains Pyrantel Pamoate, an anthelminthic, used to prevent roundworms and hookworms.

Studies have indicated that certain dogs of the herding breeds are more sensitive to the effects of ivermectin administered at elevated dose levels due to the MDR1 gene. Dog breeds that may be affected include Australian Shepherd, Australian Shepherd Mini, Border Collie, Collie and English Shepherd.


Can cause sensitivities in herding dog breeds. Heartgard Plus chewable tablets should be chewed, not swallowed whole. The tablets may be broken into pieces and fed to dogs that normally swallow treats whole. Make sure that your dog eats the entire dose. It is important to give your dog Heartgard Plus every month year-round. Do not skip winter months as your dog may become infected. If you miss than two months of dosage, please consult with your veterinarian as to whether to continue medication.

Brand Name:

Heartgard Plus (Merial), Iverhart Plus (Virbac), Tri-Heart Plus (Intervet)

Generic Name:

Ivermectin, Pyrantel pamoate

What should I discuss with my veterinarian before giving Heartgard Plus to my pet:

Tell your veterinarian if your pet has ever had an allergic reaction to the medication, any of its individual ingredients, or to beef.

How should this medication be given:

Give Heartgard Plus exactly as directed by the veterinarian. If you do not understand the directions ask the pharmacist or veterinarian to explain them to you. Heartgard Plus chewable tablets must be chewed. They should not be swallowed whole. Use with caution, Collies and other herding dog breeds have been known to have adverse reactions to ivermectin administered at elevated dose levels. Heartworm testing should be performed prior to the start of prevention therapy. If the animal is off Heartgard Plus for 6 months or less, start the medication and test after 6 months since microfilaria, that take 6 months to mature, will result in a positive test result. Store Heartgard Plus at room temperature. Do not remove the tablet from its wrapper until ready to give the medicine. Keep this medication away from children and pets. In addition, Heartgard Plus has shown a wide margin of safety at the recommended dose level in dogs including pregnant or breeding bitches, stud dogs and puppies aged 6 or more weeks.

What happens if I miss giving a dose:

Give the missed dose as soon as you remember. Do not give a double dose of the medication.

What should I avoid while giving Heartgard Plus to my pet:

Because humans can contract hookworm from animals, it is important to maintain good personal hygiene. It is also important to eliminate fleas on the pet and in the household and to not feed the pet rodents or uncooked meat or fish. To prevent reinfection, daily cleanup of stools is recommended.

What are the possible side effects of Heartgard Plus:

Side effects of Heartgard Plus are rare at the recommended heartworm prevention dose. Higher doses in dogs may cause tremors, dilated pupils, and loss of body weight and death.

What other drugs will affect Heartgard Plus:

Do not give Heartgard Plus to your pet if already taking another heartworm medication.

How to Use
  • Give Heartgard Plus Chewables once a month on the same day of each month year round.
  • Heartgard Plus Chewables are for dogs only. Do not give to cats.
  • Heartgard Plus Chewables should not be swallowed whole.
  • Chewables may be broken and fed to dogs as pieces, or crumbled and mixed with food.
  • Watch dog closely following dosing to be sure the entire dose has been swallowed. If it is not completely swallowed, give one more full recommended dose as soon as possible.

Do not remove chewable from its wrapper until ready to give to pet.

Dogs/Puppies: (6 weeks of age and older)
Up to 25 lbs
Give 1 chewable every month (Blue Box)
26-50 lbs
Give 1 chewable every month (Green Box)
51-100 lbs
Give 1 chewable every month (Brown Box)
Over 100 lbs
Give combination of chewables based on weight
Do not use!
Do not use!

Store this product at room temperature. Keep out of reach of children.

Heartgard Blue Chewables (for Dogs 1-25 lbs):
Active Ingredient
68 mcg
57 mg
Heartgard Green Chewables (for Dogs 26-50 lbs):
Active Ingredient
136 mcg
114 mg
Heartgard Brown Chewables (for Dogs 51-100 lbs):
Active Ingredient
272 mcg
227 mg
Customer Reviews
Heartgard Plus Chewables is rated 4.7964 out of 5 by 1,007.
Rated 5 out of 5 by from very satisfied My dog has done well on Heargard Plus.
Date published: 2016-06-20
Rated 4 out of 5 by from Cheweable I use to have my husband or son to help give my dog her oral heartworm med, and it was stressful especially for Mocca. Her new vet recommended Heartgard and it was bliss. I just offer it to her as a treat and done! She likes it and no side effects. Only 4 stars for now because I can't attest to its effectivity, yet. So far she's good. The price is LOT cheaper in 1800Petmeds than the pet stores even when they were on sale. Love the free delivery and the dog treat.
Date published: 2016-06-15
Rated 5 out of 5 by from easy to administer easy to give to my dog, he chewed it up like a treat. No issues.
Date published: 2016-06-15
Rated 5 out of 5 by from I've always used the product but it was so expensive coming from my vet. I was seriously paying this much for 6 months. So glad I finally found the site after seeing commercials in tv for years. Came very speedy. No issues.
Date published: 2016-06-14
Rated 4 out of 5 by from Good product, works well for near 2 years now. We will purchase again! Good product.
Date published: 2016-06-12
Rated 5 out of 5 by from My Dogs Love Heartgard Chewables Piper and Lenny love their Chewables, enthusiastically going for the each time I offer them one. We feel well-protected while using the Chewables; negative for heart worm every checkup.
Date published: 2016-06-07
Rated 5 out of 5 by from Benji loves it I give Benji heart guard every month. He loves it, he doesn't have any side effects from this medication.
Date published: 2016-06-04
Rated 5 out of 5 by from No Hassle No hassle with our dear four legged wonders eating these heartworm chews. So much better than tablets!!
Date published: 2016-05-27
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our vet wanted to do a heartworm test. but we can sign a waiver for heartgard. do you also provide a waiver that we could sign to get meds from you?

Asked by: Gordy
My heartgard has an expiration date of 3/2016 would they still be vgood
Answered by: Barbara
Date published: 2016-05-24

If the foil had a small tear & the chew is dried out and hard, is it still effective?

Asked by: Linda
It is suggested that the medication be replaced, if you haven't already done so please contact us for further assistance.
Answered by: Pharmacy Manager
Date published: 2016-04-14

Griff is a Chesapeake retriever he weighs 115 is the box for large dogs 50-100 is that enough meds this is getting expensive?

Asked by: Bella
You would need to provide Griff with the proper coverage based on his current weight, the 50-100lb dose alone would not suffice. He would also need the additional 1-25lb pack as well.
Answered by: Pharmacy Manager
Date published: 2016-04-04

does it need a prescription?

Asked by: Griffin
Yes heartworm preventatives do need a prescription.
Answered by: 1800Petmeds Pharmacist
Date published: 2016-06-14

Does this prevent fleas also

Asked by: jan55
No, Heartgard Plus is a real-beef chewable tablet for dogs that provides protection against heartworms, and treats and controls roundworms and hookworms only. If you are interested in something that covers fleas also, you may want to look into the Trifexis. Trifexis kills fleas and prevents infestations, protects against heartworms, and treats and controls adult hookworm, roundworm, and whipworm infections. You may click on the link below to view the Trifexis. Here is the link:
Answered by: Cherley Petmeds Pro
Date published: 2016-05-29

Does this require a prescription from my vet?

I have been getting the heartguard from my vet which charges for the visits. You have exactly what she is taking. Can I order this ?
Asked by: Raggedyann
Answered by: BUBBASTAMP
Date published: 2016-04-11


I had given my dog his heart guard yesterday My daughter gave him trifexis today which she didn't realize had heart worm preventative in it Will this be extremely harmful for him Should I call the vet
Asked by: Boston
Since the active ingredients are different for the 2 medications, there shouldn't be a problem with over-dosage.
Answered by: SuzyCVT
Date published: 2016-04-15

Dosage concerns

My dog is 9 weeks old and 3 pounds. He is a toy schnauzer. How can the dosage be the same for him as for a 25 pound dog?
Asked by: Rambo
Yes. The medication is very safe and since it is a beefy chew tablet, you can not be sure that the medication is evenly distributed in the chew so for proper dosage, give the entire chew tablet for the up to 25 pound size.
Answered by: SuzyCVT
Date published: 2016-02-19
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