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Compare Frontline Plus to Trifexis
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Frontline Plus
Frontline Plus
(3,926)
Starts $53.74 $38.69
Trifexis
Trifexis
(466)
Starts $137.49 $98.99
Kills Fleas
Repels Fleas
Kills Flea eggs and Larvae
Kills Ticks
Repels Ticks
Kills and/or Repels Mosquitoes *
Prevents Heartworm
Other Parasites Information Eliminates infestations with chewing lice, aids in the control of sarcoptic mange infestation Treats and controls hookworms, roundworms, and whipworms infections.
Waterproof
(shampooing once a week can reduce effectiveness)
Not Applicable
Safe for pregnant or nursing Pets Consult your veterinarian
How long does it take to work Kills Fleas within 12 hours and Ticks within 48 hours Starts to kill fleas within 30 minutes; kills 100% of fleas within 4 hours.
Taste Applied to Skin Beef Flavor
Active Ingredient(s) Fipronil/(S)-Methoprene Spinosad/Milbemycin Oxime
Rx Prescription Required(Details)
Dosage Monthly Monthly
Usage
Video
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Veterinarian Review
(Michael Dym, VMD)
I find that the effective combination of an ingredient like fipronil, along with the insect growth regulator methoprene, provides the best spectrum of activity and protection against all stages of the flea life cycle from egg through larval stage on to adult. Because of these two main ingredients and their method of action, I find that clients don't have to treat the environment as much. I find that this product tends to be safer in smaller breed animals when compared to its competition. I find its tick efficacy quite good. The fact that it is waterproof also allows clients, whose pets swim frequently, to confidently use this product during the swimming months. I also find that this product works the longest for fleas, while some of the competitive products have to be reapplied before the end of the month. The lack of label efficacy against mosquitoes and flies, as well as the fact that this product does not repel fleas or ticks are the two main disadvantages. As with any insecticidal products, I find that every pet is an individual, in terms of which of the products works best on them. When I am dealing with more of a flea issue in a patient, this is the product I will likely reach for first. An exciting and brand new product now available combines the main ingredient of Interceptor milbemycin with a powerful flea insecticide known as spinosad.  Given as a once monthly heartworm preventative, this product also will control and prevent whipworms, hookworms and roundworms, in addition to preventing heartworms. The additional ingredient spinosad allows effective flea and these internal parasite control all in one pill,  making it quite convenient for clients.  As with any pesticide rare digestive tract and neurological side effects may occur but this has not been a major problem in clinical trials. Since it is relatively new I will have to see how this product performs on the fleas but it seems to have excellent potential. I give this product an overall rating of a 5 with an ease of administration a 5 as well, taste a 5.

*Claim approved by the US Environmental Protection Agency; not by California E.P.A.

Our expert panel consists of licensed veterinarians and the knowledgeable staff of PetMed Express, Inc. d/b/a 1-800-PetMeds. Neither the Company nor any of its employees or consultants make any warranties, expressed or implied, or representations about the accuracy or completeness of the content or the content of any site or external sites. Likewise, no legal liability or responsibility is assumed for the accuracy or completeness of any information, or usefulness of products discussed. While every effort has been made to accurately represent the qualities and characteristics of each product, which for the most part were taken directly from the websites of the manufacturers, we are not responsible for any errors.

The information presented is for educational purposes only and is intended to be a supplement to, and not a substitute for, the expertise and professional judgment of your veterinarian. The information is NOT to be used for diagnosis or treatment of your pet. You should always consult your own veterinarian for specific advice concerning the treatment of your pet. The information is not intended to cover all possible uses, directions, precautions, warnings, allergic reactions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for your pet. It is not a substitute for a veterinary exam, and it does not replace the need for services provided by your veterinarian.

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