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Compare Advantage II to Advantage Multi

Advantage II  (Click for Larger Image)
Advantage II
Advantage Multi (Click for Larger Image)
Advantage Multi
Click for Rx info
Made in the USA  
Kills Fleas  
Repels Fleas  
Kills Flea eggs and Larvae  
Kills Ticks  
Repels Ticks  
Kills and/or Repels Mosquitoes  
Prevents Heartworm  
Other Parasites Information Treats, Prevents, and Controls Lice Infestations Treats and Controls some Hookworm Species, some Roundworm Species, Whipworm  
(shampooing once a week can reduce effectiveness)
Safe for pregnant or nursing Pets Consult your veterinarian Consult your veterinarian  
How long does it take to work Kills fleas in 12 hours Kills fleas 12 hours  
Taste Applied to Skin Applied To Skin  
Active Ingredient(s) Imidacloprid/Pyriproxyfen Imidacloprid/Moxidectin  
Rx Prescription Required
Dosage Monthly Monthly  
Video coming soon
Video coming soon
Veterinarian Review
(Michael Dym, VMD)
The non-greasy, non-odor formulation is a definite plus when used on sensitive patients, especially cats. I find that advantage kills fleas and larvae more quickly than some of the other products out there,  often resulting in quicker relief of flea allergy dermatitis symptoms in dogs and cats. Overall I have found it quite safe and have seen the fewest topical or rare systemic reactions in my practice over the years.  The main disadvantage I have found is that in heavy flea infestations that the efficacy may wear off in less than one month, necessitating some vets to recommend more frequent off label use of this product every few weeks.  It also does not control ticks as well on dogs and cats.  I find that advantage works most effectively when combined with good environmental flea control at home. By combining imidacloprid and moxidectin, Advantage Multi offers the wonderful benefit of broad protection against BOTH common internal and external parasites in dogs and cats. An important area of coverage includes not only adult stages, but the immature stages of roundworms and hookworms, two parasites that are a risk to people if not prevented in our pets. It also treats and controls, and prevents whipworms, which are difficult to eradicate in both dogs and the environment. When applied monthly, it is almost 100 percent effective in preventing heartworm disease in dogs and cats. Additional benefits of treating scabies and demodectic mange and ear mites make this a very attractive product. All of this with the wonderful flea control benefits of the product advantage. The greatest benefit I see with this versatile product is that it takes the labor out of administering a myriad of medications to dogs to control these varied internal and external parasites. I also find that it kills the larval stages of fleas in the home surroundings of treated pets, which is a wonderful added benefit. I have on rare occasions seen topical irritation and sensitivity at the site of application, and even more scarce neurological reactions in hypersensitive pets. The only other downside would be the potential high cost of this product, as well as the need for clients to obtain a prescription from their veterinarian. Overall, however, I have found this product to be an excellent and safe all around internal and external parasite control manager in our dogs and cats.  
Our expert panel consists of licensed veterinarians and the knowledgeable staff of PetMed Express, Inc. d/b/a 1-800-PetMeds. Neither the Company nor any of its employees or consultants make any warranties, expressed or implied, or representations about the accuracy or completeness of the content or the content of any site or external sites. Likewise, no legal liability or responsibility is assumed for the accuracy or completeness of any information, or usefulness of products discussed. While every effort has been made to accurately represent the qualities and characteristics of each product, which for the most part were taken directly from the websites of the manufacturers, we are not responsible for any errors.
The information presented is for educational purposes only and is intended to be a supplement to, and not a substitute for, the expertise and professional judgment of your veterinarian. The information is NOT to be used for diagnosis or treatment of your pet. You should always consult your own veterinarian for specific advice concerning the treatment of your pet. The information is not intended to cover all possible uses, directions, precautions, warnings, allergic reactions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for your pet. It is not a substitute for a veterinary exam, and it does not replace the need for services provided by your veterinarian.
Note: Any trademarks are the property of their respective companies.
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