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DES Compounded

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1. We'll ask for your vet's info during checkout.
2. We verify your prescription and ship your order!
Starts $38.49 $27.71 
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DES 1mg/ml 15ml Liquid
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DES 1mg/ml 30ml Liquid
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DES 1mg/ml 60ml Liquid
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DES 1mg/ml 90ml Liquid
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DES 1mg 10 Capsules
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DES 1mg 30 Capsules
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DES 2mg 10 Capsules
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DES 2mg 30 Capsules
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DES 5mg 10 Capsules
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DES 5mg 30 Capsules
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Product Info
How to Use
What is a compounded medication?
Customer Reviews
Product Info
What is DES Compounded?

DES Compounded is used to treat urinary incontinence in spayed female dogs. It mimics the effects of the natural female hormone, estrogen. Compounding is beneficial in instances where a specific dosage is unavailable or in different forms to make it easier to dose your pet. DES Compounded requires a prescription from your veterinarian.



  • Treats urinary incontinence in spayed female dogs
How it Works:

DES mimics the effects of estrogen, which works for urinary incontinence by improving the function of the nerves of the urinary sphincter.


Keep this and all drugs out of reach of children. Diethylstilbestrol is a prescription drug and should be used according to your veterinarian's directions. It should only be given to the animal for which it was prescribed. Do not give this medication to a person. Pregnant women should not come in contact with DES. DES should not be used in pregnant animals.

How to Use
  • Give this medication to your pet exactly as your veterinarian prescribes. If you miss giving your dog a dose of diethylstilbestrol, give the next dose as soon as you remember or, if it is close to the next scheduled dose, return to the regular schedule. Do not double dose to catch up.
  • DES is given by mouth and may be given with or without food.
  • When used to treat urinary incontinence, other drugs that complement the DES may be prescribed by your veterinarian.

Wash your hands after giving your pet this medication.

What is a compounded medication?
What is a Compounded Medication?

A compounded medication is the creation of a particular medication to fit the unique needs of a patient, including changing the form of the medication (e.g., from a solid pill to a liquid) for a variety reasons (e.g., to make it easier to take, to avoid a non-essential ingredient, to obtain the exact dose needed, adding favorite flavors).

If you are having difficulty giving your pet prescribed medication or need to find a discontinued medication, 1-800-PetMeds offers compounding services on select medications. We can prepare the following: (1) custom strength quantities of a medication (as capsules, liquid, chewable tablets, or transdermal (absorbed through the skin); (2) dosage forms to mask bitter or unpleasant taste (such as capsules or chewable tablets that can also be flavored); (3) dosage forms to make it easier to dose your pet such as a transdermal or liquid (that can also be flavored); and (4) discontinued products such as cisapride or DES.

Customer Reviews
DES Compounded is rated 5.0 out of 5 by 2.
Rated 5 out of 5 by from WHAT A GIFT! For a few weeks our 9 year old dog started wetting the bed. We started with basics like removing her water after 9pm but it didn't matter. Brought her to the vet, expecting some infection and going to pay hundreds. Luckily the vet perscribed DES. Gave it to her and after 2 days the wetting the bed STOPPED! Only down part is that it is a pill that your dog will need to be on for life. Well worth it though :)
Date published: 2014-05-04
Rated 5 out of 5 by from Super product for aging pet! After my 12 year old female mixed breed woke up in a puddle of urine, I thought for sure I would have to put her down. Luckily, I called the vet and she recommended DES about twice a week. It was a miracle! She has absolutely no incontinence whatsoever now, and I am so happy I'll have my girl around at least a little longer. I LOVE Petmeds! A geat company, with great customer service.
Date published: 2013-06-09
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How can I get 0.5mg capsules diethylstilbestrol

My dog is prescribed this once a week
Asked by: Tojo
We do not make 0.5mg DES capsules; however, that dose can be obtained by using 0.5 ml of the DES 1mg/ml liquid.
Answered by: Lisa M
Date published: 2015-08-19

I used to get DES from you but now you don't sell it in NC. Why is that?

Asked by: rose
The compunding pharmacy that we use in not licensed in a few states, North Carolina is one of them. We cannot ship to the states that they are not licensed in.
Answered by: Kelly P
Date published: 2015-04-09

How Much DES is needed for my 7 yr old Husky for once a week?

My husky who turned 7 was put on Des my vet. put her on one pill a week. What mg does she need. The pill last 5-6 days and not the full 7 days?
Asked by: Kathleen
Call your vet and talk to him. He may just change the frequency for her.
Answered by: gabib
Date published: 2015-04-06

Regarding DES

I am wondering if upset stomach is a side effect of DES. I am trying to eliminate possibilities. I give her one dose about twice a week - it seems like she wants to eat grass the next day, often heaves spittle and sometimes won't eat the next meal. I can't seem to find any "common denominator beyond the DES although I can't find that it has possible side effects. She is an Aussie, about 60lb and about 8 years old (rescue dog). She gets one 1mg capsule three times a week
Asked by: Shorty
We have experienced the same with our Lab mix. She didn't want to ride in the car and would eat new bamboo shoots. Now she has DES -coated with peanut butter - with her evening meal and seems to do better with the nausea.
Answered by: Tippy K
Date published: 2014-06-17

Do you carry diethylstilbestrol 1MG in capsule? I am giving my dal this medicine in capsule every other day

Asked by: Indian Girl
Yes, PetMeds sells DES 1mg capsule (quantity 30). This medication does require a prescription from your vet.
Answered by: Janine Pharmacist
Date published: 2013-10-23

DES shelf life?

What is the shelf life of DES liquid? I have about 1/2 of a 90 ML bottle and give 1/2 ML twice a week. I have a loyalty coupon that is good for one more week and could order more but wanted to find out how long the liquid DES lasts.
Asked by: Heeler Healer
Refer to the expiration date on the prescription label. Do not use the medication beyond that date.
Answered by: Pharmacy Intern
Date published: 2013-10-15

Can this be made into a chewable tablet?

My dog is currently getting 1 .5MG chewable table once a week along with Proin daily. The chews are chicken flavored and she likes them. Can these be compounded into the chewable tablet? How much would it cost?
Asked by: kli44ban
DES can be compounded into capsules or into a suspension. There are a variety of flavors available to flavor the suspension. At this time, chew tablets are not available for this medication.
Answered by: Cheryl-Pharmacist
Date published: 2013-08-11

DES 0.5mg caps?

my dog is 13 lbs and is prescribed DES 0.5 mg caps. Do you sell .5mg caps? I only saw 1mg and higher on your site.
Asked by: Cheri
We offer DES in a 1mg per ML liquid in 1/2, 1, 2 and 3 ounce bottles. If your pet is given 0.5ml then that will equal 0.5mg of DES. Since this is a liquid and not in capsule form, please discuss any change in dosage form with your veterinarian to see if the liquid is a good alternative.
Answered by: Lilli Pharmacist
Date published: 2013-08-06
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