What is Comfortis for Dogs & Cats?

Comfortis is the first FDA-approved, chewable beef-flavored tablet that kills fleas and prevents flea infestations on dogs and cats for a full month. Comfortis for Dogs & Cats requires a prescription from your veterinarian.

For:
Dogs & Cats (14 weeks of age or older)

Benefits:
•	Starts killing fleas within 30 minutes
•	Lasts a full month
•	Kills fleas before they can lay eggs
•	Comes in a convenient chewable, beef-flavored tablet
•	Spinosad, the active ingredient in Comfortis, is environmentally friendly

How it works:
Spinosad kills fleas by causing excitation of the insect's nervous system, leading to paralysis and rapid death.

Cautions:
Side effects may occur, including vomiting. If your pet is experiencing loss of appetite, lethargy, or any other difference in behavior, contact your veterinarian. The FDA has received reports of adverse reactions in dogs receiving the drug Comfortis (spinosad) concurrently with high, extra-label doses of ivermectin. Dogs receiving extra-label doses of ivermectin to treat non-responsive demodectic mange and other conditions have developed signs of ivermectin toxicity. Ivermectin is an ingredient found in heartworm preventatives such as Heartgard Plus, Heartgard, Iverhart Plus and Ivomec. In cats, the most common adverse reaction recorded in clinical trials was vomiting. Other adverse reactions were: lethargy, decreased appetite, weight loss, and diarrhea. Use with caution with concomitant extra-label use of ivermectin.

More Information:

Brand Name
Comfortis (Lilly)

Generic Name
Spinosad

What is the most important information I should know about Comfortis: Comfortis is a prescription medication FDA approved for use in dogs and puppies and cats and kittens 14 weeks of age or older to kill fleas and prevent flea infestations for one month. Comfortis is available in a Yellow box for dogs 3.3 to 9 lbs and cats 2-4 lbs (90mg), Pink box for dogs 5 to 10 lbs and cats 4-6 lbs (140mg), Orange box for dogs 10.1 to 20 lbs and cats 6.1-12 lbs (270mg), Green box for dogs 20.1 to 40 lbs and cats 12.1-24 (560mg), Blue box for dogs 40.1 to 60 lbs (810mg), and Brown box for dogs 60.1 to 120 lbs (1620mg). Please note: Cats over 24 lbs should be administered the appropriate combination of tablets.

What is Comfortis: Comfortis is a chewable, synthetic beef flavored tablet (derived from pork protein and hydrolyzed soy) that is given to a dog or cat to kill fleas and prevent flea infestations for one month. Comfortis chewable tablets are for monthly use in dogs and puppies or cats and kittens 14 weeks of age and older.

What should I discuss with my veterinarian before giving Comfortis to my pet: Tell your veterinarian if you are planning on breeding your pet. Tell your veterinarian if your dog or cat has a history of seizures (epilepsy).

How should this medication be given: Give Comfortis chewable tablets with food. Give Comfortis chewable tablets once a month. Comfortis chewable tablets may be chewed, offered in food, or administered like other tablet medications. If vomiting occurs within 1 hour of administration, redose the pet with another full dose. Store Comfortis at room temperature (68-77° F)

What happens if I miss a dose: Give the missed dose with food as soon as you remember and resume a monthly dosing schedule.

What happens if I overdose the pet: Overdose of this medication is unlikely. However, if an overdose is suspected, contact your veterinarian or veterinary emergency room. Symptoms of overdose that may occur include vomiting.

What should I avoid while giving Comfortis: Your pet may maintain normal activities and interactions while being given Comfortis. The safe use of Comfortis in breeding, pregnant, or lactating cats and dogs has not been evaluated.

What are the possible side effects of Comfortis: Side effects that may occur include vomiting. If vomiting occurs within one hour of administration, redose with another full dose. Other side effects may occur. Continue giving Comfortis chewable tablets and talk to your veterinarian if your pet experiences decreased appetite, lethargy or decreased activity, diarrhea, cough, increased thirst, vocalization, increased appetite, redness of the skin, hyperactivity and excessive salivation. Talk to your veterinarian about any side effect that seems unusual or especially bothersome to the pet.

What other drugs will affect Comfortis: Talk to your veterinarian before giving any prescription or over the counter medications.

Where can I get more information: Your pharmacist has additional information about Comfortis written for health professionals that you may read.

Directions for Comfortis for Dogs & Cats:

•	Comfortis is a prescription medication used in dogs to kill fleas and prevent flea infestations for 1 month.
•	Comfortis chewable tablets are beef flavored.
•	Comfortis can be given to dogs at least 14 weeks of age, weighing at least 3.3 lbs, and cats 14 weeks of age, weighing at least 2 lbs.

Tip: If vomiting occurs within 1 hour of administration, redose the pet with another tablet.

Dosage:

Pet	Weight	Dosage
Dogs/Puppies: (14 weeks of age or older)	3.3-4.9 lbs (Yellow Box)	Give one 90mg chewable tablet by mouth once a month. Comfortis may be chewed, offered in food, or administered like other tablet medications
	5-10 lbs (Pink Box)	Give one 140mg chewable tablet by mouth once a month. Comfortis may be chewed, offered in food, or administered like other tablet medications
	10.1-20 lbs (Orange Box)	Give one 270mg chewable tablet by mouth once a month. Comfortis may be chewed, offered in food, or administered like other tablet medications
	20.1-40 lbs (Green Box)	Give one 560mg chewable tablet by mouth once a month. Comfortis may be chewed, offered in food, or administered like other tablet medications
	40.1-60 lbs (Blue Box)	Give one 810mg chewable tablet by mouth once a month. Comfortis may be chewed, offered in food, or administered like other tablet medications
	60.1-120 lbs (Brown Box)	Give one 1620mg chewable tablet by mouth once a month. Comfortis may be chewed, offered in food, or administered like other tablet medications
	Over 120 lbs	Give the appropriate combination of tablets
Cats/Kittens: (14 weeks of age or older)	2-4 lbs (Yellow Box)	Give one 90mg chewable tablet by mouth once a month. Comfortis may be chewed, offered in food, or administered like other tablet medications
	4-6 lbs (Pink Box)	Give one 140mg chewable tablet by mouth once a month. Comfortis may be chewed, offered in food, or administered like other tablet medications
	6.1-12 lbs (Orange Box)	Give one 270mg chewable tablet by mouth once a month. Comfortis may be chewed, offered in food, or administered like other tablet medications
	12.1-24* lbs (Green Box)	Give one 560mg chewable tablet by mouth once a month. Comfortis may be chewed, offered in food, or administered like other tablet medications
Horses:

*Cats over 24 lbs should be administered the appropriate combination of tablets.
Storage: Store Comfortis at room temperature (68-77 F).

Comfortis for Dogs: 3.3-4.9 lbs - Comfortis for Cats: 2-4 lbs (Yellow Box)

Active Ingredient	Amount
Spinosad	90 mg

Comfortis for Dogs: 5-10 lbs - Comfortis for Cats: 4-6 lbs (Pink Box)

Active Ingredient	Amount
Spinosad	140 mg

Comfortis for Dogs 10.1-20 lbs - Comfortis for Cats: 6.1-12 lbs (Orange Box)

Active Ingredient	Amount
Spinosad	270 mg

Comfortis for Dogs 20.1-40 lbs - Comfortis for Cats: 12.1-24 lbs (Green Box)

Active Ingredient	Amount
Spinosad	560 mg

Comfortis for Dogs 40.1-60 lbs (Blue Box)

Active Ingredient	Amount
Spinosad	810 mg

Comfortis for Dogs 60.1-120 lbs (Brown Box)

Active Ingredient	Amount
Spinosad	1,620 mg

Comfortis 4.5 5 810 817

Fleas This products if great! I have used different types of fleas and tick products. This one is well worth the money! 06/23/2011

Good stuff It works, when all the topical stuff did not! 06/22/2011

Skin Issue's We have a white pure bred pit bull who has constant terrible skin issues. We've tried everything and his skin still breaks out in hives, even with the perscription medicated shampoo our vet perscribed us. So when it comes to flea prevention this product was the only one that worked for us. 06/13/2011

Great This stuff is AWESOME, We have industrial strength fleas which i am sure could easily survive a nuclear blast, We have had a huge flea problem due to the mild winter and spring They seem resistant to the topical treatment and I have tried many, Comfortis worked within a couple of hours. It great to see the crew minus the itch 06/13/2011

will kill the fleas We have used this for several years on our 15 inch Beagle who is allergic to fleas. Every Spring she breaks out and itches like crazy. I did not like that on the 2nd and 3rd day it makes her sick. After that she is fine. We discontinued the product for two months and used the drops, what a waste of money. So again we had to go back to Comfortis. I could not stand to see her in such pain. She only takes it in the Spring and first of Summer. One person said it hurt their pets health but Apache Rose's yearly blood tests have been fine so far. 06/13/2011